KEGG   PATHWAY: onl04082
Entry
onl04082                    Pathway                                
Name
Neuroactive ligand signaling - Oreochromis niloticus (Nile tilapia)
Description
Neuroactive ligand signaling is a process where receptors and ligands on the cell membrane initiate intracellular signaling pathways. It plays a crucial role in the development of various brain disorders.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
onl04082  Neuroactive ligand signaling
onl04082

Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100534440  chrm3a; cholinergic receptor, muscarinic 3a [KO:K04131]
100534441  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
100534442  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
100534444  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
100534510  grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100534512  gabra6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
100534513  [KO:K05190]
100534521  drd2a; D(2) dopamine receptor [KO:K04145]
100534557  gria2b; glutamate receptor 2 precursor [KO:K05198]
100534567  [KO:K04130]
100534577  [KO:K05208]
100534587  glur2a; glutamate receptor subunit 2A precursor [KO:K05198]
100689728  [KO:K05186]
100689896  [KO:K05858] [EC:3.1.4.11]
100689928  htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
100689978  [KO:K04542]
100689998  [KO:K05175]
100690061  slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
100690133  [KO:K05200]
100690173  [KO:K05208]
100690211  [KO:K00623] [EC:2.3.1.6]
100690386  [KO:K05840]
100690411  [KO:K05195]
100690895  [KO:K04819]
100691032  grik2; glutamate receptor ionotropic, kainate 2 isoform X1 [KO:K05202]
100691101  [KO:K04265]
100691116  [KO:K04809]
100691160  [KO:K04819]
100691167  gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X2 [KO:K04538]
100691177  slc17a6; vesicular glutamate transporter 2 [KO:K12302]
100691200  [KO:K07825]
100691231  adra2c; alpha-2C adrenergic receptor [KO:K04140]
100691272  [KO:K04160]
100691312  [KO:K05231]
100691355  [KO:K15015]
100691383  grik5; glutamate receptor ionotropic, kainate 5 isoform X1 [KO:K05205]
100691419  [KO:K04132]
100691431  [KO:K04819]
100691601  [KO:K05617]
100691717  [KO:K05213]
100691968  [KO:K04819]
100691998  [KO:K14387]
100692028  [KO:K04537]
100692053  [KO:K04270]
100692075  [KO:K14387]
100692136  [KO:K04809]
100692232  [KO:K12302]
100692486  [KO:K04136]
100692868  [KO:K05181]
100692877  [KO:K05214]
100692921  [KO:K04298]
100692942  [KO:K05190]
100693077  [KO:K04144]
100693191  [KO:K15015]
100693192  [KO:K08388]
100693279  [KO:K04147]
100693476  [KO:K05190]
100693586  tac1; protachykinin-1 isoform X1 [KO:K05239]
100693716  [KO:K04144]
100693864  gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100693875  [KO:K04534]
100693903  [KO:K12302]
100693904  tacr2; substance-K receptor [KO:K04223]
100693910  slc6a9; sodium- and chloride-dependent glycine transporter 1 isoform X2 [KO:K05038]
100693919  [KO:K08042] [EC:4.6.1.1]
100694014  [KO:K05197]
100694268  htr3b; 5-hydroxytryptamine receptor 3B isoform X2 [KO:K04819]
100694310  [KO:K05046]
100694359  [KO:K05196]
100694536  [KO:K04819]
100694586  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100694621  [KO:K04139]
100694807  tacr3a; tachykinin receptor 3a [KO:K04224]
100694824  [KO:K05189]
100695013  [KO:K04630]
100695029  [KO:K05217]
100695110  grm2; metabotropic glutamate receptor 2 [KO:K04605]
100695156  oprd1; delta-type opioid receptor [KO:K04213]
100695334  [KO:K04160]
100695498  [KO:K04615]
100695642  gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100695736  gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
100695768  [KO:K07825]
100695832  [KO:K04216]
100695922  [KO:K05199]
100695984  [KO:K04202]
100696068  gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100696293  [KO:K04809]
100696351  [KO:K04813]
100696482  [KO:K04547]
100696556  [KO:K05618]
100696596  [KO:K04630]
100696615  [KO:K04808]
100696649  [KO:K05211]
100696671  [KO:K04815]
100696792  gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X4 [KO:K05181]
100696880  [KO:K04809]
100696902  [KO:K04819]
100697058  [KO:K05175]
100697118  [KO:K12303]
100697180  htr1e; 5-hydroxytryptamine receptor 1E [KO:K04153]
100697329  [KO:K04213]
100697383  [KO:K04299]
100697457  hrh1; histamine H1 receptor [KO:K04149]
100697502  [KO:K04603]
100697557  [KO:K05199]
100697719  [KO:K04265]
100697798  [KO:K04819]
100697877  glra1; glycine receptor subunit alpha-1 isoform X2 [KO:K05193]
100697913  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
100697949  [KO:K04634]
100697977  [KO:K04819]
100697987  slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
100698064  [KO:K04819]
100698125  p2ry2; P2Y purinoceptor 2 [KO:K04269]
100698133  slc1a7; excitatory amino acid transporter 5 [KO:K05618]
100698156  [KO:K05613]
100698181  [KO:K04271]
100698239  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X2 [KO:K04545]
100698248  [KO:K04819]
100698389  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100698410  [KO:K04265]
100698466  [KO:K04265]
100698500  [KO:K05175]
100698517  [KO:K15840]
100698523  [KO:K02677] [EC:2.7.11.13]
100698540  gabbr1; gamma-aminobutyric acid type B receptor subunit 1 isoform X2 [KO:K04615]
100698700  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100698754  [KO:K05614]
100698769  [KO:K05192]
100698774  tacr3l; tachykinin receptor 3-like [KO:K04224]
100698779  [KO:K04819]
100698807  [KO:K25696]
100698927  p2ry6; P2Y purinoceptor 6 isoform X2 [KO:K04272]
100698985  [KO:K04347]
100699011  [KO:K04608]
100699029  [KO:K05201]
100699061  [KO:K05046]
100699144  gabra2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X2 [KO:K05175]
100699220  [KO:K05212]
100699267  [KO:K04299]
100699331  [KO:K05045]
100699333  gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100699411  gabra4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
100699420  [KO:K04132]
100699483  [KO:K04809]
100699488  htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
100699493  [KO:K19663] [EC:2.7.11.13]
100699508  p2ry1; P2Y purinoceptor 1 [KO:K04270]
100699675  grik4; glutamate receptor ionotropic, kainate 4 isoform X1 [KO:K05204]
100699691  slc18a2; synaptic vesicular amine transporter [KO:K08155]
100699865  [KO:K05045]
100699878  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100699892  [KO:K04270]
100699935  [KO:K04299]
100699977  [KO:K04345] [EC:2.7.11.11]
100700017  [KO:K04808]
100700102  [KO:K04604]
100700221  [KO:K04607]
100700254  [KO:K04609]
100700288  [KO:K04813]
100700329  slc6a2; sodium-dependent noradrenaline transporter [KO:K05035]
100700364  [KO:K14387]
100700452  [KO:K04345] [EC:2.7.11.11]
100700566  [KO:K05612]
100700618  [KO:K05045]
100700639  [KO:K14387]
100700659  [KO:K04150]
100700730  [KO:K04347]
100700744  p2rx4; P2X purinoceptor 4 [KO:K05218]
100700808  [KO:K00623] [EC:2.3.1.6]
100700872  [KO:K04131]
100700957  [KO:K05186]
100700994  drd3; D(3) dopamine receptor isoform X1 [KO:K04146]
100701095  [KO:K04542]
100701129  [KO:K05612]
100701288  adora2a; adenosine receptor A2a [KO:K04266]
100701338  slc17a9; solute carrier family 17 member 9 [KO:K12303]
100701482  ogfrl1; opioid growth factor receptor-like protein 1 [KO:K27951]
100701565  [KO:K04610]
100701604  [KO:K04138]
100701745  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100701884  [KO:K04607]
100701901  [KO:K05618]
100701911  [KO:K05046]
100701958  p2rx3; P2X purinoceptor 3 [KO:K05217]
100702054  [KO:K04539]
100702106  [KO:K04299]
100702227  [KO:K05202]
100702384  [KO:K14387]
100702460  [KO:K08046] [EC:4.6.1.1]
100702581  [KO:K04608]
100702736  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100702846  [KO:K08041] [EC:4.6.1.1]
100702900  [KO:K05045]
100702914  grik3; glutamate receptor ionotropic, kainate 3 isoform X1 [KO:K05203]
100703029  adora2b; adenosine receptor A2b [KO:K04267]
100703205  [KO:K19662] [EC:2.7.11.13]
100703248  [KO:K04819]
100703444  [KO:K04222]
100703472  slc18a1; chromaffin granule amine transporter [KO:K08155]
100703488  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100703527  [KO:K04630]
100703627  [KO:K04806]
100703648  [KO:K04265]
100703715  [KO:K05181]
100703851  asip2b; agouti-signaling protein 2b precursor [KO:K05231]
100703896  [KO:K04536]
100703903  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100704175  chrnb2; neuronal acetylcholine receptor subunit beta-2 isoform X2 [KO:K04813]
100704279  [KO:K05618]
100704341  [KO:K12302]
100704362  gabrg3; gamma-aminobutyric acid receptor subunit gamma-3 isoform X1 [KO:K05186]
100704485  adcy6; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100704531  [KO:K04147]
100704683  [KO:K04266]
100704734  [KO:K05205]
100704763  [KO:K04153]
100704837  pomc; pro-opiomelanocortin [KO:K05228]
100704862  [KO:K05045]
100704911  slc6a5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
100704945  [KO:K08043] [EC:4.6.1.1]
100705106  [KO:K04609]
100705226  htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
100705403  [KO:K05211]
100705418  [KO:K05189]
100705513  [KO:K04809]
100705532  gabrd; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
100705590  gria1; glutamate receptor 1 isoform X1 [KO:K05197]
100705754  p2ry4; P2Y purinoceptor 4 [KO:K04271]
100705767  [KO:K05046]
100705788  [KO:K04265]
100705805  [KO:K08048] [EC:4.6.1.1]
100705829  [KO:K04135]
100705871  [KO:K05201]
100705941  [KO:K04163]
100705974  [KO:K05840]
100706002  [KO:K05200]
100706029  [KO:K05046]
100706035  [KO:K08048] [EC:4.6.1.1]
100706095  [KO:K04606]
100706147  [KO:K04630]
100706405  [KO:K04634]
100706434  [KO:K08041] [EC:4.6.1.1]
100706448  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
100706475  [KO:K04142]
100706492  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X4 [KO:K05858] [EC:3.1.4.11]
100706564  [KO:K05228]
100706628  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100706693  penk; proenkephalin-A [KO:K18832]
100706726  [KO:K05219]
100706735  slc6a3; sodium-dependent dopamine transporter [KO:K05036]
100706736  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100706825  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100706838  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100706970  [KO:K04805]
100706979  [KO:K27951]
100707363  [KO:K04630]
100707451  gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
100707702  [KO:K04534]
100707705  gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100707753  [KO:K05219]
100707787  slc1a2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
100707801  [KO:K08042] [EC:4.6.1.1]
100707806  [KO:K05046]
100707925  [KO:K04157]
100708032  [KO:K05612]
100708037  [KO:K05190]
100708075  [KO:K05034]
100708081  [KO:K04144]
100708101  [KO:K05037]
100708106  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100708153  glrb; LOW QUALITY PROTEIN: glycine receptor subunit beta [KO:K05196]
100708184  [KO:K04145]
100708195  [KO:K04153]
100708260  [KO:K04547]
100708290  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
100708556  [KO:K04140]
100708712  [KO:K04605]
100708799  [KO:K05190]
100708840  [KO:K05228]
100708843  hrh3; histamine H3 receptor [KO:K04151]
100708890  [KO:K04135]
100708927  [KO:K05614]
100708943  [KO:K05037]
100709052  [KO:K04635]
100709091  [KO:K04549]
100709169  [KO:K05210]
100709194  [KO:K05212]
100709486  [KO:K05219]
100709518  [KO:K05612]
100709573  [KO:K04819]
100709658  [KO:K04633]
100709703  htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
100709845  [KO:K04819]
100709972  [KO:K14387]
100710007  [KO:K08043] [EC:4.6.1.1]
100710012  [KO:K04270]
100710051  [KO:K15015]
100710082  [KO:K04632]
100710112  [KO:K04819]
100710201  [KO:K05034]
100710216  [KO:K25696]
100710254  [KO:K08049] [EC:4.6.1.1]
100710277  [KO:K04270]
100710318  [KO:K04270]
100710383  [KO:K04635]
100710435  [KO:K05175]
100710487  [KO:K05046]
100710537  [KO:K04270]
100710626  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
100710691  gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100710701  gabrb2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
100710773  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
100710807  [KO:K04270]
100710833  adrb1; beta-1 adrenergic receptor [KO:K04141]
100710878  prkcb; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100711075  [KO:K04548]
100711263  [KO:K04214]
100711441  slc1a1; excitatory amino acid transporter 3 [KO:K05612]
100711458  drd5; D(1B) dopamine receptor [KO:K05840]
100711588  [KO:K04610]
100711747  [KO:K04142]
100711766  [KO:K05216]
100711771  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100711823  [KO:K05613]
100711863  [KO:K04347]
100711872  adra1d; alpha-1D adrenergic receptor [KO:K04137]
100712161  [KO:K04214]
100712188  [KO:K04160]
100712199  [KO:K05175]
100712216  grin3b; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
100712311  [KO:K04140]
100712332  [KO:K04215]
100712364  [KO:K04150]
100712365  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
100712467  gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X2 [KO:K05186]
100712525  [KO:K04151]
100712559  htr6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
102076535  [KO:K04299]
102076579  [KO:K04299]
102076659  [KO:K04299]
102076962  [KO:K04819]
102077656  [KO:K14636]
102078059  [KO:K04819]
102078120  adra2a; alpha-2A adrenergic receptor [KO:K04138]
102078222  [KO:K04268]
102078543  [KO:K14636]
102078911  [KO:K04299]
102079012  [KO:K04299]
102079319  [KO:K04299]
102079696  [KO:K04147]
102079892  [KO:K04271]
102080041  [KO:K04299]
102080206  [KO:K04299]
102080309  [KO:K04299]
102080330  [KO:K04299]
102080503  [KO:K04299]
102080527  [KO:K01049] [EC:3.1.1.7]
102080595  [KO:K04299]
102080687  [KO:K04299]
102080867  [KO:K04299]
102080921  [KO:K04615]
102080969  [KO:K04299]
102081136  [KO:K04299]
102082036  tac3a; tachykinin-3a precursor [KO:K05240]
102082854  htr2b; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
106096419  [KO:K12302]
106096432  [KO:K05045]
106096482  adra1b; alpha-1B adrenergic receptor [KO:K04136]
106097128  [KO:K04299]
106097434  [KO:K04299]
106097717  [KO:K04819]
106097765  [KO:K04270]
106097981  grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
106098040  [KO:K27951]
109194374  [KO:K05219]
109194741  [KO:K04819]
109194823  [KO:K04819]
109194860  [KO:K04819]
109196255  [KO:K04270]
109196862  [KO:K04299]
109196873  [KO:K04299]
109199707  [KO:K04299]
109200173  [KO:K04299]
109201767  [KO:K04819]
109202831  [KO:K04135]
109203134  [KO:K04819]
109204139  [KO:K04615]
112842169  [KO:K04271]
112843310  [KO:K04270]
112846535  [KO:K04299]
112846544  [KO:K04299]
112847337  [KO:K04270]
112847366  [KO:K04145]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00025  L-Glutamate
C00029  UDP-glucose
C00037  Glycine
C00075  UTP
C00076  Calcium cation
C00114  Choline
C00165  Diacylglycerol
C00212  Adenosine
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01330  Sodium cation
C01996  Acetylcholine
C02210  beta-Endorphin
C02758  alpha-Melanotropin
C03758  Dopamine
C11684  MET-enkephalin
C15871  Nocistatin
C16039  alpha-Neoendorphin
C16040  beta-Neoendorphin
C16041  Leu-enkephalin
C16044  Nociceptin
C16094  Substance P
C16095  Neuropeptide K
C16096  Neuropeptide gamma
C16097  Neurokinin A
C16098  Neurokinin B
C16099  Endokinin A/B
C16100  Endokinin C
C16101  Endokinin D
C16103  Agouti related protein (87-132)
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
Reference
PMID:37385351
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Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V
  Title
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications.
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Ageing Res Rev 89:101994 (2023)
DOI:10.1016/j.arr.2023.101994
Reference
PMID:31726793
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Malik AR, Willnow TE
  Title
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.
  Journal
Int J Mol Sci 20:ijms20225671 (2019)
DOI:10.3390/ijms20225671
Reference
PMID:25116141
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
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Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
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Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:35055019
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  Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
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Int J Mol Sci 23:ijms23020834 (2022)
DOI:10.3390/ijms23020834
Reference
PMID:33924731
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Wang Y, Tan B, Wang Y, Chen Z
  Title
Cholinergic Signaling, Neural Excitability, and Epilepsy.
  Journal
Molecules 26:molecules26082258 (2021)
DOI:10.3390/molecules26082258
Reference
PMID:36757901
  Authors
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  Title
Dopamine, Immunity, and Disease.
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Pharmacol Rev 75:62-158 (2023)
DOI:10.1124/pharmrev.122.000618
Reference
PMID:25037203
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Savica R, Benarroch EE
  Title
Dopamine receptor signaling in the forebrain: recent insights and clinical implications.
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Neurology 83:758-67 (2014)
DOI:10.1212/WNL.0000000000000719
Reference
PMID:33651238
  Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
  Title
The Roles of Serotonin in Neuropsychiatric Disorders.
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Cell Mol Neurobiol 42:1671-1692 (2022)
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  Authors
Chhatar S, Lal G
  Title
Role of adrenergic receptor signalling in neuroimmune communication.
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Curr Res Immunol 2:202-217 (2021)
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Reference
PMID:39337347
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Szukiewicz D
  Title
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders.
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Int J Mol Sci 25:ijms25189859 (2024)
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PMID:33907179
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Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y
  Title
From purines to purinergic signalling: molecular functions and human diseases.
  Journal
Signal Transduct Target Ther 6:162 (2021)
DOI:10.1038/s41392-021-00553-z
Reference
PMID:16715052
  Authors
Fields RD, Burnstock G
  Title
Purinergic signalling in neuron-glia interactions.
  Journal
Nat Rev Neurosci 7:423-36 (2006)
DOI:10.1038/nrn1928
Reference
PMID:26880796
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
PMID:28360832
  Authors
Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA
  Title
A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling.
  Journal
Front Neurosci 11:128 (2017)
DOI:10.3389/fnins.2017.00128
Reference
PMID:26956246
  Authors
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT
  Title
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
  Journal
Pharmacol Rev 68:419-57 (2016)
DOI:10.1124/pr.114.009209
Reference
PMID:36589829
  Authors
Campo A, Dufour S, Rousseau K
  Title
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.
  Journal
Front Endocrinol (Lausanne) 13:1056939 (2022)
DOI:10.3389/fendo.2022.1056939
Related
pathway
onl04080  Neuroactive ligand-receptor interaction
KO pathway
ko04082   

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