KEGG   PATHWAY: hrt04820
Entry
hrt04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Hirundo rustica (Barn swallow)
Class
Cellular Processes; Cell motility
Pathway map
hrt04820  Cytoskeleton in muscle cells
hrt04820

Organism
Hirundo rustica (Barn swallow) [GN:hrt]
Gene
120762707  COL1A2; collagen alpha-2(I) chain [KO:K06236]
120754934  COL3A1; collagen alpha-1(III) chain [KO:K19720]
120754982  COL5A2; collagen alpha-2(V) chain isoform X2 [KO:K19721]
120761600  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
120761647  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
120761856  collagen alpha-1(I) chain-like [KO:K19721]
120756338  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
120756698  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
120747997  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
120760260  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
120750195  COL9A1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
120751795  DCN; decorin [KO:K04660]
120765747  VCAN; versican core protein [KO:K06793]
120754998  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
120755061  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120755124  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
120754021  THBS1; thrombospondin-1 [KO:K16857]
120763296  COMP; cartilage oligomeric matrix protein [KO:K04659]
120764283  THBS3; thrombospondin-3 [KO:K04659]
120765191  THBS4; thrombospondin-4 [KO:K04659]
120750745  THBS2; thrombospondin-2 [KO:K04659]
120758569  FBN1; fibrillin-1 isoform X1 [KO:K06825]
120765579  FBN2; fibrillin-2 isoform X1 [KO:K23342]
120763302  fibrillin-2 [KO:K23342]
120757321  COL4A4; collagen alpha-4(IV) chain isoform X3 [KO:K06237]
120757322  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
120764857  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120764865  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
120761951  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
120761953  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
120751685  FBLN1; fibulin-1 isoform X1 [KO:K17307]
120762210  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X2 [KO:K06255]
120754724  NID2; nidogen-2 isoform X1 [KO:K06826]
120750350  NID1; nidogen-1 [KO:K06826]
120755371  FN1; fibronectin isoform X1 [KO:K05717]
120751108  SDC1; syndecan-1 [KO:K06257]
120756122  SDC2; syndecan-2 [KO:K16336]
120763088  SDC3; syndecan-3 isoform X1 [KO:K16337]
120760227  SDC4; syndecan-4 isoform X1 [KO:K16338]
120762248  AGRN; agrin [KO:K06254]
120763351  DSG2; desmoglein-2 isoform X1 [KO:K07597]
120752098  PKP2; plakophilin-2 [KO:K12642]
120763835  JUP; junction plakoglobin [KO:K10056]
120749578  DSP; desmoplakin isoform X1 [KO:K10381]
120758893  VIM; vimentin [KO:K07606]
120755156  DES; desmin [KO:K07610]
120749615  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120751179  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
120765242  ITGA1; integrin alpha-1 [KO:K06480]
120765354  ITGA2; integrin alpha-2 [KO:K06481]
120763589  ITGA2B; integrin alpha-IIb [KO:K06476]
120748082  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
120754962  ITGA4; integrin alpha-4 [KO:K06483]
120754919  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120764404  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
120759826  ITGA8; integrin alpha-8 [KO:K06584]
120748889  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
120758953  ITGA11; integrin alpha-11 [KO:K06587]
120754943  ITGAV; integrin alpha-V [KO:K06487]
120749084  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
120763837  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120760928  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120755010  ITGB5; integrin beta-5 [KO:K06588]
120754992  ITGB6; integrin beta-6 [KO:K06589]
120751760  ITGB8; integrin beta-8 [KO:K06591]
120758562  TLN2; talin-2 isoform X1 [KO:K06271]
120765052  TLN1; talin-1 isoform X1 [KO:K06271]
120755582  VCL; vinculin isoform X1 [KO:K05700]
120751023  ACTN2; alpha-actinin-2 [KO:K21073]
120758534  actin, cytoplasmic type 5 [KO:K05692]
120759701  ACTB; actin, cytoplasmic 1 [KO:K05692]
120760819  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120764025  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
120758237  DAG1; dystroglycan 1 [KO:K06265]
120754214  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
120752856  SGCB; beta-sarcoglycan [KO:K12566]
120759103  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
120748908  SGCG; gamma-sarcoglycan [KO:K12564]
120753334  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
120751978  SSPN; sarcospan [KO:K22194]
120764677  DMD; dystrophin isoform X1 [KO:K10366]
120760212  SNTA1; alpha-1-syntrophin [KO:K24063]
120757672  SNTB2; beta-2-syntrophin isoform X1 [KO:K24064]
120752529  SNTB1; beta-1-syntrophin [KO:K24064]
120749639  DTNA; dystrobrevin alpha isoform X11 [KO:K26998]
120751444  FLNC; filamin-C isoform X1 [KO:K27393]
120749246  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
120765106  ATP1B4; protein ATP1B4 [KO:K01540]
120765942  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
120756925  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
120756167  ANK3; ankyrin-3 isoform X7 [KO:K09259]
120761915  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
120753911  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
120749790  SPTBN1; spectrin beta chain, non-erythrocytic 1 [KO:K06115]
120747641  LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 2-like [KO:K23932]
120752220  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
120754433  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
120762741  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
120760071  MYH7B; myosin-7B [KO:K24220]
120748426  MYH15; myosin-15 [KO:K24220]
120760779  myosin heavy chain, skeletal muscle, adult-like [KO:K24220]
120760781  LOW QUALITY PROTEIN: myosin-1B [KO:K24220]
120760780  myosin-13-like [KO:K24220]
120761116  myosin-3-like [KO:K24220]
120757592  myosin-7 isoform X1 [KO:K17751]
120757601  myosin-6-like isoform X1 [KO:K17751]
120752177  MYH9; myosin-9 [KO:K10352]
120759740  MYH11; myosin-11 isoform X1 [KO:K10352]
120760999  MYH10; myosin-10 isoform X1 [KO:K10352]
120754995  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
120760922  MYL3; myosin light chain 3 [KO:K12749]
120763692  myosin light chain, embryonic [KO:K12750]
120760725  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120760134  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120751540  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
120754622  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
120762829  MYBPH; myosin-binding protein H [KO:K24494]
120751321  ACTA1; actin, alpha skeletal muscle [KO:K10354]
120754567  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
120758318  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120762781  TNNI1; LOW QUALITY PROTEIN: troponin I, slow skeletal muscle [KO:K10371]
120760297  TNNC2; troponin C, skeletal muscle [KO:K12042]
120754085  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
120753668  TNNT3; troponin T, fast skeletal muscle isoform X5 [KO:K12046]
120762725  TNNT2; troponin T, cardiac muscle [KO:K12045]
120758635  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
120765987  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
120764269  tropomyosin alpha-3 chain isoform X2 [KO:K09290]
120763331  TPM4; tropomyosin alpha-4 chain isoform X2 [KO:K10375]
120754918  TTN; LOW QUALITY PROTEIN: titin [KO:K12567] [EC:2.7.11.1]
120759040  MYOT; myotilin isoform X1 [KO:K19875]
120763827  TCAP; telethonin [KO:K19879]
120753365  SYNPO2; synaptopodin-2 [KO:K24066]
120755493  NEB; nebulin isoform X1 [KO:K18267]
120759237  MYOZ3; myozenin-3 isoform X2 [KO:K26050]
120756174  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
120764014  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
120752698  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
120759316  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
120755669  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
120751708  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
120762687  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
120762225  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120749799  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
120755596  NRAP; nebulin-related-anchoring protein [KO:K24421]
120755708  MYPN; myopalladin [KO:K22028]
120752829  PDLIM5; PDZ and LIM domain protein 5 isoform X2 [KO:K19867]
120759053  PDLIM7; PDZ and LIM domain protein 7 isoform X5 [KO:K19867]
120755648  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
120758917  tropomodulin-2 isoform X1 [KO:K10370]
120758918  tropomodulin-3 [KO:K10370]
120748165  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
120765930  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
120747737  ZYX; zyxin isoform X1 [KO:K06273]
120765040  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
120749150  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
120763185  FHL3; four and a half LIM domains protein 3 isoform X1 [KO:K24414]
120751630  LMOD2; leiomodin-2 [KO:K22030]
120758241  LMOD3; leiomodin-3 [KO:K22030]
120762885  LMOD1; leiomodin-1 isoform X1 [KO:K22030]
120756038  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
120755866  ANKRD2; ankyrin repeat domain-containing protein 2 isoform X1 [KO:K21434]
120764513  FMNL3; formin-like protein 3 [KO:K23957]
120763590  FMNL1; LOW QUALITY PROTEIN: formin-like protein 1 [KO:K23957]
120754976  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
120754180  inverted formin-2-like isoform X1 [KO:K23958]
120754147  inverted formin-2-like isoform X1 [KO:K23958]
120754010  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
120750229  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
120764822  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
120748568  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
120750711  FMN2; formin-2 isoform X1 [KO:K02184]
120763065  MYOM3; myomesin-3 [KO:K24495]
120754416  MYOM1; myomesin-1 isoform X4 [KO:K24495]
120749809  MYOM2; myomesin-2 isoform X2 [KO:K24495]
120749273  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
120762387  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
120752507  ANK2; ankyrin-2 isoform X2 [KO:K09255]
120750880  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
120762118  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
120763140  TRIM63; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
120753703  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120762840  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120762931  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
120758992  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
120753965  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
120748083  plectin-like [KO:K10388]
120753854  SYNE3; nesprin-3 isoform X1 [KO:K21761]
120750364  SYNE1; nesprin-1 isoform X1 [KO:K19326]
120753989  SYNE2; nesprin-2 isoform X1 [KO:K19346]
120751414  SUN2; SUN domain-containing protein 2 [KO:K19347]
120759883  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
120758086  TMEM43; transmembrane protein 43 [KO:K27488]
120750579  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
120764318  LMNA; lamin [KO:K12641]
120763281  LMNB2; lamin-B2 [KO:K07611]
120758943  lamin-L(III)-like isoform X1 [KO:K07611]
120765061  LMNB1; lamin-B1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
hrt04512  ECM-receptor interaction
hrt04814  Motor proteins
KO pathway
ko04820   
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