KEGG   PATHWAY: gat04621
Entry
gat04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Gasterosteus aculeatus (three-spined stickleback)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
gat04621  NOD-like receptor signaling pathway
gat04621

Organism
Gasterosteus aculeatus (three-spined stickleback) [GN:gat]
Gene
120809941  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
120815847  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
100174893  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120819606  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
120820624  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
120830767  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120832907  nfkbiab; LOW QUALITY PROTEIN: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
120808140  NF-kappa-B inhibitor alpha-like [KO:K04734]
120817215  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120821327  rela; transcription factor p65 [KO:K04735]
120831355  il1b; interleukin-1 beta [KO:K04519]
120826656  interleukin-6-like [KO:K05405]
120826067  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
120821273  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
120821274  growth-regulated alpha protein-like [KO:K10030]
120813977  cxcl8a; interleukin-8 [KO:K10030]
120812933  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
120833079  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
120808062  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120807983  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
120823950  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
120831071  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120827198  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120831463  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120817444  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
120819217  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
120820300  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120835277  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
120829497  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
120817131  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120817132  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
120809364  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
120812710  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
120828911  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
120829044  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
120831506  june; junE proto-oncogene, AP-1 transcription factor subunit isoform X1 [KO:K04448]
120824340  jun; transcription factor AP-1 [KO:K04448]
120815715  transcription factor AP-1-like [KO:K04448]
120821915  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
120810241  atg5; autophagy protein 5 [KO:K08339]
120810210  atg12; ubiquitin-like protein ATG12 [KO:K08336]
120809261  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
120809404  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
120810880  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
120821540  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
120834910  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
120809283  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
120818244  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
120825351  LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
120812227  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
120816314  sugt1; protein SGT1 homolog [KO:K12795]
120815866  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
120834859  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
120811821  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
120815969  si:dkey-181m9.8; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
120816131  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
120818475  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
120821530  trip6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
120831505  erbin; erbin isoform X1 [KO:K12796]
120821377  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
120830981  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120831561  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120831631  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
120825302  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
100174890  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120830798  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
120813859  LOW QUALITY PROTEIN: caspase recruitment domain-containing protein 9-like [KO:K12794]
120820768  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
120832442  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
120832813  traf3; TNF receptor-associated factor 3 [KO:K03174]
120817720  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
120834558  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
120834247  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
120819100  irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
120809125  irf7; interferon regulatory factor 7 [KO:K09447]
120819490  interferon a3-like [KO:K05414]
120819506  interferon a3-like [KO:K05414]
120819562  interferon a3-like [KO:K05414]
120828074  ifnphi1; interferon phi 1 [KO:K05414]
120821756  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
120831211  anthrax toxin receptor 1-like [KO:K20909]
120831521  anthrax toxin receptor 2-like isoform X1 [KO:K20909]
120832242  anthrax toxin receptor 1-like isoform X1 [KO:K20909]
120819512  antxr1c; anthrax toxin receptor 1 [KO:K20909]
120820421  antxr1d; anthrax toxin receptor 1 [KO:K20909]
120811227  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
120811228  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
120824590  caspa; caspase a [KO:K01370] [EC:3.4.22.36]
120814011  caspase a-like [KO:K01370] [EC:3.4.22.36]
120814012  caspase a-like [KO:K01370] [EC:3.4.22.36]
120815681  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
120834920  bcl-2-like protein 1 [KO:K04570]
120828689  bcl2l1; bcl-2-like protein 1 [KO:K04570]
120831608  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
120807896  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
120818017  pannexin-1-like [KO:K03443]
120824799  pannexin-1-like [KO:K03443]
120834411  trpm2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
120830706  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
120821234  casr; extracellular calcium-sensing receptor [KO:K04612]
120808435  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
120808536  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
120832519  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
120808412  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
120808518  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
120820843  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
120822086  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
120835398  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120835789  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120808946  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
120812471  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
120829151  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
120821969  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120819421  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
120820659  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120831086  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120831755  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
120820866  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
120822739  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
120816655  mfn1a; LOW QUALITY PROTEIN: mitofusin-1 [KO:K21356] [EC:3.6.5.-]
120823943  mfn1b; mitofusin-1b [KO:K21356] [EC:3.6.5.-]
120829200  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
120815607  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
120808783  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
120812610  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
120822400  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
120831057  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120809093  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120817758  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120834841  nampt2; nicotinamide phosphoribosyltransferase 2 isoform X1 [KO:K03462] [EC:2.4.2.12]
120817431  nampt1; LOW QUALITY PROTEIN: nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
120819589  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
120810816  cytochrome b-245 light chain [KO:K08009]
120826422  txnipa; thioredoxin interacting protein a [KO:K20910]
120823027  txn; thioredoxin [KO:K03671]
120828159  txn2; thioredoxin, mitochondrial [KO:K03671]
120832091  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
120807920  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
120808194  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
120808195  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
120835114  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
120809034  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a isoform X1 [KO:K12804]
120812726  proline-serine-threonine phosphatase-interacting protein 1-like isoform X1 [KO:K12804]
120816322  caspase-8-like [KO:K04398] [EC:3.4.22.61]
100653426  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100653427  casp10; truncated caspase-10 [KO:K04398] [EC:3.4.22.61]
120832244  fadd; protein FADD [KO:K02373]
120834638  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
120808934  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
120835726  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
120829263  rho-related GTP-binding protein RhoA-D [KO:K04513]
120829343  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
120828808  rho-related GTP-binding protein RhoA-C [KO:K04513]
120829067  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
120825257  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
120827489  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
120816221  pkn2a; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
120835221  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
120821399  14-3-3 protein epsilon isoform X1 [KO:K06630]
120833783  interferon lambda receptor 1-like isoform X1 [KO:K05131]
120824018  jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120828372  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
120834093  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
120826627  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
120835023  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
120814847  irf9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
120816503  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
120811549  myeloid differentiation primary response protein MyD88-like [KO:K04729]
120811921  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
120809229  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
120817637  sting1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
gat04010  MAPK signaling pathway
gat04140  Autophagy - animal
gat04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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