KEGG   PATHWAY: cdk04810
Entry
cdk04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Camelus dromedarius (Arabian camel)
Class
Cellular Processes; Cell motility
Pathway map
cdk04810  Regulation of actin cytoskeleton
cdk04810

Other DBs
GO: 0030036
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105084260  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
105084263  ITGA2; integrin alpha-2 [KO:K06481]
105084385  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105084484  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105084672  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105084809  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
105084810  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
105084895  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
105084907  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
105084979  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105084996  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105085072  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105085346  [KO:K23612]
105085529  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
105085609  [KO:K05764]
105085620  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105085708  GNA13; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
105085847  KNG1; kininogen-1 isoform X2 [KO:K03898]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105086067  [KO:K12757]
105086071  [KO:K12757]
105086159  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105086272  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
105086302  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105086549  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
105086605  FN1; fibronectin isoform X1 [KO:K05717]
105086641  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
105086681  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105086689  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105086777  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
105087311  ITGA11; integrin alpha-11 [KO:K06587]
105087660  VAV1; proto-oncogene vav [KO:K05730]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105088123  CRK; adapter molecule crk isoform X1 [KO:K04438]
105088151  SSH2; protein phosphatase Slingshot homolog 2 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105088154  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
105088693  SCIN; adseverin [KO:K05768]
105088868  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105088933  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
105088954  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105089077  ACTR3; actin-related protein 3 [KO:K18584]
105089379  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105089494  PFN2; profilin-2 isoform X1 [KO:K05759]
105089630  NRAS; GTPase NRas [KO:K07828]
105089680  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
105089720  ITGAX; integrin alpha-X [KO:K06462]
105089721  ITGAM; integrin alpha-M [KO:K06461]
105089741  ITGAD; LOW QUALITY PROTEIN: integrin alpha-D [KO:K06594]
105089905  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105089979  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105090092  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
105090126  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
105090229  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
105090274  ITGB5; integrin beta-5 [KO:K06588]
105090282  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105090426  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105090659  MSN; LOW QUALITY PROTEIN: moesin [KO:K05763]
105090729  ITGA9; integrin alpha-9 [KO:K06585]
105090755  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
105090762  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
105090799  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
105090819  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105091094  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105091154  MYH11; myosin-11 isoform X2 [KO:K10352]
105091178  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
105091254  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
105091325  FGF6; fibroblast growth factor 6 [KO:K04358]
105091333  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
105091467  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105091516  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105091619  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105091663  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105091789  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105091934  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105092280  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105092329  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105092385  MYL10; myosin regulatory light chain 10 [KO:K12756]
105092450  VCL; vinculin isoform X1 [KO:K05700]
105092629  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105092814  C8B; complement component C8 beta chain [KO:K03998]
105092815  C8A; complement component C8 alpha chain [KO:K03997]
105092896  ITGB8; integrin beta-8 [KO:K06591]
105092913  [KO:K02649]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093119  BRK1; protein BRICK1 isoform X1 [KO:K05752]
105093134  [KO:K05755]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105093311  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093420  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105093550  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
105093669  FGF2; fibroblast growth factor 2 [KO:K18497]
105093695  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105094171  CFL2; cofilin-2 isoform X1 [KO:K05765]
105094425  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
105094574  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
105094701  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
105095121  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
105095140  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105095221  CRKL; crk-like protein [KO:K04438]
105095381  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
105095501  BDKRB2; B2 bradykinin receptor [KO:K03916]
105095510  BDKRB1; B1 bradykinin receptor [KO:K03915]
105095567  FGF16; fibroblast growth factor 16 [KO:K04358]
105095759  ITGAE; integrin alpha-E [KO:K06524]
105096071  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105096222  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105096404  FGF9; LOW QUALITY PROTEIN: fibroblast growth factor 9 [KO:K04358]
105096422  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
105096434  [KO:K04289]
105096447  FAM49B; protein FAM49B isoform X2 [KO:K27976]
105096591  RDX; radixin isoform X1 [KO:K05762]
105096888  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
105096922  ITGA8; integrin alpha-8 [KO:K06584]
105097053  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
105097105  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X2 [KO:K05753]
105097166  FAM49A; protein FAM49A isoform X1 [KO:K27976]
105097456  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105098214  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
105098486  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105098499  RGCC; regulator of cell cycle RGCC [KO:K26108]
105098564  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105098690  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
105098747  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
105098775  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
105098905  NCKAP1; nck-associated protein 1 isoform X3 [KO:K05750]
105098976  ITGAV; integrin alpha-V precursor [KO:K06487]
105098980  ABI2; abl interactor 2 isoform X3 [KO:K05751]
105098992  MYH10; myosin-10 isoform X1 [KO:K10352]
105099063  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105099363  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
105099397  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105099426  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
105099582  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105099591  PFN3; profilin-3 [KO:K05759]
105099759  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
105100025  PFN4; profilin-4 [KO:K05759]
105100066  KRAS; GTPase KRas isoform X1 [KO:K07827]
105100175  MYH14; myosin-14 isoform X1 [KO:K10352]
105100199  RRAS; ras-related protein R-Ras [KO:K07829]
105100301  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
105100338  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
105100650  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
105100703  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
105100710  WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
105100801  MYL5; myosin light chain 5 [KO:K12753]
105100824  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
105100875  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105101000  NCKAP1L; nck-associated protein 1-like [KO:K05750]
105101003  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
105101177  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105101260  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
105101281  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105101469  PFN1; profilin-1 [KO:K05759]
105101515  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
105101582  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105101646  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
105101782  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105102004  PXN; paxillin isoform X1 [KO:K05760]
105102061  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105102082  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105102215  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105102396  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
105102482  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
105102484  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
105102494  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105102587  CFL1; cofilin-1 [KO:K05765]
105102665  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105102736  ITGAL; integrin alpha-L isoform X4 [KO:K05718]
105102741  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105102810  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
105102821  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105102848  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
105102899  FGF21; fibroblast growth factor 21 [KO:K22429]
105103128  EZR; ezrin isoform X1 [KO:K08007]
105103212  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [KO:K00889] [EC:2.7.1.68]
105103256  [KO:K05720]
105103397  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105103654  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105103737  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
105103934  ARHGEF7; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 7 [KO:K13710]
105104034  ARHGAP35; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
105104035  [KO:K05764]
105104060  FGFR2; fibroblast growth factor receptor 2 isoform X4 [KO:K05093] [EC:2.7.10.1]
105104066  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X3 [KO:K04347]
105104077  [KO:K05692]
105104128  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
105104247  ACTB; actin, cytoplasmic 1 [KO:K05692]
105104430  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105104434  SSH3; protein phosphatase Slingshot homolog 3 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105104437  GSN; gelsolin [KO:K05768]
105104468  FGF4; fibroblast growth factor 4 [KO:K04358]
105104469  FGF19; fibroblast growth factor 19 [KO:K22603]
105104653  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
105104667  C5; complement C5 [KO:K03994]
105104761  FGF7; fibroblast growth factor 7 [KO:K04358]
105104827  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105105212  MYH9; myosin-9 [KO:K10352]
105105270  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105105372  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105105642  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
105105673  INSRR; LOW QUALITY PROTEIN: insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
105105716  [KO:K05692]
105105749  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105105882  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105105927  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
105105952  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
105106006  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
105106195  [KO:K03999]
105106632  [KO:K06583]
105106860  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
105106867  F2; LOW QUALITY PROTEIN: prothrombin [KO:K01313] [EC:3.4.21.5]
105106878  C9; complement component C9 [KO:K04000]
105106955  C7; complement component C7 [KO:K03996]
105106962  C6; complement component C6 [KO:K03995]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105107141  [KO:K05759]
105107148  FGF10; fibroblast growth factor 10 [KO:K04358]
116150665  [KO:K05692]
116150826  TMSB4X; thymosin beta-4 [KO:K05764]
116150927  [KO:K05752]
116151035  [KO:K23612]
116152037  INS; insulin [KO:K04526]
116154059  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
116155424  PDGFD; platelet-derived growth factor D [KO:K05450]
116155497  [KO:K23612]
116156911  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116157091  [KO:K04358]
116158162  [KO:K05763]
116158292  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
cdk04010  MAPK signaling pathway
cdk04510  Focal adhesion
cdk04520  Adherens junction
KO pathway
ko04810   

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