KEGG   PATHWAY: mleu04510
Entry
mleu04510                   Pathway                                
Name
Focal adhesion - Mandrillus leucophaeus (drill)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mleu04510  Focal adhesion
mleu04510

Other DBs
GO: 0005925
Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105553265  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105535560  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
105544943  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
105546552  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105546564  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
105541413  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
105541512  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
105543172  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105543173  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105551554  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
105551555  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
105539834  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
105538157  collagen alpha-4(VI) chain-like [KO:K06238]
105538158  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
105538159  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
105531466  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
105548366  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105537944  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105551977  LAMA2; laminin subunit alpha-2 [KO:K05637]
105549719  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105545233  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
105548407  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
105532439  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
105544087  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
105540363  LAMB2; laminin subunit beta-2 [KO:K06243]
105536421  LAMB3; laminin subunit beta-3 [KO:K06244]
105544107  LAMB4; laminin subunit beta-4 [KO:K06245]
105550421  LAMC1; laminin subunit gamma-1 [KO:K05635]
105550424  LAMC2; laminin subunit gamma-2 [KO:K06246]
105532867  LAMC3; laminin subunit gamma-3 [KO:K06247]
105553257  CHAD; chondroadherin [KO:K06248]
105543273  RELN; reelin [KO:K06249] [EC:3.4.21.-]
105546194  THBS1; thrombospondin-1 [KO:K16857]
105553558  THBS2; thrombospondin-2 [KO:K04659]
105547095  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105548283  THBS4; thrombospondin-4 [KO:K04659]
105544845  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105528087  FN1; fibronectin [KO:K05717]
105547229  SPP1; osteopontin isoform X1 [KO:K06250]
105552039  VTN; vitronectin isoform X1 [KO:K06251]
105531513  TNXB; tenascin-X [KO:K06252]
105552734  TNC; tenascin isoform X1 [KO:K06252]
105540723  TNN; tenascin-N [KO:K06252]
105540726  TNR; tenascin-R [KO:K06252]
105541774  VWF; von Willebrand factor [KO:K03900]
105547231  IBSP; bone sialoprotein 2 [KO:K06253]
105552123  ITGA1; integrin alpha-1 [KO:K06480]
105552128  ITGA2; integrin alpha-2 [KO:K06481]
105543805  ITGA2B; integrin alpha-IIb [KO:K06476]
105553271  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
105553874  ITGA4; integrin alpha-4 [KO:K06483]
105548552  ITGA5; integrin alpha-5 [KO:K06484]
105548065  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105532010  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105530532  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105553436  ITGA9; integrin alpha-9 [KO:K06585]
105550282  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
105530986  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
105553894  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105549004  ITGB1; integrin beta-1 [KO:K05719]
105534546  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105528575  ITGB4; integrin beta-4 [KO:K06525]
105533226  ITGB5; integrin beta-5 [KO:K06588]
105547780  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
105555020  ITGB7; integrin beta-7 [KO:K06590]
105534972  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105545269  EMP2; epithelial membrane protein 2 [KO:K26256]
105537884  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105538858  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105532330  PDGFC; platelet-derived growth factor C [KO:K05450]
105542755  PDGFD; platelet-derived growth factor D [KO:K05450]
105532399  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105530906  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105544346  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105549166  VEGFB; vascular endothelial growth factor B [KO:K16858]
105540798  PGF; placenta growth factor isoform X1 [KO:K16859]
105543587  VEGFC; vascular endothelial growth factor C [KO:K05449]
105550584  FIGF; vascular endothelial growth factor D [KO:K05449]
105543916  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105529382  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
105543434  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105531828  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105548470  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105529594  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105553816  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105537301  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105553697  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105553066  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105549194  EMP1; epithelial membrane protein 1 [KO:K26255]
105535793  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105531723  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
105553448  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
105540348  RHOA; transforming protein RhoA [KO:K04513]
105534889  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
105551188  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105528513  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105532701  MYL5; myosin light chain 5 [KO:K12753]
105541942  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
105533817  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
105552261  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K12756]
105543340  MYL10; myosin regulatory light chain 10 [KO:K12756]
105551171  myosin regulatory light chain 12A [KO:K12757]
105551173  MYL12B; myosin regulatory light chain 12B [KO:K12757]
105541434  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105552307  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
105533954  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
105544467  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
105540701  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
105547100  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
105551618  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
105539494  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105533181  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105542846  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
105555490  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
105532065  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
105534790  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
105530091  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
105551087  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105549083  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105542260  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105554489  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
105534584  ACTN4; alpha-actinin-4 [KO:K05699]
105554418  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105539716  TLN1; talin-1 [KO:K06271]
105530250  TLN2; talin-2 [KO:K06271]
105555383  FLNA; filamin-A [KO:K04437]
105552667  FLNB; filamin-B isoform X1 [KO:K27392]
105527924  paxillin isoform X1 [KO:K05760]
105533899  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
105546624  ZYX; zyxin [KO:K06273]
105535860  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
105547512  VCL; vinculin isoform X1 [KO:K05700]
105534331  PARVA; alpha-parvin [KO:K06275]
105542452  PARVB; beta-parvin isoform X1 [KO:K06275]
105542453  PARVG; gamma-parvin [KO:K06275]
105541556  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105540494  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105541755  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105542359  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105544615  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105542652  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105548239  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105545146  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105539692  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105546847  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105539923  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105552763  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105549588  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105547376  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105543389  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105531763  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105546962  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105547822  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105530127  VAV1; proto-oncogene vav [KO:K05730]
105531076  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
105551438  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105546567  ras-related protein Rac1-like [KO:K04392]
105538902  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105531520  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105546511  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105538759  PAK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105542811  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
105534636  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
105552841  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
105546184  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
105546828  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105537242  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
105553544  CRK; adapter molecule crk [KO:K04438]
105544751  CRKL; crk-like protein [KO:K04438]
105530187  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
105554935  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
105554311  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
105537110  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
105547365  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105554734  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105537274  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105534921  JUN; transcription factor AP-1 [KO:K04448]
105550515  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105553699  CAV1; caveolin-1 isoform X1 [KO:K06278]
105554255  CAV3; caveolin-3 [KO:K12959]
105532442  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
105544828  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105548833  SHC2; SHC-transforming protein 2 [KO:K17447]
105535962  SHC3; SHC-transforming protein 3 [KO:K17448]
105529990  SHC4; SHC-transforming protein 4 [KO:K17449]
105538707  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105551898  SOS1; son of sevenless homolog 1 [KO:K03099]
105553627  SOS2; son of sevenless homolog 2 [KO:K03099]
105549333  HRAS; GTPase HRas isoform X1 [KO:K02833]
105542175  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105530797  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105541405  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105544764  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105541696  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105544506  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105551132  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
105544297  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
105542732  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105542734  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
105554881  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105549098  BAD; bcl2-associated agonist of cell death [KO:K02158]
105535165  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mleu04010  MAPK signaling pathway
mleu04060  Cytokine-cytokine receptor interaction
mleu04070  Phosphatidylinositol signaling system
mleu04110  Cell cycle
mleu04151  PI3K-Akt signaling pathway
mleu04310  Wnt signaling pathway
mleu04512  ECM-receptor interaction
mleu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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