KEGG   PATHWAY: clud04620
Entry
clud04620                   Pathway                                
Name
Toll-like receptor signaling pathway - Canis lupus dingo (dingo)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
clud04620  Toll-like receptor signaling pathway
clud04620

Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112641287  TNF; tumor necrosis factor [KO:K03156]
112641479  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112641481  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112642928  TLR5; toll-like receptor 5 isoform X2 [KO:K10168]
112643194  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3 [KO:K07211] [EC:2.7.11.10]
112644286  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
112644385  CXCL11; LOW QUALITY PROTEIN: C-X-C motif chemokine 11 [KO:K12672]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112645138  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645608  SPP1; osteopontin isoform X1 [KO:K06250]
112645861  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
112645941  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112646333  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112647088  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
112647115  JUN; transcription factor Jun [KO:K04448]
112647170  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112647216  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112647348  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112650004  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112650215  IFNB1; interferon beta [KO:K05415]
112650216  [KO:K05414]
112650218  [KO:K05414]
112650347  [KO:K05414]
112650391  [KO:K05414]
112650394  [KO:K05414]
112650424  [KO:K05414]
112650509  [KO:K05414]
112651834  IL12B; interleukin-12 subunit beta [KO:K05425]
112652282  CXCL8; interleukin-8 [KO:K10030]
112652877  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
112652898  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
112652913  TLR8; toll-like receptor 8 [KO:K10170]
112653490  [KO:K10169]
112654591  TLR2; toll-like receptor 2 isoform X2 [KO:K10159]
112655299  CCL5; C-C motif chemokine 5 [KO:K12499]
112655308  [KO:K05408]
112655370  [KO:K05408]
112655372  [KO:K05408]
112655373  CCL4; C-C motif chemokine 4 [KO:K12964]
112656000  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
112656324  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112656364  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112656934  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112657153  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112657364  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112657374  FOS; protein c-Fos [KO:K04379]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112658720  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112658985  CD14; monocyte differentiation antigen CD14 [KO:K04391]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112659329  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112659577  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112661621  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
112661687  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112662614  [KO:K05414]
112662615  [KO:K05414]
112662616  [KO:K05414]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112663192  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
112663244  [KO:K05402]
112663495  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112663568  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
112663999  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
112664386  IL1B; interleukin-1 beta [KO:K04519]
112665560  MAPK11; mitogen-activated protein kinase 11 isoform X3 [KO:K04441] [EC:2.7.11.24]
112665622  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
112665875  TLR9; LOW QUALITY PROTEIN: toll-like receptor 9 [KO:K10161]
112666294  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
112666319  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112666418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112666499  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112667628  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
112668352  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
112668372  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112668882  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112669083  [KO:K04371] [EC:2.7.11.24]
112670385  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
112670562  IL6; interleukin-6 [KO:K05405]
112671091  [KO:K05403]
112671968  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
112672189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112673935  [KO:K05399]
112674058  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
112675069  IRF5; interferon regulatory factor 5 isoform X1 [KO:K09446]
112675199  TLR3; toll-like receptor 3 [KO:K05401]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112677363  CD86; T-lymphocyte activation antigen CD86 isoform X3 [KO:K05413]
112677731  CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412]
112677914  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
112678012  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112678201  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112678621  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
118350179  [KO:K05414]
118350181  [KO:K05414]
118350183  [KO:K05414]
118350222  [KO:K05414]
118350223  [KO:K05414]
118350228  [KO:K05414]
125756056  [KO:K05414]
125756057  [KO:K05414]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
clud04010  MAPK signaling pathway
clud04060  Cytokine-cytokine receptor interaction
clud04064  NF-kappa B signaling pathway
clud04120  Ubiquitin mediated proteolysis
clud04151  PI3K-Akt signaling pathway
clud04210  Apoptosis
clud04610  Complement and coagulation cascades
clud04630  JAK-STAT signaling pathway
KO pathway
ko04620   

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