Entry
Name
PI3K-Akt signaling pathway - Budorcas taxicolor (takin)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Budorcas taxicolor (takin) [GN:
btax ]
Gene
128050008 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
128062082 FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497 ]
128065733 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
128068711 VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
128065569 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
128056068 LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439 ]
128056134 LOW QUALITY PROTEIN: placental prolactin-related protein 1-like [KO:K05439 ]
128066061 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
128063317 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
128045256 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
128050602 COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238 ]
128045803 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
128061813 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
128068699 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
128050540 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
128044474 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
128066235 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
128061341 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
128068195 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
128047979 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
128050433 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
128054091 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
128068668 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
128048580 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
128046927 guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
128046735 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
128065234 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290 ]
128065366 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
128065538 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
128064589 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
128059988 eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205 ]
128068203 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205 ]
128056769 LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259 ]
128050970 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
128061904 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
128047355 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
128043844 MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631 ]
128046206 MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629 ]
128051757 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
128063523 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
128070222 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456 ]
128070224 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456 ]
128060694 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456 ]
128051169 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
128052002 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354 ]
128067781 PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
128049472 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
128069911 PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583 ]
128066441 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
128066723 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
128047773 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583 ]
128056208 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
128066367 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
128053851 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584 ]
128061157 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
128068474 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
128044579 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
128061812 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
128071103 cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
128061475 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
128065610 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
128047885 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
128048350 LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374 ]
128044759 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
128051508 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
128052214 CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
128046532 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
128060385 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
128046584 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
128056429 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049 ]
128045164 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
128049417 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
Compound
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Engelman JA, Luo J, Cantley LC
Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Journal
Reference
Authors
Song G, Ouyang G, Bao S
Title
The activation of Akt/PKB signaling pathway and cell survival.
Journal
Reference
Authors
Hers I, Vincent EE, Tavare JM
Title
Akt signalling in health and disease.
Journal
Reference
Authors
Duronio V
Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
Journal
Reference
Authors
Kim D, Chung J.
Title
Akt: versatile mediator of cell survival and beyond.
Journal
Reference
Authors
Koyasu S
Title
The role of PI3K in immune cells.
Journal
Reference
Authors
Okkenhaug K, Vanhaesebroeck B.
Title
PI3K in lymphocyte development, differentiation and activation.
Journal
Reference
Authors
Richardson CJ, Schalm SS, Blenis J
Title
PI3-kinase and TOR: PIKTORing cell growth.
Journal
Reference
Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
Title
Akt, FoxO and regulation of apoptosis.
Journal
Reference
Authors
Georgescu MM
Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
Journal
Reference
Authors
West KA, Castillo SS, Dennis PA
Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Journal
Reference
Authors
Wymann MP, Pirola L
Title
Structure and function of phosphoinositide 3-kinases.
Journal
Reference
Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
Title
Regulation of Raf-Akt Cross-talk.
Journal
Reference
Authors
Kikani CK, Dong LQ, Liu F
Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
Journal
Reference
Authors
Blume-Jensen P, Hunter T
Title
Oncogenic kinase signalling.
Journal
Reference
Authors
Osaki M, Oshimura M, Ito H
Title
PI3K-Akt pathway: its functions and alterations in human cancer.
Journal
Reference
Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Related pathway
btax04620 Toll-like receptor signaling pathway
KO pathway
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