KEGG   PATHWAY: hsp04218
Entry
hsp04218                    Pathway                                
Name
Cellular senescence - Hippoglossus stenolepis (Pacific halibut)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
hsp04218  Cellular senescence
hsp04218

Other DBs
GO: 0090398
Organism
Hippoglossus stenolepis (Pacific halibut) [GN:hsp]
Gene
118105944  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
118112176  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
118113442  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
118099356  transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
118116105  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
118098266  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
118119939  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118113748  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118124881  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
118115022  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
118106013  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
118109592  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
118123919  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
118104894  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
118122946  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118124774  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
118110121  G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
118113286  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
118123678  ccndx; cyclin Dx [KO:K10151]
118110057  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
118101630  G1/S-specific cyclin-D2 [KO:K10151]
118103957  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
118122075  rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
118105029  rbl1; retinoblastoma-like protein 1 [KO:K04681]
118110020  rbl2; retinoblastoma-like protein 2 [KO:K16332]
118111424  e2f1; transcription factor E2F1 [KO:K17454]
118116888  e2f2; transcription factor E2F2 [KO:K09389]
118114023  transcription factor E2F3 isoform X1 [KO:K06620]
118124747  e2f3; transcription factor E2F3 [KO:K06620]
118109161  e2f4; transcription factor E2F4 [KO:K04682]
118109921  transcription factor E2F4 [KO:K04682]
118117249  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
118106261  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118117868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118111369  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
118121033  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118102955  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118114686  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
118117905  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118117936  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118120979  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
118125392  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118120902  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118106156  foxo1a; forkhead box protein O1-A [KO:K07201]
124854860  forkhead box protein O1-A-like [KO:K07201]
118099779  foxo3b; forkhead box protein O3B [KO:K09408]
118117011  foxo3a; forkhead box protein O3a [KO:K09408]
118125222  foxo6b; forkhead box protein O6b [KO:K09408]
118101413  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
118105387  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
118105369  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
118106705  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
118113100  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
118124633  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
118125177  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
118125178  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
118124636  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
118122338  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
118122500  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
124851125  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein [KO:K06751]
118124626  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein [KO:K06751]
118124642  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
118124682  major histocompatibility complex class I-related gene protein-like [KO:K06751]
124851132  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
118109259  kras; GTPase KRas isoform X1 [KO:K07827]
118123859  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
118104419  rras2; ras-related protein R-Ras2 [KO:K07830]
118119875  mrasa; ras-related protein M-Ras [KO:K07831]
118109904  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
118106240  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118098902  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118121900  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118116209  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118118965  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118114670  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
118125796  tsc1b; TSC complex subunit 1b [KO:K07206]
118118306  tsc2; tuberin isoform X1 [KO:K07207]
118118332  rheb; GTP-binding protein Rheb [KO:K07208]
118105477  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
118110357  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118100343  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118118921  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118119243  sirt1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
118122266  ccna1; cyclin-A1 [KO:K06627]
118112624  ccna2; cyclin-A2 [KO:K06627]
118105437  mybl2b; v-myb avian myeloblastosis viral oncogene homolog-like 2b isoform X1 [KO:K21769]
118099901  lin9; protein lin-9 homolog [KO:K21773]
118113607  lin37; protein lin-37 homolog [KO:K21774]
118116976  lin52; protein lin-52 homolog [KO:K21775]
118126068  lin54; protein lin-54 homolog isoform X1 [KO:K21776]
118116140  histone-binding protein RBBP4 isoform X1 [KO:K10752]
118104852  histone-binding protein RBBP7 isoform X1 [KO:K10752]
118124817  rbbp4; histone-binding protein RBBP4 [KO:K10752]
118101430  foxm1; forkhead box protein M1 isoform X1 [KO:K09406]
118098820  myca; transcriptional regulator Myc-A [KO:K04377]
118104858  mych; myelocytomatosis oncogene homolog [KO:K04377]
118101287  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
118102319  tp53; cellular tumor antigen p53 [KO:K04451]
118104916  rassf5; ras association domain-containing protein 5 [KO:K08015]
118112053  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
118105894  hipk3b; LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
118109311  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
118109874  homeodomain-interacting protein kinase 3-like isoform X1 [KO:K08826] [EC:2.7.11.1]
118110863  hipk1a; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
118104793  hipk1b; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
118114879  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
118123457  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
118099407  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118116488  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118100486  serine/threonine-protein phosphatase alpha-2 isoform isoform X1 [KO:K06269] [EC:3.1.3.16]
118102789  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
118111456  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
118109512  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124854736  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
118114727  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
118122982  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118106116  ets1; protein C-ets-1 isoform X1 [KO:K02678]
118123527  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
118100279  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118109156  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118101535  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
118101536  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
118110753  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
118111319  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118111462  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
118104855  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
118098216  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
118098217  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118115579  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
118115882  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118118323  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
118121000  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
118121018  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118119385  cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118098128  ccnb1; G2/mitotic-specific cyclin-B1 isoform X2 [KO:K05868]
118106162  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
118106347  cyclin N-terminal domain-containing protein 2 [KO:K21770]
118106167  mre11a; double-strand break repair protein MRE11 [KO:K10865]
118122427  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
118113848  nbn; nibrin [KO:K10867]
118106665  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
118114701  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
118112300  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
118114878  rad9b; cell cycle checkpoint control protein RAD9B [KO:K10995]
118125657  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
118098797  hus1; checkpoint protein HUS1 [KO:K10903]
118116838  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
118122685  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
118111928  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
118099517  gata4; transcription factor GATA-4 [KO:K09183]
118099092  traf3ip2a; E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
118115950  E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
118120598  traf3ip2l; uncharacterized protein traf3ip2l [KO:K21124]
118111826  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118102445  rela; transcription factor p65 isoform X1 [KO:K04735]
118124722  interleukin-6 [KO:K05405]
118121600  interleukin-8 [KO:K10030]
118103008  interleukin-8 [KO:K10030]
118118138  insulin-like growth factor-binding protein 3 [KO:K10138]
118120960  insulin-like growth factor-binding protein 3 [KO:K10138]
118102255  serpine1; LOW QUALITY PROTEIN: plasminogen activator inhibitor 1 [KO:K03982]
118115008  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
118125727  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118104584  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
118106597  zgc:114130; mRNA decay activator protein ZFP36L1 [KO:K18753]
118106615  mRNA decay activator protein ZFP36L1 [KO:K18753]
118099552  zfp36l1b; mRNA decay activator protein ZFP36L1b [KO:K18753]
118116472  zfp36l1a; mRNA decay activator protein ZFP36L1a [KO:K18753]
118118962  zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
118111329  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
118105190  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
118115642  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
118105808  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
118116387  calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
118122368  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
118102443  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
118119433  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
118116972  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
118119322  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118119434  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118119503  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118119505  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118120876  calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
118106082  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
118099217  calm1b; calmodulin-1b [KO:K02183]
118115889  calm1a; calmodulin-1a [KO:K02183]
118109799  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
118111614  calml4a; calmodulin-like protein 4a [KO:K02183]
118118820  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
118105150  calglandulin [KO:K02183]
118115697  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
118121862  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118102577  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118112713  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118125882  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
118122573  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
118118945  calcineurin subunit B type 1 isoform X1 [KO:K06268]
118114042  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118125071  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118110914  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118105503  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
118109638  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
118110108  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118118435  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
118104834  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118105042  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118109898  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118111281  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118122211  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
118112501  slc25a5; ADP/ATP translocase 2 [KO:K05863]
118119927  slc25a4; ADP/ATP translocase 1 [KO:K05863]
118112147  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
118122322  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118100678  voltage-dependent anion-selective channel protein 2 [KO:K15040]
118119002  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118114625  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118125628  zgc:56235; voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
124854553  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
hsp04020  Calcium signaling pathway
hsp04068  FoxO signaling pathway
hsp04110  Cell cycle
hsp04115  p53 signaling pathway
hsp04150  mTOR signaling pathway
KO pathway
ko04218   
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