KEGG   PATHWAY: oro04010
Entry
oro04010                    Pathway                                
Name
MAPK signaling pathway - Odobenus rosmarus divergens (Pacific walrus)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
oro04010  MAPK signaling pathway
oro04010

Other DBs
GO: 0000165
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101378448  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105758129  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
101365624  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101383514  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101364776  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101364481  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101372746  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
101383587  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
101375448  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101385947  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101373490  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3 [KO:K04858]
101372567  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
101369586  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101374807  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101369484  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
101384101  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
101372967  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101374377  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101385170  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101371776  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101380585  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101385471  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101385761  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101363836  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101363554  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101369649  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101367408  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101383001  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101386060  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101380879  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101363254  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101371250  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101379027  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101374080  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101368814  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
101363063  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101363831  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101385000  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101386271  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
101368686  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101362541  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101363140  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101372513  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101369676  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101371588  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101365772  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101373494  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
101378635  NF1; neurofibromin isoform X1 [KO:K08052]
101372560  RASA1; ras GTPase-activating protein 1 [KO:K04352]
101366946  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101375466  RAP1A; ras-related protein Rap-1A [KO:K04353]
101383971  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101377629  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101384783  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101367107  EREG; proepiregulin isoform X2 [KO:K09784]
101367396  AREG; amphiregulin isoform X1 [KO:K09782]
101363195  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101369428  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101377940  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101370946  FGF4; fibroblast growth factor 4 [KO:K04358]
101379461  FGF18; fibroblast growth factor 18 [KO:K04358]
101379943  FGF20; fibroblast growth factor 20 [KO:K04358]
101382345  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101366748  FGF10; fibroblast growth factor 10 [KO:K04358]
101385349  FGF3; fibroblast growth factor 3 [KO:K04358]
101382205  FGF22; fibroblast growth factor 22 [KO:K04358]
101366655  FGF16; fibroblast growth factor 16 [KO:K04358]
101373546  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101379430  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101381072  FGF9; fibroblast growth factor 9 [KO:K04358]
101364070  FGF6; fibroblast growth factor 6 [KO:K04358]
101385649  FGF19; fibroblast growth factor 19 [KO:K22603]
101373782  FGF21; fibroblast growth factor 21 [KO:K22429]
101363779  FGF23; fibroblast growth factor 23 [KO:K22428]
101384791  NGF; beta-nerve growth factor [KO:K02582]
101372507  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101386733  NTF3; neurotrophin-3 [KO:K04356]
101369695  NTF4; neurotrophin-4 [KO:K12457]
101383590  INS; insulin [KO:K04526]
101386334  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101384061  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
101386160  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101370194  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
101363701  PDGFD; platelet-derived growth factor D [KO:K05450]
101378889  PDGFC; platelet-derived growth factor C [KO:K05450]
101365427  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101378811  KITLG; kit ligand isoform X1 [KO:K05461]
101383895  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
101363442  VEGFA; vascular endothelial growth factor A [KO:K05448]
101377548  VEGFB; vascular endothelial growth factor B [KO:K16858]
101369724  PGF; placenta growth factor [KO:K16859]
101372364  FIGF; vascular endothelial growth factor D [KO:K05449]
101375487  VEGFC; vascular endothelial growth factor C [KO:K05449]
101373766  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101373650  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101366974  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101371627  ANGPT4; angiopoietin-4 [KO:K05467]
101362498  EFNA5; ephrin-A5 [KO:K05462]
101374175  EFNA2; ephrin-A2 [KO:K05462]
101369919  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
101370418  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101370908  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
101379435  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101365865  NRTN; LOW QUALITY PROTEIN: neurturin [KO:K25414]
101378458  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
101363290  PSPN; persephin [KO:K25416]
101386858  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101364161  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101385903  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101371484  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101364849  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
101381278  FGFR2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
101381434  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101381264  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
101365058  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101374117  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101364921  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101363371  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101386211  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101372359  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101374793  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101374504  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101372059  KIT; mast/stem cell growth factor receptor Kit isoform X7 [KO:K05091] [EC:2.7.10.1]
101382975  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101383542  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101382368  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101371459  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101365730  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101367636  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101383361  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101372117  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101362094  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101385114  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101369947  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101367134  GTPase HRas-like [KO:K02833]
101372786  HRAS; GTPase HRas isoform X1 [KO:K02833]
101370458  KRAS; GTPase KRas isoform X2 [KO:K07827]
101363525  NRAS; GTPase NRas [KO:K07828]
101385933  RRAS; ras-related protein R-Ras [KO:K07829]
101370485  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101362579  MRAS; ras-related protein M-Ras [KO:K07831]
101372839  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101377465  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101372149  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101365373  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101376586  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101366818  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
101372573  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101382213  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101370796  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101368987  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
101384669  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
101362329  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
101375077  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X3 [KO:K04373] [EC:2.7.11.1]
101374068  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
101368122  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101373422  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101362376  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101369253  MYC; myc proto-oncogene protein [KO:K04377]
101381964  SRF; serum response factor isoform X1 [KO:K04378]
101366773  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
101371518  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
101380354  STMN1; stathmin [KO:K04381]
101377203  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101377493  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101374803  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101362322  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
101386671  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101368209  TNF; tumor necrosis factor [KO:K03156]
101382716  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101383005  IL1B; interleukin-1 beta [KO:K04519]
101385166  TGFB1; transforming growth factor beta-1 [KO:K13375]
101380860  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101364584  TGFB3; transforming growth factor beta-3 [KO:K13377]
101386839  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101381751  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101372824  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
101379465  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101364575  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101381319  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101369551  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101376703  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101378519  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101366544  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101385830  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101374128  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101364638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101368290  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101371336  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101371938  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101377893  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
101363951  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101382179  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101380365  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101362953  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101374376  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101374334  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101363875  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101369401  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101369627  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101364495  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
101370836  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101380207  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101365168  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101365642  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101369067  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101382383  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101364004  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
101368484  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
101385184  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101366511  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101382287  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X2 [KO:K04419] [EC:2.7.11.25]
101368270  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101375291  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
101379119  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
101375908  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101365627  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
101365423  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
101370047  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
101381295  mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
101374941  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101374728  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101376824  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101379514  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101370505  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
101373319  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
101386468  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101386473  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [KO:K04430] [EC:2.7.12.2]
101382078  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101378651  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101382167  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101362732  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
101377995  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101363715  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101380560  FLNA; filamin-A [KO:K04437]
101369015  CRKL; crk-like protein [KO:K04438]
101384062  CRK; adapter molecule crk isoform X1 [KO:K04438]
101382651  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101380767  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101367488  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101374143  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101376185  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101377143  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101377430  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101382259  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101382558  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101383640  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
101362132  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 5-like [KO:K04442] [EC:2.7.11.1]
101380197  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
101374104  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101380272  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101371636  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101366762  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101385449  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101378978  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101368207  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
101373268  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
101374034  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101362427  TP53; cellular tumor antigen p53 [KO:K04451]
101380889  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101385122  MAX; protein max isoform X1 [KO:K04453]
101370419  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101364789  HSPB1; heat shock protein beta-1 [KO:K04455]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101367915  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
101366502  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101371264  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X4 [KO:K18018] [EC:3.1.3.48]
101368865  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101376261  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101378307  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101370923  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101371435  DUSP7; dual specificity protein phosphatase 7 isoform X2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101373538  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101386622  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101380502  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101378028  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101376069  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101368450  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101377892  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101372386  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
101384232  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101376115  HSPA1L; heat shock 70 kDa protein 1-like isoform X2 [KO:K03283]
101376406  heat shock 70 kDa protein 1 [KO:K03283]
101370862  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
101375744  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
101371103  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
101384287  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X4 [KO:K04462] [EC:2.1.1.367]
101383722  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101365927  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101375462  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101363246  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101364103  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101375346  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101384959  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
101382029  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101371488  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101381073  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101381225  RELA; transcription factor p65 [KO:K04735]
101384789  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Methods Mol Biol 846:1-12 (2012)
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
oro04070  Phosphatidylinositol signaling system
oro04110  Cell cycle
oro04115  p53 signaling pathway
oro04210  Apoptosis
oro04310  Wnt signaling pathway
oro04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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