KEGG   PATHWAY: csab05203
Entry
csab05203                   Pathway                                
Name
Viral carcinogenesis - Chlorocebus sabaeus (green monkey)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
csab05203  Viral carcinogenesis
csab05203

Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214281  CCNA1; cyclin A1 [KO:K06627]
103214406  RB1; RB transcriptional corepressor 1 [KO:K06618]
103215131  SKP2; S-phase kinase associated protein 2 [KO:K03875]
103215465  EGR3; early growth response 3 [KO:K12497]
103215580  GTF2E2; general transcription factor IIE subunit 2 [KO:K03137]
103215689  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
103215691  VDAC3; voltage dependent anion channel 3 [KO:K15041]
103216128  EGR2; early growth response 2 [KO:K12496]
103216148  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103216431  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
103217002  [KO:K00873] [EC:2.7.1.40]
103217363  ATF2; activating transcription factor 2 [KO:K04450]
103217637  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103217717  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103218036  SP100; SP100 nuclear antigen [KO:K15413]
103218195  HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
103218410  CCND2; cyclin D2 [KO:K10151]
103218448  LTBR; lymphotoxin beta receptor [KO:K03159]
103218457  CHD4; chromodomain helicase DNA binding protein 4 [KO:K11643] [EC:5.6.2.-]
103218647  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
103218674  HIST4H4; histone cluster 4, H4 [KO:K11254]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103218908  GSN; gelsolin [KO:K05768]
103218917  TRAF1; TNF receptor associated factor 1 [KO:K03172]
103219209  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
103219354  [KO:K06621]
103219356  CDKN2B; cyclin dependent kinase inhibitor 2B [KO:K04685]
103219549  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
103219668  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
103219736  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103220205  REL; REL proto-oncogene, NF-kB subunit [KO:K09254]
103220306  GTF2A1L; general transcription factor IIA subunit 1 like [KO:K03122]
103220482  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103220843  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
103221038  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103221471  SRF; serum response factor [KO:K04378]
103221504  CCND3; cyclin D3 [KO:K10152]
103221583  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103221611  IL6ST; interleukin 6 signal transducer [KO:K05060]
103221651  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
103221718  ATF6B; activating transcription factor 6 beta [KO:K09049]
103221775  Chsa-B; HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751]
103221786  Chsa-B; class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103221812  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
103221831  MRPS18B; mitochondrial ribosomal protein S18B [KO:K16174]
103221837  Chsa-A; popy class I histocompatibility antigen, alpha chain E [KO:K06751]
103221863  [KO:K06751]
103221933  HIST1H2BO; histone cluster 1, H2bo [KO:K11252]
103221937  [KO:K11252]
103221938  [KO:K11254]
103221940  [KO:K11252]
103221948  [KO:K11252]
103221969  [KO:K11252]
103221971  [KO:K11254]
103221972  [KO:K11252]
103221993  [KO:K11254]
103221994  [KO:K11252]
103221996  [KO:K11252]
103221998  [KO:K11252]
103222000  [KO:K11254]
103222001  [KO:K11252]
103222007  [KO:K11254]
103222008  [KO:K11254]
103222010  [KO:K11252]
103222011  [KO:K11252]
103222015  [KO:K11252]
103222019  [KO:K11252]
103222030  [KO:K11252]
103222031  [KO:K11252]
103222361  [KO:K06751]
103222362  [KO:K06751]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103222816  GTF2H2; general transcription factor IIH subunit 2 [KO:K03142]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103222986  RANBP1; RAN binding protein 1 [KO:K15306]
103223201  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
103223345  ATF4; activating transcription factor 4 [KO:K04374]
103223371  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
103223554  HDAC10; histone deacetylase 10 [KO:K18671] [EC:3.5.1.98]
103223942  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103224483  GTF2B; general transcription factor IIB [KO:K03124]
103224540  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103224682  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103224726  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103224971  CDC20; cell division cycle 20 [KO:K03363]
103225192  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103225423  CDC42; cell division cycle 42 [KO:K04393]
103225484  UBR4; ubiquitin protein ligase E3 component n-recognin 4 [KO:K10691] [EC:2.3.2.27]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103226003  IRF7; interferon regulatory factor 7 [KO:K09447]
103226299  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
103226420  HDAC9; histone deacetylase 9 [KO:K11409] [EC:3.5.1.98]
103226465  SCIN; scinderin [KO:K05768]
103226555  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103226850  SND1; staphylococcal nuclease and tudor domain containing 1 [KO:K15979]
103226974  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103227249  [KO:K11252]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103227533  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
103227535  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
103227629  RHOA; ras homolog family member A [KO:K04513]
103228040  HDAC11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
103228044  USP7; ubiquitin specific peptidase 7 [KO:K11838] [EC:3.4.19.12]
103228203  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
103228710  IRF9; interferon regulatory factor 9 [KO:K04693]
103228823  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103229232  ACTN1; actinin alpha 1 [KO:K05699]
103229400  SNW1; SNW domain containing 1 [KO:K06063]
103229444  GTF2A1; general transcription factor IIA subunit 1 [KO:K03122]
103229536  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
103229744  TRAF3; TNF receptor associated factor 3 [KO:K03174]
103229900  TBPL2; TATA-box binding protein like 2 [KO:K03120]
103229948  [KO:K11252]
103229949  HIST3H2BB; histone cluster 3, H2bb [KO:K11252]
103230138  TRAF5; TNF receptor associated factor 5 [KO:K09849]
103230194  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103231770  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
103231778  DNAJA3; DnaJ heat shock protein family (Hsp40) member A3 [KO:K09504]
103231828  DDX3X; DEAD-box helicase 3, X-linked [KO:K11594] [EC:3.6.4.13]
103231941  HDAC6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
103232180  HDAC8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
103232425  [KO:K11252]
103232427  [KO:K11252]
103232429  [KO:K11252]
103232430  [KO:K11252]
103232431  [KO:K11252]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103232914  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
103233164  VAC14; Vac14, PIKFYVE complex component [KO:K15305]
103233279  ATP6V0D1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
103233291  TRADD; TNFRSF1A associated via death domain [KO:K03171]
103233293  BAD; BCL2 associated agonist of cell death [KO:K02158]
103233716  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
103234155  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
103234342  C3; complement C3 [KO:K03990]
103234377  [KO:K04345] [EC:2.7.11.11]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103234463  DDB1; damage specific DNA binding protein 1 [KO:K10610]
103234489  HPN; hepsin [KO:K08665] [EC:3.4.21.106]
103234638  ACTN4; actinin alpha 4 [KO:K05699]
103235004  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
103235050  IRF3; interferon regulatory factor 3 [KO:K05411]
103235482  CCNE1; cyclin E1 [KO:K06626]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103236201  CCNA2; cyclin A2 [KO:K06627]
103236571  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103236614  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103236819  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
103237075  ATP6V0D2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
103237156  CCNE2; cyclin E2 [KO:K06626]
103237221  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
103237590  SCRIB; scribbled planar cell polarity protein [KO:K16175]
103238208  HDAC7; histone deacetylase 7 [KO:K11408] [EC:3.5.1.98]
103238495  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103238589  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103238687  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103239237  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
103239245  PXN; paxillin [KO:K05760]
103239334  GTF2H3; general transcription factor IIH subunit 3 [KO:K03143]
103239354  [KO:K06067] [EC:3.5.1.98]
103239600  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103240341  TBPL1; TATA-box binding protein like 1 [KO:K03120]
103240535  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103241044  TBP; TATA-box binding protein [KO:K03120]
103241568  RASA2; RAS p21 protein activator 2 [KO:K08053]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103241748  KAT2B; lysine acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
103241836  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
103241973  DLG1; discs large MAGUK scaffold protein 1 [KO:K12076]
103242121  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
103242323  TP53; tumor protein p53 [KO:K04451]
103243048  GRB2; growth factor receptor bound protein 2 [KO:K04364]
103243334  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
103243410  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103243412  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
103243413  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
103243423  KAT2A; lysine acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
103244700  HDAC3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
103245400  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like [KO:K06053]
103245470  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
103245539  GTF2A2; general transcription factor IIA subunit 2 [KO:K03123]
103246026  UBE3A; ubiquitin protein ligase E3A [KO:K10587] [EC:2.3.2.26]
103246072  PKM; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
103246259  RBPJ; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103246384  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103246489  CCND1; cyclin D1 [KO:K04503]
103246662  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103246871  MAD1L1; MAD1 mitotic arrest deficient like 1 [KO:K06679]
103247140  Chsa-A; HLA class I histocompatibility antigen, A-11 alpha chain [KO:K06751]
103247147  [KO:K06751]
103247165  [KO:K11252]
103247167  HIST2H2BE; histone cluster 2 H2B family member e [KO:K11252]
103247796  [KO:K11254]
103248769  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
  Authors
Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
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Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
  Authors
Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
  Journal
Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427
Reference
PMID:16039586
  Authors
Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
Reference
PMID:16939421
  Authors
Mukherji A, Janbandhu VC, Kumar V
  Title
HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.
  Journal
Biochem J 401:247-56 (2007)
DOI:10.1042/BJ20061091
Reference
PMID:15173177
  Authors
Yoo YG, Lee MO
  Title
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
  Journal
J Biol Chem 279:36242-9 (2004)
DOI:10.1074/jbc.M401290200
Reference
PMID:11604508
  Authors
Waris G, Huh KW, Siddiqui A
  Title
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.
  Journal
Mol Cell Biol 21:7721-30 (2001)
DOI:10.1128/MCB.21.22.7721-7730.2001
Reference
PMID:17894800
  Authors
Kasprzak A, Adamek A
  Title
Role of hepatitis C virus proteins (C, NS3, NS5A) in hepatic oncogenesis.
  Journal
Hepatol Res 38:1-26 (2008)
DOI:10.1111/j.1872-034X.2007.00261.x
Reference
PMID:9882379
  Authors
You LR, Chen CM, Lee YH
  Title
Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha.
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Related
pathway
csab03022  Basal transcription factors
csab03320  PPAR signaling pathway
csab04010  MAPK signaling pathway
csab04062  Chemokine signaling pathway
csab04064  NF-kappa B signaling pathway
csab04110  Cell cycle
csab04115  p53 signaling pathway
csab04142  Lysosome
csab04151  PI3K-Akt signaling pathway
csab04210  Apoptosis
csab04630  JAK-STAT signaling pathway
csab04662  B cell receptor signaling pathway
csab04810  Regulation of actin cytoskeleton
csab05160  Hepatitis C
csab05161  Hepatitis B
csab05165  Human papillomavirus infection
csab05166  Human T-cell leukemia virus 1 infection
csab05167  Kaposi sarcoma-associated herpesvirus infection
csab05169  Epstein-Barr virus infection
KO pathway
ko05203   

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