KEGG   PATHWAY: clud04151
Entry
clud04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Canis lupus dingo (dingo)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
clud04151  PI3K-Akt signaling pathway
clud04151

Other DBs
GO: 0043491
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112671646  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112674472  TGFA; protransforming growth factor alpha [KO:K08774]
112652315  EREG; proepiregulin [KO:K09784]
112652277  AREG; amphiregulin [KO:K09782]
112659082  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
112642713  FGF2; fibroblast growth factor 2 isoform X2 [KO:K18497]
112646589  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112669052  FGF6; fibroblast growth factor 6 [KO:K04358]
112669538  FGF9; fibroblast growth factor 9 [KO:K04358]
112669777  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112671881  FGF16; fibroblast growth factor 16 [KO:K04358]
112672591  FGF8; fibroblast growth factor 8 [KO:K04358]
112663090  FGF3; fibroblast growth factor 3 [KO:K04358]
112663188  FGF4; fibroblast growth factor 4 [KO:K04358]
112651446  FGF10; fibroblast growth factor 10 [KO:K04358]
112651532  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
112675596  FGF20; fibroblast growth factor 20 [KO:K04358]
112666152  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
112675956  FGF7; fibroblast growth factor 7 [KO:K04358]
112663089  FGF19; fibroblast growth factor 19 [KO:K22603]
112645189  FGF21; fibroblast growth factor 21 [KO:K22429]
112669051  FGF23; fibroblast growth factor 23 [KO:K22428]
112664154  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
112667789  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112669071  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
112645173  NTF4; neurotrophin-4 [KO:K12457]
112663225  INS; insulin [KO:K04526]
112654388  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
112663224  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
112640154  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
112667672  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
112671430  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112654298  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
112640696  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112654459  KITLG; kit ligand isoform X3 [KO:K05461]
112645147  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
112641644  VEGFA; vascular endothelial growth factor A [KO:K05448]
112659346  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112657742  PGF; placenta growth factor isoform X1 [KO:K16859]
112651106  VEGFC; vascular endothelial growth factor C [KO:K05449]
112653161  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
112661349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112662054  ANGPT1; angiopoietin-1 isoform X5 [KO:K05465]
112659164  ANGPT2; angiopoietin-2 [KO:K05466]
112673729  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
112648941  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
112648944  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
112648951  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
112654163  EFNA5; ephrin-A5 isoform X2 [KO:K05462]
112666182  EFNA2; ephrin-A2 [KO:K05462]
112652720  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112666351  NRTN; neurturin [KO:K25414]
112666348  neurturin [KO:K25414]
112642631  ARTN; artemin [KO:K25415]
112666370  PSPN; persephin [KO:K25416]
112661500  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112655065  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
112678033  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112656400  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
112649669  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112672433  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112653432  FGFR3; fibroblast growth factor receptor 3 isoform X2 [KO:K05094] [EC:2.7.10.1]
112651476  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112655628  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112648872  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112644636  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112666443  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112653816  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112652233  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112651939  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112651311  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112652143  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
112669483  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
112669481  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
112659573  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112652118  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112670796  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
112650526  TEK; angiopoietin-1 receptor isoform X3 [KO:K05121] [EC:2.7.10.1]
112660092  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
112672017  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112672798  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112657995  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112664493  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112665533  KRAS; GTPase KRas isoform X1 [KO:K07827]
112664166  NRAS; GTPase NRas [KO:K07828]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112666294  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112669083  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
112669817  IRS1; insulin receptor substrate 1 [KO:K16172]
112654591  TLR2; toll-like receptor 2 isoform X2 [KO:K10159]
112650004  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112646333  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
125755517  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
112644845  SYK; tyrosine-protein kinase SYK isoform X3 [KO:K05855] [EC:2.7.10.2]
112640024  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
112672121  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
112652976  somatotropin isoform X1 [KO:K05438]
112657409  PRL; prolactin [KO:K05439]
112676800  OSM; oncostatin-M [KO:K05418]
112642744  IL2; interleukin-2 [KO:K05429]
112670562  IL6; interleukin-6 [KO:K05405]
112678641  IL7; interleukin-7 [KO:K05431]
112650216  interferon alpha-1/2 [KO:K05414]
112650218  interferon alpha-1/2 [KO:K05414]
112650347  interferon alpha-1/2-like [KO:K05414]
112650391  interferon alpha-1/2-like [KO:K05414]
112650394  interferon alpha-1/2-like [KO:K05414]
112650424  interferon alpha-1/2 [KO:K05414]
112662614  interferon alpha-1/2 [KO:K05414]
112662615  interferon alpha-1/2-like [KO:K05414]
112662616  interferon alpha-2-like [KO:K05414]
112650509  interferon alpha-1/2-like [KO:K05414]
118350223  interferon alpha-3 [KO:K05414]
118350179  interferon alpha-1/2 [KO:K05414]
118350228  interferon alpha-1/2 [KO:K05414]
125756056  interferon alpha-1/2 [KO:K05414]
118350222  interferon alpha-1/2 [KO:K05414]
125756057  interferon alpha-1/2 [KO:K05414]
118350183  interferon alpha-1/2 [KO:K05414]
118350181  interferon alpha-1/2-like [KO:K05414]
112650215  IFNB1; interferon beta [KO:K05415]
112646224  EPO; erythropoietin [KO:K05437]
112655620  CSF3; granulocyte colony-stimulating factor [KO:K05423]
112652645  GHR; growth hormone receptor isoform X1 [KO:K05080]
112652692  PRLR; prolactin receptor isoform X1 [KO:K05081]
112652647  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
112658965  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
112668470  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
112671816  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
112651949  IL3RA; interleukin-3 receptor subunit alpha isoform X2 [KO:K04737]
112647724  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
112640010  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
112652729  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
112661621  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
112661687  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112666540  EPOR; erythropoietin receptor [KO:K05079]
112642387  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
112647170  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112644815  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
112666727  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
112674906  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112655086  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
112678247  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
112669820  COL4A4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
112669822  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
112649263  COL4A5; collagen alpha-5(IV) chain isoform X2 [KO:K06237]
112649264  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
112656116  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
112656117  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
112669237  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112669238  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
112661076  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
112661147  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
112661094  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
112669965  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112674244  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
112642312  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
112658392  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
112648045  LAMA1; laminin subunit alpha-1 [KO:K05637]
112644554  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
112647953  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
112674230  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
112658627  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
112661476  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
112665771  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
112648343  LAMB3; laminin subunit beta-3 [KO:K06244]
112661363  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
112648478  LAMC1; laminin subunit gamma-1 [KO:K05635]
112648481  LAMC2; laminin subunit gamma-2 [KO:K06246]
112677344  LAMC3; laminin subunit gamma-3 isoform X2 [KO:K06247]
112655130  CHAD; chondroadherin [KO:K06248]
112661278  RELN; reelin [KO:K06249] [EC:3.4.21.-]
112676140  THBS1; thrombospondin-1 [KO:K16857]
112666762  cartilage oligomeric matrix protein [KO:K04659]
112644448  THBS2; thrombospondin-2 [KO:K04659]
112648934  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112653497  THBS4; thrombospondin-4 [KO:K04659]
112656719  FN1; fibronectin isoform X1 [KO:K05717]
112645608  SPP1; osteopontin isoform X1 [KO:K06250]
112677673  VTN; vitronectin [KO:K06251]
112648572  TNR; LOW QUALITY PROTEIN: tenascin-R [KO:K06252]
112648576  TNN; tenascin-N isoform X1 [KO:K06252]
112649762  TNC; tenascin isoform X1 [KO:K06252]
112641331  TNXB; tenascin-X isoform X1 [KO:K06252]
112669074  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
112645619  bone sialoprotein 2 [KO:K06253]
112651694  ITGA1; integrin alpha-1 [KO:K06480]
112651978  ITGA2; integrin alpha-2 [KO:K06481]
112655470  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
112655049  ITGA3; integrin alpha-3 [KO:K06482]
112668203  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
112667148  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
112668097  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112678053  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112658818  ITGA8; integrin alpha-8 [KO:K06584]
112668768  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
112664057  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112675693  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
112668239  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
112679018  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
112652894  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
112672808  ITGB4; integrin beta-4 isoform X5 [KO:K06525]
112676939  ITGB5; integrin beta-5 [KO:K06588]
112674692  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112667269  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
112670545  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
112662017  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112653184  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
112659439  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
112670443  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112650565  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
112666792  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
112640969  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
112671892  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
112675336  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
112678898  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
112646989  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
112646227  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
112675357  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
112662839  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
112675918  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
112657088  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
112659234  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
112660832  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112640978  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112674423  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
112641449  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
112666239  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112643889  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
112649667  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
112674912  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
112641086  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112666571  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112640603  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
112674914  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
112655071  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112661375  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
112647383  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
112647384  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X4 [KO:K21290]
112640520  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112666174  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
112647094  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112652680  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112651535  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
112677368  TSC1; hamartin isoform X1 [KO:K07206]
112640546  TSC2; tuberin isoform X1 [KO:K07207]
112663472  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
112640538  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
112678102  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112672911  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
112648317  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112644896  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
112669908  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
112651698  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
112656570  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
125754673  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
112655510  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112659290  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
112667199  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
112650443  RPS6; 40S ribosomal protein S6 isoform X1 [KO:K02991]
118351175  40S ribosomal protein S6-like [KO:K02991]
112645871  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
118354148  40S ribosomal protein S6-like [KO:K02991]
112647577  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
112654846  40S ribosomal protein S6-like [KO:K02991]
112666468  40S ribosomal protein S6-like [KO:K02991]
112677796  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
112652873  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
112666630  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
112640927  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
112677281  PKN3; serine/threonine-protein kinase N3 isoform X2 [KO:K23692] [EC:2.7.11.13]
112644153  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
112673975  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
112678557  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112666031  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
112661274  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
112656209  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112663941  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
112649885  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112643039  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112671356  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
112643382  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
112669708  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
112660214  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112672520  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112653371  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X3 [KO:K04354]
112657125  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
112661059  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
112651920  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
112657077  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
112657523  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112659327  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112648383  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112641606  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112657069  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112641656  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
112659659  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
112668821  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
112654292  HSP90B1; endoplasmin [KO:K09487]
112666500  CDC37; hsp90 co-chaperone Cdc37 isoform X2 [KO:K09554]
112647744  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
112644033  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
112646599  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
112657414  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
112657416  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
112668335  MTCP1; protein p13 MTCP-1 [KO:K16837]
112663787  NOS3; nitric oxide synthase, endothelial isoform X3 [KO:K13242] [EC:1.14.13.39]
112655359  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
112677588  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
112645175  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
112665506  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
112657245  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
112674170  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
112655217  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
112655440  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
112668280  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
112662261  MYC; myc proto-oncogene protein [KO:K04377]
112663184  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112641497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112665406  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112678040  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112677962  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112654545  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
112674930  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
112669048  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112641579  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
112645606  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112650816  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112658587  FOXO3; forkhead box protein O3 [KO:K09408]
112660467  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
112648603  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112664417  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
112671427  14-3-3 protein theta-like [KO:K16197]
112661983  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
112674006  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
112664855  YWHAQ; 14-3-3 protein theta [KO:K16197]
112654641  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
112661372  14-3-3 protein zeta/delta-like [KO:K16197]
112671739  14-3-3 protein theta-like [KO:K16197]
112665948  14-3-3 protein zeta/delta-like [KO:K16197]
112677584  YWHAE; 14-3-3 protein epsilon isoform X4 [KO:K06630]
112648525  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
112646175  YWHAG; 14-3-3 protein gamma [KO:K16198]
112676845  YWHAH; 14-3-3 protein eta [KO:K16198]
112649868  14-3-3 protein gamma [KO:K16198]
112659359  BAD; bcl2-associated agonist of cell death [KO:K02158]
112673768  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112644027  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
112659987  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112656471  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112668134  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112667576  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112647736  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
112670436  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
112650165  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
112663293  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
112666968  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
112670641  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
112641337  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
112664006  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
112677388  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
112667240  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112668352  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
112672189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112656000  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112644160  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
112677878  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112647438  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
clud00010  Glycolysis / Gluconeogenesis
clud04010  MAPK signaling pathway
clud04012  ErbB signaling pathway
clud04062  Chemokine signaling pathway
clud04064  NF-kappa B signaling pathway
clud04068  FoxO signaling pathway
clud04110  Cell cycle
clud04115  p53 signaling pathway
clud04150  mTOR signaling pathway
clud04210  Apoptosis
clud04370  VEGF signaling pathway
clud04510  Focal adhesion
clud04620  Toll-like receptor signaling pathway
clud04630  JAK-STAT signaling pathway
clud04662  B cell receptor signaling pathway
clud04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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