KEGG   PATHWAY: mthb05208
Entry
mthb05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Macaca thibetana thibetana (Pere David's macaque)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mthb05208  Chemical carcinogenesis - reactive oxygen species
mthb05208

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126962756  arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
126930060  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126930154  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
126930168  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
126954620  microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
126931359  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
126963047  glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
126963049  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
126946285  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
126952227  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
126941935  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
126929522  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
126929523  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
126929524  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
126929525  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126953690  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
126953691  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
126953692  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
126947324  NADH-ubiquinone oxidoreductase chain 5-like [KO:K03883] [EC:7.1.1.2]
126935373  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
126930135  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
126941129  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
126950655  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
126932207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126946139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
126941467  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126957346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
126950258  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
126942379  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
126942872  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126943346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
126944267  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126956821  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126930414  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126962403  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126956036  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949986  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
126963966  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126945886  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126958389  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126960684  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949375  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126938104  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126949807  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
126960621  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126953759  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126963639  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
126942854  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
126937961  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
126931739  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
126932556  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
126937587  acyl carrier protein, mitochondrial-like [KO:K03955]
126944402  acyl carrier protein, mitochondrial [KO:K03955]
126951198  acyl carrier protein, mitochondrial-like [KO:K03955]
126942837  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
126932729  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
126930310  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
126942362  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
126959705  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
126948765  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
126949662  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
126932125  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
126934097  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126958757  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126934260  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126949249  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
126939064  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126935141  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126948391  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
126937431  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
126942449  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
126963088  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126944751  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126939420  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126950876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126934694  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126961397  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
126944752  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
126930302  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
126945660  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
126932178  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
126935729  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
126935957  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
126936392  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
126945830  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
126956863  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
126938277  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126963401  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126960994  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
126961122  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126957428  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
126942790  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
126935402  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
126954622  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
126935701  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
126956207  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
126957442  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
126955714  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
126961462  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126936808  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
126962850  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126956192  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126950253  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126961220  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126935807  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
126930673  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
126943623  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
126960981  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
126948676  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
126944495  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
126954785  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
126961549  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
126937178  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126934429  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126960839  cytochrome b-c1 complex subunit 7 [KO:K00417]
126954793  cytochrome b-c1 complex subunit 8-like [KO:K00418]
126956035  cytochrome b-c1 complex subunit 8 [KO:K00418]
126963991  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
126942883  cytochrome b-c1 complex subunit 10 [KO:K00420]
126944333  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
126964308  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
126934981  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
126959142  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
126960028  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
126936073  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126956094  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126934339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126944266  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
126946802  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
126943264  cytochrome c oxidase subunit 6B2 [KO:K02267]
126939820  cytochrome c oxidase subunit 6B1-like [KO:K02267]
126941943  cytochrome c oxidase subunit 6B1 [KO:K02267]
126954498  cytochrome c oxidase subunit 6C [KO:K02268]
126961151  cytochrome c oxidase subunit 6C [KO:K02268]
126946168  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126934205  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
126946829  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
126951565  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126952142  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
126942121  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
126955253  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
126946324  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126942189  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126930116  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126943807  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126956722  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126938620  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957169  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957397  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126958011  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126933618  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126946671  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126958869  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126952688  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126960733  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126959711  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
126935615  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
126941410  ATP synthase subunit alpha, mitochondrial [KO:K02132]
126930379  ATP synthase subunit beta, mitochondrial isoform X1 [KO:K02133] [EC:7.1.2.2]
126962920  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
126942994  ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
126929356  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
126930054  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126955326  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126951623  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
126954576  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126942840  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126930915  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126931179  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
126963773  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126932708  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126964152  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
126939892  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
126940287  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126959053  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
126949063  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
126954618  ATP synthase subunit d, mitochondrial-like [KO:K02138]
126939263  ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
126934985  ATP synthase subunit d, mitochondrial-like [KO:K02138]
126933171  ATP synthase subunit O, mitochondrial-like [KO:K02137]
126950727  ATP synthase subunit O, mitochondrial [KO:K02137]
126950759  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
126953664  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
126956005  voltage-dependent anion-selective channel protein 1 [KO:K05862]
126962446  voltage-dependent anion-selective channel protein 2 [KO:K15040]
126960768  voltage-dependent anion-selective channel protein 3 [KO:K15041]
126955617  ADP/ATP translocase 4 isoform X1 [KO:K05863]
126955724  ADP/ATP translocase 1 [KO:K05863]
126946121  ADP/ATP translocase 2 [KO:K05863]
126946856  ADP/ATP translocase 3 [KO:K05863]
126947143  ADP/ATP translocase 3 [KO:K05863]
126962461  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
126951704  superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
126936228  catalase [KO:K03781] [EC:1.11.1.6]
126954824  sulfate anion transporter 1 isoform X1 [KO:K14700]
126956589  sulfate transporter [KO:K14701]
126948652  solute carrier family 26 member 6 isoform X1 [KO:K14704]
126939538  solute carrier family 26 member 9 [KO:K14706]
126959999  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
126963293  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
126963295  cytochrome P450 2E1-like isoform X1 [KO:K07415] [EC:1.14.14.-]
126942014  cytochrome P450 2F5 isoform X1 [KO:K07416] [EC:1.14.14.1]
126942068  cytochrome P450 2F5-like [KO:K07416] [EC:1.14.14.1]
126960000  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
126933548  cytochrome P450 1B1 isoform X1 [KO:K07410] [EC:1.14.14.1]
126937150  epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
126961771  bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
126942283  epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
126946799  epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
126960362  aldo-keto reductase family 1 member A1 isoform X1 [KO:K00002] [EC:1.1.1.2]
126963006  aldo-keto reductase family 1 member C1 isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
126963009  aldo-keto reductase family 1 member C1-like isoform X1 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
126963005  putative aldo-keto reductase family 1 member C8 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126963008  aldo-keto reductase family 1 member C3 isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126963422  aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
126963007  aldo-keto reductase family 1 member C4 isoform X1 [KO:K00037] [EC:1.1.1.50 1.1.1.357 1.1.1.225]
126944082  NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
126951561  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
126950004  aryl hydrocarbon receptor [KO:K09093]
126939442  lactoperoxidase [KO:K12550] [EC:1.11.1.7]
126934745  NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
126944340  cytochrome b-245 light chain isoform X1 [KO:K08009]
126945851  NADPH oxidase 1 [KO:K08008]
126950372  neutrophil cytosol factor 1 [KO:K08011]
126940149  neutrophil cytosol factor 2 isoform X1 [KO:K08010]
126954925  pro-epidermal growth factor isoform X1 [KO:K04357]
126950202  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
126949900  hepatocyte growth factor isoform X1 [KO:K05460]
126951204  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
126939255  growth factor receptor-bound protein 2 [KO:K04364]
126933534  son of sevenless homolog 1 isoform X1 [KO:K03099]
126958499  son of sevenless homolog 2 isoform X1 [KO:K03099]
126935869  GTPase HRas isoform X1 [KO:K02833]
126931572  GTPase KRas [KO:K07827]
126930824  GTPase NRas [KO:K07828]
126945567  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126949633  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
126949054  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126957976  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126942673  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126944456  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
126929669  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126952847  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
126939572  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
126942652  dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126952773  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126952775  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126929437  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126929447  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126962798  transcription factor Jun [KO:K04448]
126959543  protein c-Fos [KO:K04379]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126944637  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
126944712  LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126953626  forkhead box protein O3 [KO:K09408]
126935617  bcl2-associated agonist of cell death [KO:K02158]
126964386  tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126963067  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126945470  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126959170  NF-kappa-B inhibitor alpha [KO:K04734]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126948783  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
126936273  receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
126931525  low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
126933465  low molecular weight phosphotyrosine protein phosphatase isoform X1 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
126931454  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
126964210  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
126936893  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
126950153  tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
126943412  serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
126933541  serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
126959387  serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
126961367  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126939667  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
126948354  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
126938709  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
126958962  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
126931516  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
126952424  vascular endothelial growth factor A isoform X1 [KO:K05448]
126932076  nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
126964018  heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mthb00190  Oxidative phosphorylation
mthb00980  Metabolism of xenobiotics by cytochrome P450
mthb04010  MAPK signaling pathway
mthb04064  NF-kappa B signaling pathway
mthb04066  HIF-1 signaling pathway
mthb04151  PI3K-Akt signaling pathway
mthb04370  VEGF signaling pathway
mthb05207  Chemical carcinogenesis - receptor activation
mthb05211  Renal cell carcinoma
mthb05215  Prostate cancer
mthb05219  Bladder cancer
mthb05221  Acute myeloid leukemia
mthb05222  Small cell lung cancer
mthb05223  Non-small cell lung cancer
mthb05224  Breast cancer
mthb05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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