KEGG   PATHWAY: nvs04936
Entry
nvs04936                    Pathway                                
Name
Alcoholic liver disease - Neogale vison (American mink)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
nvs04936  Alcoholic liver disease
nvs04936

Organism
Neogale vison (American mink) [GN:nvs]
Gene
122898607  C1QA; complement C1q subcomponent subunit A [KO:K03986]
122898609  C1QB; complement C1q subcomponent subunit B [KO:K03987]
122898608  C1QC; complement C1q subcomponent subunit C [KO:K03988]
122911435  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
122911388  C4A; complement C4-A [KO:K03989]
122909817  C3; complement C3 [KO:K03990]
122891436  C3AR1; C3a anaphylatoxin chemotactic receptor [KO:K04009]
122917302  C5; complement C5 [KO:K03994]
122913892  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
122915567  lipopolysaccharide-binding protein-like [KO:K05399]
122915569  lipopolysaccharide-binding protein-like [KO:K05399]
122890567  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122903936  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
122917312  TLR4; toll-like receptor 4 [KO:K10160]
122912424  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
122909079  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
122891544  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122896442  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
122912847  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122891933  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122905565  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122904521  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122901015  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122889856  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122897563  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122893621  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
122913121  RELA; transcription factor p65 [KO:K04735]
122889330  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122899945  TNF; tumor necrosis factor isoform X1 [KO:K03156]
122915760  IL1B; interleukin-1 beta [KO:K04519]
122904064  IL6; interleukin-6 [KO:K05405]
122910459  IL12A; interleukin-12 subunit alpha [KO:K05406]
122901988  IL12B; interleukin-12 subunit beta [KO:K05425]
122919291  CXCL8; interleukin-8 [KO:K10030]
122909849  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
122894215  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
122918861  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
122891093  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
122911811  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
122916735  interferon alpha-1/2-like [KO:K05414]
122916921  interferon alpha-1/2-like [KO:K05414]
122916922  interferon alpha-1/2-like [KO:K05414]
122916923  interferon alpha-1/2-like [KO:K05414]
122916924  interferon alpha-3-like [KO:K05414]
122916925  interferon alpha-1/2-like [KO:K05414]
122916926  interferon alpha-1/2-like [KO:K05414]
122916927  interferon alpha-1/2-like [KO:K05414]
122916929  interferon alpha-1/2-like [KO:K05414]
122916930  interferon alpha-3-like [KO:K05414]
122916931  interferon alpha-1/2-like [KO:K05414]
122916932  interferon alpha-1/2-like [KO:K05414]
122916933  interferon alpha-1/2-like [KO:K05414]
122916934  interferon alpha-1/2-like [KO:K05414]
122916935  interferon alpha-1/2-like [KO:K05414]
122916936  interferon alpha-1/2-like [KO:K05414]
122916937  interferon alpha-2-like [KO:K05414]
122917563  interferon alpha-1/2-like [KO:K05414]
122917564  interferon alpha-1/2-like [KO:K05414]
122916938  IFNB1; interferon beta [KO:K05415]
122899698  IL17A; interleukin-17A [KO:K05489]
122892663  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
122909217  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
122919245  growth-regulated alpha protein-like [KO:K05505]
122919267  growth-regulated protein homolog gamma-like [KO:K05505]
122919268  growth-regulated protein homolog gamma-like [KO:K05505]
122918121  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122900656  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122913265  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
122892505  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122911363  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122902190  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
122889990  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
122912358  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
122897683  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
122906856  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
122905866  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
122906479  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
122889487  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
122901019  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
122915307  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
122916072  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
122903007  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
122900725  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
122904906  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
122908777  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
122908788  ADIPOQ; adiponectin [KO:K07296]
122918804  ADIPOR1; adiponectin receptor protein 1 [KO:K07297]
122892060  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
122903449  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
122900018  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122894750  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122900404  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
122903371  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
122905216  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
122891254  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122901740  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
122907042  FOXO1; forkhead box protein O1 [KO:K07201]
122904039  FOXO3; forkhead box protein O3 [KO:K09408]
122890143  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
122892035  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
122913275  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
122906685  ACADVL; very long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09479] [EC:1.3.8.9]
122900100  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
122919084  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
122905967  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
122915751  FABP1; fatty acid-binding protein, liver [KO:K08750]
122890452  alcohol dehydrogenase E chain [KO:K13951] [EC:1.1.1.1]
122889356  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 isoform X1 [KO:K13980] [EC:1.1.1.1]
122889357  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
122890457  alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
122911824  ALDH16A1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
122906882  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
122903423  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
122917439  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
122916525  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122918401  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
122899062  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
122903326  ACACB; acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
122911189  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
122891358  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
122911809  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
122912502  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
122918524  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122912036  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122894172  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122908538  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122908975  CTNNB1; catenin beta-1 [KO:K02105]
122891699  TCF7; transcription factor 7 isoform X1 [KO:K02620]
122915045  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
122901120  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
122889282  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
122913270  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
122906270  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122906771  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122909795  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122889452  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122900866  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122915651  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122906843  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122906041  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122891909  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122891975  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122910068  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
122910086  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122906116  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
nvs00061  Fatty acid biosynthesis
nvs00071  Fatty acid degradation
nvs01040  Biosynthesis of unsaturated fatty acids
nvs03040  Spliceosome
nvs04010  MAPK signaling pathway
nvs04064  NF-kappa B signaling pathway
nvs04152  AMPK signaling pathway
nvs04210  Apoptosis
nvs04310  Wnt signaling pathway
nvs04610  Complement and coagulation cascades
nvs04620  Toll-like receptor signaling pathway
nvs04657  IL-17 signaling pathway
nvs04668  TNF signaling pathway
nvs04920  Adipocytokine signaling pathway
nvs05034  Alcoholism
nvs05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

DBGET integrated database retrieval system