KEGG   PATHWAY: mdt04010
Entry
mdt04010                    Pathway                                
Name
MAPK signaling pathway - Myotis daubentonii (Daubenton's bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mdt04010  MAPK signaling pathway
mdt04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Myotis daubentonii (Daubenton's bat) [GN:mdt]
Gene
132211195  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
132211797  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
132211847  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
132212039  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
132212192  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
132212581  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
132212630  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
132212793  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
132212977  IL1R1; LOW QUALITY PROTEIN: interleukin-1 receptor type 1 [KO:K04386]
132212982  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
132213081  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132213109  IL1A; interleukin-1 alpha [KO:K04383]
132213110  IL1B; interleukin-1 beta [KO:K04519]
132213237  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
132213277  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
132213409  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
132213444  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
132213451  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
132213481  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
132213655  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
132214229  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
132214277  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
132214325  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132214489  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132214561  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
132214715  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132214757  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
132214826  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132214841  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
132214976  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
132215279  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
132215285  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
132215333  [KO:K04381]
132215436  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132215483  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
132215521  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
132215552  [KO:K03283]
132215631  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
132215694  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132215714  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
132215747  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
132215788  [KO:K03283]
132215793  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132215814  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
132215818  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
132215821  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
132216217  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
132216226  RRAS; ras-related protein R-Ras [KO:K07829]
132216318  FGF21; fibroblast growth factor 21 [KO:K22429]
132216546  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
132216547  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
132216548  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
132216549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132216614  NTF4; neurotrophin-4 [KO:K12457]
132216686  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
132216708  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132216748  RELB; transcription factor RelB isoform X1 [KO:K09253]
132216839  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
132216889  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132216892  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
132216939  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
132216946  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
132217017  [KO:K04392]
132217428  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132217491  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
132217892  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
132217935  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
132217961  AREG; amphiregulin [KO:K09782]
132217993  EREG; proepiregulin [KO:K09784]
132217995  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
132218058  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
132218117  ARRB2; beta-arrestin-2 [KO:K04439]
132218258  CRK; adapter molecule crk isoform X1 [KO:K04438]
132218285  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
132218324  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
132218330  NF1; neurofibromin isoform X1 [KO:K08052]
132218542  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
132218565  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
132218604  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
132218605  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
132218607  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
132218608  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
132218710  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
132218783  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
132218821  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
132218853  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132218933  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
132218945  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
132218985  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
132219013  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
132219031  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
132219042  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
132219091  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
132219231  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
132219614  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
132219684  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
132219747  MYC; myc proto-oncogene protein [KO:K04377]
132219953  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
132220261  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
132220296  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
132220304  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
132220343  NGF; beta-nerve growth factor [KO:K02582]
132220415  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132220464  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
132220680  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132220702  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
132220747  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
132220792  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
132220794  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
132220796  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
132221210  NRAS; GTPase NRas [KO:K07828]
132221856  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
132221880  CRKL; crk-like protein [KO:K04438]
132221963  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
132222009  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
132222289  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132222407  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132222472  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
132222491  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132222573  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
132222581  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
132222608  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
132222644  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
132222752  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
132222850  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
132223240  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
132223323  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
132223358  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
132224055  FLNA; filamin-A isoform X1 [KO:K04437]
132224109  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132224380  FGF16; fibroblast growth factor 16 [KO:K04358]
132224466  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
132224478  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132224555  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
132224643  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
132224732  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
132224970  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
132225132  [KO:K05096] [EC:2.7.10.1]
132225178  [KO:K07836]
132226467  FGF20; fibroblast growth factor 20 [KO:K04358]
132226829  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
132226843  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
132226858  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132226928  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
132226935  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
132226940  [KO:K04403]
132226946  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132227006  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132227032  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
132227107  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132227172  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
132227181  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
132227184  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
132227301  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132227384  KRAS; GTPase KRas isoform X1 [KO:K07827]
132227478  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
132227521  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
132227615  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
132227672  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
132227742  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
132227812  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
132227892  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
132227933  [KO:K04458] [EC:3.1.3.48]
132227995  KITLG; kit ligand isoform X1 [KO:K05461]
132227996  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
132228039  FGF23; fibroblast growth factor 23 [KO:K22428]
132228044  FGF6; fibroblast growth factor 6 [KO:K04358]
132228093  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
132228098  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
132228126  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132228127  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
132228208  FGF9; fibroblast growth factor 9 [KO:K04358]
132228444  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132228611  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
132228629  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132228681  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132228749  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
132228769  VEGFC; vascular endothelial growth factor C [KO:K05449]
132228794  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
132229726  [KO:K04457] [EC:3.1.3.16]
132230085  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
132230191  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
132230235  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
132230275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
132230524  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
132230901  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132230958  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132230960  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
132231012  JUN; transcription factor Jun [KO:K04448]
132231120  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
132231126  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
132231183  ARTN; artemin [KO:K25415]
132231259  FOS; protein c-Fos [KO:K04379]
132231353  PGF; placenta growth factor isoform X1 [KO:K16859]
132231460  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
132231484  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
132231504  STMN1; stathmin [KO:K04381]
132231564  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132231587  [KO:K04393]
132231637  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
132232321  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
132232562  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
132232567  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
132232673  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132232773  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
132232782  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132232903  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
132233171  MAX; protein max isoform X1 [KO:K04453]
132233214  HSPB1; heat shock protein beta-1 [KO:K04455]
132233377  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
132233439  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
132233445  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
132233465  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
132233543  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
132233699  FGF10; fibroblast growth factor 10 [KO:K04358]
132233748  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
132233809  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
132234095  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132234588  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132234601  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132234607  [KO:K04456] [EC:2.7.11.1]
132234623  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
132234663  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
132234728  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132234808  JUND; transcription factor JunD [KO:K04449]
132234916  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
132234940  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
132234959  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132234986  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132235020  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
132235122  PSPN; persephin [KO:K25416]
132235138  NRTN; neurturin [KO:K25414]
132235183  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132235230  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
132235244  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
132235249  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
132235276  EFNA2; ephrin-A2 [KO:K05462]
132235309  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132235370  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132235407  PDGFC; platelet-derived growth factor C [KO:K05450]
132235421  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
132235554  FGF2; fibroblast growth factor 2 [KO:K18497]
132235579  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132235729  CD14; monocyte differentiation antigen CD14 [KO:K04391]
132235794  FGF1; fibroblast growth factor 1 [KO:K18496]
132235845  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
132235846  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
132235958  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
132235968  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
132236015  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132236042  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
132236071  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
132236583  TNF; tumor necrosis factor [KO:K03156]
132236704  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
132236716  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
132236801  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
132236918  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
132237065  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
132237283  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132237302  SRF; serum response factor [KO:K04378]
132237395  FGF7; fibroblast growth factor 7 [KO:K04358]
132237408  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
132237411  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132237469  DAXX; death domain-associated protein 6 [KO:K02308]
132237693  [KO:K03283]
132237695  [KO:K03283]
132237696  [KO:K03283]
132238194  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
132238509  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
132238525  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
132238639  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
132238642  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
132238656  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
132238737  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
132239164  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
132239402  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
132239461  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
132239710  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132239912  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
132240569  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132240766  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132240789  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
132240997  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
132241082  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
132241226  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
132241254  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
132241300  FGF19; fibroblast growth factor 19 isoform X1 [KO:K22603]
132241412  RELA; transcription factor p65 isoform X1 [KO:K04735]
132241415  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
132241456  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
132241461  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
132241464  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
132241479  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132241616  [KO:K04526]
132241629  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132241831  HRAS; GTPase HRas isoform X1 [KO:K02833]
132241832  IGF2; insulin-like growth factor II [KO:K13769]
132241847  [KO:K04526]
132241904  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
132241978  [KO:K04526]
132241979  [KO:K04526]
132242328  FGF3; fibroblast growth factor 3 [KO:K04358]
132242329  FGF4; fibroblast growth factor 4 [KO:K04358]
132242351  [KO:K04526]
132242352  [KO:K04526]
132242482  [KO:K04453]
132242672  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
132242766  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
132242840  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
132242888  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132242889  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mdt04070  Phosphatidylinositol signaling system
mdt04110  Cell cycle
mdt04115  p53 signaling pathway
mdt04210  Apoptosis
mdt04310  Wnt signaling pathway
mdt04668  TNF signaling pathway
KO pathway
ko04010   

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