KEGG   PATHWAY: cmao04020
Entry
cmao04020                   Pathway                                
Name
Calcium signaling pathway - Colossoma macropomum (tambaqui)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
cmao04020  Calcium signaling pathway
cmao04020

Other DBs
GO: 0019722
Organism
Colossoma macropomum (tambaqui) [GN:cmao]
Gene
118796652  [KO:K05085] [EC:2.7.10.1]
118796721  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118796732  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
118796940  pde1cb; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
118796942  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
118797055  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
118797143  [KO:K04446]
118797172  [KO:K04322]
118797265  plcd1b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1b isoform X1 [KO:K05857] [EC:3.1.4.11]
118797368  htr5aa; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a [KO:K04161]
118797821  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118797878  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
118797979  grin2ab; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118798118  si:dkey-1h24.2; cholecystokinin receptor [KO:K04194]
118798257  [KO:K23445]
118798294  ednrba; endothelin receptor Ba [KO:K04198]
118798605  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
118798611  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
118798654  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118798677  ntrk1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
118798758  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118798830  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
118798957  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118799252  tfeb; transcription factor EB isoform X1 [KO:K15590]
118799299  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
118799312  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
118799368  camk1b; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
118799526  [KO:K04851]
118799559  [KO:K05865]
118799574  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
118799577  p2rx8; purinergic receptor P2X, ligand-gated ion channel, 8 [KO:K05219]
118799785  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
118799802  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118799959  camk1ga; calcium/calmodulin-dependent protein kinase IGa [KO:K08794] [EC:2.7.11.17]
118799996  hrh1; histamine H1 receptor [KO:K04149]
118800439  gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
118800552  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
118801273  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
118801283  [KO:K06856]
118801443  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
118801618  ednrbb; LOW QUALITY PROTEIN: endothelin receptor type B [KO:K04198]
118801690  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
118801957  fgf8b; LOW QUALITY PROTEIN: fibroblast growth factor 8b [KO:K04358]
118802149  prkcba; protein kinase C, beta a [KO:K19662] [EC:2.7.11.13]
118802290  [KO:K22642]
118802306  p2rx7; P2X purinoceptor 7 [KO:K05220]
118802308  p2rx4b; P2X purinoceptor 4b isoform X1 [KO:K05218]
118802310  adora2aa; adenosine A2a receptor a [KO:K04266]
118802488  cacna1aa; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
118802702  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
118802704  grpr; gastrin-releasing peptide receptor [KO:K04169]
118802799  [KO:K06856]
118802890  cysltr2b; cysteinyl leukotriene receptor 2 [KO:K04323]
118802955  mcoln1a; mucolipin-1a [KO:K04992]
118802987  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
118803042  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118803094  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
118803172  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118803545  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
118803798  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
118803808  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
118803952  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
118804005  [KO:K13241] [EC:1.14.13.39]
118804008  fgf7; fibroblast growth factor 7 [KO:K04358]
118804014  [KO:K13241] [EC:1.14.13.39]
118804193  tacr3l; tachykinin receptor 3-like [KO:K04224]
118804330  [KO:K05085] [EC:2.7.10.1]
118804604  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
118804610  [KO:K04359]
118804635  si:ch211-79m20.1; LIM domain-containing protein A isoform X1 [KO:K17386]
118804788  agtr1a; type-1B angiotensin II receptor [KO:K04166]
118804864  [KO:K04718] [EC:2.7.1.91]
118804919  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
118804967  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
118804974  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
118805313  mcoln1b; mucolipin-1b [KO:K04992]
118805335  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118805420  adcy2b; adenylate cyclase type 2b [KO:K08042] [EC:4.6.1.1]
118805692  cacna1ha; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
118805887  [KO:K05210]
118805967  chrna11; cholinergic receptor, nicotinic, alpha 11 [KO:K04809]
118806091  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
118806194  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118806353  [KO:K14077]
118806401  [KO:K04129]
118806475  egf; pro-epidermal growth factor [KO:K04357]
118806539  ntrk3a; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
118806701  [KO:K22428]
118806702  fgf6a; fibroblast growth factor 6a [KO:K04358]
118806734  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118806754  chrm2b; muscarinic acetylcholine receptor M2 [KO:K04130]
118806788  atp2b1b; plasma membrane calcium-transporting ATPase 1b [KO:K05850] [EC:7.2.2.10]
118806853  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
118806916  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
118806955  fgf20b; fibroblast growth factor 20b [KO:K04358]
118807040  p2rx3a; P2X purinoceptor 3a [KO:K05217]
118807128  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
118807172  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118807177  slc25a5; ADP/ATP translocase 2 [KO:K05863]
118807284  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
118807325  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118807349  fgf16; fibroblast growth factor 16 [KO:K04358]
118807370  [KO:K04198]
118807374  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
118807428  htr2ab; 5-hydroxytryptamine receptor 2A [KO:K04157]
118807435  [KO:K04856]
118807477  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
118807507  [KO:K05863]
118807564  ngfb; nerve growth factor [KO:K02582]
118807581  [KO:K02183]
118807601  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
118807762  mylkb; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118807929  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
118807948  [KO:K04718] [EC:2.7.1.91]
118808209  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
118808278  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118808331  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
118808352  oxtr; oxytocin receptor [KO:K04229]
118808408  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
118808451  oxtrl; oxytocin receptor like [KO:K04229]
118808458  camk1a; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
118808517  [KO:K17332]
118808554  mst1; hepatocyte growth factor-like protein [KO:K23441]
118808558  cysltr3; cysteinyl leukotriene receptor 2 [KO:K04322]
118808568  mst1ra; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
118808730  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
118808870  [KO:K04163]
118808958  [KO:K05857] [EC:3.1.4.11]
118809001  [KO:K15040]
118809007  ppifb; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118809054  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
118809055  [KO:K04131]
118809144  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
118809279  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
118809337  grin2cb; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
118809351  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
118809413  adrb1; beta-1 adrenergic receptor [KO:K04141]
118809440  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
118809456  cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
118809553  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
118809704  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118809723  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
118809820  casq2; calsequestrin-2 [KO:K23445]
118809953  tacr2; substance-K receptor [KO:K04223]
118810022  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
118810105  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118810135  ppp3r1a; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118810162  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
118810219  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
118810287  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
118810340  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118810361  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
118810433  ppifa; peptidylprolyl isomerase Fa isoform X1 [KO:K09565] [EC:5.2.1.8]
118810478  fgf8a; fibroblast growth factor 8 [KO:K04358]
118810504  ret; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
118810530  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118810544  p2rx3b; P2X purinoceptor 3b [KO:K05217]
118810601  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118810812  fgf9; fibroblast growth factor 4B [KO:K04358]
118810813  vegfc; vascular endothelial growth factor C [KO:K05449]
118810838  ednraa; endothelin receptor type Aa [KO:K04197]
118811046  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
118811193  fgf6b; fibroblast growth factor 6b [KO:K04358]
118811273  drd1a; D(1) dopamine receptor [KO:K04144]
118811370  fgf23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
118811423  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
118811440  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118811450  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
118811497  hrh2a; histamine receptor H2a isoform X1 [KO:K04150]
118811620  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118811710  htr2aa; 5-hydroxytryptamine receptor 2A [KO:K04157]
118811827  [KO:K04809]
118811833  calml4b; calmodulin-like protein 4 [KO:K02183]
118811837  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
118811887  camk1db; calcium/calmodulin-dependent protein kinase 1Db [KO:K08794] [EC:2.7.11.17]
118811992  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
118812079  hgfa; hepatocyte growth factor a [KO:K05460]
118812101  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
118812272  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
118812293  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
118812554  avpr1ab; arginine vasopressin receptor 1Ab [KO:K04226]
118812570  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
118812597  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
118812645  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
118812796  [KO:K22429]
118812863  fgf17; fibroblast growth factor 17 [KO:K04358]
118812912  [KO:K04282]
118812943  [KO:K04211]
118813013  orai1a; calcium release-activated calcium channel protein 1 [KO:K16056]
118813159  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
118813179  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
118813294  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
118813304  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
118813305  adrb3a; adrenoceptor beta 3a [KO:K04143]
118813320  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
118813363  [KO:K04632]
118813381  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118813462  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
118813513  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118813635  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
118813746  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118813753  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
118813837  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118813982  atp2b3a; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3a [KO:K05850] [EC:7.2.2.10]
118814116  [KO:K04852]
118814329  orai2; protein orai-2 [KO:K16057]
118814354  adora2b; adenosine receptor A2b [KO:K04267]
118814433  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
118814462  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
118814581  gnaq; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
118814582  [KO:K04636]
118814584  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
118814587  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
118814685  [KO:K05212]
118814703  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
118814706  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
118814782  p2rx5; P2X purinoceptor 5 [KO:K05219]
118814835  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
118815041  chrm1b; muscarinic acetylcholine receptor M1 [KO:K04129]
118815216  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
118815384  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118815391  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
118815470  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118815521  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
118815567  [KO:K05858] [EC:3.1.4.11]
118815569  [KO:K05858] [EC:3.1.4.11]
118815642  ryr3; ryanodine receptor 3 [KO:K04963]
118815644  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
118815652  mylk4b; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
118815749  pln; cardiac phospholamban [KO:K05852]
118815768  trdn; neurofilament heavy polypeptide isoform X1 [KO:K23449]
118815852  agtr1b; type-1 angiotensin II receptor [KO:K04166]
118815893  grm1a; metabotropic glutamate receptor 1 [KO:K04603]
118815984  calm1b; calmodulin-1b [KO:K02183]
118816015  [KO:K08043] [EC:4.6.1.1]
118816110  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118816218  si:dkey-63b1.1; B2 bradykinin receptor [KO:K03916]
118816629  adra1d; alpha-1D adrenergic receptor [KO:K04137]
118816638  [KO:K04248]
118816654  ltb4r2a; leukotriene B4 receptor 2a [KO:K04297]
118816704  casq1b; calsequestrin-1b [KO:K23468]
118816831  [KO:K04160]
118816878  tacr3a; LOW QUALITY PROTEIN: tachykinin receptor 3a [KO:K04224]
118816911  fgf20a; fibroblast growth factor 20a [KO:K04358]
118816960  stim2a; stromal interaction molecule 2 [KO:K18196]
118817036  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
118817054  slc25a4; ADP/ATP translocase 1 [KO:K05863]
118817078  chrna8; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
118817328  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
118817411  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118817450  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118817618  calml4a; calmodulin-like protein 4a [KO:K02183]
118817642  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
118817769  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
118817771  [KO:K04961]
118817776  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
118817902  [KO:K05460]
118818001  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118818167  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118818595  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
118818670  [KO:K13755] [EC:3.1.4.17]
118818725  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
118818804  [KO:K04635]
118818812  [KO:K04637]
118818861  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118818959  tpcn2; two pore calcium channel protein 2 [KO:K14077]
118819076  fgf3; fibroblast growth factor 3 [KO:K04358]
118819295  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
118819317  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
118819340  fgf19; fibroblast growth factor 19 [KO:K22603]
118819378  ntrk3b; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
118819431  chrna7a; neuronal acetylcholine receptor subunit alpha-7a [KO:K04809]
118819460  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118819465  fgf4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
118819505  grin3bb; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
118819537  fgf22; fibroblast growth factor 22 [KO:K04358]
118819572  mcoln2; mucolipin-2 [KO:K04993]
118819670  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118819693  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
118819728  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118819751  slc25a6; ADP/ATP translocase 3 [KO:K05863]
118819769  stim1b; stromal interaction molecule 1b isoform X1 [KO:K16059]
118819795  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
118819825  adora2ab; adenosine A2a receptor b [KO:K04266]
118819885  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
118819918  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118819934  p2rx4a; P2X purinoceptor 4a [KO:K05218]
118819941  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118819972  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
118820020  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
118820044  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118820061  adrb2b; adrenoceptor beta 2, surface b [KO:K04142]
118820063  fgf10a; fibroblast growth factor 10a [KO:K04358]
118820141  fgf1b; fibroblast growth factor 1b [KO:K18496]
118820167  [KO:K05448]
118820271  cysltr2a; cysteinyl leukotriene receptor 2 [KO:K04323]
118820314  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
118820484  [KO:K03914]
118820576  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
118820617  drd1b; dopamine receptor D1b [KO:K04144]
118820642  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
118820672  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
118820709  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
118820893  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118820906  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
118820916  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
118820923  fgf21; fibroblast growth factor 21 [KO:K22429]
118821042  drd5a; D(1) dopamine receptor [KO:K05840]
118821109  fgf2; fibroblast growth factor 2 [KO:K18497]
118821144  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118821231  cacna1ia; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
118821383  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
118821607  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
118821634  [KO:K08049] [EC:4.6.1.1]
118821661  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118821681  ptger1b; prostaglandin E receptor 1b (subtype EP1) [KO:K04258]
118821927  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
118821936  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118822020  tnnc1b; troponin C type 1b (slow) [KO:K05865]
118822100  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118822113  [KO:K12042]
118822114  tnnc2; troponin C, skeletal muscle [KO:K12042]
118822118  atp2b3b; plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
118822143  [KO:K04224]
118822368  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
118822378  tnnc1a; troponin C type 1a (slow) [KO:K05865]
118822545  [KO:K08794] [EC:2.7.11.17]
118822546  [KO:K08794] [EC:2.7.11.17]
118822594  nfatc2a; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
118822605  [KO:K00907] [EC:2.7.11.18]
118822959  ednrab; LOW QUALITY PROTEIN: endothelin receptor type Ab [KO:K04197]
118822975  [KO:K04633]
118823003  ntsr1; neurotensin receptor type 1 [KO:K04211]
118823015  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
118823096  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118823119  ngfa; neurotrophin-7 [KO:K02582]
118823220  [KO:K04361] [EC:2.7.10.1]
118823245  [KO:K04963]
118823278  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
118823305  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
118823433  [KO:K05858] [EC:3.1.4.11]
118823435  [KO:K05858] [EC:3.1.4.11]
118823514  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
118823590  calm1a; calmodulin-1a [KO:K02183]
118823684  [KO:K03916]
118823712  bdkrb1; B1 bradykinin receptor [KO:K03916]
118823717  [KO:K04163]
118823730  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118823766  [KO:K05840]
118823794  [KO:K03916]
118823890  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118824045  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
118824088  ptafr; platelet-activating factor receptor [KO:K04279]
118824151  [KO:K05852]
118824173  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
118824178  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
118824301  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
118824349  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
118824380  ryr1a; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
118824567  tacr1b; tachykinin receptor 1b [KO:K04222]
118824602  zgc:56235; voltage-dependent anion-selective channel protein 2 [KO:K15041]
118824710  [KO:K05093] [EC:2.7.10.1]
118824735  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
118824814  hrh2b; histamine receptor H2b [KO:K04150]
118824845  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
118824989  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
118825065  [KO:K04515] [EC:2.7.11.17]
118825156  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
118825233  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
118825253  fgf18b; fibroblast growth factor 18b [KO:K04358]
118825265  adrb3b; adrenoceptor beta 3b isoform X1 [KO:K04143]
118825403  [KO:K04194]
118825512  mylk4a; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118825515  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
118825616  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
118825617  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
118825690  unm_hu7910; calponin homology domain-containing protein DDB_G0272472 isoform X1 [KO:K00476] [EC:1.14.11.16]
118825744  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118825888  cacna1eb; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
118825899  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
118826183  cckar; cholecystokinin receptor type A [KO:K04194]
118826289  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
118826294  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
118826319  mcoln3a; mucolipin-3 isoform X1 [KO:K04994]
118826421  casq1a; LOW QUALITY PROTEIN: calsequestrin-1a [KO:K23468]
118826461  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118826564  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
118826566  adcy1b; LOW QUALITY PROTEIN: adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
118826616  [KO:K04348] [EC:3.1.3.16]
118826741  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
118826758  grin3ba; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
118826839  ppp3cca; LOW QUALITY PROTEIN: protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
118826950  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
118826955  f2r; proteinase-activated receptor 1 [KO:K03914]
118827000  fgf10b; fibroblast growth factor 10b [KO:K04358]
118827050  [KO:K05452]
118827091  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a [KO:K04849]
118827176  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
118827366  p2rx2; P2X purinoceptor 2 [KO:K05216]
118827487  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118827564  fgf5; fibroblast growth factor 5 [KO:K04358]
118827614  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
118827666  tacr1a; tachykinin receptor 1a [KO:K04222]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
cmao04010  MAPK signaling pathway
cmao04070  Phosphatidylinositol signaling system
cmao04210  Apoptosis
KO pathway
ko04020   

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