Entry
Name
Cytokine-cytokine receptor interaction - Canis lupus dingo (dingo)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
clud04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Canis lupus dingo (dingo) [GN:
clud ]
Gene
112652150 growth-regulated protein homolog gamma-like isoform X2 [KO:K05505 ]
112652148 growth-regulated protein homolog gamma-like isoform X1 [KO:K05505 ]
112644385 CXCL11; LOW QUALITY PROTEIN: C-X-C motif chemokine 11 [KO:K12672 ]
112650098 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
112659431 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
112664381 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
112640696 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
112666922 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
112648603 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
112650582 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
112645969 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
112678837 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
112647450 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
112650203 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
112666382 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
112648235 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
112648598 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
112647449 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
112656037 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
112645426 TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375 ]
112643136 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
112666223 AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665 ]
112658965 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
112668470 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
112671816 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
112640010 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
112652729 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
112659058 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
112651949 IL3RA; interleukin-3 receptor subunit alpha isoform X2 [KO:K04737 ]
112651927 granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
112651941 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066 ]
112649178 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
112649211 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X5 [KO:K05077 ]
112642387 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
112647724 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
112660681 IL6ST; LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta [KO:K05060 ]
112649975 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
112666733 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
112647203 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
112666614 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
112660592 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
112649683 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
112652647 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
112661558 IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135 ]
112644177 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
112661123 IL20RB; interleukin-20 receptor subunit beta isoform X3 [KO:K05137 ]
112669080 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158 ]
112669082 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
112646972 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
112674277 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
112656223 FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390 ]
112646925 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
112641697 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
112652362 tumor necrosis factor receptor superfamily member 21-like [KO:K05157 ]
112669438 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
112655628 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
112662449 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
112644038 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
112640492 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
112678125 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X5 [KO:K05145 ]
112674058 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
112646898 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X2 [KO:K05146 ]
112647022 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
112647025 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
112679076 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
112647227 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
112666847 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
112669528 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
112667449 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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