Entry Name Influenza A - Anas platyrhynchos (mallard)
Description Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class Human Diseases; Infectious disease: viralBRITE hierarchy
Pathway map Ortholog table Organism Anas platyrhynchos (mallard) [GN:
apla ]
Gene 101795433 TMPRSS4; transmembrane protease serine 4 [KO:K09635 ] [EC:3.4.21.-]
119718226 LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 1-like [KO:K09507 ]
110353866 EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195 ] [EC:2.7.11.1 ]
101803281 EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237 ]
101797184 CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348 ]
101800153 IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211 ] [EC:2.7.11.10 ]
101797621 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
101800211 IL12B; LOW QUALITY PROTEIN: interleukin-12 subunit beta [KO:K05425 ]
101795022 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
119714613 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
101799854 IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132 ]
119718679 HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752 ]
119715062 HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752 ]
119718678 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
119718708 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
119718710 class II histocompatibility antigen, B-L beta chain-like isoform X1 [KO:K06752 ]
101789604 class II histocompatibility antigen, B-L beta chain precursor [KO:K06752 ]
101803461 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101799717 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
101795759 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101796183 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101800900 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101802796 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101797713 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
101799861 tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
119713491 tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722 ]
101801884 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
101796331 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
101801004 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
101799807 TRADD; LOW QUALITY PROTEIN: tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
101803948 VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
101799443 APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084 ]
101804883 CPSF4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404 ]
101791322 PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396 ]
101800274 NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297 ]
101791352 RSAD2; radical S-adenosyl methionine domain-containing protein 2 precursor [KO:K15045 ]
101791037 MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368 ] [EC:2.7.12.2 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Edinger TO, Pohl MO, Stertz S
Title Entry of influenza A virus: host factors and antiviral targets.
Journal Reference Authors Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Title Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
Journal J Mol Genet Med 3:167-75 (2008)
Reference Authors Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
Title A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Journal Reference Authors Thanh TT, van Doorn HR, de Jong MD
Title Human H5N1 influenza: current insight into pathogenesis.
Journal Reference Authors Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Title Influenza A induced cellular signal transduction pathways.
Journal Reference Authors Hale BG, Albrecht RA, Garcia-Sastre A
Title Innate immune evasion strategies of influenza viruses.
Journal Reference Authors Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Title Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Journal Reference Authors Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Title Interplay between influenza A virus and the innate immune signaling.
Journal Reference Authors van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title Evasion of influenza A viruses from innate and adaptive immune responses.
Journal Reference Authors Long JS, Mistry B, Haslam SM, Barclay WS
Title Host and viral determinants of influenza A virus species specificity.
Journal Reference Authors Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Title Host Immune Response to Influenza A Virus Infection.
Journal Reference Authors Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
Title The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
Journal Reference Authors Ichinohe T, Iwasaki A, Hasegawa H
Title Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Journal Reference Authors Le Sage V, Cinti A, Amorim R, Mouland AJ
Title Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Journal Reference Authors Fan Y, Sanyal S, Bruzzone R
Title Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal Reference Authors Varga ZT, Palese P
Title The influenza A virus protein PB1-F2: killing two birds with one stone?
Journal Reference Authors Atkin-Smith GK, Duan M, Chen W, Poon IKH
Title The induction and consequences of Influenza A virus-induced cell death.
Journal Reference Authors Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Title Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Journal Reference Authors Dai X, Zhang L, Hong T
Title Host cellular signaling induced by influenza virus.
Journal Reference Authors Li J, Yu M, Zheng W, Liu W
Title Nucleocytoplasmic shuttling of influenza A virus proteins.
Journal Reference Authors Dou D, Revol R, Ostbye H, Wang H, Daniels R
Title Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Journal Reference Authors Paterson D, Fodor E
Title Emerging roles for the influenza A virus nuclear export protein (NEP).
Journal Related apla04620 Toll-like receptor signaling pathway
apla04621 NOD-like receptor signaling pathway
apla04622 RIG-I-like receptor signaling pathway
KO pathway LinkDB All DBs
