KEGG   PATHWAY: nvs04010
Entry
nvs04010                    Pathway                                
Name
MAPK signaling pathway - Neogale vison (American mink)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
nvs04010  MAPK signaling pathway
nvs04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122889097  FGF20; fibroblast growth factor 20 [KO:K04358]
122889210  FGF5; fibroblast growth factor 5 [KO:K04358]
122889250  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
122889261  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
122889330  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122889339  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122889352  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
122889387  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
122889423  AREG; amphiregulin [KO:K09782]
122889452  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122889497  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122889517  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122889778  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122889792  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122889856  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122889876  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122889883  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122889955  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122889990  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
122890020  VEGFC; vascular endothelial growth factor C [KO:K05449]
122890038  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
122890087  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122890262  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
122890516  EREG; proepiregulin [KO:K09784]
122890567  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122890843  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
122890844  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
122891068  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
122891244  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
122891302  NTF3; neurotrophin-3 [KO:K04356]
122891452  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
122891486  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122891544  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122891553  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
122891627  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
122891672  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122891725  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122891803  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
122891883  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122891909  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122891933  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122891954  FGF6; fibroblast growth factor 6 [KO:K04358]
122891975  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122892018  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
122892167  FGF23; fibroblast growth factor 23 [KO:K22428]
122892168  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
122892214  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
122892324  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122892334  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
122892381  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122892446  KRAS; GTPase KRas isoform X1 [KO:K07827]
122892505  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
122892516  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
122892522  RAP1B; ras-related protein Rap-1b [KO:K07836]
122892537  KITLG; kit ligand isoform X1 [KO:K05461]
122892677  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
122892752  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122892878  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
122892906  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
122892965  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122892980  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122893035  PGF; placenta growth factor isoform X1 [KO:K16859]
122893141  MAX; protein max isoform X1 [KO:K04453]
122893231  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
122893272  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
122893478  FOS; proto-oncogene c-Fos [KO:K04379]
122893649  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
122893729  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
122893816  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
122893817  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
122893980  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
122894113  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122894134  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
122894136  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
122894172  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122894224  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
122894274  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122894305  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
122894342  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
122895287  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
122895305  HSPB1; heat shock protein beta-1 [KO:K04455]
122895339  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122895342  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122895441  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
122895627  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122895713  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
122895963  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122896083  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
122896088  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122896303  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
122896442  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
122896725  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
122897137  FGF16; fibroblast growth factor 16 [KO:K04358]
122897243  FLNA; filamin-A isoform X1 [KO:K04437]
122897329  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
122897429  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122897554  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122897556  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122897563  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122897579  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122898999  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122899136  [KO:K07828]
122899273  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122899490  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122899548  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122899600  STMN1; stathmin [KO:K04381]
122899613  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122899632  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
122899868  ARTN; artemin [KO:K25415]
122899928  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
122899945  TNF; tumor necrosis factor isoform X1 [KO:K03156]
122900023  JUN; transcription factor AP-1 [KO:K04448]
122900071  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122900073  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122900129  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122900302  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122900324  RAP1A; ras-related protein Rap-1A [KO:K04353]
122900359  NRAS; GTPase NRas [KO:K07828]
122900366  NGF; beta-nerve growth factor [KO:K02582]
122900591  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
122900656  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
122900795  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122900866  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122901015  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122901055  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
122901106  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122901170  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122901177  VEGFA; vascular endothelial growth factor A [KO:K05448]
122901810  [KO:K04393]
122902211  FGF10; fibroblast growth factor 10 [KO:K04358]
122902255  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122902268  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122902498  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
122902601  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
122902614  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122902642  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
122902757  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
122902766  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122902796  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122903191  CRKL; crk-like protein [KO:K04438]
122903200  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122903375  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
122903424  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
122904298  MYC; myc proto-oncogene protein [KO:K04377]
122904371  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122904404  STK3; serine/threonine-protein kinase 3 [KO:K04412]
122904521  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122904647  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122904762  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122904763  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
122905007  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122905138  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122905415  [KO:K03283]
122905565  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122905874  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
122905991  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122906041  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122906063  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
122906090  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
122906106  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
122906116  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
122906156  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122906270  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122906299  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122906308  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
122906356  CRK; adapter molecule crk isoform X1 [KO:K04438]
122906386  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
122906425  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
122906430  NF1; neurofibromin isoform X1 [KO:K08052]
122906574  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122906596  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122906677  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
122906719  TP53; cellular tumor antigen p53 [KO:K04451]
122906771  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122906843  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122906879  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
122906918  FGF9; fibroblast growth factor 9 [KO:K04358]
122906985  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122906988  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
122907306  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
122907554  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122907555  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
122908450  SRF; serum response factor [KO:K04378]
122908552  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
122908678  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122908771  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
122908806  [KO:K04723]
122908833  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122908906  MRAS; ras-related protein M-Ras [KO:K07831]
122909050  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122909079  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
122909192  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122909333  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122909338  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122909369  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122909386  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
122909390  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
122909589  JUND; transcription factor jun-D [KO:K04449]
122909651  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122909666  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
122909693  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
122909703  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
122909778  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122909795  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122909871  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122909911  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122909963  EFNA2; ephrin-A2 [KO:K05462]
122909984  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
122910068  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
122910086  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122910778  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
122910806  PSPN; persephin [KO:K25416]
122910810  [KO:K25414]
122910812  [KO:K25414]
122911312  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122911363  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122911515  [KO:K03283]
122911522  [KO:K03283]
122911635  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
122911639  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
122911684  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
122911685  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122911814  RRAS; ras-related protein R-Ras [KO:K07829]
122911823  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122911839  NTF4; neurotrophin-4 [KO:K12457]
122911921  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122911957  RELB; transcription factor RelB isoform X1 [KO:K09253]
122912031  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
122912036  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122912064  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
122912247  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122912388  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
122912557  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
122912577  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
122912742  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
122912774  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
122912801  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
122912847  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122912872  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
122913054  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122913067  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
122913071  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122913074  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
122913120  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
122913121  RELA; transcription factor p65 [KO:K04735]
122913220  HRAS; GTPase HRas isoform X1 [KO:K02833]
122913242  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122913248  IGF2; insulin-like growth factor II [KO:K13769]
122913721  FGF3; fibroblast growth factor 3 [KO:K04358]
122913844  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
122913846  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122913879  FGF21; fibroblast growth factor 21 [KO:K22429]
122914590  INS; insulin [KO:K04526]
122914602  FGF4; fibroblast growth factor 4 [KO:K04358]
122914603  FGF19; fibroblast growth factor 19 [KO:K22603]
122915134  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122915138  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122915157  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122915444  TGFA; protransforming growth factor alpha [KO:K08774]
122915575  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122915651  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122915760  IL1B; interleukin-1 beta [KO:K04519]
122915761  IL1A; interleukin-1 alpha [KO:K04383]
122915770  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122916041  STK4; serine/threonine-protein kinase 4 [KO:K04411]
122916188  ANGPT4; angiopoietin-4 [KO:K05467]
122916228  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
122916351  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
122916392  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122916395  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
122916992  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122917048  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
122917051  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
122917083  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
122917394  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122917415  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
122917546  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122917648  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122917653  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122917736  RASA1; ras GTPase-activating protein 1 [KO:K04352]
122918058  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122918121  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122918247  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
122918249  EFNA4; ephrin-A4 [KO:K05462]
122918264  EFNA1; ephrin-A1 [KO:K05462]
122918316  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
122918413  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122918428  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122918524  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122918592  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122918634  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
122918746  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122918773  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122918793  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
122918846  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
122919116  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122919222  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
nvs04070  Phosphatidylinositol signaling system
nvs04110  Cell cycle
nvs04115  p53 signaling pathway
nvs04210  Apoptosis
nvs04310  Wnt signaling pathway
nvs04668  TNF signaling pathway
KO pathway
ko04010   

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