KEGG   PATHWAY: epz05208
Entry
epz05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Equus przewalskii (Przewalski's horse)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
epz05208  Chemical carcinogenesis - reactive oxygen species
epz05208

Organism
Equus przewalskii (Przewalski's horse) [GN:epz]
Gene
103557886  AS3MT; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
103544321  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
103544337  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103549793  GSTO1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
103549794  GSTO2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
103547342  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103553247  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
103553249  GSTA4; glutathione S-transferase alpha 4 [KO:K00799] [EC:2.5.1.18]
103551021  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103557993  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103557994  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103557534  GSTM3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
103557535  GSTM4; glutathione S-transferase mu 4 [KO:K00799] [EC:2.5.1.18]
103557536  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
103557537  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
103560741  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
103561732  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103544102  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
103561728  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
19019447  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
19019453  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
19019452  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
19019457  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
19019455  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
19019456  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
19019458  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103543520  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
103554157  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
103543621  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
103542030  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
103548020  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
103556206  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
103550197  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
103559793  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
103560647  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
103541993  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
103543131  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
103555436  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
103557841  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
103542864  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
103562661  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
103547291  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
103561320  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
103557592  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
103555337  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
103565995  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
103547430  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
103551266  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
103550255  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
103565662  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
103562516  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
103562831  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
103540170  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
103540472  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
103556536  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
103559989  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
103561111  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
103558133  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
103551236  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
103544273  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
103543618  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
103549007  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
103553808  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
103560327  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
103540492  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
103560002  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
103565881  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
103542603  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
19019459  CYTB; cytochrome b [KO:K00412]
103560809  cytochrome c1, heme protein, mitochondrial [KO:K00413]
103556020  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
103565266  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
103551865  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
103555106  cytochrome b-c1 complex subunit 7 [KO:K00417]
103563123  cytochrome b-c1 complex subunit 8 [KO:K00418]
103548091  cytochrome b-c1 complex subunit 9 [KO:K00419]
103544594  cytochrome b-c1 complex subunit 10 [KO:K00420]
19019448  COX3; cytochrome c oxidase subunit III [KO:K02262]
19019454  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
19019450  COX2; cytochrome c oxidase subunit II [KO:K02261]
103548795  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
103559167  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
103552342  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103561437  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103540592  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
103547253  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
103566080  cytochrome c oxidase subunit 6B1 [KO:K02267]
103564642  cytochrome c oxidase subunit 6C [KO:K02268]
103552395  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103557604  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
103561571  uncharacterized LOC103561571 [KO:K02270]
103551834  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
103541818  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103555318  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
103557901  uncharacterized LOC103557901 [KO:K02273]
103565278  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
103560399  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
103565328  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
103556812  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
103545532  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
103565405  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
19019449  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103547799  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
103556107  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
103553755  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
103559309  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
103546567  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
103549004  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
103547123  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
19019451  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103558454  SOD2; superoxide dismutase 2 [KO:K04564] [EC:1.15.1.1]
103566485  VDAC1; voltage dependent anion channel 1 [KO:K05862]
103560633  VDAC2; voltage dependent anion channel 2 [KO:K15040]
103540389  VDAC3; voltage dependent anion channel 3 [KO:K15041]
103549138  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
103545106  ADP/ATP translocase 3-like [KO:K05863]
103562821  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
103540840  ADP/ATP translocase 3-like [KO:K05863]
103548120  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
103567259  SOD1; superoxide dismutase 1 [KO:K04565] [EC:1.15.1.1]
103544556  catalase [KO:K03781] [EC:1.11.1.6]
103565372  SLC26A1; solute carrier family 26 member 1 [KO:K14700]
103560146  SLC26A2; solute carrier family 26 member 2 [KO:K14701]
103556018  cadherin EGF LAG seven-pass G-type receptor 3 [KO:K14704]
103553840  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
103552315  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
103556383  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
103565413  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
103540570  cytochrome P450 2F5-like [KO:K07416] [EC:1.14.14.1]
103552317  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
103548412  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
103543505  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
103550424  EPHX2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
103563921  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
103553727  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
103551882  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
103540778  aldo-keto reductase family 1 member C23-like [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
103541473  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103542048  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103541472  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103540777  aldo-keto reductase family 1 member C23-like protein [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
103549827  NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2]
103548815  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
103548838  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
103550950  AHR; aryl hydrocarbon receptor [KO:K09093]
103541609  neuronal PAS domain-containing protein 3-like [KO:K09093]
103546342  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
103547856  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
103567392  NOX1; NADPH oxidase 1 [KO:K08008]
103556000  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
103552012  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
103543333  pro-epidermal growth factor-like [KO:K04357]
103560128  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103563173  HGF; hepatocyte growth factor [KO:K05460]
103562070  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
103546580  GRB2; growth factor receptor bound protein 2 [KO:K04364]
103553088  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103556123  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103567332  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103546629  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103552675  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103555338  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103554541  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103549630  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103543290  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
103547261  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103562408  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103556363  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103567795  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
103543808  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103549414  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103553980  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103567629  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103565534  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103563198  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103559485  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103559491  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103548618  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103548220  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103551868  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103561550  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103549076  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103554655  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
103552150  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103552260  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
103551639  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103560497  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103540249  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103555421  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103551216  FOXO3; forkhead box O3 [KO:K09408]
103542187  BAD; BCL2 associated agonist of cell death [KO:K02158]
103560571  PTPN1; protein tyrosine phosphatase, non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
103561454  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103567228  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103562903  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103543979  NF-kappa-B essential modulator-like [KO:K07210]
103546400  NFKBIA; NFKB inhibitor alpha [KO:K04734]
103543692  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103556719  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103546514  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
103565396  PTPRJ; protein tyrosine phosphatase, receptor type J [KO:K05698] [EC:3.1.3.48]
103558849  ACP1; acid phosphatase 1, soluble [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103557133  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103558567  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
103560907  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103562771  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
103552276  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
103552099  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
103548402  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
103542502  serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
103561848  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103546360  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103560664  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
103554685  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103562790  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
103547639  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
103548136  VEGFA; vascular endothelial growth factor A [KO:K05448]
103562410  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
103561798  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
103543240  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
epz00190  Oxidative phosphorylation
epz00980  Metabolism of xenobiotics by cytochrome P450
epz04010  MAPK signaling pathway
epz04064  NF-kappa B signaling pathway
epz04066  HIF-1 signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04370  VEGF signaling pathway
epz05207  Chemical carcinogenesis - receptor activation
epz05211  Renal cell carcinoma
epz05215  Prostate cancer
epz05219  Bladder cancer
epz05221  Acute myeloid leukemia
epz05222  Small cell lung cancer
epz05223  Non-small cell lung cancer
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
KO pathway
ko05208   
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