Entry
Name
MAPK signaling pathway - Austrofundulus limnaeus (annual killifish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Austrofundulus limnaeus (annual killifish) [GN:
alim ]
Gene
106527230 cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344 ]
106535455 voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344 ]
106528746 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
106527650 voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849 ]
106515158 voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850 ]
106513069 cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
106516186 voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851 ]
106533741 voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852 ]
106512154 cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852 ]
106533880 voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853 ]
106519282 cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
106523414 voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853 ]
106535834 voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854 ]
106532607 voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854 ]
106516530 voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855 ]
106526322 voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856 ]
106522481 cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856 ]
106525038 cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
106514761 voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858 ]
106520335 cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858 ]
106516038 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
106516127 cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859 ]
106534307 voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859 ]
106523972 voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860 ]
106516185 voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860 ]
106521797 voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861 ]
106522094 voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861 ]
106515162 cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
106534934 cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
106520966 cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
106522508 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864 ]
106525262 voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04864 ]
106536644 voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865 ]
106529643 voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865 ]
106522067 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
106534954 voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866 ]
106518875 cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
106519665 voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868 ]
106516519 voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868 ]
106523251 cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
106536765 voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04869 ]
106523250 cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870 ]
106518741 voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870 ]
106519607 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
106520514 voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871 ]
106519610 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
106520515 voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872 ]
106519608 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
106536814 voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873 ]
106519647 gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
106535814 guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346 ]
106536284 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
106528821 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347 ]
106520346 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347 ]
106524411 serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
106521933 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
106514880 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
106518966 ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349 ]
106522196 ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326 ]
106513653 rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326 ]
106513263 rapgef2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018 ]
106520044 vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
106515731 vegfb; vascular endothelial growth factor B isoform X1 [KO:K05448 ]
106521396 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
106527237 ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
106517788 tumor necrosis factor receptor superfamily member 16-like [KO:K02583 ]
106522498 atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
106529152 tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
106512210 tumor necrosis factor ligand superfamily member 6-like [KO:K04389 ]
106535067 tumor necrosis factor receptor superfamily member 6-like [KO:K04390 ]
106531821 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
106531970 tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
106513380 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
106513707 gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
106531141 gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
106528824 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
106510938 growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402 ]
106530368 growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402 ]
106532660 growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402 ]
106522488 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403 ]
106537013 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
106535334 ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405 ]
106519098 mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434 ]
106533742 C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434 ]
106520310 C-Jun-amino-terminal kinase-interacting protein 2-like isoform X1 [KO:K04435 ]
106516473 mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436 ]
106529394 nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446 ]
106525012 nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446 ]
106514987 nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
106523419 nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333 ]
106512883 atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450 ]
106517503 mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
106533816 nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
alim04070 Phosphatidylinositol signaling system
KO pathway
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