KEGG   PATHWAY: clud04010
Entry
clud04010                   Pathway                                
Name
MAPK signaling pathway - Canis lupus dingo (dingo)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
clud04010  MAPK signaling pathway
clud04010

Other DBs
GO: 0000165
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112666862  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
112677513  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X4 [KO:K04849]
112668971  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X3 [KO:K04850]
112665919  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112648457  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
112673110  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
112655056  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
112640592  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
112675168  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
112667091  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
112661473  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
112665719  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
112665928  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
112669087  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
112655098  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
112659104  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
112678271  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
112673312  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
112652989  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112668629  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
112640229  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
112652955  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
112652974  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
112645034  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
112645033  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
112643683  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
112666620  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112640987  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112652873  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
112640230  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112645036  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112640210  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
112641086  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112666571  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112644642  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
112669758  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
112651490  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112650031  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
112673922  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
112653482  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
112653131  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
112676148  RASGRP1; RAS guanyl-releasing protein 1 isoform X2 [KO:K04350]
112659488  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
112664548  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
112645519  RASGRP4; RAS guanyl-releasing protein 4 isoform X4 [KO:K12363]
112654608  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
112677691  NF1; neurofibromin isoform X1 [KO:K08052]
112653254  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
112660974  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
112663891  RAP1A; ras-related protein Rap-1A [KO:K04353]
112677882  RAP1B; ras-related protein Rap-1b [KO:K07836]
112671646  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112674472  TGFA; protransforming growth factor alpha [KO:K08774]
112652315  EREG; proepiregulin [KO:K09784]
112652277  AREG; amphiregulin [KO:K09782]
112659082  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
112642713  FGF2; fibroblast growth factor 2 isoform X2 [KO:K18497]
112646589  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112669052  FGF6; fibroblast growth factor 6 [KO:K04358]
112669538  FGF9; fibroblast growth factor 9 [KO:K04358]
112669777  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112671881  FGF16; fibroblast growth factor 16 [KO:K04358]
112672591  FGF8; fibroblast growth factor 8 [KO:K04358]
112663090  FGF3; fibroblast growth factor 3 [KO:K04358]
112663188  FGF4; fibroblast growth factor 4 [KO:K04358]
112651446  FGF10; fibroblast growth factor 10 [KO:K04358]
112651532  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
112675596  FGF20; fibroblast growth factor 20 [KO:K04358]
112666152  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
112675956  FGF7; fibroblast growth factor 7 [KO:K04358]
112663089  FGF19; fibroblast growth factor 19 [KO:K22603]
112645189  FGF21; fibroblast growth factor 21 [KO:K22429]
112669051  FGF23; fibroblast growth factor 23 [KO:K22428]
112664154  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
112667789  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112669071  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
112645173  NTF4; neurotrophin-4 [KO:K12457]
112663225  INS; insulin [KO:K04526]
112654388  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
112663224  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
112640154  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
112667672  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
112671430  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112654298  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
112640696  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112654459  KITLG; kit ligand isoform X3 [KO:K05461]
112645147  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
112641644  VEGFA; vascular endothelial growth factor A [KO:K05448]
112659346  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112657742  PGF; placenta growth factor isoform X1 [KO:K16859]
112651106  VEGFC; vascular endothelial growth factor C [KO:K05449]
112653161  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
112661349  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112662054  ANGPT1; angiopoietin-1 isoform X5 [KO:K05465]
112659164  ANGPT2; angiopoietin-2 [KO:K05466]
112673729  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
112648941  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
112648944  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
112648951  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
112654163  EFNA5; ephrin-A5 isoform X2 [KO:K05462]
112666182  EFNA2; ephrin-A2 [KO:K05462]
112652720  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
112666351  NRTN; neurturin [KO:K25414]
112666348  neurturin [KO:K25414]
112642631  ARTN; artemin [KO:K25415]
112666370  PSPN; persephin [KO:K25416]
112661500  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112655065  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
112678033  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112656400  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
112649669  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112672433  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112653432  FGFR3; fibroblast growth factor receptor 3 isoform X2 [KO:K05094] [EC:2.7.10.1]
112651476  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112655628  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
112648872  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112644636  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112666443  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112653816  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112652233  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112651939  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112651311  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112652143  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
112669483  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
112669481  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
112659573  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112652118  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112670796  MET; hepatocyte growth factor receptor isoform X3 [KO:K05099] [EC:2.7.10.1]
112650526  TEK; angiopoietin-1 receptor isoform X3 [KO:K05121] [EC:2.7.10.1]
112660092  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
112672017  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112672798  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112657995  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112664493  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112665533  KRAS; GTPase KRas isoform X1 [KO:K07827]
112664166  NRAS; GTPase NRas [KO:K07828]
112645140  RRAS; ras-related protein R-Ras [KO:K07829]
112667665  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
112660985  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
112673245  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112650991  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112675721  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112666294  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
112644759  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
112654731  ragulator complex protein LAMTOR3-like [KO:K04370]
112640050  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112677029  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112669083  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
112666215  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
112642541  MKNK1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
112644423  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
112660010  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112649503  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
112654011  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
112667576  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
112673250  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112643215  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
112662261  MYC; myc proto-oncogene protein [KO:K04377]
112641615  SRF; serum response factor isoform X1 [KO:K04378]
112657374  FOS; protein c-Fos [KO:K04379]
112653038  MAPT; microtubule-associated protein tau isoform X4 [KO:K04380]
112660118  STMN1; stathmin isoform X2 [KO:K04381]
112648524  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
112676070  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
112676071  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112676072  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
112676074  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
112641287  TNF; tumor necrosis factor [KO:K03156]
112664387  IL1A; interleukin-1 alpha [KO:K04383]
112664386  IL1B; interleukin-1 beta [KO:K04519]
112645426  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
112643136  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
112657820  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
112669080  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
112669932  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
112645830  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
112649823  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
112668662  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
112648603  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112656223  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
112658985  CD14; monocyte differentiation antigen CD14 [KO:K04391]
112646333  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
112668452  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
112672959  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112659940  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112672066  cell division control protein 42 homolog [KO:K04393]
112660852  cell division control protein 42 homolog [KO:K04393]
112675684  cell division control protein 42 homolog [KO:K04393]
112646480  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112675231  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112677465  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
112641390  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
112668882  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112668372  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112678201  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112663495  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112644859  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112641088  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112666236  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112667628  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
112644286  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
112666549  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
112664485  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X2 [KO:K04406] [EC:2.7.11.1]
112669971  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
112645516  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
112642133  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112676536  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
112674009  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
112662539  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
112659360  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
112670385  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
112659920  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
112659238  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
112652434  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
112652993  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
112657061  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
112645461  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
112660778  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
112667177  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X2 [KO:K04423] [EC:2.7.11.25]
112662626  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
112668110  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
112660380  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
112644173  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112658720  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112643465  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X3 [KO:K04428] [EC:2.7.11.25]
112677630  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
112640059  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
112676638  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
112647348  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
112666418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112647216  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112652877  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
112663278  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
112665407  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
112640569  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
112668365  FLNA; filamin-A isoform X1 [KO:K04437]
112677583  CRK; adapter molecule crk isoform X1 [KO:K04438]
112677012  CRKL; crk-like protein isoform X1 [KO:K04438]
112667412  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
112647518  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
112645941  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112659577  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112671968  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
112641479  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112641481  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112665560  MAPK11; mitogen-activated protein kinase 11 isoform X3 [KO:K04441] [EC:2.7.11.24]
112665622  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
112676559  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
112648298  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
112665838  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
112656869  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
112659380  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
112673655  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
112643925  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X3 [KO:K04446]
112646526  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112647115  JUN; transcription factor Jun [KO:K04448]
112666741  JUND; transcription factor JunD [KO:K04449]
112668134  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112647438  TP53; cellular tumor antigen p53 [KO:K04451]
112677982  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
112657138  MAX; protein max isoform X1 [KO:K04453]
112654137  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
112646174  HSPB1; heat shock protein beta-1 [KO:K04455]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112657745  PPM1A; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
112677854  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
112667741  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X5 [KO:K18018] [EC:3.1.3.48]
112667060  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
112651454  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
112672324  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112663240  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112640380  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112664441  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112665872  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112665403  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
112654542  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
112668394  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
112643106  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
112654964  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
112645268  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
112671320  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
112671161  HSPA8; heat shock cognate 71 kDa protein isoform X2 [KO:K03283]
112641324  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
112641325  heat shock 70 kDa protein 1 [KO:K03283]
112650061  heat shock cognate 71 kDa protein-like [KO:K03283]
125752189  heat shock 70 kDa protein 1 [KO:K03283]
112645928  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
112675702  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
112647275  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
112667240  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
112655568  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
112672189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112656000  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
112668352  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
112677681  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112672242  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112645315  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
clud04070  Phosphatidylinositol signaling system
clud04110  Cell cycle
clud04115  p53 signaling pathway
clud04210  Apoptosis
clud04310  Wnt signaling pathway
clud04668  TNF signaling pathway
KO pathway
ko04010   
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