KEGG   PATHWAY: alim04010
Entry
alim04010                   Pathway                                
Name
MAPK signaling pathway - Austrofundulus limnaeus (annual killifish)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
alim04010  MAPK signaling pathway
alim04010

Other DBs
GO: 0000165
Organism
Austrofundulus limnaeus (annual killifish) [GN:alim]
Gene
106527230  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
106535455  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like isoform X1 [KO:K04344]
106528746  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106527650  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
106515158  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
106513069  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106516186  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
106533741  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
106512154  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
106533880  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
106519282  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
106523414  voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
106535834  voltage-dependent T-type calcium channel subunit alpha-1G-like [KO:K04854]
106532607  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
106516530  voltage-dependent T-type calcium channel subunit alpha-1H-like [KO:K04855]
106526322  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
106522481  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
106525038  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
106514761  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
106520335  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
106516038  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
106516127  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
106534307  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
106523972  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
106516185  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
106521797  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
106522094  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
106515162  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
106534934  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
106520966  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
106522508  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04864]
106525262  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04864]
106536644  voltage-dependent L-type calcium channel subunit beta-4-like [KO:K04865]
106529643  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
106522067  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
106534954  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
106518875  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
106519665  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
106516519  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
106523251  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
106536765  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04869]
106523250  cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
106518741  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
106519607  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
106520514  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
106519610  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106520515  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
106519608  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
106536814  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
106511338  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106526233  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
106534672  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106533807  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
106518739  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106534248  prkcb; protein kinase C beta type isoform X1 [KO:K02677] [EC:2.7.11.13]
106519663  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106516520  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106520517  protein kinase C alpha type-like [KO:K19663] [EC:2.7.11.13]
106519647  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
106535814  guanine nucleotide-binding protein subunit alpha-12-like [KO:K04346]
106536284  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106528821  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106520346  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
106514051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106531460  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
106524411  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
106521933  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
106514880  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
106529812  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
106518966  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
106514342  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
106522196  ras-specific guanine nucleotide-releasing factor 2-like isoform X1 [KO:K12326]
106513653  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
106520349  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
106536568  RAS guanyl-releasing protein 1-like [KO:K04350]
106528460  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
106513388  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
106513263  rapgef2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
106537030  rasa1; ras GTPase-activating protein 1 [KO:K04352]
106524371  rasa2; ras GTPase-activating protein 2 [KO:K08053]
106515116  rap1a; ras-related protein Rap-1A [KO:K04353]
106531700  ras-related protein Rap-1b [KO:K04353]
106527728  ras-related protein Rap-1b-like [KO:K04353]
106513245  pro-epidermal growth factor-like [KO:K04357]
106516091  tgfa; protransforming growth factor alpha [KO:K08774]
106519890  ereg; proepiregulin [KO:K09784]
106534413  fgf1; fibroblast growth factor 1 [KO:K18496]
106523408  fibroblast growth factor 1-like [KO:K18496]
106533273  fibroblast growth factor 10-like [KO:K04358]
106528328  fibroblast growth factor 20-like [KO:K04358]
106532969  fibroblast growth factor 7-like [KO:K04358]
106526565  fgf3; fibroblast growth factor 3 [KO:K04358]
106526566  fgf4; fibroblast growth factor 4 isoform X1 [KO:K04358]
106511287  fibroblast growth factor 18-like isoform X1 [KO:K04358]
106528858  fgf20; fibroblast growth factor 20 [KO:K04358]
106514408  fibroblast growth factor 10-like [KO:K04358]
106511033  fibroblast growth factor 4-like isoform X1 [KO:K04358]
106534548  fibroblast growth factor 4-like [KO:K04358]
106515330  fibroblast growth factor 8-like isoform X1 [KO:K04358]
106521899  fibroblast growth factor 17-like [KO:K04358]
106536855  fgf6; fibroblast growth factor 6 [KO:K04358]
106514811  fibroblast growth factor 6-like [KO:K04358]
106518787  fibroblast growth factor 8b-like isoform X1 [KO:K04358]
106535895  fgf7; fibroblast growth factor 7 [KO:K04358]
106525890  fibroblast growth factor 18-like isoform X1 [KO:K04358]
106515002  fgf22; fibroblast growth factor 22 [KO:K04358]
106517995  fgf16; fibroblast growth factor 16 [KO:K04358]
106526567  fgf19; fibroblast growth factor 19 [KO:K22603]
106517425  fibroblast growth factor 21-like isoform X1 [KO:K22429]
106514814  fgf23; fibroblast growth factor 23 [KO:K22428]
106536862  fibroblast growth factor 23-like [KO:K22428]
106524130  nerve growth factor-like [KO:K02582]
106517676  nerve growth factor-like [KO:K02582]
106530394  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
106524591  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
106529800  insulin-like [KO:K04526]
106525530  insulin-like [KO:K04526]
106536859  insulin-like [KO:K04526]
106530265  igf1; insulin-like growth factor I [KO:K05459]
106529338  insulin-like growth factor I [KO:K05459]
106515666  igf2; insulin-like growth factor II [KO:K13769]
106518714  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
106522509  platelet-derived growth factor subunit A-like [KO:K04359]
106522503  uncharacterized protein LOC106522503 isoform X1 [KO:K17386]
106513253  pdgfc; platelet-derived growth factor C [KO:K05450]
106521430  pdgfd; platelet-derived growth factor D [KO:K05450]
106521770  uncharacterized protein LOC106521770 isoform X1 [KO:K05461]
106524000  kitlg; kit ligand [KO:K05461]
106520044  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
106515731  vegfb; vascular endothelial growth factor B isoform X1 [KO:K05448]
106520837  pgf; placenta growth factor [KO:K16859]
106535210  vascular endothelial growth factor A-like [KO:K16859]
106531787  vascular endothelial growth factor C-like [KO:K05449]
106520334  hgf; hepatocyte growth factor [KO:K05460]
106514764  hepatocyte growth factor-like isoform X1 [KO:K05460]
106525030  angpt4; angiopoietin-4 [KO:K05465]
106521364  angpt2; angiopoietin-2 [KO:K05466]
106525471  angiopoietin-2-like [KO:K05466]
106513706  efna5; ephrin-A5 [KO:K05462]
106527651  ephrin-A5-like [KO:K05462]
106526652  ephrin-A2-like isoform X1 [KO:K05462]
106531280  efna1; ephrin-A1 [KO:K05462]
106511478  ephrin-A2-like [KO:K05462]
106532917  ephrin-A3-like isoform X1 [KO:K05462]
106520884  ephrin-A1-like [KO:K05462]
106520885  ephrin-A3-like [KO:K05462]
106514450  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
106526208  glial cell line-derived neurotrophic factor-like [KO:K05452]
106516883  neurturin-like [KO:K25414]
106531424  glial cell line-derived neurotrophic factor-like [KO:K25415]
106525101  persephin-like [KO:K25416]
106531647  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
106533007  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106521372  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
106518025  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
106536334  receptor tyrosine-protein kinase erbB-3-like isoform X1 [KO:K05084] [EC:2.7.10.1]
106519748  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
106525812  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
106529794  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
106524404  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
106530655  tyrosine kinase receptor Cad96Ca-like [KO:K04362] [EC:2.7.10.1]
106526530  fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
106519945  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
106533801  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
106521396  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
106527237  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
106517788  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
106528305  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
106516247  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
106534176  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
106516858  insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
106511880  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106514315  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106531111  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106524096  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106532997  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
106517359  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106517374  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
106532555  macrophage colony-stimulating factor 1 receptor 2-like isoform X1 [KO:K05090] [EC:2.7.10.1]
106524095  kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
106515208  mast/stem cell growth factor receptor kita-like isoform X1 [KO:K05091] [EC:2.7.10.1]
106513431  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
106513437  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
106515430  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
106515980  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
106534849  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
106518848  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
106511318  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
106518936  ephrin type-A receptor 2-like [KO:K05103] [EC:2.7.10.1]
106516040  epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
106525613  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
106523871  growth factor receptor-bound protein 2 [KO:K04364]
106528413  sos2; son of sevenless homolog 2 [KO:K03099]
106536500  son of sevenless homolog 1-like [KO:K03099]
106515650  hras; GTPase HRas [KO:K02833]
106515615  kras; GTPase KRas isoform X1 [KO:K07827]
106528169  GTPase HRas-like [KO:K07827]
106526372  rras; ras-related protein R-Ras [KO:K07830]
106530897  rras2; ras-related protein R-Ras2 [KO:K07830]
106526991  mras; ras-related protein M-Ras [KO:K07831]
106533959  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
106527181  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
106519055  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106521211  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106515024  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106519992  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
106537032  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106530982  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106516482  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106513890  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
106516809  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
106531839  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
106533968  ribosomal protein S6 kinase 2 alpha isoform X1 [KO:K04373] [EC:2.7.11.1]
106527242  rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
106513171  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
106522498  atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106534845  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
106532784  ETS domain-containing protein Elk-3-like [KO:K04375]
106529224  ETS domain-containing protein Elk-4-like [KO:K04376]
106531183  transcriptional regulator Myc-B-like [KO:K04377]
106525658  myc; myc proto-oncogene protein [KO:K04377]
106529105  transcriptional regulator Myc-2-like [KO:K04377]
106510847  serum response factor-like [KO:K04378]
106536703  serum response factor-like [KO:K04378]
106522227  srf; serum response factor isoform X1 [KO:K04378]
106520572  proto-oncogene c-Fos-like isoform X1 [KO:K04379]
106516915  proto-oncogene c-Fos-like [KO:K04379]
106516916  proto-oncogene c-Fos-like [KO:K04379]
106528105  microtubule-associated protein tau-like isoform X1 [KO:K04380]
106521996  microtubule-associated protein tau-like isoform X1 [KO:K04380]
106524157  stathmin-like [KO:K04381]
106533799  stathmin-like [KO:K04381]
106529930  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
106529932  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
106516826  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
106512019  tumor necrosis factor-like [KO:K03156]
106522184  interleukin-1 beta-like [KO:K04519]
106510763  il1b; interleukin-1 beta [KO:K04519]
106529655  transforming growth factor beta-1-like [KO:K13375]
106515824  transforming growth factor beta-2-like [KO:K13376]
106520481  tgfb3; transforming growth factor beta-3 [KO:K13377]
106525282  transforming growth factor beta-3-like [KO:K13377]
106529152  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106535277  interleukin-18 receptor 1-like [KO:K04386]
106536072  interleukin-1 receptor type 1-like [KO:K04386]
106511885  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
106536182  interleukin-1 receptor accessory protein-like [KO:K04723]
106519000  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106520852  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
106519273  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
106525496  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
106512210  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
106535067  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
106531815  rho-related protein racD-like [KO:K04392]
106531821  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
106531822  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106537026  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106518736  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
106522484  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
106535622  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
106535925  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
106528512  cell division control protein 42 homolog isoform X1 [KO:K04393]
106519594  cell division control protein 42 homolog [KO:K04393]
106519316  cell division control protein 42 homolog isoform X1 [KO:K04393]
106529148  cell division control protein 42 homolog [KO:K04393]
106531970  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106532390  caspase-3-like [KO:K02187] [EC:3.4.22.56]
106532391  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
106525841  caspase-3-like [KO:K02187] [EC:3.4.22.56]
106534871  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106522826  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
106525877  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
106519570  daxx; death domain-associated protein 6 [KO:K02308]
106513380  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
106511233  interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
106526262  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
106523547  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106513707  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106531141  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106528824  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106510938  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
106530368  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106532660  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106522488  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
106537013  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
106535334  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
106523971  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
106529284  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
106531478  mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
106522761  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
106523594  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
106512366  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106511269  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106525027  serine/threonine-protein kinase 4-like [KO:K04411]
106518168  stk3; serine/threonine-protein kinase 3 [KO:K04412]
106526860  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
106524835  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
106523723  mitogen-activated protein kinase kinase kinase 11-like [KO:K04419] [EC:2.7.11.25]
106531440  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
106513381  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
106534689  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106534763  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
106530138  mitogen-activated protein kinase kinase kinase 9-like [KO:K04417] [EC:2.7.11.25]
106527840  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
106536215  mitogen-activated protein kinase kinase kinase MLK4-like isoform X1 [KO:K17534] [EC:2.7.11.25]
106527991  mitogen-activated protein kinase kinase kinase 12-like [KO:K04423] [EC:2.7.11.25]
106514729  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
106535790  map3k13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
106526174  serine/threonine-protein kinase 26-like isoform X1 [KO:K04424] [EC:2.7.11.25]
106512865  mitogen-activated protein kinase kinase kinase MLT isoform X1 [KO:K04424] [EC:2.7.11.25]
106524693  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
106528005  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106535535  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
106519963  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
106518124  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
106510852  serine/threonine-protein kinase TAO2-like [KO:K04429] [EC:2.7.11.1]
106519456  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
106521373  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
106523502  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
106514462  serine/threonine-protein kinase TAO3-like [KO:K04429] [EC:2.7.11.1]
106520394  serine/threonine-protein kinase TAO1-like [KO:K04429] [EC:2.7.11.1]
106531926  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
106535063  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106515295  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106528548  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106529047  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
106519098  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
106533742  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
106520310  C-Jun-amino-terminal kinase-interacting protein 2-like isoform X1 [KO:K04435]
106516473  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
106523011  filamin-A-like [KO:K04437]
106514621  adapter molecule crk-like [KO:K04438]
106513537  crkl; crk-like protein [KO:K04438]
106532740  adapter molecule crk-like [KO:K04438]
106533380  beta-arrestin-1 [KO:K04439]
106533651  arrb2; beta-arrestin-2 [KO:K04439]
106516220  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
106524736  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106517558  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106523196  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106513331  mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
106525575  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106531213  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106531214  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
106525512  mitogen-activated protein kinase 14B-like isoform X1 [KO:K04441] [EC:2.7.11.24]
106518909  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
106533634  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
106513301  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
106525176  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04444] [EC:2.7.11.1]
106518005  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
106529795  rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
106534420  ribosomal protein S6 kinase alpha-4-like [KO:K16510] [EC:2.7.11.1]
106524274  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
106529394  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106525012  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
106514987  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
106523419  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
106534447  transcription factor AP-1-like [KO:K04448]
106521291  jun; transcription factor AP-1 [KO:K04448]
106519240  jund; transcription factor jun-D [KO:K04449]
106512883  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
106525321  tp53; cellular tumor antigen p53 [KO:K04451]
106514742  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
106511380  protein max-like isoform X1 [KO:K04453]
106522426  protein max isoform X1 [KO:K04453]
106517503  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
106525425  hspb1; heat shock protein beta-1 [KO:K04455]
106514413  heat shock protein beta-1-like [KO:K04455]
106535280  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106525629  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106519981  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106521340  ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
106516403  protein phosphatase 1A-like [KO:K04457] [EC:3.1.3.16]
106537388  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
106515673  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
106527881  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
106510863  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106526370  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106514716  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106532156  dusp16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106519052  LOW QUALITY PROTEIN: dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106521083  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106513650  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106515672  dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106513524  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106537018  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106536807  LOW QUALITY PROTEIN: dual specificity protein phosphatase 6-like [KO:K21946] [EC:3.1.3.16 3.1.3.48]
106522449  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106535762  dusp3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
106529681  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
106535158  protein phosphatase 1B-like [KO:K04461] [EC:3.1.3.16]
106534162  ppm1b; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
106535866  heat shock cognate 70 kDa protein [KO:K03283]
106525681  heat shock 70 kDa protein [KO:K03283]
106517696  heat shock cognate 71 kDa protein-like [KO:K03283]
106520367  heat shock cognate 71 kDa protein-like [KO:K03283]
106522528  heat shock 70 kDa protein-like [KO:K03283]
106523993  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
106512959  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
106521362  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
106513281  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
106522968  nuclear receptor subfamily 4 group A member 1-like [KO:K04465]
106528348  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
106522002  map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
106533626  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106521989  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
106536414  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106523021  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106510762  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
106535832  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
106536450  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
106533816  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
106523725  putative transcription factor p65 homolog [KO:K04735]
106527850  transcription factor p65-like isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
alim04070  Phosphatidylinositol signaling system
alim04110  Cell cycle
alim04115  p53 signaling pathway
alim04210  Apoptosis
alim04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system