KEGG   PATHWAY: eai04936
Entry
eai04936                    Pathway                                
Name
Alcoholic liver disease - Equus asinus (ass)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
eai04936  Alcoholic liver disease
eai04936

Organism
Equus asinus (ass) [GN:eai]
Gene
106839999  C1QA; complement C1q subcomponent subunit A [KO:K03986]
106839997  C1QB; complement C1q subcomponent subunit B [KO:K03987]
106839998  C1QC; complement C1q subcomponent subunit C [KO:K03988]
106831000  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
106831006  complement C4-A-like [KO:K03989]
106832730  complement C3 [KO:K03990]
106827903  complement C3-like [KO:K03990]
106837440  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
106824223  C5; complement C5 isoform X1 [KO:K03994]
106845159  C5AR1; C5a anaphylatoxin chemotactic receptor 1 isoform X2 [KO:K04010]
106835090  lipopolysaccharide-binding protein-like [KO:K05399]
106835071  lipopolysaccharide-binding protein [KO:K05399]
106823774  CD14; monocyte differentiation antigen CD14 [KO:K04391]
106839182  LY96; lymphocyte antigen 96 [KO:K05400]
106824214  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
106834020  toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
106825588  toll/interleukin-1 receptor domain-containing adapter protein-like [KO:K05403]
106834265  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
106828056  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
106825607  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
106837480  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106836857  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
106837218  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
106847421  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106846705  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106828957  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
106828814  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106838803  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
106833569  RELA; transcription factor p65 isoform X1 [KO:K04735]
106825951  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106825034  TNF; tumor necrosis factor isoform X1 [KO:K03156]
106838557  LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
123286234  interleukin-1 beta-like [KO:K04519]
123286693  interleukin-1 beta-like [KO:K04519]
106824372  IL6; interleukin-6 [KO:K05405]
106824114  IL12A; interleukin-12 subunit alpha [KO:K05406]
106832166  IL12B; interleukin-12 subunit beta [KO:K05425]
106835113  CXCL8; interleukin-8 [KO:K10030]
106832333  TICAM1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
106839629  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
106823378  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
106824389  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
106824161  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
106824699  interferon alpha-2 [KO:K05414]
106824700  LOW QUALITY PROTEIN: interferon alpha-4 [KO:K05414]
106824701  interferon alpha-2-like [KO:K05414]
106828271  interferon alpha-2-like [KO:K05414]
106824784  interferon alpha-2 isoform X2 [KO:K05414]
106824785  interferon alpha-2-like [KO:K05414]
106824786  interferon alpha-6-like [KO:K05414]
106833890  interferon alpha-2-like [KO:K05414]
123280233  interferon alpha-2-like [KO:K05414]
123280237  interferon alpha-2-like [KO:K05414]
123280245  interferon alpha-2-like [KO:K05414]
123280259  interferon alpha-2-like [KO:K05414]
106828272  interferon beta-like [KO:K05415]
106834164  interferon beta-like [KO:K05415]
106834179  interferon beta-like [KO:K05415]
106834202  interferon beta [KO:K05415]
123280255  interferon beta [KO:K05415]
123280293  interferon beta-like [KO:K05415]
106827018  IL17A; interleukin-17A [KO:K05489]
106839456  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
106835618  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
106829729  growth-regulated protein homolog gamma-like [KO:K05505]
106829714  growth-regulated protein homolog gamma-like [KO:K05505]
106829728  growth-regulated protein homolog gamma-like [KO:K05505]
106838669  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
106822180  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
106822169  FADD; FAS-associated death domain protein [KO:K02373]
106831483  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106822449  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106823493  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
106830081  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
106847888  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
106832710  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
106840596  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
106846150  FASN; fatty acid synthase isoform X1 [KO:K00665] [EC:2.3.1.85]
106844682  ACACA; acetyl-CoA carboxylase 1 isoform X4 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106846485  SCD5; LOW QUALITY PROTEIN: stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
106846751  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
106825863  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
106834355  LPIN3; phosphatidate phosphatase LPIN3 isoform X3 [KO:K15728] [EC:3.1.3.4]
106835604  LPIN1; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
106837268  LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
106844414  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
106824343  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
106834493  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
106832542  ADIPOQ; adiponectin [KO:K07296]
106840175  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
106839429  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
106842289  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
106824750  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
106833475  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
106847656  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
106844778  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
123280843  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
106823337  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
106836814  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
106838460  PRKAG3; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
106848479  FOXO1; forkhead box protein O1 [KO:K07201]
106829766  FOXO3; forkhead box protein O3 [KO:K09408]
106829954  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3 [KO:K07202]
106845979  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
106844268  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
106844174  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K09479] [EC:1.3.8.9]
106836523  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
106840065  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
106830317  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
106838573  FABP1; fatty acid-binding protein, liver [KO:K08750]
106834449  LOW QUALITY PROTEIN: alcohol dehydrogenase E chain-like [KO:K13951] [EC:1.1.1.1]
106827762  alcohol dehydrogenase S chain [KO:K13951] [EC:1.1.1.1]
106827761  all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
123275609  all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
106846359  ADH5; alcohol dehydrogenase class-3 isoform X2 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
106827758  LOW QUALITY PROTEIN: alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
123283859  LOW QUALITY PROTEIN: alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
106838849  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
106843896  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
106842261  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
106838292  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
106842819  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
106831128  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
106841091  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
106848074  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106832111  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
106846020  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
106824163  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
106822678  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
106835457  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106839597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106843289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106829188  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106828390  CTNNB1; catenin beta-1 [KO:K02105]
106834657  TCF7; transcription factor 7 isoform X1 [KO:K02620]
106838609  TCF7L1; transcription factor 7-like 1 [KO:K04490]
106848101  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
106829814  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
106844248  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
106837192  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106845730  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
106844503  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106839421  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
106831384  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106843729  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106825518  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
106830236  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
106824547  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106824582  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846005  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846006  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
106836478  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
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Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
eai00061  Fatty acid biosynthesis
eai00071  Fatty acid degradation
eai01040  Biosynthesis of unsaturated fatty acids
eai03040  Spliceosome
eai04010  MAPK signaling pathway
eai04064  NF-kappa B signaling pathway
eai04152  AMPK signaling pathway
eai04210  Apoptosis
eai04310  Wnt signaling pathway
eai04610  Complement and coagulation cascades
eai04620  Toll-like receptor signaling pathway
eai04657  IL-17 signaling pathway
eai04668  TNF signaling pathway
eai04920  Adipocytokine signaling pathway
eai05034  Alcoholism
eai05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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