KEGG   PATHWAY: ogo04110
Entry
ogo04110                    Pathway                                
Name
Cell cycle - Oncorhynchus gorbuscha (pink salmon)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
ogo04110  Cell cycle
ogo04110

Other DBs
GO: 0000278
Organism
Oncorhynchus gorbuscha (pink salmon) [GN:ogo]
Gene
123989480  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123990534  [KO:K06637] [EC:2.7.11.1]
123990583  [KO:K11584]
123990608  [KO:K16197]
123990647  [KO:K02178] [EC:2.7.11.1]
123990752  [KO:K11268] [EC:2.3.1.-]
123990825  knl1; uncharacterized protein knl1 [KO:K11542]
123990967  [KO:K11584]
123991258  cul1b; cullin-1b [KO:K03347]
123991347  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
123991377  [KO:K04402]
123991530  [KO:K13377]
123991535  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
123991710  [KO:K04377]
123992407  [KO:K10779]
123992755  ywhag2; 14-3-3 protein gamma-2 [KO:K16198]
123992982  [KO:K06630]
123993117  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
123993122  [KO:K11479] [EC:2.7.11.1]
123993566  [KO:K06671]
123993567  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
123993600  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
123993708  [KO:K04382] [EC:3.1.3.16]
123993881  [KO:K25228]
123994121  [KO:K06627]
123994446  [KO:K02607]
123994501  [KO:K10151]
123994661  [KO:K06625]
123994811  [KO:K09392]
123994854  [KO:K11584]
123994871  [KO:K16197]
123995092  [KO:K11268] [EC:2.3.1.-]
123995312  [KO:K11584]
123995452  [KO:K13377]
123995625  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
123995640  [KO:K02178] [EC:2.7.11.1]
123995658  [KO:K06067] [EC:3.5.1.98]
123996632  [KO:K04402]
123996637  orc1; origin recognition complex subunit 1 [KO:K02603]
123996660  [KO:K06626]
123996715  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like isoform X1 [KO:K02541] [EC:5.6.2.3]
123996771  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
123996826  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
123996931  [KO:K03364]
123997078  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
123997110  [KO:K11266]
123997359  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
123997770  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
123997775  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
123997833  [KO:K04501]
123998211  [KO:K13376]
123998271  [KO:K06629]
123998727  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
123998749  [KO:K06630]
123998802  [KO:K04498] [EC:2.3.1.48]
123998998  [KO:K10151]
123999105  [KO:K04501]
123999110  [KO:K06672]
123999186  [KO:K11266]
123999378  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123999415  [KO:K04498] [EC:2.3.1.48]
123999595  [KO:K03875]
123999655  [KO:K06671]
123999690  [KO:K04382] [EC:3.1.3.16]
123999806  [KO:K10779]
124000287  [KO:K03868] [EC:2.3.2.32]
124000414  [KO:K02209] [EC:5.6.2.3]
124000513  [KO:K03094]
124000591  [KO:K16198]
124000726  cdk21; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
124001142  [KO:K11584]
124001172  [KO:K06067] [EC:3.5.1.98]
124001250  orc3; origin recognition complex subunit 3 [KO:K02605]
124001311  [KO:K11584]
124001369  [KO:K16197]
124001773  [KO:K09389]
124002004  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
124002151  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
124002294  [KO:K05866] [EC:3.1.3.48]
124002608  [KO:K02213]
124003072  [KO:K02206] [EC:2.7.11.22]
124003111  [KO:K02089] [EC:2.7.11.22]
124003143  [KO:K10151]
124003201  e2f4; transcription factor E2F4 [KO:K04682]
124003263  [KO:K16197]
124003414  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
124003459  [KO:K02540] [EC:5.6.2.3]
124003490  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
124003497  espl1; separin [KO:K02365] [EC:3.4.22.49]
124003794  [KO:K03358]
124003811  [KO:K16332]
124003998  [KO:K04377]
124004130  [KO:K04503]
124004172  ccnd3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
124004686  [KO:K04728] [EC:2.7.11.1]
124004833  [KO:K03456]
124005023  [KO:K04501]
124005378  ttk; dual specificity protein kinase Ttk [KO:K08866] [EC:2.7.12.1]
124005493  tp53; cellular tumor antigen p53 [KO:K04451]
124005573  [KO:K06626]
124005576  [KO:K06630]
124005799  [KO:K16198]
124006045  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
124006344  [KO:K25228]
124006436  [KO:K03355]
124006497  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
124006633  [KO:K04402]
124006697  [KO:K06619] [EC:2.7.10.2]
124006758  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
124006939  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
124006978  [KO:K13375]
124007131  [KO:K03349]
124007134  [KO:K05868]
124007157  [KO:K21771]
124007161  [KO:K03355]
124007199  [KO:K04402]
124007279  [KO:K05867] [EC:3.1.3.48]
124007282  [KO:K17390]
124007328  ccna1; cyclin-A1 [KO:K06627]
124007390  [KO:K16198]
124007511  [KO:K13375]
124007528  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
124007563  [KO:K17390]
124008155  [KO:K04451]
124008166  [KO:K16197]
124008172  [KO:K04377]
124008301  [KO:K06671]
124008362  [KO:K03083] [EC:2.7.11.26]
124008407  [KO:K02537]
124008444  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
124008672  [KO:K21771]
124009101  fzr1b; fizzy-related protein homolog [KO:K03364]
124009107  [KO:K10779]
124009115  [KO:K02212] [EC:5.6.2.3]
124009482  [KO:K06671]
124009515  mcm6; LOW QUALITY PROTEIN: DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
124009627  [KO:K11266]
124009652  [KO:K03347]
124009678  rb1; retinoblastoma-associated protein [KO:K06618]
124009719  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
124009768  [KO:K03364]
124009786  orc2; origin recognition complex subunit 2 [KO:K02604]
124009915  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
124010168  mycb; transcriptional regulator Myc-B [KO:K04377]
124010227  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
124010242  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124010570  [KO:K06671]
124010592  [KO:K03083] [EC:2.7.11.26]
124010804  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
124010911  [KO:K04382] [EC:3.1.3.16]
124010998  [KO:K06671]
124011022  orc4; origin recognition complex subunit 4 [KO:K02606]
124011081  [KO:K10779]
124011431  [KO:K06627]
124011536  pttg1; securin isoform X1 [KO:K06635]
124011565  [KO:K10779]
124012147  [KO:K02091] [EC:2.7.11.22]
124012379  [KO:K06670]
124012568  [KO:K06067] [EC:3.5.1.98]
124012615  cdkn1cb; cyclin-dependent kinase inhibitor 1B [KO:K09993]
124012747  [KO:K06630]
124012981  [KO:K06620]
124013125  [KO:K04501]
124013201  sgo1; shugoshin 1 isoform X1 [KO:K11580]
124013707  [KO:K04382] [EC:3.1.3.16]
124013717  [KO:K03094]
124013774  [KO:K02607]
124013972  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
124014035  [KO:K06624]
124014152  [KO:K06625]
124014241  [KO:K10151]
124014289  [KO:K04451]
124014475  [KO:K02537]
124014488  [KO:K11584]
124014729  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
124015302  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
124015383  [KO:K10151]
124015491  [KO:K02209] [EC:5.6.2.3]
124015543  [KO:K03350]
124015661  [KO:K03868] [EC:2.3.2.32]
124015936  [KO:K04498] [EC:2.3.1.48]
124015947  cdc6; cell division control protein 6 homolog isoform X1 [KO:K02213]
124016146  [KO:K03358]
124016160  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
124016518  crebbpa; LOW QUALITY PROTEIN: histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
124016626  [KO:K04382] [EC:3.1.3.16]
124017019  [KO:K06629]
124017503  [KO:K11584]
124018364  [KO:K02180]
124018750  [KO:K06643] [EC:2.3.2.27]
124018751  [KO:K06643] [EC:2.3.2.27]
124019047  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
124019911  [KO:K06625]
124020704  [KO:K09993]
124020707  [KO:K09993]
124021596  [KO:K26116]
124021791  [KO:K06631] [EC:2.7.11.21]
124021895  [KO:K11267]
124022048  [KO:K06620]
124022322  [KO:K16197]
124022339  [KO:K06679]
124022872  [KO:K06631] [EC:2.7.11.21]
124024619  [KO:K06679]
124024976  [KO:K04683]
124025725  [KO:K02540] [EC:5.6.2.3]
124026228  [KO:K16197]
124027494  [KO:K11267]
124027618  [KO:K22399]
124027946  [KO:K02180]
124028019  [KO:K22399]
124028264  [KO:K23605]
124029680  [KO:K02180]
124030327  [KO:K02180]
124031195  [KO:K02206] [EC:2.7.11.22]
124031204  [KO:K02089] [EC:2.7.11.22]
124031320  [KO:K10152]
124031666  [KO:K16197]
124032010  [KO:K10500]
124032072  [KO:K17454]
124032292  [KO:K06636]
124033147  [KO:K10727]
124033162  [KO:K06626]
124033208  [KO:K04503]
124033224  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
124033274  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
124033346  [KO:K11479] [EC:2.7.11.1]
124033419  [KO:K11547]
124033421  [KO:K11547]
124033610  [KO:K06632] [EC:2.7.11.1]
124033709  [KO:K04682]
124033750  [KO:K21770]
124033795  [KO:K16332]
124033899  [KO:K04503]
124033974  [KO:K04382] [EC:3.1.3.16]
124034089  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124034195  [KO:K04802]
124034338  [KO:K04682]
124034419  [KO:K03354]
124034437  [KO:K10151]
124034501  [KO:K04500]
124034548  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
124034568  [KO:K06641] [EC:2.7.11.1]
124034657  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
124034665  nipbla; nipped-B-like protein A [KO:K06672]
124035070  [KO:K05868]
124035086  [KO:K06626]
124035186  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
124035240  cdc45; cell division control protein 45 homolog [KO:K06628]
124035481  [KO:K23605]
124035558  [KO:K16332]
124035595  [KO:K06632] [EC:2.7.11.1]
124035689  [KO:K04682]
124035731  [KO:K21770]
124035819  [KO:K10727]
124035824  [KO:K04503]
124035852  orc6; origin recognition complex subunit 6 [KO:K02608]
124035966  [KO:K04501]
124036011  ccnh; cyclin-H isoform X1 [KO:K06634]
124036029  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
124036068  ddx11; LOW QUALITY PROTEIN: ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
124036100  [KO:K04500]
124036184  [KO:K03354]
124036453  [KO:K04802]
124036554  [KO:K04402]
124036556  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124037012  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
124037254  [KO:K10292]
124037288  [KO:K26093]
124037523  ticrr; treslin isoform X1 [KO:K26117]
124037900  [KO:K04402]
124038185  [KO:K11584]
124038297  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124038324  [KO:K03348]
124038476  [KO:K06624]
124038761  [KO:K04498] [EC:2.3.1.48]
124039262  [KO:K06632] [EC:2.7.11.1]
124039768  [KO:K04377]
124040006  waplb; wings apart-like protein homolog isoform X1 [KO:K25163]
124040150  [KO:K04498] [EC:2.3.1.48]
124040993  [KO:K04402]
124041087  [KO:K25229]
124041088  [KO:K25229]
124041157  fbxo5; F-box only protein 5 [KO:K10292]
124041195  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124041218  [KO:K25163]
124041319  si:ch211-269e2.1; cohesin subunit SA-2 [KO:K06671]
124041352  [KO:K11584]
124041402  [KO:K03353]
124041520  [KO:K03364]
124041670  [KO:K11266]
124041755  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
124041801  [KO:K03363]
124041817  [KO:K03347]
124042045  cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
124042259  [KO:K03359]
124042663  [KO:K06067] [EC:3.5.1.98]
124043076  [KO:K06620]
124043251  [KO:K02091] [EC:2.7.11.22]
124043467  [KO:K04501]
124043643  [KO:K06670]
124043740  [KO:K03353]
124044135  [KO:K03083] [EC:2.7.11.26]
124044209  [KO:K04683]
124044231  tfdp1a; transcription factor Dp-1a isoform X1 [KO:K04683]
124045084  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
124045106  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
124045205  e2f2; transcription factor E2F2 [KO:K09389]
124045371  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
124045643  [KO:K16197]
124045724  [KO:K03083] [EC:2.7.11.26]
124045822  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
124045852  [KO:K17454]
124046108  [KO:K06636]
124046206  [KO:K11584]
124046306  [KO:K16197]
124046370  [KO:K06067] [EC:3.5.1.98]
124046457  [KO:K13377]
124046529  [KO:K11584]
124047621  dbf4b; protein DBF4 homolog B [KO:K06629]
124047696  [KO:K03359]
124047880  [KO:K05868]
124047881  [KO:K04402]
124047882  [KO:K04402]
124048188  [KO:K25163]
124048497  pkmyt1; LOW QUALITY PROTEIN: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
124048756  [KO:K06672]
124048761  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
124048867  ywhah; LOW QUALITY PROTEIN: 14-3-3 protein eta [KO:K16198]
124048965  [KO:K06619] [EC:2.7.10.2]
124048986  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Related
pathway
ogo03030  DNA replication
ogo04010  MAPK signaling pathway
ogo04120  Ubiquitin mediated proteolysis
ogo04210  Apoptosis
KO pathway
ko04110   

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