KEGG   PATHWAY: maua04020
Entry
maua04020                   Pathway                                
Name
Calcium signaling pathway - Mesocricetus auratus (golden hamster)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
maua04020  Calcium signaling pathway
maua04020

Other DBs
GO: 0019722
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101842252  Slc8a3; sodium/calcium exchanger 3 isoform X2 [KO:K05849]
101823918  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
101828775  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
101825024  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101840779  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X5 [KO:K05850] [EC:7.2.2.10]
101838198  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
121136402  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
101826619  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
121138665  plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101828505  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
101827236  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
101827372  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
101824159  Adora2a; adenosine receptor A2a [KO:K04266]
101832697  Adora2b; adenosine receptor A2b [KO:K04267]
101830640  Adrb1; beta-1 adrenergic receptor [KO:K04141]
101836719  Adrb2; beta-2 adrenergic receptor [KO:K04142]
101825029  Adrb3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
101843956  Drd1; D(1A) dopamine receptor [KO:K04144]
101833579  Drd5; D(1B) dopamine receptor [KO:K05840]
101844473  Hrh2; histamine H2 receptor isoform X1 [KO:K04150]
101836030  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
101832575  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
101835411  5-hydroxytryptamine receptor 5B [KO:K04161]
101833956  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101842111  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
101834728  Gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
101834284  neuroendocrine secretory protein 55 [KO:K04632]
101826012  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
101822607  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101836580  Adcy2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
101844476  Adcy3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101841504  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101839314  Adcy7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101827170  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101842546  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
101841299  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101840885  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101844657  Pln; cardiac phospholamban [KO:K05852]
101835409  Sln; sarcolipin [KO:K22642]
106021191  Mrln; myoregulin [KO:K22643]
101823832  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
106021131  Smim6; small integral membrane protein 6 isoform X1 [KO:K26468]
101841211  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101828431  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
101824306  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101823693  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
101825321  Stim1; stromal interaction molecule 1 isoform X2 [KO:K16059]
101840724  Stim2; LOW QUALITY PROTEIN: stromal interaction molecule 2 [KO:K18196]
101830091  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
101825687  Orai2; protein orai-2 [KO:K16057]
101826669  Orai3; protein orai-3 [KO:K16058]
101834428  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X23 [KO:K04850]
101825756  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
101830198  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101835763  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101838455  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101836565  Cacna1b; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101833242  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
101838668  Cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101842724  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101835044  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
101844432  Chrna7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101827090  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
101824116  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101824692  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101826172  Grin2c; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101822703  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101834481  Grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101838616  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101828164  P2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
101842393  P2rx2; P2X purinoceptor 2 [KO:K05216]
101842305  P2rx3; P2X purinoceptor 3 isoform X1 [KO:K05217]
101840398  P2rx4; P2X purinoceptor 4 [KO:K05218]
101833138  P2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
101844204  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
101840681  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
101840708  Ryr1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
101841801  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
101829120  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
106023025  Trdn; triadin [KO:K23449]
101830350  Casq1; calsequestrin-1 [KO:K23468]
101829540  Casq2; calsequestrin-2 isoform X1 [KO:K23445]
101826336  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X4 [KO:K00476] [EC:1.14.11.16]
101826850  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
101832100  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
101844151  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
101834375  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101843941  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
101828790  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
101840244  type-1A angiotensin II receptor [KO:K04166]
101834569  Agtr1; type-1 angiotensin II receptor [KO:K04166]
101832204  Ednra; endothelin-1 receptor [KO:K04197]
101826701  Ednrb; endothelin receptor type B [KO:K04198]
101844170  F2r; proteinase-activated receptor 1 [KO:K03914]
101831018  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101840496  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101826103  Grpr; gastrin-releasing peptide receptor [KO:K04169]
121132724  Hrh1; LOW QUALITY PROTEIN: histamine H1 receptor [KO:K04149]
101833748  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
101836394  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
106022163  Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
101835084  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101842879  Ntsr1; neurotensin receptor type 1 [KO:K04211]
101833814  Oxtr; oxytocin receptor [KO:K04229]
121143268  Avpr1a; vasopressin V1a receptor [KO:K04226]
101837620  Avpr1b; vasopressin V1b receptor [KO:K04227]
101840764  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
101822595  Ptafr; platelet-activating factor receptor [KO:K04279]
101837043  Ptger1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
101837737  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101834313  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
101837673  Bdkrb1; B1 bradykinin receptor [KO:K03915]
101837939  Bdkrb2; B2 bradykinin receptor [KO:K03916]
101830983  Tacr1; substance-P receptor [KO:K04222]
101839819  Tacr2; substance-K receptor [KO:K04223]
101840845  Tacr3; neuromedin-K receptor [KO:K04224]
101843090  Tbxa2r; thromboxane A2 receptor [KO:K04264]
101827570  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
101844194  thyrotropin-releasing hormone receptor isoform X2 [KO:K04282]
101841605  Cckar; cholecystokinin receptor type A [KO:K04194]
101827214  Cckbr; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
101843789  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
101825355  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101839416  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101825095  guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
101839158  Gna15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
101830366  Egf; pro-epidermal growth factor [KO:K04357]
101823727  Tgfa; protransforming growth factor alpha [KO:K08774]
101832477  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101835912  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101834115  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101829713  Pdgfc; platelet-derived growth factor C [KO:K05450]
101823630  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101834448  Fgf2; fibroblast growth factor 2 [KO:K18497]
101830284  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101838365  Fgf4; fibroblast growth factor 4 [KO:K04358]
101838622  Fgf3; fibroblast growth factor 3 [KO:K04358]
101837518  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101841394  Fgf22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101831487  Fgf18; fibroblast growth factor 18 [KO:K04358]
101835364  Fgf6; fibroblast growth factor 6 [KO:K04358]
101828598  Fgf16; fibroblast growth factor 16 [KO:K04358]
101828286  Fgf9; fibroblast growth factor 9 [KO:K04358]
101828703  Fgf7; fibroblast growth factor 7 [KO:K04358]
101837923  Fgf20; fibroblast growth factor 20 [KO:K04358]
101838888  Fgf10; fibroblast growth factor 10 [KO:K04358]
106021596  fibroblast growth factor 8-like [KO:K04358]
101828257  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101838091  Fgf19; fibroblast growth factor 19 [KO:K22603]
101842115  Fgf21; fibroblast growth factor 21 [KO:K22429]
101835630  Fgf23; fibroblast growth factor 23 [KO:K22428]
101839822  Vegfa; vascular endothelial growth factor A precursor [KO:K05448]
101834505  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
101823025  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
101828877  Vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
110342135  Ngf; beta-nerve growth factor [KO:K02582]
101829822  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101837529  Mst1; hepatocyte growth factor-like protein isoform X2 [KO:K23441]
101835435  Gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101838749  Egfr; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101822760  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101828925  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101831481  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101822506  Pdgfra; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101840188  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101842486  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
101837200  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101826351  Fgfr3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
101828736  Fgfr4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101840690  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101835846  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101844417  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101843619  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101839587  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101843505  Ntrk3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
101825509  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101834466  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
101835994  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101823723  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
101829109  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
101832098  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
101842030  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101830949  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101834708  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101834401  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101824564  Plcg1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
101831758  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101832834  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [KO:K05860] [EC:3.1.4.11]
101829797  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
101836776  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101835945  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101838704  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101825392  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
101841015  Tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
101836761  Tpcn2; two pore calcium channel protein 2 isoform X2 [KO:K14077]
101824034  Mcoln1; mucolipin-1 isoform X1 [KO:K04992]
101843249  Mcoln2; mucolipin-2 isoform X2 [KO:K04993]
101828749  Mcoln3; mucolipin-3 [KO:K04994]
101840320  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101822923  Sphk1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
101823726  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
106023283  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101826831  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101833472  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121134224  ADP/ATP translocase 2-like [KO:K05863]
121134132  ADP/ATP translocase 2-like [KO:K05863]
106021192  ADP/ATP translocase 2 [KO:K05863]
101823968  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
101832622  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110343395  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
121140901  ADP/ATP translocase 1-like [KO:K05863]
101825364  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101822799  Tnnc1; troponin C, slow skeletal and cardiac muscles isoform X3 [KO:K05865]
101826574  Tnnc2; troponin C, skeletal muscle [KO:K12042]
121135759  Calml6; calmodulin-like protein 6 [KO:K02183]
101825969  calmodulin-1-like [KO:K02183]
101840179  calmodulin-like protein 3 [KO:K02183]
101840457  calmodulin-4 [KO:K02183]
101823161  Calm3; calmodulin-3 [KO:K02183]
101832379  Calm2; calmodulin-2 [KO:K02183]
101828975  Calm1; calmodulin-1 [KO:K02183]
121136988  calmodulin-alpha-like [KO:K02183]
101834468  Calml4; calmodulin-like protein 4 [KO:K02183]
101833206  calmodulin-A-like [KO:K02183]
101828949  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101840125  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
101844140  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
101828720  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101839230  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
101827753  Mylk; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101843459  Mylk3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
101836507  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
101835727  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101834500  Camk1g; calcium/calmodulin-dependent protein kinase type 1G isoform X2 [KO:K08794] [EC:2.7.11.17]
101830491  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
101830635  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
101833722  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13 [KO:K04515] [EC:2.7.11.17]
101833285  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101841273  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101841141  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
101833150  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101838431  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101840210  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121134668  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
106021831  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
101831663  Tfeb; LOW QUALITY PROTEIN: transcription factor EB [KO:K15590]
101844781  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101823473  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101823564  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101826846  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101830457  Nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101823656  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101838293  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101830844  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101828595  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101843288  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101835508  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101834939  Itpka; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
101824042  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
101834744  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
101837515  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101824743  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101828136  Prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
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Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
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L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
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Reference
PMID:11299192
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Ferrier GR, Howlett SE.
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Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
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Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
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Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
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Reference
PMID:9149541
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Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
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Reference
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Fukunaga K, Miyamoto E.
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A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
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Reference
PMID:9235901
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
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J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
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J Physiol 529 Pt 1:11-21 (2000)
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Reference
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Extracellular-signal-regulated kinase signalling in neurons.
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Curr Opin Neurobiol 9:544-53 (1999)
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Reference
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Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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Mol Cell Biol 23:7068-81 (2003)
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Reference
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Hutchins JR, Dikovskaya D, Clarke PR.
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Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
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Reference
PMID:21338471
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Tornquist K
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Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
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Acta Physiol (Oxf) 204:151-7 (2012)
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Reference
PMID:22129055
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Feske S
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Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
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Reference
PMID:22002090
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Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
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Reference
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
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Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
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The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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Pflugers Arch 458:869-76 (2009)
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Reference
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Beard NA, Wei L, Dulhunty AF
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Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
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Eur Biophys J 39:27-36 (2009)
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Reference
PMID:26228554
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Marty I
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Triadin regulation of the ryanodine receptor complex.
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J Physiol 593:3261-6 (2015)
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Reference
PMID:20807542
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Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
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J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
maua04010  MAPK signaling pathway
maua04070  Phosphatidylinositol signaling system
maua04210  Apoptosis
maua04720  Long-term potentiation
maua04730  Long-term depression
KO pathway
ko04020   
LinkDB

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