KEGG   PATHWAY: cimi04810
Entry
cimi04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Cebus imitator (Panamanian white-faced capuchin)
Class
Cellular Processes; Cell motility
Pathway map
cimi04810  Regulation of actin cytoskeleton
cimi04810

Other DBs
GO: 0030036
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108281256  PFN1; profilin-1 [KO:K05759]
108281588  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
108281659  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
108281740  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
108281793  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108282680  [KO:K04368] [EC:2.7.12.2]
108282896  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
108283094  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
108283268  [KO:K04132]
108283288  LIMK2; LIM domain kinase 2 isoform X7 [KO:K05744] [EC:2.7.11.1]
108283419  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108283832  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
108283895  FGF21; fibroblast growth factor 21 [KO:K22429]
108284272  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108284600  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
108284634  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108284665  BRK1; protein BRICK1 [KO:K05752]
108284680  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
108284810  PTK2; focal adhesion kinase 1 isoform X11 [KO:K05725] [EC:2.7.10.2]
108284857  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
108284916  ITGA5; integrin alpha-5 [KO:K06484]
108284917  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
108285094  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
108285158  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
108285172  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
108285266  [KO:K12757]
108285696  [KO:K05765]
108285727  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X6 [KO:K12330]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108285847  C5; complement C5 [KO:K03994]
108285851  GSN; gelsolin isoform X1 [KO:K05768]
108285893  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286155  RGCC; regulator of cell cycle RGCC [KO:K26108]
108286191  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108286458  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108287271  C8G; complement component C8 gamma chain isoform X3 [KO:K03999]
108287474  C9; complement component C9 [KO:K04000]
108287595  IQGAP1; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP1 [KO:K16848]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108287866  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
108287883  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
108287976  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108288453  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108288466  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108288670  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
108288726  INS; insulin [KO:K04526]
108288791  HRAS; GTPase HRas isoform X1 [KO:K02833]
108288896  [KO:K05764]
108288968  MYLK; myosin light chain kinase, smooth muscle isoform X4 [KO:K00907] [EC:2.7.11.18]
108289011  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108289094  [KO:K05756]
108289120  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
108289162  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
108289201  [KO:K07828]
108289213  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
108289377  [KO:K05764]
108289469  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108290027  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108290241  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
108290256  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
108290419  PXN; paxillin isoform X4 [KO:K05760]
108291105  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108291676  MSN; moesin [KO:K05763]
108291683  [KO:K05759]
108291709  ITGAE; integrin alpha-E [KO:K06524]
108291826  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108292003  MYH14; myosin-14 [KO:K10352]
108292150  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108292161  PFN3; profilin-3 [KO:K05759]
108292302  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
108292594  CFL2; cofilin-2 isoform X1 [KO:K05765]
108292610  ITGA11; integrin alpha-11 [KO:K06587]
108292967  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X2 [KO:K05729]
108293133  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
108293223  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
108293365  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
108293384  SPATA13; spermatogenesis-associated protein 13 isoform X3 [KO:K05769]
108293443  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108293672  ITGA10; integrin alpha-10 [KO:K06586]
108293763  SOS1; son of sevenless homolog 1 [KO:K03099]
108293784  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
108293857  ITGAX; integrin alpha-X [KO:K06462]
108293872  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
108293915  ITGAD; integrin alpha-D isoform X2 [KO:K06594]
108293916  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
108294085  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
108294129  FGF19; fibroblast growth factor 19 [KO:K22603]
108294131  FGF3; fibroblast growth factor 3 [KO:K04358]
108294146  FGF4; fibroblast growth factor 4 [KO:K04358]
108294289  ITGA2B; integrin alpha-IIb [KO:K06476]
108294535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108294558  ITGB5; integrin beta-5 [KO:K06588]
108295040  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
108295373  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108295532  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
108295602  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108296197  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108296215  CRKL; crk-like protein [KO:K04438]
108296539  MYH9; myosin-9 isoform X5 [KO:K10352]
108296617  [KO:K04393]
108296669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108296682  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
108296753  [KO:K04513]
108296818  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
108297030  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
108297097  [KO:K05757]
108297155  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
108297310  [KO:K06269] [EC:3.1.3.16]
108297500  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
108298112  FGF16; fibroblast growth factor 16 [KO:K04358]
108298389  RRAS; ras-related protein R-Ras [KO:K07829]
108299017  [KO:K05759]
108299165  [KO:K12755]
108299697  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
108299971  [KO:K07830]
108300154  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108300161  PFN2; profilin-2 isoform X1 [KO:K05759]
108300272  KRAS; GTPase KRas isoform X2 [KO:K07827]
108300657  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108300962  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
108301162  NRAS; GTPase NRas isoform X2 [KO:K07828]
108301260  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
108301473  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
108301641  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
108301684  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108301701  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
108301891  SCIN; adseverin [KO:K05768]
108301984  [KO:K12329]
108302246  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
108302426  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108302480  [KO:K12757]
108302481  [KO:K12757]
108302497  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
108302725  ENAH; protein enabled homolog isoform X4 [KO:K05746]
108303062  PFN4; profilin-4 [KO:K05759]
108303183  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
108303383  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
108303482  [KO:K04392]
108303732  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
108303733  F2R; proteinase-activated receptor 1 [KO:K03914]
108304114  BDKRB2; B2 bradykinin receptor [KO:K03916]
108304115  BDKRB1; B1 bradykinin receptor [KO:K03915]
108304180  FGF2; fibroblast growth factor 2 [KO:K18497]
108304185  MRAS; ras-related protein M-Ras [KO:K07831]
108304214  VAV1; proto-oncogene vav [KO:K05730]
108304861  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
108304872  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
108304905  [KO:K05764]
108305181  ITGA8; integrin alpha-8 [KO:K06584]
108305527  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
108305732  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
108306138  [KO:K05735] [EC:2.7.11.1]
108306328  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
108306401  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108306518  MYH10; myosin-10 isoform X1 [KO:K10352]
108306733  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108306963  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108306984  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
108307078  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108307097  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
108307307  NCKAP1; nck-associated protein 1 [KO:K05750]
108307357  ITGA4; integrin alpha-4 isoform X2 [KO:K06483]
108307420  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
108307689  C7; complement component C7 [KO:K03996]
108307691  C6; complement component C6 [KO:K03995]
108307726  MYH11; myosin-11 isoform X1 [KO:K10352]
108307737  FGF10; fibroblast growth factor 10 [KO:K04358]
108307754  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
108307755  ITGA1; integrin alpha-1 [KO:K06480]
108307856  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
108307868  ARPC1B; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1B [KO:K05757]
108307873  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108307882  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
108308048  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
108308110  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
108308136  ACTB; actin, cytoplasmic 1 [KO:K05692]
108308737  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
108308813  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
108308919  FN1; fibronectin isoform X1 [KO:K05717]
108309049  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
108309195  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
108309304  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
108309429  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108309620  ACTR3; actin-related protein 3 [KO:K18584]
108309660  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
108309970  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
108310119  ABI2; abl interactor 2 isoform X1 [KO:K05751]
108310357  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108310362  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
108310391  CFL1; LOW QUALITY PROTEIN: cofilin-1 [KO:K05765]
108310399  [KO:K05765]
108310755  DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
108310962  [KO:K00920] [EC:2.7.1.149]
108310980  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108311051  KNG1; kininogen-1 [KO:K03898]
108311104  EZR; ezrin isoform X1 [KO:K08007]
108311252  ITGB2; integrin beta-2 [KO:K06464]
108311368  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
108311536  MYL5; myosin light chain 5 [KO:K12753]
108311571  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108311906  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108311978  FGF20; fibroblast growth factor 20 [KO:K04358]
108312284  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
108312367  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108313073  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108313339  CRK; adapter molecule crk isoform X1 [KO:K04438]
108313547  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
108313674  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108313677  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
108313709  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
108313731  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108314503  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
108314544  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
108314807  FGF7; fibroblast growth factor 7 [KO:K04358]
108314882  C8A; complement component C8 alpha chain [KO:K03997]
108314883  C8B; complement component C8 beta chain [KO:K03998]
108314985  [KO:K05692]
108315299  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
108315446  PDGFD; platelet-derived growth factor D [KO:K05450]
108315634  ITGAV; integrin alpha-V [KO:K06487]
108315960  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108316317  FGF23; fibroblast growth factor 23 [KO:K22428]
108316319  FGF6; fibroblast growth factor 6 [KO:K04358]
108316332  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108316440  PIP5K1A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
108316604  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
108316723  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
108316791  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
108316930  RDX; radixin isoform X1 [KO:K05762]
108317207  [KO:K04393]
108317309  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
108317321  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108317559  FGF9; fibroblast growth factor 9 [KO:K04358]
108317590  [KO:K05764]
108317695  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
108317861  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
108317868  VCL; vinculin isoform X1 [KO:K05700]
108318297  ITGB3; integrin beta-3 [KO:K06493]
108318544  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119471502  [KO:K05764]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
cimi04010  MAPK signaling pathway
cimi04510  Focal adhesion
cimi04520  Adherens junction
KO pathway
ko04810   

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