KEGG   PATHWAY: clud04936
Entry
clud04936                   Pathway                                
Name
Alcoholic liver disease - Canis lupus dingo (dingo)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
clud04936  Alcoholic liver disease
clud04936

Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112660138  C1QA; complement C1q subcomponent subunit A [KO:K03986]
112660280  C1QB; complement C1q subcomponent subunit B [KO:K03987]
112660137  C1QC; complement C1q subcomponent subunit C [KO:K03988]
112641335  C2; complement C2 isoform X1 [KO:K01332] [EC:3.4.21.43]
112641333  complement C4-A-like isoform X2 [KO:K03989]
112666383  C3; complement C3 [KO:K03990]
112675393  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
112649922  C5; complement C5 isoform X1 [KO:K03994]
112645243  C5AR1; C5a anaphylatoxin chemotactic receptor 1 isoform X2 [KO:K04010]
112673935  LOW QUALITY PROTEIN: lipopolysaccharide-binding protein [KO:K05399]
112658985  CD14; monocyte differentiation antigen CD14 [KO:K04391]
112678621  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
112650004  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
112671091  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
112668882  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112678201  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112668372  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112663495  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112667628  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
112644286  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
112658720  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112672189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112656000  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
112668352  IKBKG; NF-kappa-B essential modulator isoform X6 [KO:K07210]
112657364  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112659193  RELA; transcription factor p65 isoform X1 [KO:K04735]
112644595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
112641287  TNF; tumor necrosis factor [KO:K03156]
112664386  IL1B; interleukin-1 beta [KO:K04519]
112670562  IL6; interleukin-6 [KO:K05405]
112645861  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
112651834  IL12B; interleukin-12 subunit beta [KO:K05425]
112652282  CXCL8; interleukin-8 [KO:K10030]
112666319  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112656934  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112643194  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X3 [KO:K07211] [EC:2.7.11.10]
112677914  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
112645138  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
112650216  interferon alpha-1/2 [KO:K05414]
112650218  interferon alpha-1/2 [KO:K05414]
112650347  interferon alpha-1/2-like [KO:K05414]
112650391  interferon alpha-1/2-like [KO:K05414]
112650394  interferon alpha-1/2-like [KO:K05414]
112650424  interferon alpha-1/2 [KO:K05414]
112662614  interferon alpha-1/2 [KO:K05414]
112662615  interferon alpha-1/2-like [KO:K05414]
112662616  interferon alpha-2-like [KO:K05414]
112650509  interferon alpha-1/2-like [KO:K05414]
118350223  interferon alpha-3 [KO:K05414]
118350179  interferon alpha-1/2 [KO:K05414]
118350228  interferon alpha-1/2 [KO:K05414]
125756056  interferon alpha-1/2 [KO:K05414]
118350222  interferon alpha-1/2 [KO:K05414]
125756057  interferon alpha-1/2 [KO:K05414]
118350183  interferon alpha-1/2 [KO:K05414]
118350181  interferon alpha-1/2-like [KO:K05414]
112650215  IFNB1; interferon beta [KO:K05415]
112641209  IL17A; interleukin-17A [KO:K05489]
112668970  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
112662026  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
112652150  growth-regulated protein homolog gamma-like isoform X2 [KO:K05505]
112652148  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
112648603  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112656223  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
112663192  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
112669080  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X2 [KO:K03158]
112646480  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
112656364  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112675231  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112659329  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112654742  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
112647246  SREBF1; sterol regulatory element-binding protein 1 isoform X2 [KO:K07197]
112672967  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
112655082  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
112646313  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
112672195  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
112648011  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
112673960  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
112664817  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
112651335  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
112670576  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
112662647  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
112666835  transformer-2 protein homolog beta-like [KO:K12897]
112662739  ADIPOQ; adiponectin isoform X1 [KO:K07296]
112667041  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
112668989  ADIPOR2; adiponectin receptor protein 2 isoform X3 [KO:K07297]
112676516  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
112647094  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112652680  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112664082  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
112676653  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
112656757  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X3 [KO:K07200]
112678282  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
112663432  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
112669362  FOXO1; forkhead box protein O1 [KO:K07201]
112658587  FOXO3; forkhead box protein O3 [KO:K09408]
112654092  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
112665976  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
112659228  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
112647487  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09479] [EC:1.3.8.9]
112641041  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
112672818  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
112653068  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
112664353  FABP1; fatty acid-binding protein, liver [KO:K08750]
112644849  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
112644872  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
112644886  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
112650106  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
112676558  ALDH2; aldehyde dehydrogenase, mitochondrial isoform X2 [KO:K00128] [EC:1.2.1.3]
112645149  ALDH16A1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
112649908  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
112643080  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
112672552  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
112676715  ACACB; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
112646735  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
112665387  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X3 [KO:K19523] [EC:2.3.1.21]
112645134  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
112642040  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
112658031  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112648737  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112645463  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112677588  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
112668716  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112650538  TCF7; transcription factor 7 isoform X3 [KO:K02620]
112664304  TCF7L1; transcription factor 7-like 1 [KO:K04490]
112672346  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112671621  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
112663184  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112644173  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112647348  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
112666418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
112645941  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112659577  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112671968  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
112647216  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112652877  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
112641479  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112641481  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112665560  MAPK11; mitogen-activated protein kinase 11 isoform X3 [KO:K04441] [EC:2.7.11.24]
112665622  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
112655568  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
clud00061  Fatty acid biosynthesis
clud00071  Fatty acid degradation
clud01040  Biosynthesis of unsaturated fatty acids
clud03040  Spliceosome
clud04010  MAPK signaling pathway
clud04064  NF-kappa B signaling pathway
clud04152  AMPK signaling pathway
clud04210  Apoptosis
clud04310  Wnt signaling pathway
clud04610  Complement and coagulation cascades
clud04620  Toll-like receptor signaling pathway
clud04657  IL-17 signaling pathway
clud04668  TNF signaling pathway
clud04920  Adipocytokine signaling pathway
clud05034  Alcoholism
clud05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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