KEGG   PATHWAY: lcat05208
Entry
lcat05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Lemur catta (Ring-tailed lemur)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
lcat05208  Chemical carcinogenesis - reactive oxygen species
lcat05208

Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620436  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
123620754  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
123621038  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
123621224  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123621237  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
123621470  [KO:K02138]
123621509  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123621590  [KO:K03948]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621881  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123621919  [KO:K02271]
123622157  SLC26A1; sulfate anion transporter 1 [KO:K14700]
123622325  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123622720  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
123622847  [KO:K02263]
123623042  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
123623043  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
123623044  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
123623047  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
123623170  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
123623307  SLC26A6; solute carrier family 26 member 6 isoform X1 [KO:K14704]
123623309  [KO:K00414]
123623914  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
123624236  [KO:K02128]
123624263  [KO:K02271]
123624276  [KO:K00411] [EC:7.1.1.8]
123624297  [KO:K07416] [EC:1.14.14.1]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123624369  [KO:K07408] [EC:1.14.14.1]
123624379  [KO:K07409] [EC:1.14.14.1]
123624433  [KO:K02270]
123624463  [KO:K02264]
123624466  [KO:K02267]
123624681  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123624699  [KO:K02267]
123625151  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
123625340  [KO:K02263]
123625377  [KO:K08009]
123625715  [KO:K00799] [EC:2.5.1.18]
123625716  [KO:K00799] [EC:2.5.1.18]
123625717  [KO:K00799] [EC:2.5.1.18]
123625718  [KO:K00799] [EC:2.5.1.18]
123625742  [KO:K00799] [EC:2.5.1.18]
123625743  [KO:K00799] [EC:2.5.1.18]
123625744  [KO:K00799] [EC:2.5.1.18]
123625745  [KO:K00799] [EC:2.5.1.18]
123625824  [KO:K00419]
123625931  [KO:K02266]
123626029  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626307  [KO:K03940] [EC:7.1.1.2]
123626606  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123626609  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123626651  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
123626873  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123627031  NCF2; neutrophil cytosol factor 2 [KO:K08010]
123627044  [KO:K00415]
123627119  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627522  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123627957  [KO:K02268]
123628071  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123628501  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123628637  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123628649  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123628780  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123628789  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630171  [KO:K02127]
123630263  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123630288  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123630502  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123630658  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
123630679  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
123630707  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123630719  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123630720  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123630721  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123630722  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
123630777  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123631474  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123631504  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123631545  [KO:K03938]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631742  [KO:K03947]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123632466  [KO:K00415]
123632485  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123632639  NCF1; neutrophil cytosol factor 1 [KO:K08011]
123632685  [KO:K02266]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123632797  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
123632845  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123632873  [KO:K00420]
123632947  [KO:K00799] [EC:2.5.1.18]
123632948  [KO:K00799] [EC:2.5.1.18]
123632949  [KO:K00799] [EC:2.5.1.18]
123632950  [KO:K00799] [EC:2.5.1.18]
123632953  [KO:K00799] [EC:2.5.1.18]
123632954  [KO:K00799] [EC:2.5.1.18]
123633005  [KO:K02270]
123633137  FOXO3; forkhead box protein O3 [KO:K09408]
123633303  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123633420  [KO:K03960]
123633424  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123633914  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
123634125  [KO:K03963]
123634180  [KO:K00416]
123634187  [KO:K02649]
123634201  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
123634265  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123634926  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
123635005  [KO:K00799] [EC:2.5.1.18]
123635006  [KO:K00799] [EC:2.5.1.18]
123635007  [KO:K00799] [EC:2.5.1.18]
123635008  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
123635009  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
123635033  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
123635081  NRAS; GTPase NRas [KO:K07828]
123635220  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123635226  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123635258  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
123635409  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
123635482  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123635558  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
123635592  JUN; transcription factor AP-1 [KO:K04448]
123635659  [KO:K03948]
123635724  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123635928  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
123636458  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123636554  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
123636802  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
123636812  [KO:K07410] [EC:1.14.14.1]
123636823  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123636835  EPHX3; epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
123636840  [KO:K02270]
123636997  [KO:K03963]
123637222  [KO:K02265]
123637707  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123637759  [KO:K00418]
123637772  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123637866  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123637869  [KO:K03963]
123638077  SLC26A2; sulfate transporter [KO:K14701]
123638078  [KO:K00416]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123638210  [KO:K03948]
123638412  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123638555  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
123638560  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123638639  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123639320  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
123639435  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123639613  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123639636  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123639645  [KO:K03957]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123639755  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123639921  KRAS; GTPase KRas [KO:K07827]
123639957  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
123640141  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
123640204  [KO:K02268]
123640284  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123640642  [KO:K02268]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123641447  [KO:K02273]
123641584  [KO:K02268]
123641691  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
123642096  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
123642236  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
123642293  [KO:K03968]
123642582  CAT; catalase [KO:K03781] [EC:1.11.1.6]
123642684  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123642737  [KO:K03945]
123642823  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
123642832  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123643524  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
123643576  [KO:K00417]
123643743  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123643900  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123644027  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123644088  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123644332  [KO:K02268]
123644357  [KO:K03959]
123644439  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123644528  [KO:K00417]
123644587  [KO:K00417]
123644599  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123644675  [KO:K02268]
123644875  [KO:K00413]
123645117  [KO:K02273]
123645245  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123645738  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123646230  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
123646445  [KO:K03945]
123646534  FOS; proto-oncogene c-Fos [KO:K04379]
123646592  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123647132  AHR; aryl hydrocarbon receptor [KO:K09093]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123647253  [KO:K02272]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123647452  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
123647642  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123647646  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
123647735  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123648206  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
123648307  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
123648345  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123648630  [KO:K02272]
123648644  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123649468  SOS2; son of sevenless homolog 2 [KO:K03099]
123649624  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
123649856  [KO:K07415] [EC:1.14.14.-]
123649962  [KO:K02135]
123650070  AS3MT; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
123650126  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
123650127  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
123650134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123650270  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123650328  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123650352  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123650451  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
123650461  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650775  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
68929161  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
68929162  COX3; cytochrome c oxidase subunit III [KO:K02262]
68929165  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
68929167  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
68929174  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
68929177  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
68929182  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
68929184  COX2; cytochrome c oxidase subunit II [KO:K02261]
68929185  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
68929186  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
68929187  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
68929190  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
68929191  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
lcat00190  Oxidative phosphorylation
lcat00980  Metabolism of xenobiotics by cytochrome P450
lcat04010  MAPK signaling pathway
lcat04064  NF-kappa B signaling pathway
lcat04066  HIF-1 signaling pathway
lcat04151  PI3K-Akt signaling pathway
lcat04370  VEGF signaling pathway
lcat05207  Chemical carcinogenesis - receptor activation
lcat05211  Renal cell carcinoma
lcat05215  Prostate cancer
lcat05219  Bladder cancer
lcat05221  Acute myeloid leukemia
lcat05222  Small cell lung cancer
lcat05223  Non-small cell lung cancer
lcat05224  Breast cancer
lcat05225  Hepatocellular carcinoma
KO pathway
ko05208   

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