KEGG   PATHWAY: oro04020
Entry
oro04020                    Pathway                                
Name
Calcium signaling pathway - Odobenus rosmarus divergens (Pacific walrus)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
oro04020  Calcium signaling pathway
oro04020

Other DBs
GO: 0019722
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101373996  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
101364689  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
101367838  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
101374723  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X2 [KO:K05850] [EC:7.2.2.10]
101376015  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
101368088  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101377158  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101380644  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101362497  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101363589  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101380968  ADORA2A; adenosine receptor A2a [KO:K04266]
101362544  ADORA2B; adenosine receptor A2b [KO:K04267]
101365047  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101369132  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101386439  ADRB3; beta-3 adrenergic receptor [KO:K04143]
101368015  DRD1; D(1A) dopamine receptor [KO:K04144]
101380571  DRD5; D(1B) dopamine receptor [KO:K05840]
101363420  HRH2; histamine H2 receptor [KO:K04150]
101368249  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101377489  5-hydroxytryptamine receptor 5B [KO:K04161]
101373554  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101372756  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101384881  5-hydroxytryptamine receptor 7 [KO:K04163]
101364060  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105757053  neuroendocrine secretory protein 55 [KO:K04632]
101380718  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
101379158  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101365382  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101368682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101374313  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101377421  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101370350  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101364108  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101367408  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101383001  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101379994  PLN; cardiac phospholamban [KO:K05852]
101376225  SLN; sarcolipin [KO:K22642]
105757746  MRLN; myoregulin [KO:K22643]
101371487  LOW QUALITY PROTEIN: uncharacterized protein C4orf3 homolog [KO:K26467]
105758244  uncharacterized protein C4orf3-like [KO:K26467]
105757119  SMIM6; small integral membrane protein 6 [KO:K26468]
101365162  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
101384489  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101375916  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101381812  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101384093  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
101370709  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
101368790  ORAI1; LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1 [KO:K16056]
101385776  ORAI2; protein orai-2 isoform X2 [KO:K16057]
101376699  ORAI3; protein orai-3 [KO:K16058]
101365624  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101383514  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101364481  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101385947  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101378448  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105758129  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
101364776  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101372746  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101383587  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101375448  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101363826  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
101368224  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101378928  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101365544  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101369978  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101383267  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101368398  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101374464  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101384775  P2RX1; P2X purinoceptor 1 [KO:K05215]
101370874  P2RX2; P2X purinoceptor 2 isoform X2 [KO:K05216]
101362559  P2RX3; P2X purinoceptor 3 [KO:K05217]
101366441  P2RX4; P2X purinoceptor 4 [KO:K05218]
101362420  P2RX5; P2X purinoceptor 5 [KO:K05219]
101384051  P2RX6; P2X purinoceptor 6 [KO:K05221]
101366160  P2RX7; P2X purinoceptor 7 [KO:K05220]
101364655  RYR1; ryanodine receptor 1 [KO:K04961]
101372904  RYR2; ryanodine receptor 2 [KO:K04962]
101368222  ryanodine receptor 2-like [KO:K04962]
101385528  RYR3; ryanodine receptor 3 [KO:K04963]
101374417  TRDN; triadin [KO:K23449]
101379932  CASQ1; calsequestrin-1 [KO:K23468]
101367828  CASQ2; calsequestrin-2 [KO:K23445]
101373057  ASPH; LOW QUALITY PROTEIN: aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
101366264  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
101384329  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
101386108  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101384467  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
101371896  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101370400  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101377034  AGTR1; type-1 angiotensin II receptor [KO:K04166]
101363432  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101375015  EDNRB; endothelin B receptor isoform X1 [KO:K04198]
101364644  F2R; proteinase-activated receptor 1 [KO:K03914]
101372426  metabotropic glutamate receptor 5 [KO:K04604]
101362417  GRPR; gastrin-releasing peptide receptor [KO:K04169]
101367199  HRH1; histamine H1 receptor [KO:K04149]
101363070  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
101380929  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101370581  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101372292  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101369761  NTSR1; neurotensin receptor type 1 [KO:K04211]
101367602  OXTR; oxytocin receptor [KO:K04229]
101367239  AVPR1A; vasopressin V1a receptor [KO:K04226]
101365450  AVPR1B; vasopressin V1b receptor [KO:K04227]
101374596  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
101362393  PTAFR; platelet-activating factor receptor [KO:K04279]
101385186  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
101371218  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
101373972  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
101383369  BDKRB1; B1 bradykinin receptor [KO:K03915]
101383657  BDKRB2; B2 bradykinin receptor [KO:K03916]
101384608  TACR1; substance-P receptor [KO:K04222]
101373686  TACR2; LOW QUALITY PROTEIN: substance-K receptor [KO:K04223]
101377113  TACR3; neuromedin-K receptor [KO:K04224]
101380456  TBXA2R; thromboxane A2 receptor [KO:K04264]
101378393  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
101362456  thyrotropin-releasing hormone receptor-like [KO:K04282]
101371996  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
101369318  CCKAR; cholecystokinin receptor type A [KO:K04194]
101382765  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
101372091  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
101384596  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101385358  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101385168  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
101385055  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
101377629  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101384783  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101386160  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101370194  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
101363701  PDGFD; platelet-derived growth factor D [KO:K05450]
101378889  PDGFC; platelet-derived growth factor C [KO:K05450]
101363195  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101369428  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101377940  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101370946  FGF4; fibroblast growth factor 4 [KO:K04358]
101379461  FGF18; fibroblast growth factor 18 [KO:K04358]
101379943  FGF20; fibroblast growth factor 20 [KO:K04358]
101382345  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101366748  FGF10; fibroblast growth factor 10 [KO:K04358]
101385349  FGF3; fibroblast growth factor 3 [KO:K04358]
101382205  FGF22; fibroblast growth factor 22 [KO:K04358]
101366655  FGF16; fibroblast growth factor 16 [KO:K04358]
101373546  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101379430  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101381072  FGF9; fibroblast growth factor 9 [KO:K04358]
101364070  FGF6; fibroblast growth factor 6 [KO:K04358]
101385649  FGF19; fibroblast growth factor 19 [KO:K22603]
101373782  FGF21; fibroblast growth factor 21 [KO:K22429]
101363779  FGF23; fibroblast growth factor 23 [KO:K22428]
101363442  VEGFA; vascular endothelial growth factor A [KO:K05448]
101377548  VEGFB; vascular endothelial growth factor B [KO:K16858]
101372364  FIGF; vascular endothelial growth factor D [KO:K05449]
101375487  VEGFC; vascular endothelial growth factor C [KO:K05449]
101384791  NGF; beta-nerve growth factor [KO:K02582]
101373766  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101386282  MST1; hepatocyte growth factor-like protein [KO:K23441]
101379435  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101386858  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101364161  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101385903  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101371484  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101372359  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101374793  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101364849  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101381278  FGFR2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
101381434  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101381264  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
101383542  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101382368  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101371459  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101374117  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101364921  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101382416  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
101365730  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101364199  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
101372117  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101370467  uncharacterized protein LOC101370467 [KO:K06856]
101372489  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
101364713  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
101364446  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
101379806  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101375710  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101386162  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
101386750  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101380728  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101378505  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101367598  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
101377048  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101367743  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101377380  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101380808  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
101364829  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101370929  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
101371838  TPCN2; two pore calcium channel protein 2 [KO:K14077]
101363074  MCOLN1; mucolipin-1 [KO:K04992]
101362883  MCOLN2; mucolipin-2 [KO:K04993]
101362389  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
101376404  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
101375807  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
101376167  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101375766  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
101374903  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101374285  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101374369  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
101366629  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101372733  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101371414  ADP/ATP translocase 3 [KO:K05863]
101367537  ADP/ATP translocase 2 [KO:K05863]
101384049  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101374224  ADP/ATP translocase 3-like [KO:K05863]
101380401  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101367695  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
101377125  TNNC2; troponin C, skeletal muscle [KO:K12042]
101377410  troponin C, skeletal muscle [KO:K12042]
101373722  calmodulin-alpha-like [KO:K02183]
101384567  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101376564  CALML5; calmodulin-like protein 5 [KO:K02183]
101370824  CALML6; calmodulin-like protein 6 [KO:K02183]
101376265  CALML3; calmodulin-like protein 3 [KO:K02183]
101371788  CALM3; calmodulin [KO:K02183]
101386691  calmodulin-like [KO:K02183]
101372085  calmodulin-A-like [KO:K02183]
101379187  CALM1; calmodulin isoform X1 [KO:K02183]
101366685  CALM2; calmodulin isoform X1 [KO:K02183]
101366392  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101373618  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101367461  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
101368489  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
101382433  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X2 [KO:K07190]
101368074  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101370711  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
101378973  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101381609  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101375985  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
101368451  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
101363153  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
101375584  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
101375944  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101367567  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
101384300  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
101369425  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101363063  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101363831  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101385000  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101386271  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101368686  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101370536  TFEB; transcription factor EB [KO:K15590]
101385449  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101379396  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101378978  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101373256  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
101375441  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101380967  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101382350  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
101365244  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101380225  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
101363002  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101373391  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101371630  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101386647  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101364992  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101386060  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101380879  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101363254  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
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PMID:11413485
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The versatility and universality of calcium signalling.
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Nat Rev Mol Cell Biol 1:11-21 (2000)
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PMID:15111104
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Reference
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
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J Bioenerg Biomembr 35:577-98 (2003)
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Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Neurosci Res 38:3-17 (2000)
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
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Reference
PMID:7861177
  Authors
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  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
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Reference
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Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
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Cell Calcium 34:431-44 (2003)
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Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
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Mol Cell Biochem 193:89-98 (1999)
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Reference
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Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Seikagaku 80:1123-8 (2008)
Reference
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
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Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
oro04010  MAPK signaling pathway
oro04070  Phosphatidylinositol signaling system
oro04210  Apoptosis
oro04720  Long-term potentiation
oro04730  Long-term depression
KO pathway
ko04020   
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