KEGG   PATHWAY: csab04062
Entry
csab04062                   Pathway                                
Name
Chemokine signaling pathway - Chlorocebus sabaeus (green monkey)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
csab04062  Chemokine signaling pathway
csab04062

Other DBs
GO: 0070098
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214852  GRK1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
103214981  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
103215218  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
103215524  PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
103215555  [KO:K07836]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103215781  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103216606  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
103216995  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
103217191  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
103217529  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
103217855  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
103217856  CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
103218000  CCL20; C-C motif chemokine ligand 20 [KO:K14625]
103218476  GNB3; G protein subunit beta 3 [KO:K07825]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103219014  GNG10; G protein subunit gamma 10 [KO:K04545]
103219132  GRK2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
103219246  [KO:K16062]
103219249  CCL19; C-C motif chemokine ligand 19 [KO:K05512]
103219250  [KO:K16062]
103219254  CCL27; C-C motif chemokine ligand 27 [KO:K16598]
103219496  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103219549  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
103219624  GNAQ; G protein subunit alpha q [KO:K04634]
103219725  SHC3; SHC adaptor protein 3 [KO:K17448]
103220440  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103220665  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
103220805  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
103221038  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
103221039  CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
103221209  GNB4; G protein subunit beta 4 [KO:K04538]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103222670  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103222955  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
103223079  GRK3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
103223272  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103223899  SHC1; SHC adaptor protein 1 [KO:K06279]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103224221  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
103224284  GNAI3; G protein subunit alpha i3 [KO:K04630]
103224335  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
103224540  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103225283  FGR; FGR proto-oncogene, Src family tyrosine kinase [KO:K08891] [EC:2.7.10.2]
103225423  CDC42; cell division cycle 42 [KO:K04393]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103225772  PRKCZ; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
103225777  GNB1; G protein subunit beta 1 [KO:K04536]
103226115  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
103226216  ELMO1; engulfment and cell motility 1 [KO:K12366]
103226542  [KO:K04546]
103226652  GNAI1; G protein subunit alpha i1 [KO:K04630]
103226710  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
103227022  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103227526  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
103227527  CXCR6; C-X-C motif chemokine receptor 6 [KO:K04191]
103227530  XCR1; X-C motif chemokine receptor 1 [KO:K04193]
103227531  CCR1; C-C motif chemokine receptor 1 [KO:K04176]
103227533  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
103227534  CCR2; C-C motif chemokine receptor 2 [KO:K04177]
103227535  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
103227576  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
103227629  RHOA; ras homolog family member A [KO:K04513]
103227664  GNAI2; G protein subunit alpha i2 [KO:K04630]
103227755  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103228169  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103228726  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
103228823  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103228953  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103228983  GNG2; G protein subunit gamma 2 [KO:K07826]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103230637  [KO:K05507]
103230639  [KO:K05507]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103231940  WAS; Wiskott-Aldrich syndrome [KO:K05747]
103232166  CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188]
103232667  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103233057  CCL22; C-C motif chemokine ligand 22 [KO:K21095]
103233058  CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
103233059  CCL17; C-C motif chemokine ligand 17 [KO:K21083]
103233086  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
103233293  BAD; BCL2 associated agonist of cell death [KO:K02158]
103233299  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
103233309  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
103233371  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
103233559  SHC2; SHC adaptor protein 2 [KO:K17447]
103233652  GNG7; G protein subunit gamma 7 [KO:K04543]
103233784  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
103233831  CCL25; C-C motif chemokine ligand 25 [KO:K13072]
103233940  GNG3; G protein subunit gamma 3 [KO:K04540]
103234155  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
103234377  [KO:K04345] [EC:2.7.11.11]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103234643  NFKBIB; NFKB inhibitor beta [KO:K02581]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103234762  GSK3A; glycogen synthase kinase 3 alpha [KO:K08822] [EC:2.7.11.26]
103234920  GNG8; G protein subunit gamma 8 [KO:K04544]
103235786  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103235787  CXCL6; C-X-C motif chemokine ligand 6 [KO:K05506]
103235788  PF4V1; platelet factor 4 variant 1 [KO:K05407]
103235789  CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505]
103235792  [KO:K05505]
103235793  [KO:K05407]
103235794  PPBP; pro-platelet basic protein [KO:K10029]
103235795  [KO:K05506]
103235797  CXCL5; C-X-C motif chemokine ligand 5 [KO:K05506]
103235798  CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505]
103235823  CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]
103235824  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
103235825  CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416]
103235849  CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103236336  GNG5; G protein subunit gamma 5 [KO:K04542]
103236682  [KO:K05505]
103236819  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
103237447  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
103237724  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103238107  PARD3; par-3 family cell polarity regulator [KO:K04237]
103238242  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
103238525  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103238680  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
103239245  PXN; paxillin [KO:K05760]
103239674  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
103240621  FOXO3; forkhead box O3 [KO:K09408]
103240925  CCR6; C-C motif chemokine receptor 6 [KO:K04181]
103241564  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103241836  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
103242119  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
103242194  ARRB2; arrestin beta 2 [KO:K04439]
103242198  CXCL16; C-X-C motif chemokine ligand 16 [KO:K10035]
103242366  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
103242368  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
103242710  [KO:K14624]
103242711  CCL7; C-C motif chemokine ligand 7 [KO:K05509]
103242712  CCL11; C-C motif chemokine ligand 11 [KO:K16597]
103242713  CCL8; C-C motif chemokine ligand 8 [KO:K16596]
103242714  CCL13; C-C motif chemokine ligand 13 [KO:K16595]
103242715  CCL1; C-C motif chemokine ligand 1 [KO:K05514]
103242750  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
103242756  CCL16; C-C motif chemokine ligand 16 [KO:K21093]
103242759  CCL14; C-C motif chemokine ligand 14 [KO:K21092]
103242760  CCL15; C-C motif chemokine ligand 15 [KO:K05511]
103242761  CCL23; C-C motif chemokine ligand 23 [KO:K05511]
103242763  CCL18; C-C motif chemokine ligand 18 [KO:K21094]
103242764  [KO:K12964]
103242767  CCL3; C-C motif chemokine ligand 3 [KO:K05408]
103242769  [KO:K12964]
103243048  GRB2; growth factor receptor bound protein 2 [KO:K04364]
103243392  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
103243410  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
103243413  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
103243510  CCR7; C-C motif chemokine receptor 7 [KO:K04182]
103243636  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103243748  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
103244577  CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033]
103244634  PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [KO:K12365]
103244862  ITK; IL2 inducible T-cell kinase [KO:K07363] [EC:2.7.10.2]
103244950  DOCK2; dedicator of cytokinesis 2 [KO:K12367]
103245054  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103245611  GNB5; G protein subunit beta 5 [KO:K04539]
103245659  SHC4; SHC adaptor protein 4 [KO:K17449]
103245842  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
103245987  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103246384  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103246447  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
103246591  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
103246614  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
103246650  CCL24; C-C motif chemokine ligand 24 [KO:K21097]
103246652  CCL26; C-C motif chemokine ligand 26 [KO:K21096]
103246657  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
103246723  GNB2; G protein subunit beta 2 [KO:K04537]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103247783  [KO:K12964]
103247784  [KO:K05408]
103248056  ARRB1; arrestin beta 1 [KO:K04439]
103248093  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103248155  HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
103248608  CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
csab04010  MAPK signaling pathway
csab04060  Cytokine-cytokine receptor interaction
csab04120  Ubiquitin mediated proteolysis
csab04630  JAK-STAT signaling pathway
csab04670  Leukocyte transendothelial migration
csab04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

DBGET integrated database retrieval system