KEGG   PATHWAY: btax04630
Entry
btax04630                   Pathway                                
Name
JAK-STAT signaling pathway - Budorcas taxicolor (takin)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
btax04630  JAK-STAT signaling pathway
btax04630

Other DBs
GO: 0007259
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128062529  IL2; interleukin-2 [KO:K05429]
128051558  IL4; interleukin-4 [KO:K05430]
128059511  IL7; interleukin-7 [KO:K05431]
128050264  IL9; interleukin-9 [KO:K05432]
128062532  IL15; interleukin-15 [KO:K05433]
128062628  IL21; interleukin-21 [KO:K05434]
128058762  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
128048204  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
128070243  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
128063317  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
128066211  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
128043537  IL9R; interleukin-9 receptor [KO:K05073]
128058419  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
128043756  IL21R; interleukin-21 receptor [KO:K05075]
128069677  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
128051755  interleukin-3 [KO:K04736]
128051671  IL5; interleukin-5 [KO:K05428]
128051607  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
128070407  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
128054154  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
128070001  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
128047746  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
128046952  IL6; interleukin-6 [KO:K05405]
128063566  IL11; interleukin-11 [KO:K05417]
128051691  IL13; interleukin-13 [KO:K05435]
128043707  IL27; interleukin-27 subunit alpha [KO:K22629]
128062617  OSM; oncostatin-M [KO:K05418]
128062119  LIF; leukemia inhibitory factor [KO:K05419]
128060931  CNTF; ciliary neurotrophic factor [KO:K05420]
128043253  CTF1; cardiotrophin-1 [KO:K05422]
128043829  cardiotrophin-2-like [KO:K24382]
128069009  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
128045517  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
128066072  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
128052326  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
128069823  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
128070543  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
128050825  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
128066191  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
128066061  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
128066085  LIFR; leukemia inhibitory factor receptor [KO:K05058]
128052177  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
128061792  IL10; interleukin-10 [KO:K05443]
128061793  IL19; interleukin-19 [KO:K05444]
128048882  IL22; interleukin-22 [KO:K05445]
128061821  IL20; interleukin-20 [KO:K22667]
128061741  IL24; interleukin-24 [KO:K22668]
128048928  IL26; interleukin-26 [KO:K05446]
128060929  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
128053481  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
128056199  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
128071495  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
128053508  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
128050368  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
128051514  IL12B; interleukin-12 subunit beta [KO:K05425]
128047301  IL23A; interleukin-23 subunit alpha [KO:K05426]
128051171  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
128045352  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
128045723  IL23R; interleukin-23 receptor [KO:K05065]
128043795  EPO; erythropoietin [KO:K05437]
128065055  GH1; somatotropin [KO:K05438]
128056068  LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439]
128056134  LOW QUALITY PROTEIN: placental prolactin-related protein 1-like [KO:K05439]
128056189  chorionic somatomammotropin hormone 2-like [KO:K05439]
128056261  placental prolactin-related protein 1-like [KO:K05439]
128056286  placental prolactin-related protein 4-like [KO:K05439]
128056321  placental prolactin-related protein 3-like [KO:K05439]
128056535  prolactin [KO:K05439]
128055157  chorionic somatomammotropin hormone [KO:K05439]
128055513  chorionic somatomammotropin hormone 2-like [KO:K05439]
128050927  THPO; thrombopoietin isoform X1 [KO:K06854]
128065541  CSF3; granulocyte colony-stimulating factor [KO:K05423]
128046617  LEP; leptin [KO:K05424]
128051628  EPOR; erythropoietin receptor [KO:K05079]
128065987  GHR; growth hormone receptor isoform X1 [KO:K05080]
128066145  PRLR; prolactin receptor [KO:K05081]
128045373  MPL; thrombopoietin receptor [KO:K05082]
128045256  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
128045230  LEPR; leptin receptor [KO:K05062]
128052429  interferon alpha-H-like [KO:K05414]
128052430  interferon alpha-H-like [KO:K05414]
128052431  interferon alpha-H [KO:K05414]
128052432  interferon alpha-1-like [KO:K05414]
128052433  interferon alpha-H-like [KO:K05414]
128052459  interferon alpha-H-like [KO:K05414]
128052476  interferon alpha-H-like [KO:K05414]
128052682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
128052694  interferon alpha-H-like [KO:K05414]
128052696  interferon alpha-H-like [KO:K05414]
128052697  interferon alpha-1-like [KO:K05414]
128052706  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
128052625  interferon beta-2-like [KO:K05415]
128052626  interferon beta-2-like [KO:K05415]
128052627  interferon beta-2-like [KO:K05415]
128052628  interferon beta-2 [KO:K05415]
128052635  interferon beta-2-like [KO:K05415]
128052636  interferon beta-2-like [KO:K05415]
128052637  interferon beta-2-like [KO:K05415]
128052638  interferon beta-2-like [KO:K05415]
128052639  interferon beta-2-like [KO:K05415]
128052640  interferon beta-2-like [KO:K05415]
128052652  interferon beta-2-like [KO:K05415]
128052870  IFNE; interferon epsilon [KO:K05442]
128052304  IFNK; interferon kappa [KO:K05441]
128063710  interferon lambda-3-like [KO:K22669]
128063821  interferon lambda-3-like [KO:K22669]
128052039  interferon omega-1-like [KO:K05440]
128052245  interferon omega-1-like [KO:K05440]
128052258  interferon omega-1-like [KO:K05440]
128052262  interferon omega-1-like [KO:K05440]
128052280  interferon omega-1-like [KO:K05440]
128052283  interferon omega-1-like [KO:K05440]
128052288  interferon omega-1-like [KO:K05440]
128052291  interferon omega-1 [KO:K05440]
128052292  interferon omega-1-like [KO:K05440]
128052294  interferon omega-1-like [KO:K05440]
128052295  interferon omega-1-like [KO:K05440]
128052300  interferon omega-1-like [KO:K05440]
128052306  interferon omega-1-like [KO:K05440]
128052318  interferon omega-1-like [KO:K05440]
128052331  interferon omega-1-like [KO:K05440]
128052351  interferon omega-1-like [KO:K05440]
128052435  interferon omega-1-like [KO:K05440]
128052311  interferon tau-like [KO:K05440]
128044048  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
128055500  interferon alpha/beta receptor 2 [KO:K05131]
128071166  IFNLR1; interferon lambda receptor 1 [KO:K05140]
128048506  IFNG; interferon gamma [KO:K04687]
128053263  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
128047334  IFNGR2; interferon gamma receptor 2 [KO:K05133]
128050008  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
128065733  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128050429  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128044816  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
128052316  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
128051234  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
128050301  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
128071221  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
128047300  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
128065049  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
128066701  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
128065012  signal transducer and activator of transcription 5A [KO:K11223]
128064838  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
128048609  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
128054182  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
128049458  CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
128043765  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
128047912  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
128064715  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
128053868  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
128056471  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
128064624  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
128067427  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
128067358  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
128045164  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
128058470  BCL2L1; bcl-2-like protein 1 [KO:K04570]
128059210  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
128056115  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128048410  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
128055411  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128064585  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
128064782  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
128060881  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
128064990  GFAP; glial fibrillary acidic protein [KO:K05640]
128058274  STAM; signal transducing adapter molecule 1 [KO:K04705]
128060657  STAM2; signal transducing adapter molecule 2 [KO:K04705]
128067581  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
128047743  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
128043638  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
128047516  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
128053751  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
128067265  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
128045739  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
128050831  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
128070354  FHL1; four and a half LIM domains protein 1 [KO:K14365]
128062064  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
128061515  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
btax04010  MAPK signaling pathway
btax04060  Cytokine-cytokine receptor interaction
btax04110  Cell cycle
btax04120  Ubiquitin mediated proteolysis
btax04151  PI3K-Akt signaling pathway
btax04210  Apoptosis
KO pathway
ko04630   
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