Entry Name JAK-STAT signaling pathway - Macaca mulatta (rhesus monkey)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 106995138 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
574127 IL6ST; interleukin-6 receptor subunit beta precursor [KO:K05060 ]
574128 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
574129 STAT5A; signal transducer and activator of transcription 5A isoform 2 [KO:K11223 ]
574199 IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063 ]
574300 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
574371 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
641338 IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070 ]
693445 PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706 ] [EC:2.3.2.-]
693569 OSMR; oncostatin-M-specific receptor subunit beta isoform X2 [KO:K05057 ]
693650 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
693737 SOCS7; suppressor of cytokine signaling 7 isoform X5 [KO:K04699 ]
693854 STAT4; signal transducer and activator of transcription 4 isoform X2 [KO:K11222 ]
694139 LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058 ]
694747 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
694806 IL19; LOW QUALITY PROTEIN: interleukin-19 [KO:K05444 ]
695286 STAM2; signal transducing adapter molecule 2 [KO:K04705 ]
696146 SOCS4; suppressor of cytokine signaling 4 [KO:K04697 ]
696331 IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069 ]
696737 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X4 [KO:K16063 ] [EC:2.3.2.-]
697508 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
698619 EGF; pro-epidermal growth factor isoform X2 [KO:K04357 ]
698961 CSF3; granulocyte colony-stimulating factor [KO:K05423 ]
698996 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
699604 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
699726 IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131 ]
699869 IL7R; interleukin-7 receptor subunit alpha [KO:K05072 ]
700201 IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056 ]
700677 IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064 ]
700959 CNTFR; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059 ]
701456 CISH; cytokine-inducible SH2-containing protein [KO:K04701 ]
702041 GRB2; growth factor receptor-bound protein 2 [KO:K04364 ]
703173 PDGFB; platelet-derived growth factor subunit B [KO:K17386 ]
704108 SOCS6; suppressor of cytokine signaling 6 [KO:K04699 ]
704383 IL10RA; interleukin-10 receptor subunit alpha [KO:K05134 ]
704649 IL5RA; interleukin-5 receptor subunit alpha [KO:K05067 ]
704890 IL20RA; interleukin-20 receptor subunit alpha isoform X3 [KO:K05136 ]
705404 IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071 ]
706012 IL10RB; interleukin-10 receptor subunit beta isoform X2 [KO:K05135 ]
706026 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
706775 PIAS3; LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS3 [KO:K16064 ] [EC:2.3.2.-]
707310 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
707539 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
707725 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
708339 IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077 ]
709719 IL31RA; interleukin-31 receptor subunit alpha [KO:K22630 ]
709760 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
709959 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
710552 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
710692 FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
710986 IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076 ]
711059 IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139 ]
711180 SOCS1; suppressor of cytokine signaling 1 [KO:K04694 ]
711625 IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140 ]
712554 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
712627 IL23A; interleukin-23 subunit alpha precursor [KO:K05426 ]
712694 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
712788 IL15RA; interleukin-15 receptor subunit alpha isoform 2 precursor [KO:K05074 ]
712941 GFAP; glial fibrillary acidic protein isoform X2 [KO:K05640 ]
713485 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
713777 SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099 ]
714159 STAT6; signal transducer and activator of transcription 6 [KO:K11225 ]
714998 SOCS5; suppressor of cytokine signaling 5 [KO:K04698 ]
715456 LIF; leukemia inhibitory factor isoform X1 [KO:K05419 ]
715680 SOCS3; suppressor of cytokine signaling 3 [KO:K04696 ]
715772 SOCS2; suppressor of cytokine signaling 2 [KO:K04695 ]
716098 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
716690 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
716769 IL20RB; interleukin-20 receptor subunit beta [KO:K05137 ]
717549 IL27RA; interleukin-27 receptor subunit alpha [KO:K19598 ]
717562 CSH2; chorionic somatomammotropin hormone 2 precursor [KO:K05438 ]
718135 CSH3; chorionic somatommamotropin hormone 3 precursor [KO:K05438 ]
719199 CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
719264 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
719367 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related mcc04060 Cytokine-cytokine receptor interaction
KO pathway
