KEGG   PATHWAY: lve04072
Entry
lve04072                    Pathway                                
Name
Phospholipase D signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
lve04072  Phospholipase D signaling pathway
lve04072

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103089216  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103085145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103085046  PDGFD; platelet-derived growth factor D-like isoform X1 [KO:K05450]
103076387  PDGFC; platelet-derived growth factor C [KO:K05450]
103080643  KITLG; kit ligand isoform X1 [KO:K05461]
103085742  INS; insulin [KO:K04526]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103082363  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103070834  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103085622  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103085000  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
103079396  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
103074885  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
103088833  SHC2; SHC-transforming protein 2 [KO:K17447]
103078122  SHC3; SHC-transforming protein 3 [KO:K17448]
103088900  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
103088783  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103087313  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103070662  RRAS; ras-related protein R-Ras [KO:K07829]
103069562  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103086535  RALGDS; ral guanine nucleotide dissociation stimulator [KO:K08732]
103072770  RALA; ras-related protein Ral-A [KO:K07834]
103077787  RALB; ras-related protein Ral-B [KO:K07835]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103088278  TSC1; hamartin isoform X1 [KO:K07206]
103075350  TSC2; tuberin [KO:K07207]
103080271  RHEB; GTP-binding protein Rheb [KO:K07208]
103069618  GTP-binding protein Rheb-like [KO:K07208]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103088013  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
103089703  ADP-ribosylation factor 2-like isoform X1 [KO:K07937]
103082078  ARF6; ADP-ribosylation factor 6 [KO:K07941]
103068930  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
103070997  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
103075075  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856]
103075361  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856]
103077379  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
103091403  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
103085198  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
103071829  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
103079796  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103069742  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
103084538  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
103090681  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
103090934  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
103089071  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
103083510  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
103083784  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
103091658  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
103089330  LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta-like [KO:K13509] [EC:2.3.1.51]
103080863  uncharacterized protein LOC103080863 [KO:K13509] [EC:2.3.1.51]
103072754  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103082200  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
103075414  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
103072023  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
103079519  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103081872  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103080867  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103084474  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103090970  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
103071254  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
103069905  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
103073740  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
103085422  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
103091179  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
103069401  DGKD; LOW QUALITY PROTEIN: diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
103084721  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
103090511  DGKE; LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
103090793  DGKI; LOW QUALITY PROTEIN: diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
103077334  PPAP2A; lipid phosphate phosphohydrolase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
103089367  PPAP2C; LOW QUALITY PROTEIN: lipid phosphate phosphohydrolase 2 [KO:K01080] [EC:3.1.3.4]
103068920  PPAP2B; lipid phosphate phosphohydrolase 3 [KO:K01080] [EC:3.1.3.4]
103082406  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103078157  AGT; angiotensinogen [KO:K09821]
103076585  AVP; vasopressin-neurophysin 2-copeptin [KO:K05242]
103086219  IL8; interleukin-8 [KO:K10030]
103090648  AGTR1; type-1 angiotensin II receptor [KO:K04166]
103078013  F2R; proteinase-activated receptor 1 [KO:K03914]
103085587  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
103079932  GRM2; metabotropic glutamate receptor 2 [KO:K04605]
103089829  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
103071494  GRM4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
103089884  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
103072025  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
103080976  metabotropic glutamate receptor 7-like isoform X1 [KO:K04609]
103079834  metabotropic glutamate receptor 7-like [KO:K04609]
103084596  metabotropic glutamate receptor 8-like [KO:K04610]
103090583  metabotropic glutamate receptor 8-like [KO:K04610]
103086677  GRM8; metabotropic glutamate receptor 8 [KO:K04610]
103084102  AVPR1A; vasopressin V1a receptor [KO:K04226]
103079749  AVPR1B; vasopressin V1b receptor [KO:K04227]
103069934  AVPR2; vasopressin V2 receptor [KO:K04228]
103091078  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103074802  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103073033  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103078023  LPAR4; lysophosphatidic acid receptor 4 isoform X1 [KO:K04275]
103071546  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103071883  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103081415  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
103068417  c-X-C chemokine receptor type 2-like [KO:K04175]
103068692  CXCR2; c-X-C chemokine receptor type 2 [KO:K05050]
103086280  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103083884  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
103078639  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
103079287  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
103069136  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103083166  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103071564  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
103069455  PIK3CG; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103076917  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103076642  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103073910  CYTH3; cytohesin-3 [KO:K18441]
103077566  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
103076266  CYTH4; cytohesin-4 [KO:K18441]
103070852  CYTH1; cytohesin-1 [KO:K18441]
103089051  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
103085385  neuroendocrine secretory protein 55-like [KO:K04632]
103081539  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103084817  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103076182  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103075499  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103091169  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
103075153  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103078677  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103085845  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103070451  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103080613  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
103078675  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
103090124  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
103074090  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
103085901  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
lve00561  Glycerolipid metabolism
lve04010  MAPK signaling pathway
lve04014  Ras signaling pathway
lve04020  Calcium signaling pathway
lve04024  cAMP signaling pathway
lve04071  Sphingolipid signaling pathway
lve04144  Endocytosis
lve04150  mTOR signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
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