KEGG   PATHWAY: mdt04510
Entry
mdt04510                    Pathway                                
Name
Focal adhesion - Myotis daubentonii (Daubenton's bat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mdt04510  Focal adhesion
mdt04510

Other DBs
GO: 0005925
Organism
Myotis daubentonii (Daubenton's bat) [GN:mdt]
Gene
132211132  LAMB4; laminin subunit beta-4 [KO:K06245]
132211195  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
132211551  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
132211802  SHC3; SHC-transforming protein 3 [KO:K17448]
132211969  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
132212126  TLN1; talin-1 isoform X1 [KO:K06271]
132212335  TNC; tenascin isoform X1 [KO:K06252]
132212494  LAMC3; laminin subunit gamma-3 [KO:K06247]
132212498  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
132212530  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
132212742  [KO:K06269] [EC:3.1.3.16]
132213451  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
132213506  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
132213639  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
132214445  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
132214715  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132214806  VCL; vinculin isoform X1 [KO:K05700]
132214841  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
132214965  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
132215129  CAV3; caveolin-3 [KO:K12959]
132215242  FLNB; filamin-B isoform X1 [KO:K27392]
132215436  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132215517  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132215576  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
132215577  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
132215581  [KO:K06238]
132215708  ITGA9; integrin alpha-9 [KO:K06585]
132215742  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
132215861  RHOA; transforming protein RhoA [KO:K04513]
132215871  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
132216059  [KO:K04513]
132216491  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
132216549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132216553  SPP1; osteopontin [KO:K06250]
132216690  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
132216708  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132216730  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
132216889  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132216915  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
132216931  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
132217017  [KO:K04392]
132217325  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
132217627  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
132218258  CRK; adapter molecule crk isoform X1 [KO:K04438]
132218317  VTN; vitronectin [KO:K06251]
132218548  ITGB3; integrin beta-3 [KO:K06493]
132218608  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
132218743  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
132218835  CHAD; chondroadherin [KO:K06248]
132218840  COL1A1; collagen alpha-1(I) chain [KO:K06236]
132218842  ITGA3; integrin alpha-3 [KO:K06482]
132218945  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
132218985  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
132219042  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
132219091  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
132219108  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
132219202  ACTG1; actin, cytoplasmic 2 [KO:K05692]
132219231  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
132219787  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
132220410  TNR; tenascin-R isoform X1 [KO:K06252]
132220499  LAMC1; laminin subunit gamma-1 [KO:K05635]
132220561  LAMB3; laminin subunit beta-3 [KO:K06244]
132220579  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
132220603  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
132220747  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
132220766  TNN; tenascin-N [KO:K06252]
132220881  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
132220900  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
132220983  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
132221162  THBS3; thrombospondin-3 [KO:K04659]
132221703  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
132221766  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
132221880  CRKL; crk-like protein [KO:K04438]
132221903  PXN; paxillin isoform X1 [KO:K05760]
132222289  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132222407  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132222451  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
132222466  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
132222752  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
132222759  MYL5; myosin light chain 5 [KO:K12753]
132222850  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
132223870  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
132224055  FLNA; filamin-A isoform X1 [KO:K04437]
132224354  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
132224466  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
132224555  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
132224935  [KO:K12958]
132224937  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
132224938  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
132225132  [KO:K05096] [EC:2.7.10.1]
132225178  [KO:K07836]
132226592  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
132226894  PARVG; gamma-parvin [KO:K06275]
132226895  PARVB; beta-parvin isoform X1 [KO:K06275]
132226946  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132227006  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132227107  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132227134  IBSP; bone sialoprotein 2 [KO:K06253]
132227175  VWF; von Willebrand factor [KO:K03900]
132227325  EMP1; epithelial membrane protein 1 [KO:K26255]
132227506  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
132227656  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
132227705  ITGA5; integrin alpha-5 [KO:K06484]
132227715  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
132227892  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
132228041  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
132228126  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132228358  [KO:K00907] [EC:2.7.11.18]
132228444  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132228537  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
132228539  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
132228769  VEGFC; vascular endothelial growth factor C [KO:K05449]
132229982  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
132229983  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
132230128  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132230275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
132230321  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
132230328  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
132230375  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
132230544  [KO:K16060]
132230648  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
132231012  JUN; transcription factor Jun [KO:K04448]
132231240  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132231248  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
132231353  PGF; placenta growth factor isoform X1 [KO:K16859]
132231564  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132231587  [KO:K04393]
132231710  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132232673  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132232753  MYL11; myosin regulatory light chain 11 [KO:K12758]
132232770  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
132232782  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132232956  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
132233077  EMP2; epithelial membrane protein 2 [KO:K26256]
132233231  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
132233477  THBS4; thrombospondin-4 [KO:K04659]
132233575  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132233784  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
132233791  ITGA2; integrin alpha-2 [KO:K06481]
132234588  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132234601  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132234607  [KO:K04456] [EC:2.7.11.1]
132234789  COMP; cartilage oligomeric matrix protein [KO:K04659]
132234815  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132234986  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132235106  VAV1; proto-oncogene vav [KO:K05730]
132235167  ITGA11; integrin alpha-11 [KO:K06587]
132235189  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
132235316  SHC2; SHC-transforming protein 2 [KO:K17447]
132235370  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132235407  PDGFC; platelet-derived growth factor C [KO:K05450]
132235774  [KO:K05740]
132235846  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
132236015  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132236028  ACTB; actin, cytoplasmic 1 [KO:K05692]
132236071  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
132236077  TLN2; talin-2 isoform X1 [KO:K06271]
132236688  THBS2; thrombospondin-2 [KO:K04659]
132236877  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
132236980  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
132236985  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
132237173  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
132237283  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132237332  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
132237519  SHC4; SHC-transforming protein 4 [KO:K17449]
132237677  TNXB; tenascin-X isoform X1 [KO:K06252]
132238032  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
132238200  FN1; fibronectin isoform X1 [KO:K05717]
132238301  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
132238302  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
132238394  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
132238466  ITGA4; integrin alpha-4 [KO:K06483]
132238530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
132238606  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
132239072  LAMA1; laminin subunit alpha-1 [KO:K05637]
132239073  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
132239152  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
132239155  THBS1; thrombospondin-1 [KO:K16857]
132239166  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
132239362  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
132239493  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
132239578  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
132239597  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132239657  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
132239734  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
132239766  [KO:K12757]
132239767  [KO:K12757]
132240074  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
132240569  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132240624  BIRC2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
132240625  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
132240692  [KO:K04513]
132240766  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132240917  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
132240975  PARVA; alpha-parvin [KO:K06275]
132241301  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
132241338  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
132241452  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
132241476  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
132241479  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132241831  HRAS; GTPase HRas isoform X1 [KO:K02833]
132242580  ITGA8; integrin alpha-8 [KO:K06584]
132242668  CAV2; caveolin-2 [KO:K12958]
132242670  CAV1; caveolin-1 isoform X1 [KO:K06278]
132242672  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
132242840  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
132242864  ZYX; zyxin [KO:K06273]
132242888  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132242951  COL1A2; collagen alpha-2(I) chain [KO:K06236]
132243017  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
132243125  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
132243131  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
132243153  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mdt04010  MAPK signaling pathway
mdt04060  Cytokine-cytokine receptor interaction
mdt04070  Phosphatidylinositol signaling system
mdt04110  Cell cycle
mdt04151  PI3K-Akt signaling pathway
mdt04310  Wnt signaling pathway
mdt04512  ECM-receptor interaction
mdt04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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