KEGG   PATHWAY: clud04630
Entry
clud04630                   Pathway                                
Name
JAK-STAT signaling pathway - Canis lupus dingo (dingo)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
clud04630  JAK-STAT signaling pathway
clud04630

Other DBs
GO: 0007259
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112642744  IL2; interleukin-2 [KO:K05429]
112678641  IL7; interleukin-7 [KO:K05431]
112650504  IL9; interleukin-9 [KO:K05432]
112669320  IL15; interleukin-15 [KO:K05433]
112642745  IL21; interleukin-21 [KO:K05434]
118354319  thymic stromal lymphopoietin [KO:K05436]
112658965  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
112668470  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
112671816  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
112640010  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
112652729  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
112668507  IL9R; LOW QUALITY PROTEIN: interleukin-9 receptor [KO:K05073]
112640657  interleukin-9 receptor-like isoform X1 [KO:K05073]
112659058  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
112640012  IL21R; interleukin-21 receptor [KO:K05075]
112651926  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
112650471  IL5; interleukin-5 [KO:K05428]
112650098  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
112651949  IL3RA; interleukin-3 receptor subunit alpha isoform X2 [KO:K04737]
112662971  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
112651927  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
112651941  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like isoform X1 [KO:K05066]
112668541  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
112670562  IL6; interleukin-6 [KO:K05405]
112649805  IL13; interleukin-13 [KO:K05435]
112640038  IL27; interleukin-27 subunit alpha isoform X1 [KO:K22629]
112676352  IL31; interleukin-31 [KO:K22631]
112676800  OSM; oncostatin-M [KO:K05418]
112676797  LIF; leukemia inhibitory factor [KO:K05419]
112663394  CNTF; ciliary neurotrophic factor [KO:K05420]
112640126  CTF1; cardiotrophin-1 [KO:K05422]
112679039  cardiotrophin-2-like [KO:K24382]
112659431  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
112647724  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
112660681  IL6ST; LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta [KO:K05060]
112649975  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
112649178  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
112649211  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X5 [KO:K05077]
112666614  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
112660592  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
112652647  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
112652806  LIFR; leukemia inhibitory factor receptor [KO:K05058]
112649683  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
112648300  IL10; interleukin-10 [KO:K05443]
112648336  IL19; interleukin-19 [KO:K05444]
112677804  IL22; interleukin-22 [KO:K05445]
112648495  IL20; interleukin-20 isoform X1 [KO:K22667]
112648706  IL24; interleukin-24 [KO:K22668]
112677805  IL26; interleukin-26 [KO:K05446]
112671256  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
112661558  IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135]
112644177  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
112661123  IL20RB; interleukin-20 receptor subunit beta isoform X3 [KO:K05137]
112660287  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
112644178  IL22RA2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
112645861  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
112651834  IL12B; interleukin-12 subunit beta [KO:K05425]
112678015  IL23A; interleukin-23 subunit alpha [KO:K05426]
112666733  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
112647203  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
112647201  IL23R; interleukin-23 receptor [KO:K05065]
112646224  EPO; erythropoietin [KO:K05437]
112652976  somatotropin isoform X1 [KO:K05438]
112657409  PRL; prolactin [KO:K05439]
112662717  THPO; thrombopoietin isoform X1 [KO:K06854]
112655620  CSF3; granulocyte colony-stimulating factor [KO:K05423]
112675047  leptin [KO:K05424]
112666540  EPOR; erythropoietin receptor [KO:K05079]
112652645  GHR; growth hormone receptor isoform X1 [KO:K05080]
112652692  PRLR; prolactin receptor isoform X1 [KO:K05081]
112642222  MPL; thrombopoietin receptor [KO:K05082]
112642387  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
112647177  LEPR; leptin receptor isoform X1 [KO:K05062]
112650216  interferon alpha-1/2 [KO:K05414]
112650218  interferon alpha-1/2 [KO:K05414]
112650347  interferon alpha-1/2-like [KO:K05414]
112650391  interferon alpha-1/2-like [KO:K05414]
112650394  interferon alpha-1/2-like [KO:K05414]
112650424  interferon alpha-1/2 [KO:K05414]
112662614  interferon alpha-1/2 [KO:K05414]
112662615  interferon alpha-1/2-like [KO:K05414]
112662616  interferon alpha-2-like [KO:K05414]
112650509  interferon alpha-1/2-like [KO:K05414]
118350223  interferon alpha-3 [KO:K05414]
118350179  interferon alpha-1/2 [KO:K05414]
118350228  interferon alpha-1/2 [KO:K05414]
125756056  interferon alpha-1/2 [KO:K05414]
118350222  interferon alpha-1/2 [KO:K05414]
125756057  interferon alpha-1/2 [KO:K05414]
118350183  interferon alpha-1/2 [KO:K05414]
118350181  interferon alpha-1/2-like [KO:K05414]
112650215  IFNB1; interferon beta [KO:K05415]
112650511  IFNK; interferon kappa [KO:K05441]
112673407  interferon lambda-1-like [KO:K05447]
112643898  interferon lambda-1-like [KO:K05447]
112643716  interferon lambda-3 [KO:K22669]
112661621  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
112661687  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112660377  IFNLR1; interferon lambda receptor 1 [KO:K05140]
112677888  IFNG; interferon gamma [KO:K04687]
112644179  IFNGR1; interferon gamma receptor 1 [KO:K05132]
112661608  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
112671646  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112640154  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
112667672  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
112661500  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112652233  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112651939  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112647170  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112644815  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
112666727  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
112666499  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112656324  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112678012  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112654961  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112656334  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
112655519  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
112655520  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
112677992  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
112657153  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112665840  CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
112640373  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
112654340  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
125754135  LOW QUALITY PROTEIN: suppressor of cytokine signaling 2-like [KO:K04695]
112672873  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112656872  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
112671668  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
112643987  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
112665335  LOW QUALITY PROTEIN: suppressor of cytokine signaling 6-like [KO:K04699]
112655064  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
112644027  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
112664006  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
112673768  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112641512  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
112662261  MYC; myc proto-oncogene protein [KO:K04377]
112663184  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112669048  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112641579  CCND3; G1/S-specific cyclin-D3 isoform X2 [KO:K10152]
112641497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112656511  aldehyde oxidase 4-like isoform X1 [KO:K00157] [EC:1.2.3.1]
112656803  LOW QUALITY PROTEIN: aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
112656802  aldehyde oxidase 2-like [KO:K00157] [EC:1.2.3.1]
112655595  glial fibrillary acidic protein isoform X1 [KO:K05640]
112673314  STAM2; signal transducing adapter molecule 2 isoform X3 [KO:K04705]
112658813  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
112648110  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
112675367  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
112667202  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112640446  CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
112675696  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
112647778  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
112664059  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
112666292  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X2 [KO:K16065] [EC:2.3.2.27]
112668497  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
112676579  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112647029  AGRN; agrin isoform X15 [KO:K07293] [EC:3.1.3.48]
112672798  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112657995  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
112664493  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112663536  HRAS; GTPase HRas isoform X1 [KO:K02833]
112661394  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112646871  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5 [KO:K00922] [EC:2.7.1.153]
112661215  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112662621  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112666735  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112660199  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112642563  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112678102  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
clud04010  MAPK signaling pathway
clud04060  Cytokine-cytokine receptor interaction
clud04110  Cell cycle
clud04120  Ubiquitin mediated proteolysis
clud04151  PI3K-Akt signaling pathway
clud04210  Apoptosis
KO pathway
ko04630   
LinkDB

DBGET integrated database retrieval system