KEGG   PATHWAY: bbis04151
Entry
bbis04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Bison bison bison (American bison)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
bbis04151  PI3K-Akt signaling pathway
bbis04151

Other DBs
GO: 0043491
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104979678  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
104979715  NRTN; neurturin [KO:K25414]
104979781  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
104979792  EPOR; erythropoietin receptor [KO:K05079]
104979825  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
104979900  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104979915  PSPN; persephin [KO:K25416]
104980138  OSM; oncostatin-M [KO:K05418]
104980172  YWHAH; 14-3-3 protein eta [KO:K16198]
104980294  [KO:K06240]
104980438  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
104980781  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
104980934  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
104980990  [KO:K04570]
104981040  VEGFC; vascular endothelial growth factor C [KO:K05449]
104981573  NGF; beta-nerve growth factor [KO:K02582]
104981582  NRAS; GTPase NRas [KO:K07828]
104981661  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
104981835  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
104981942  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
104982022  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
104982141  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104982142  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104982191  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
104982278  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104982427  BDNF; brain-derived neurotrophic factor [KO:K04355]
104982620  MTCP1; protein p13 MTCP-1 [KO:K16837]
104982643  KITLG; kit ligand [KO:K05461]
104982921  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
104982983  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
104982995  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
104983344  ITGB8; integrin beta-8 [KO:K06591]
104983362  GHR; growth hormone receptor isoform X1 [KO:K05080]
104983412  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104983551  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
104983695  [KO:K05415]
104983738  ITGA10; integrin alpha-10 [KO:K06586]
104983944  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
104983973  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
104983977  TNXB; tenascin-X [KO:K06252]
104984118  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104984171  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
104984201  ITGA4; integrin alpha-4 [KO:K06483]
104984370  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
104984522  ITGB5; integrin beta-5 [KO:K06588]
104984659  ITGA11; integrin alpha-11 [KO:K06587]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104984732  THBS4; thrombospondin-4 [KO:K04659]
104984744  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
104984810  [KO:K05414]
104984862  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104984999  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
104985000  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
104985059  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
104985125  TNC; tenascin [KO:K06252]
104985138  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
104985235  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
104985375  ITGA9; integrin alpha-9 [KO:K06585]
104985507  [KO:K05414]
104985533  [KO:K07207]
104985678  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
104985766  PDGFC; platelet-derived growth factor C [KO:K05450]
104985778  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
104986201  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104986245  [KO:K04456] [EC:2.7.11.1]
104986263  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104986307  [KO:K08524]
104986342  LAMB3; laminin subunit beta-3 [KO:K06244]
104986404  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
104986452  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104986454  IRS1; insulin receptor substrate 1 [KO:K16172]
104986509  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104986596  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
104986609  CD19; B-lymphocyte antigen CD19 [KO:K06465]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104986784  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
104986857  COL2A1; collagen alpha-1(II) chain [KO:K19719]
104986929  FGF4; fibroblast growth factor 4 [KO:K04358]
104986966  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
104987029  RELA; transcription factor p65 [KO:K04735]
104987053  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
104987054  FGF19; fibroblast growth factor 19 [KO:K22603]
104987056  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104987131  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104987135  EPO; erythropoietin [KO:K05437]
104987190  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
104987202  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
104987248  VEGFB; vascular endothelial growth factor B [KO:K16858]
104987308  EREG; proepiregulin [KO:K09784]
104987323  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
104987338  AREG; amphiregulin [KO:K09782]
104987347  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
104987407  THBS3; thrombospondin-3 [KO:K04659]
104987413  EFNA1; ephrin-A1 [KO:K05462]
104987414  EFNA3; ephrin-A3 [KO:K05462]
104987415  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
104987448  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104987449  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
104987452  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
104987482  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
104987508  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104987708  MCL1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
104987728  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
104987748  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
104987781  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
104987815  PDGFD; platelet-derived growth factor D [KO:K05450]
104987936  IL6; interleukin-6 [KO:K05405]
104988000  [KO:K08524]
104988050  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
104988058  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
104988133  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104988151  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
104988255  FGF7; fibroblast growth factor 7 [KO:K04358]
104988442  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104988445  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104988446  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
104988453  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
104988664  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
104988726  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
104988728  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104988870  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
104988876  [KO:K04358]
104989082  [KO:K05414]
104989153  TLR2; toll-like receptor 2 [KO:K10159]
104989301  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104989342  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
104989482  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
104989637  [KO:K04456] [EC:2.7.11.1]
104989700  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
104989710  LAMB1; laminin subunit beta-1 [KO:K05636]
104989732  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
104989769  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
104989915  BCL2L1; bcl-2-like protein 1 [KO:K04570]
104989962  PCK1; LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
104990016  ANGPT4; angiopoietin-4 [KO:K05467]
104990035  LAMA5; laminin subunit alpha-5 [KO:K06240]
104990172  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104990266  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
104990277  SOS2; son of sevenless homolog 2 [KO:K03099]
104990283  [KO:K06249] [EC:3.4.21.-]
104990331  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
104990403  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
104990412  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
104990519  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
104990532  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104990595  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104990600  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104990610  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
104990617  COL1A1; collagen alpha-1(I) chain [KO:K06236]
104990622  CHAD; chondroadherin [KO:K06248]
104990630  [KO:K16197]
104990727  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
104990761  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
104990883  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
104991173  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
104991180  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104991399  ITGA6; integrin alpha-6 [KO:K06485]
104991680  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
104991686  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104991741  MYC; myc proto-oncogene protein [KO:K04377]
104991861  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104991914  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
104991946  EFNA2; ephrin-A2 [KO:K05462]
104991948  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104992176  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104992190  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104992206  NTF3; neurotrophin-3 [KO:K04356]
104992215  FGF6; fibroblast growth factor 6 [KO:K04358]
104992217  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
104992296  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
104992339  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
104992344  FGF23; fibroblast growth factor 23 [KO:K22428]
104992483  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104992537  FGF17; fibroblast growth factor 17 [KO:K04358]
104992606  [KO:K05414]
104992619  [KO:K05439]
104992620  [KO:K05439]
104992622  [KO:K05439]
104992623  [KO:K05439]
104992624  [KO:K05439]
104992625  [KO:K05439]
104992626  [KO:K05439]
104992627  [KO:K05439]
104992629  [KO:K05439]
104992631  [KO:K05439]
104992632  [KO:K05439]
104992637  [KO:K05439]
104992684  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
104992716  [KO:K02649]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104992840  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104992905  FGF5; fibroblast growth factor 5 [KO:K04358]
104993012  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
104993223  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
104993343  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104993411  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
104993494  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
104993843  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104993897  COMP; cartilage oligomeric matrix protein [KO:K04659]
104994019  FIGF; vascular endothelial growth factor D [KO:K05449]
104994159  F2R; proteinase-activated receptor 1 [KO:K03914]
104994293  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
104994333  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104994392  THBS1; thrombospondin-1 [KO:K16857]
104994504  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
104994516  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
104994563  [KO:K06630]
104994637  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104994667  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
104994732  [KO:K05414]
104994776  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
104994804  [KO:K13304] [EC:2.7.11.1]
104994833  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
104994949  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
104995049  IL7; interleukin-7 isoform X1 [KO:K05431]
104995056  [KO:K05414]
104995356  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104995460  [KO:K04382] [EC:3.1.3.16]
104995620  [KO:K04371] [EC:2.7.11.24]
104995622  FGF21; fibroblast growth factor 21 [KO:K22429]
104995634  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
104995639  NTF4; neurotrophin-4 [KO:K12457]
104995658  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
104995820  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104995846  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
104995929  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104995965  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
104995998  TNN; tenascin-N [KO:K06252]
104996001  TNR; tenascin-R [KO:K06252]
104996058  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104996149  [KO:K05415]
104996170  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104996248  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104996269  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104996310  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104996312  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
104996613  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
104996628  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
104996675  [KO:K05414]
104996813  FGF9; fibroblast growth factor 9 [KO:K04358]
104996835  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
104996840  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104996912  FGF18; fibroblast growth factor 18 [KO:K04358]
104996944  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
104996946  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
104996980  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
104997014  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
104997052  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
104997220  [KO:K06243]
104997293  [KO:K06243]
104997328  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104997350  YWHAQ; 14-3-3 protein theta [KO:K16197]
104997486  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
104997583  [KO:K05414]
104997725  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
104997842  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
104997987  FGF10; fibroblast growth factor 10 [KO:K04358]
104998031  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
104998109  LAMC2; laminin subunit gamma-2 [KO:K06246]
104998110  LAMC1; laminin subunit gamma-1 [KO:K05635]
104998255  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
104998313  HSP90B1; endoplasmin [KO:K09487]
104998318  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
104998445  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104998527  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
104998537  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
104998543  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
104998559  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104998561  PRLR; prolactin receptor isoform X1 [KO:K05081]
104998666  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
104998683  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
104998747  ANGPT2; angiopoietin-2 [KO:K05466]
104998960  YWHAG; 14-3-3 protein gamma [KO:K16198]
104999231  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
104999274  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
104999800  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
104999818  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
104999859  [KO:K04347]
104999941  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104999951  [KO:K05414]
104999978  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104999981  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105000064  PGF; placenta growth factor isoform X1 [KO:K16859]
105000165  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105000210  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
105000225  KRAS; GTPase KRas isoform X1 [KO:K07827]
105000345  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105000351  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105000418  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105000519  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105000525  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105000612  [KO:K05438]
105000633  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105000706  FOXO3; forkhead box protein O3 [KO:K09408]
105000743  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105000744  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105000759  [KO:K06238]
105000810  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
105000870  TSC1; hamartin [KO:K07206]
105000876  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
105000953  RPS6; 40S ribosomal protein S6 [KO:K02991]
105000961  IFNB1; interferon beta [KO:K05415]
105000962  [KO:K05415]
105000963  [KO:K05415]
105000964  [KO:K05414]
105001056  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105001060  ITGA1; integrin alpha-1 [KO:K06480]
105001181  RHEB; GTP-binding protein Rheb [KO:K07208]
105001191  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105001287  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
105001536  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105001572  ITGB7; integrin beta-7 [KO:K06590]
105001611  ITGA5; integrin alpha-5 [KO:K06484]
105001723  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105001799  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105001822  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
105001963  FGF20; fibroblast growth factor 20 [KO:K04358]
105002073  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105002174  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105002357  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
105002400  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105002469  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
105002554  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105002719  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105002745  PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
105002795  FGF8; fibroblast growth factor 8 [KO:K04358]
105002846  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105002847  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105002851  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105002887  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105002941  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105002990  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105003040  ITGA8; integrin alpha-8 [KO:K06584]
105003123  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105003125  [KO:K05414]
105003180  SPP1; osteopontin [KO:K06250]
105003182  IBSP; bone sialoprotein 2 [KO:K06253]
105003236  IL2; interleukin-2 [KO:K05429]
105003247  FGF2; fibroblast growth factor 2 [KO:K18497]
105003263  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
105003295  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
105003360  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105003412  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
105003509  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105003597  [KO:K04456] [EC:2.7.11.1]
105003692  HRAS; GTPase HRas [KO:K02833]
105003702  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105003731  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105003740  FN1; fibronectin isoform X1 [KO:K05717]
105003907  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105003960  VTN; vitronectin [KO:K06251]
105004076  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105004344  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
105004429  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
105004621  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
105004624  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
105004742  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
105004989  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105005078  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
105005197  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105005203  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105005228  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
105005247  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105005375  [KO:K04542]
105005461  ANGPT1; angiopoietin-1 [KO:K05465]
105005492  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105005553  [KO:K04736]
105005564  IL4; interleukin-4 [KO:K05430]
105005584  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
bbis00010  Glycolysis / Gluconeogenesis
bbis04010  MAPK signaling pathway
bbis04012  ErbB signaling pathway
bbis04062  Chemokine signaling pathway
bbis04064  NF-kappa B signaling pathway
bbis04068  FoxO signaling pathway
bbis04110  Cell cycle
bbis04115  p53 signaling pathway
bbis04150  mTOR signaling pathway
bbis04210  Apoptosis
bbis04370  VEGF signaling pathway
bbis04510  Focal adhesion
bbis04620  Toll-like receptor signaling pathway
bbis04630  JAK-STAT signaling pathway
bbis04662  B cell receptor signaling pathway
bbis04910  Insulin signaling pathway
KO pathway
ko04151   

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