KEGG   PATHWAY: alim04020
Entry
alim04020                   Pathway                                
Name
Calcium signaling pathway - Austrofundulus limnaeus (annual killifish)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
alim04020  Calcium signaling pathway
alim04020

Other DBs
GO: 0019722
Organism
Austrofundulus limnaeus (annual killifish) [GN:alim]
Gene
106523123  sodium/calcium exchanger 1-like [KO:K05849]
106535153  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
106530136  sodium/calcium exchanger 3-like [KO:K05849]
106531371  sodium/calcium exchanger 2-like [KO:K05849]
106536796  sodium/calcium exchanger 2-like [KO:K05849]
106523970  slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
106524974  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
106523016  atp2b3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
106526679  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
106514712  atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
106515142  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
106522336  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
106512464  muscarinic acetylcholine receptor M3-like [KO:K04131]
106532143  chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
106520150  muscarinic acetylcholine receptor M5-like [KO:K04133]
106522438  chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
106514582  adenosine receptor A2a-like [KO:K04266]
106527481  adenosine receptor A2a-like [KO:K04266]
106525392  adora2b; adenosine receptor A2b [KO:K04267]
106516953  adrb1; beta-1 adrenergic receptor [KO:K04141]
106521922  beta-2 adrenergic receptor-like [KO:K04142]
106524031  beta-2 adrenergic receptor-like [KO:K04142]
106520159  beta-2 adrenergic receptor-like [KO:K04143]
106521907  D(1) dopamine receptor-like [KO:K04144]
106524941  drd1; D(1A) dopamine receptor [KO:K04144]
106520919  D(1) dopamine receptor-like [KO:K04144]
106520069  D(1)-like dopamine receptor [KO:K05840]
106518536  D(1B) dopamine receptor-like [KO:K05840]
106516726  histamine H2 receptor-like [KO:K04150]
106535581  histamine H2 receptor-like [KO:K04150]
106517147  5-hydroxytryptamine receptor 4-like [KO:K04160]
106513522  5-hydroxytryptamine receptor 4-like [KO:K04160]
106536772  htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
106521000  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
106522395  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
106525095  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
106529513  5-hydroxytryptamine receptor 7-like [KO:K04163]
106513057  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
106515123  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
106537305  guanine nucleotide-binding protein G(olf) subunit alpha-like [KO:K04633]
106520735  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
106533941  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
106532267  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106516755  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
106514248  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
106530667  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106527078  adenylate cyclase type 4-like isoform X1 [KO:K08044] [EC:4.6.1.1]
106527041  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106527219  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
106531266  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
106532502  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
106518708  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
106511338  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106526233  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
106534672  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106533807  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
106534615  pln; cardiac phospholamban [KO:K05852]
106521476  sln; sarcolipin [KO:K22642]
106528045  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
106532815  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
106511749  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
106511750  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
106514585  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
106516485  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
106521356  sarcoplasmic reticulum histidine-rich calcium-binding protein-like [KO:K23450]
106533718  stromal interaction molecule 1-like [KO:K16059]
106535748  stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
106515195  stromal interaction molecule 2-like [KO:K18196]
106522925  stim2; stromal interaction molecule 2 [KO:K18196]
106516709  calcium release-activated calcium channel protein 1-like isoform X1 [KO:K16056]
106514480  orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
106514602  protein orai-2-like [KO:K16057]
106515158  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
106513069  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106516186  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
106533880  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
106519282  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
106523414  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
106525038  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
106527230  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
106535455  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
106528746  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106527650  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106533741  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
106512154  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
106535834  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
106532607  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
106516530  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
106526322  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
106522481  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
106535356  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
106535357  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
106516270  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
106512978  chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
106520877  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
106533737  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
106527817  glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
106516529  grin2a; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
106515218  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
106520716  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
106534318  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
106520718  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
106519017  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
106518886  grin2c; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
106529429  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
106520516  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
106519542  serine/arginine repetitive matrix protein 1-like [KO:K05212]
106513607  glutamate receptor ionotropic, NMDA 3A-like isoform X1 [KO:K05213]
106532226  glutamate receptor ionotropic, NMDA 3A-like [KO:K05214]
106528733  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
106511522  glutamate receptor ionotropic, NMDA 2D-like [KO:K05214]
106525389  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
106521654  p2rx2; P2X purinoceptor 2 [KO:K05216]
106516443  P2X purinoceptor 3-like [KO:K05217]
106533595  p2rx3; P2X purinoceptor 3 isoform X1 [KO:K05217]
106527483  P2X purinoceptor 4-like [KO:K05218]
106525400  p2rx5; P2X purinoceptor 5 [KO:K05219]
106521874  p2rx7; P2X purinoceptor 7 [KO:K05220]
106529663  ryanodine receptor 1-like [KO:K04961]
106514048  LOW QUALITY PROTEIN: ryanodine receptor 1-like [KO:K04961]
106512392  ryanodine receptor 2-like [KO:K04962]
106520141  ryanodine receptor 3-like [KO:K04963]
106522435  ryr3; ryanodine receptor 3 [KO:K04963]
106536800  probable serine/threonine-protein kinase kinX [KO:K23449]
106517901  calsequestrin-1-like [KO:K23468]
106532859  calsequestrin-1-like [KO:K23468]
106519171  calsequestrin-2-like [KO:K23445]
106530638  calsequestrin-2-like [KO:K23445]
106536003  aspartyl/asparaginyl beta-hydroxylase-like [KO:K00476] [EC:1.14.11.16]
106527660  asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
106510936  cysteinyl leukotriene receptor 2-like [KO:K04322]
106532894  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
106527427  muscarinic acetylcholine receptor M2-like [KO:K04130]
106520277  muscarinic acetylcholine receptor M2-like [KO:K04130]
106536457  alpha-1A adrenergic receptor-like [KO:K04135]
106520122  alpha-1A adrenergic receptor [KO:K04135]
106517703  adra1b; alpha-1B adrenergic receptor [KO:K04136]
106517148  adra1d; alpha-1D adrenergic receptor [KO:K04137]
106513363  agtr1; type-1 angiotensin II receptor [KO:K04166]
106514699  endothelin B receptor-like [KO:K04197]
106527550  ednra; endothelin-1 receptor [KO:K04197]
106530016  endothelin B receptor-like [KO:K04198]
106524760  endothelin B receptor-like [KO:K04198]
106513815  endothelin B receptor-like [KO:K04198]
106517457  f2r; proteinase-activated receptor 1 [KO:K03914]
106519782  grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
106514124  metabotropic glutamate receptor 5-like [KO:K04604]
106517252  grm5; metabotropic glutamate receptor 5 [KO:K04604]
106523949  grpr; gastrin-releasing peptide receptor [KO:K04169]
106514692  hrh1; histamine H1 receptor [KO:K04149]
106527196  5-hydroxytryptamine receptor 2C-like [KO:K04157]
106533066  5-hydroxytryptamine receptor 2A-like [KO:K04157]
106511036  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
106515974  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
106518304  ntsr1; neurotensin receptor type 1 [KO:K04211]
106516075  isotocin receptor-like [KO:K04229]
106517984  oxtr; oxytocin receptor [KO:K04229]
106531197  arg8-vasotocin receptor-like [KO:K04226]
106532751  avpr1a; vasopressin V1a receptor [KO:K04226]
106528622  leukotriene B4 receptor 1-like [KO:K04297]
106520774  leukotriene B4 receptor 1-like [KO:K04297]
106526342  ptafr; platelet-activating factor receptor [KO:K04279]
106526907  prostaglandin E2 receptor EP1 subtype-like isoform X1 [KO:K04258]
106517831  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
106511166  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
106513771  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
106526339  B2 bradykinin receptor-like [KO:K03916]
106526341  B2 bradykinin receptor-like [KO:K03916]
106526361  B2 bradykinin receptor-like [KO:K03916]
106526343  B2 bradykinin receptor-like [KO:K03916]
106532124  substance-P receptor-like [KO:K04222]
106521942  substance-P receptor-like [KO:K04222]
106511076  substance-P receptor-like [KO:K04223]
106517157  neuromedin-K receptor-like [KO:K04224]
106517034  neuromedin-K receptor-like [KO:K04224]
106519210  tbxa2r; thromboxane A2 receptor [KO:K04264]
106522957  thyrotropin-releasing hormone receptor-like [KO:K04282]
106529401  trhr; thyrotropin-releasing hormone receptor [KO:K04282]
106533733  thyrotropin-releasing hormone receptor-like [KO:K04282]
106534281  cholecystokinin receptor type A-like [KO:K04194]
106523930  cholecystokinin receptor-like [KO:K04194]
106519142  cholecystokinin receptor-like isoform X1 [KO:K04194]
106525767  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
106522573  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4-like [KO:K04189]
106516252  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04634]
106523804  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106521552  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
106528393  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
106516251  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
106523807  guanine nucleotide-binding protein subunit alpha-14-like isoform X1 [KO:K04636]
106521554  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
106513245  pro-epidermal growth factor-like [KO:K04357]
106516091  tgfa; protransforming growth factor alpha [KO:K08774]
106518714  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
106522509  platelet-derived growth factor subunit A-like [KO:K04359]
106522503  uncharacterized protein LOC106522503 isoform X1 [KO:K17386]
106513253  pdgfc; platelet-derived growth factor C [KO:K05450]
106521430  pdgfd; platelet-derived growth factor D [KO:K05450]
106534413  fgf1; fibroblast growth factor 1 [KO:K18496]
106523408  fibroblast growth factor 1-like [KO:K18496]
106533273  fibroblast growth factor 10-like [KO:K04358]
106528328  fibroblast growth factor 20-like [KO:K04358]
106532969  fibroblast growth factor 7-like [KO:K04358]
106526565  fgf3; fibroblast growth factor 3 [KO:K04358]
106526566  fgf4; fibroblast growth factor 4 isoform X1 [KO:K04358]
106511287  fibroblast growth factor 18-like isoform X1 [KO:K04358]
106528858  fgf20; fibroblast growth factor 20 [KO:K04358]
106514408  fibroblast growth factor 10-like [KO:K04358]
106511033  fibroblast growth factor 4-like isoform X1 [KO:K04358]
106534548  fibroblast growth factor 4-like [KO:K04358]
106515330  fibroblast growth factor 8-like isoform X1 [KO:K04358]
106521899  fibroblast growth factor 17-like [KO:K04358]
106536855  fgf6; fibroblast growth factor 6 [KO:K04358]
106514811  fibroblast growth factor 6-like [KO:K04358]
106518787  fibroblast growth factor 8b-like isoform X1 [KO:K04358]
106535895  fgf7; fibroblast growth factor 7 [KO:K04358]
106525890  fibroblast growth factor 18-like isoform X1 [KO:K04358]
106515002  fgf22; fibroblast growth factor 22 [KO:K04358]
106517995  fgf16; fibroblast growth factor 16 [KO:K04358]
106526567  fgf19; fibroblast growth factor 19 [KO:K22603]
106517425  fibroblast growth factor 21-like isoform X1 [KO:K22429]
106514814  fgf23; fibroblast growth factor 23 [KO:K22428]
106536862  fibroblast growth factor 23-like [KO:K22428]
106520044  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
106515731  vegfb; vascular endothelial growth factor B isoform X1 [KO:K05448]
106531787  vascular endothelial growth factor C-like [KO:K05449]
106524130  nerve growth factor-like [KO:K02582]
106517676  nerve growth factor-like [KO:K02582]
106520334  hgf; hepatocyte growth factor [KO:K05460]
106514764  hepatocyte growth factor-like isoform X1 [KO:K05460]
106534308  mst1; hepatocyte growth factor-like protein [KO:K23441]
106514450  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
106526208  glial cell line-derived neurotrophic factor-like [KO:K05452]
106531647  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
106533007  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106521372  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
106518025  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
106536334  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
106519748  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
106525812  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
106524096  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106532997  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
106517359  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106529794  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
106524404  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
106530655  tyrosine kinase receptor Cad96Ca-like [KO:K04362] [EC:2.7.10.1]
106526530  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
106519945  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
106533801  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
106513437  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
106515430  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
106515980  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
106534849  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
106528305  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
106516247  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
106534176  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
106532941  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
106522525  ntrk3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
106518848  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
106511318  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
106516033  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
106527734  mst1r; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
106525613  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
106526304  uncharacterized protein LOC106526304 [KO:K06856]
106516944  uncharacterized protein LOC106516944 [KO:K06856]
106537318  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
106513384  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
106530942  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
106532460  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
106527597  plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
106517910  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
106519799  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
106524973  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
106529251  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106518551  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
106518553  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
106526007  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
106523657  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
106536649  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
106533025  plce1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
106523397  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861] [EC:3.1.4.11]
106518058  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
106527163  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
106515612  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
106527884  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
106515510  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
106515511  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
106521726  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
106512949  tpcn2; two pore calcium channel protein 2 [KO:K14077]
106515287  mucolipin-1-like [KO:K04992]
106517836  mucolipin-1-like isoform X1 [KO:K04992]
106511455  mcoln2; mucolipin-2 [KO:K04993]
106528257  mucolipin-3-like [KO:K04994]
106532920  mucolipin-3-like [KO:K04994]
106536159  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
106534563  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
106518760  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
106537015  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
106515933  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
106524568  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
106517011  voltage-dependent anion-selective channel protein 2 [KO:K15040]
106515335  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
106536415  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
106512179  voltage-dependent anion-selective channel protein 2-like [KO:K15041]
106533592  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
106515500  ADP/ATP translocase 2 [KO:K05863]
106515506  ADP/ATP translocase 3-like [KO:K05863]
106526139  ADP/ATP translocase 2-like [KO:K05863]
106536224  slc25a4; ADP/ATP translocase 1 [KO:K05863]
106517023  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
106515345  ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
106535138  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
106532892  troponin C, slow skeletal and cardiac muscles [KO:K05865]
106523008  troponin C, skeletal muscle [KO:K12042]
106523009  troponin C, skeletal muscle-like [KO:K12042]
106527471  calmodulin [KO:K02183]
106526330  calmodulin [KO:K02183]
106515407  calm3; calmodulin [KO:K02183]
106526525  calmodulin-like [KO:K02183]
106512977  calml4; calmodulin-like protein 4 [KO:K02183]
106515467  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
106517365  phosphorylase b kinase gamma catalytic chain, liver/testis isoform-like [KO:K00871] [EC:2.7.11.19]
106524270  phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
106524447  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
106532074  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
106530234  mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
106524197  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
106528162  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
106533840  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
106516998  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
106529840  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
106534020  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
106516074  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
106534703  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
106511644  calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
106523895  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
106530901  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
106533117  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
106516639  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
106531119  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
106515369  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
106536360  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like [KO:K04515] [EC:2.7.11.17]
106524495  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
106519470  calcium/calmodulin-dependent protein kinase type II delta chain-like [KO:K04515] [EC:2.7.11.17]
106531135  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
106514051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106531460  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106524411  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
106521933  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
106514880  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106529812  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
106513314  tfeb; transcription factor EB isoform X1 [KO:K15590]
106529394  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106525012  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106532385  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
106533682  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
106514987  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
106523419  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
106520755  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
106519449  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
106514724  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
106524532  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
106537366  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
106537272  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
106529652  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
106525285  ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
106514037  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
106519391  itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
106521602  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
106536770  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
106520010  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
106518739  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106534248  prkcb; protein kinase C beta type isoform X1 [KO:K02677] [EC:2.7.11.13]
106519663  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106516520  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106520517  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
alim04010  MAPK signaling pathway
alim04070  Phosphatidylinositol signaling system
alim04210  Apoptosis
KO pathway
ko04020   
LinkDB

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