KEGG   PATHWAY: dro05206
Entry
dro05206                    Pathway                                
Name
MicroRNAs in cancer - Desmodus rotundus (common vampire bat)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
dro05206  MicroRNAs in cancer
dro05206

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112307354  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112318485  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
112321610  TIMP3; metalloproteinase inhibitor 3 [KO:K16866]
112318275  KRAS; LOW QUALITY PROTEIN: GTPase KRas [KO:K07827]
112304041  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
112319896  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112309765  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
112304072  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
112318157  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
112318994  HMGA2; high mobility group protein HMGI-C [KO:K09283]
112317273  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112312821  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112296785  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112315543  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112301790  CRKL; crk-like protein [KO:K04438]
112308445  CRK; adapter molecule crk isoform X1 [KO:K04438]
112307724  HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
112298594  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
112301222  FOXP1; forkhead box protein P1 isoform X1 [KO:K23582]
112302187  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
112300421  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
112297754  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
112304113  DNMT3B; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
112313500  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
112306912  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112302143  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112316715  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
112318906  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
112297289  EZR; LOW QUALITY PROTEIN: ezrin [KO:K08007]
112300323  PDCD4; programmed cell death protein 4 [KO:K16865]
112321623  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
112298356  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
112311121  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
112310803  SPRY2; protein sprouty homolog 2 [KO:K17383]
112322759  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
112323025  SERPINB5; serpin B5 [KO:K10139]
112301895  ST14; suppressor of tumorigenicity 14 protein [KO:K08670] [EC:3.4.21.109]
112298126  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
112299108  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112298706  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
112304205  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform X1 [KO:K07436] [EC:1.14.15.16]
112316215  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112319025  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
112306226  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
112308468  TP63; tumor protein 63 isoform X1 [KO:K10149]
112313118  ZEB2; zinc finger E-box-binding homeobox 2 [KO:K23560]
112319599  FSCN1; fascin [KO:K23551]
112309542  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
112305809  HOXD10; homeobox protein Hox-D10 [KO:K09295]
112305601  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
112311408  BMF; LOW QUALITY PROTEIN: bcl-2-modifying factor [KO:K17460]
112320090  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
112304108  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
112296203  SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863]
112319678  CCNG1; LOW QUALITY PROTEIN: cyclin-G1 [KO:K10145]
112321737  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
112299484  STMN1; stathmin [KO:K04381]
112298562  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
112315592  MYC; myc proto-oncogene protein [KO:K04377]
112306749  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112317099  HRAS; GTPase HRas isoform X1 [KO:K02833]
112313707  NRAS; GTPase NRas [KO:K07828]
112301543  DNMT1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
112312489  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
112307214  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112307950  IRS1; insulin receptor substrate 1 [KO:K16172]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112308530  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112304436  HNRNPK; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein K [KO:K12886]
112304449  RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461]
112309256  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
112321408  IRS2; insulin receptor substrate 2 [KO:K07187]
112306567  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
112314013  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
112305046  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
112302312  NOTCH4; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 [KO:K20996]
112319054  BMI1; polycomb complex protein BMI-1 [KO:K11459]
112319558  polycomb complex protein BMI-1-like [KO:K11459]
112310311  MMP16; matrix metalloproteinase-16 [KO:K07996] [EC:3.4.24.-]
112314280  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
112314971  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
112303287  CD44; CD44 antigen isoform X1 [KO:K06256]
112311150  DICER1; LOW QUALITY PROTEIN: endoribonuclease Dicer [KO:K11592] [EC:3.1.26.-]
112312643  FZD3; frizzled-3 [KO:K02329]
112318448  ITGA5; integrin alpha-5 [KO:K06484]
112314186  RDX; radixin isoform X1 [KO:K05762]
112309492  RHOA; transforming protein RhoA [KO:K04513]
112307557  transforming protein RhoA-like isoform X1 [KO:K04513]
112305567  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
112302219  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112315520  ZFPM2; zinc finger protein ZFPM2 isoform X1 [KO:K17442]
112316322  ITGB3; integrin beta-3 [KO:K06493]
112298275  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
112309224  SOX4; transcription factor SOX-4 [KO:K23581]
112296964  TNR; tenascin-R [KO:K06252]
112296971  TNN; tenascin-N [KO:K06252]
112306301  TNC; tenascin isoform X1 [KO:K06252]
112302461  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
112302615  ABCB1; multidrug resistance protein 1 [KO:K05658] [EC:7.6.2.2]
112314786  ABCC1; multidrug resistance-associated protein 1 [KO:K05665] [EC:7.6.2.3]
112298867  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
112302262  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112316763  EFNA1; ephrin-A1 [KO:K05462]
112314348  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
112312180  EFNA2; ephrin-A2 [KO:K05462]
112307205  EFNA5; ephrin-A5 [KO:K05462]
112315548  EFNA3; ephrin-A3 [KO:K05462]
112311111  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
112316358  IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391]
112309507  TRIM71; E3 ubiquitin-protein ligase TRIM71 [KO:K12035] [EC:2.3.2.27]
112317867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112321547  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112296707  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
112304801  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112301746  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112298645  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112311411  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
112308825  TP53; cellular tumor antigen p53 [KO:K04451]
112319061  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112317977  MDM4; protein Mdm4 [KO:K10127]
112316918  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
112303845  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112300725  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112301126  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112311345  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112312483  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112297971  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112310995  SOS2; son of sevenless homolog 2 [KO:K03099]
112316734  SHC1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
112319719  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
112311774  SHC4; SHC-transforming protein 4 [KO:K17449]
112321825  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112319577  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
112303722  E2F1; transcription factor E2F1 [KO:K17454]
112298997  E2F2; transcription factor E2F2 [KO:K09389]
112319403  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
112307666  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
112299318  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
112297024  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
112308348  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
112307781  GLS; glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
112319120  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
112305485  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
112316534  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112304943  WNT3A; protein Wnt-3a [KO:K00312]
112317033  CDCA5; sororin [KO:K17390]
112322916  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
112297947  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
112318097  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
112318828  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
dro05210  Colorectal cancer
dro05214  Glioma
dro05215  Prostate cancer
dro05219  Bladder cancer
dro05222  Small cell lung cancer
dro05223  Non-small cell lung cancer
KO pathway
ko05206   
LinkDB

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