KEGG   PATHWAY: cimi05165
Entry
cimi05165                   Pathway                                
Name
Human papillomavirus infection - Cebus imitator (Panamanian white-faced capuchin)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
cimi05165  Human papillomavirus infection
cimi05165

Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108316031  WNT1; proto-oncogene Wnt-1 [KO:K03209]
108308992  WNT2; protein Wnt-2 [KO:K00182]
108301213  WNT2B; protein Wnt-2b [KO:K00182]
108296722  WNT3; proto-oncogene Wnt-3 [KO:K00312]
108306898  WNT3A; protein Wnt-3a [KO:K00312]
108296623  WNT4; protein Wnt-4 [KO:K00408]
108314559  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
108315842  WNT5B; protein Wnt-5b [KO:K00444]
108309074  WNT6; protein Wnt-6 [KO:K00445]
108304973  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
108286911  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
108284297  WNT8A; protein Wnt-8a [KO:K00714]
108306366  WNT8B; protein Wnt-8b [KO:K00714]
108296730  WNT9B; protein Wnt-9b [KO:K01064]
108306896  WNT9A; protein Wnt-9a [KO:K01064]
108309075  WNT10A; protein Wnt-10a [KO:K01357]
108316035  WNT10B; protein Wnt-10b [KO:K01357]
108307609  WNT11; protein Wnt-11 [KO:K01384]
108292788  WNT16; protein Wnt-16 [KO:K01558]
108309892  FZD1; frizzled-1 [KO:K02432]
108295974  FZD7; frizzled-7 [KO:K02432]
108318308  FZD2; frizzled-2 [KO:K02235]
108312490  FZD3; frizzled-3 isoform X1 [KO:K02329]
108290723  FZD4; frizzled-4 isoform X1 [KO:K02354]
108309175  FZD8; frizzled-8 [KO:K02375]
108316712  FZD5; frizzled-5 [KO:K02375]
108304662  FZD6; frizzled-6 [KO:K02376]
108307909  FZD9; frizzled-9 [KO:K02842]
108286590  FZD10; frizzled-10 [KO:K02842]
108289056  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
108311070  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
108313930  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
108306601  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
108292532  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108290841  AXIN1; axin-1 isoform X1 [KO:K02157]
108281649  AXIN2; axin-2 isoform X1 [KO:K04385]
108293133  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
108303383  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
108312809  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
108310833  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
108283379  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
108306412  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
108294169  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
108307147  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
108295686  TCF7L1; transcription factor 7-like 1 [KO:K04490]
108311134  transcription factor 7-like 2 isoform X1 [KO:K04491]
108314477  LOW QUALITY PROTEIN: ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
108288133  TLR3; toll-like receptor 3 [KO:K05401]
108304274  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
108304024  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
108301897  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
108288399  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108298392  IRF3; interferon regulatory factor 3 isoform X3 [KO:K05411]
108296169  IFNB1; interferon beta [KO:K05415]
108290506  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
108286559  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
108284679  TADA3; transcriptional adapter 3 isoform X1 [KO:K11315]
108306559  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108294016  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3 [KO:K05631]
108309821  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108309185  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
108281330  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
108311808  PARD6A; partitioning defective 6 homolog alpha isoform X3 [KO:K06093]
108286618  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
108284994  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
108313954  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
108296617  cell division control protein 42 homolog [KO:K04393]
108317207  cell division control protein 42 homolog [KO:K04393]
108291295  SCRIB; protein scribble homolog isoform X4 [KO:K16175]
108300264  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
108315579  DLG2; disks large homolog 2 isoform X2 [KO:K12075]
108297590  DLG3; disks large homolog 3 isoform X2 [KO:K21098]
108309422  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
108293469  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
108304223  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
108313217  PATJ; inaD-like protein [KO:K06092]
108284057  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
108316350  VWF; von Willebrand factor [KO:K03900]
108306127  THBS1; thrombospondin-1 [KO:K16857]
108288458  THBS4; thrombospondin-4 [KO:K04659]
108288622  THBS2; thrombospondin-2 [KO:K04659]
108292480  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
108284565  cartilage oligomeric matrix protein [KO:K04659]
108308919  FN1; fibronectin isoform X1 [KO:K05717]
108301835  COL1A2; collagen alpha-2(I) chain [KO:K06236]
108312289  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
108304847  COL2A1; collagen alpha-1(II) chain isoform X2 [KO:K19719]
108284882  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
108284888  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
108304798  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
108304799  collagen alpha-3(IV) chain isoform X1 [KO:K06237]
108316552  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
108316553  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
108310668  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
108311184  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
108311185  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
108290359  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
108290360  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
108290362  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
108318375  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
108288833  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
108285965  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
108307784  LAMA2; laminin subunit alpha-2 [KO:K05637]
108314822  LAMA1; laminin subunit alpha-1 [KO:K05637]
108282567  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
108285951  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
108289721  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
108316760  LAMB1; laminin subunit beta-1 [KO:K05636]
108287982  LAMB2; laminin subunit beta-2 [KO:K06243]
108302115  LAMB3; laminin subunit beta-3 [KO:K06244]
108316764  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
108301352  LAMC1; laminin subunit gamma-1 [KO:K05635]
108301356  LAMC2; laminin subunit gamma-2 [KO:K06246]
108283047  LAMC3; laminin subunit gamma-3 [KO:K06247]
108312303  CHAD; chondroadherin [KO:K06248]
108300364  RELN; reelin [KO:K06249] [EC:3.4.21.-]
108315672  SPP1; osteopontin [KO:K06250]
108313596  VTN; vitronectin [KO:K06251]
108299803  TNXB; tenascin-X [KO:K06252]
108293330  tenascin [KO:K06252]
108305347  TNR; tenascin-R isoform X1 [KO:K06252]
108305357  TNN; tenascin-N [KO:K06252]
108305511  TNC; tenascin [KO:K06252]
108315674  bone sialoprotein 2 [KO:K06253]
108307755  ITGA1; integrin alpha-1 [KO:K06480]
108307754  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
108294289  ITGA2B; integrin alpha-IIb [KO:K06476]
108312284  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
108307357  ITGA4; integrin alpha-4 isoform X2 [KO:K06483]
108284916  ITGA5; integrin alpha-5 [KO:K06484]
108310980  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108296818  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
108305181  ITGA8; integrin alpha-8 [KO:K06584]
108289120  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
108293672  ITGA10; integrin alpha-10 [KO:K06586]
108292610  ITGA11; integrin alpha-11 [KO:K06587]
108315634  ITGAV; integrin alpha-V [KO:K06487]
108309195  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
108318297  ITGB3; integrin beta-3 [KO:K06493]
108309429  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108294558  ITGB5; integrin beta-5 [KO:K06588]
108317309  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
108284857  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
108303183  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
108284810  PTK2; focal adhesion kinase 1 isoform X11 [KO:K05725] [EC:2.7.10.2]
108290419  PXN; paxillin isoform X4 [KO:K05760]
108299857  TNF; tumor necrosis factor [KO:K03156]
108316345  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108311730  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
108305379  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
108305380  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108290337  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
108294124  FADD; FAS-associated death domain protein [KO:K02373]
108315757  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108288114  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
108310786  caspase-3-like [KO:K02187] [EC:3.4.22.56]
108309381  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
108309569  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108307144  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108286254  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
108295463  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
108311624  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
108312452  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3 [KO:K04354]
108292377  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108292565  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
108295976  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
108284343  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
108318295  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like [KO:K11583]
108306054  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
108308224  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
108310266  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
108301909  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
108304047  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
108317111  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
108295422  TSC1; hamartin [KO:K07206]
108290925  TSC2; tuberin isoform X1 [KO:K07207]
108297459  RHEB; GTP-binding protein Rheb [KO:K07208]
108285700  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
108309889  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
108310354  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
108312078  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108300037  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108310302  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108306401  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108313887  FOXO1; forkhead box protein O1 [KO:K07201]
108304025  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108299987  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108294139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108316314  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108317085  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
108309741  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108304334  LOW QUALITY PROTEIN: cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
108313247  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
108309877  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108310921  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
108301073  G1/S-specific cyclin-E1-like [KO:K06626]
108283527  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108296806  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108309540  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
108291086  RBL1; retinoblastoma-like protein 1 [KO:K04681]
108305445  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
108298258  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
108301412  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
108292968  E2F1; transcription factor E2F1 [KO:K17454]
108310820  CCNA1; cyclin-A1 [KO:K06627]
108281889  CCNA2; cyclin-A2 [KO:K06627]
108316892  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
108300826  ATR; serine/threonine-protein kinase ATR isoform X2 [KO:K06640] [EC:2.7.11.1]
108317142  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
108306378  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108316185  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108298093  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108289254  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108310400  RELA; transcription factor p65 isoform X2 [KO:K04735]
108300229  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108314176  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
108303947  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
108306044  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
108316331  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
108307173  IRF1; interferon regulatory factor 1 [KO:K09444]
108284001  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
108294070  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
108295249  TATA-box-binding protein isoform X1 [KO:K03120]
108297411  patr class I histocompatibility antigen, A-2 alpha chain isoform X2 [KO:K06751]
108298047  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119466666  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X2 [KO:K06751]
108298050  saoe class I histocompatibility antigen, A alpha chain-like isoform X4 [KO:K06751]
108298051  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
108298501  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X4 [KO:K06751]
108298504  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
108298705  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
108298732  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
108298843  patr class I histocompatibility antigen, CH28 alpha chain-like isoform X3 [KO:K06751]
108300114  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain-like isoform X2 [KO:K06751]
108290625  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
108290578  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
108290635  mamu class I histocompatibility antigen, alpha chain F-like isoform X1 [KO:K06751]
119468491  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
108290580  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
108290620  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
108290621  saoe class I histocompatibility antigen, A alpha chain isoform X1 [KO:K06751]
108290623  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
108290634  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
108298999  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
108312236  LOW QUALITY PROTEIN: B-cell receptor-associated protein 31-like [KO:K14009]
108294750  BCAP31; B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
108317406  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
108285879  LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform-like [KO:K02147]
108299631  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X2 [KO:K02147]
108312016  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
108302163  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
108304661  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
108284134  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
108289712  V-type proton ATPase subunit E 1 [KO:K02150]
108292087  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
108294865  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
108318474  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
108287566  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
108299860  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
108305590  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
108306704  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
108310171  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
108289768  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 [KO:K02154]
108315197  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
108286441  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
108299485  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
108311748  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
108298133  V-type proton ATPase subunit e 2 [KO:K02153]
108288290  V-type proton ATPase subunit e 1-like [KO:K02153]
108290299  V-type proton ATPase subunit e 1-like [KO:K02153]
108291022  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
108312715  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
108298084  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
108290027  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108294535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108309416  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108287976  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
108293763  SOS1; son of sevenless homolog 1 [KO:K03099]
108288791  HRAS; GTPase HRas isoform X1 [KO:K02833]
108300272  KRAS; GTPase KRas isoform X2 [KO:K07827]
108289201  GTPase NRas-like [KO:K07828]
108301162  NRAS; GTPase NRas isoform X2 [KO:K07828]
108284634  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108282680  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
108288453  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108296669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108296197  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108301379  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
108307682  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
108298696  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
108285919  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X5 [KO:K04632]
108285920  neuroendocrine secretory protein 55 [KO:K04632]
108309036  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
108284294  LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
108281936  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
108283458  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108314512  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108287107  apoptosis regulator BAX-like [KO:K02159]
108283911  BAX; apoptosis regulator BAX [KO:K02159]
108316708  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108288452  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108292437  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108314253  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
108304874  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108286451  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
108303281  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
108285780  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
108289766  tubulin gamma-2 chain-like [KO:K10389]
108289817  TUBG2; tubulin gamma-2 chain isoform X1 [KO:K10389]
108284721  tubulin gamma-1 chain [KO:K10389]
108301202  LOW QUALITY PROTEIN: pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
108312869  pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
108317529  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
108296181  interferon alpha-8-like [KO:K05414]
108296168  interferon alpha-8-like [KO:K05414]
108296165  IFNA21; interferon alpha-21 [KO:K05414]
108296167  interferon alpha-2-like [KO:K05414]
108296180  interferon alpha-5-like [KO:K05414]
108296183  interferon alpha-1/13 [KO:K05414]
108296184  interferon alpha-8-like [KO:K05414]
108302441  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108302508  interferon alpha/beta receptor 2 isoform X3 [KO:K05131]
108313230  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108283688  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
108284049  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108309779  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
108315378  IRF9; interferon regulatory factor 9 isoform X2 [KO:K04693]
108308872  EIF2AK2; LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
108290450  OASL; 2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
108311237  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
108311238  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
108313913  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
108300950  JAG1; protein jagged-1 isoform X1 [KO:K06052]
108287313  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
108299168  neurogenic locus notch homolog protein 2-like [KO:K20994]
108296607  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
108300104  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
108304377  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
108289452  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
108301635  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
108293013  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
108308338  mastermind-like protein 3 [KO:K06061]
108295212  MAML1; mastermind-like protein 1 [KO:K06061]
108287117  MAML2; mastermind-like protein 2 [KO:K06061]
108313014  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
108286958  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
108302925  HES1; transcription factor HES-1 [KO:K06054]
108310690  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
108282375  HES2; transcription factor HES-2 [KO:K09087]
108306539  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
108282371  HES3; transcription factor HES-3 [KO:K09088]
108313912  HES4; transcription factor HES-4 [KO:K09089]
108313966  HES5; transcription factor HES-5 [KO:K06055]
108307848  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
108288856  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
108299527  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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The molecular biology of cervical cancer.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
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Related
pathway
cimi04064  NF-kappa B signaling pathway
cimi04110  Cell cycle
cimi04115  p53 signaling pathway
cimi04150  mTOR signaling pathway
cimi04151  PI3K-Akt signaling pathway
cimi04210  Apoptosis
cimi04310  Wnt signaling pathway
cimi04330  Notch signaling pathway
cimi04510  Focal adhesion
cimi04520  Adherens junction
cimi04530  Tight junction
cimi04612  Antigen processing and presentation
cimi04620  Toll-like receptor signaling pathway
cimi04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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