KEGG   PATHWAY: ogo04110
Entry
ogo04110                    Pathway                                
Name
Cell cycle - Oncorhynchus gorbuscha (pink salmon)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
ogo04110  Cell cycle
ogo04110

Other DBs
GO: 0000278
Organism
Oncorhynchus gorbuscha (pink salmon) [GN:ogo]
Gene
124033208  G1/S-specific cyclin-D1-like [KO:K04503]
124033899  G1/S-specific cyclin-D1 [KO:K04503]
124004130  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
124035824  G1/S-specific cyclin-D1-like [KO:K04503]
123994501  G1/S-specific cyclin-D2-like [KO:K10151]
124003143  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
124034437  G1/S-specific cyclin-D2-like [KO:K10151]
123998998  G1/S-specific cyclin-D2-like [KO:K10151]
124014241  G1/S-specific cyclin-D2-like [KO:K10151]
124015383  G1/S-specific cyclin-D2-like [KO:K10151]
124004172  ccnd3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
124031320  G1/S-specific cyclin-D2-like [KO:K10152]
124003111  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
124031204  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
124012147  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
124043251  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
124000726  cdk21; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
124009678  rb1; retinoblastoma-associated protein [KO:K06618]
124003414  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
124033795  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
124003811  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
124035558  retinoblastoma-like protein 2 [KO:K16332]
124048965  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
124006697  tyrosine-protein kinase ABL1-like isoform X1 [KO:K06619] [EC:2.7.10.2]
123995658  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
124012568  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
124042663  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
124001172  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
124046370  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
124045852  transcription factor E2F1-like [KO:K17454]
124032072  LOW QUALITY PROTEIN: transcription factor E2F1-like [KO:K17454]
124045205  e2f2; transcription factor E2F2 [KO:K09389]
124001773  transcription factor E2F2-like [KO:K09389]
124022048  transcription factor E2F3-like [KO:K06620]
124012981  transcription factor E2F3-like [KO:K06620]
124043076  transcription factor E2F3-like [KO:K06620]
124003201  e2f4; transcription factor E2F4 [KO:K04682]
124010227  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
124033709  transcription factor E2F4-like isoform X1 [KO:K04682]
124034338  transcription factor E2F4-like [KO:K04682]
124035689  transcription factor E2F4-like [KO:K04682]
124024976  transcription factor Dp-1-like [KO:K04683]
124044209  transcription factor Dp-1-like isoform X1 [KO:K04683]
124044231  tfdp1a; transcription factor Dp-1a isoform X1 [KO:K04683]
123994811  transcription factor Dp-2-like isoform X1 [KO:K09392]
124010592  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124044135  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
124045724  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124008362  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124006497  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
124006978  transforming growth factor beta-1 proprotein-like [KO:K13375]
124007511  transforming growth factor beta-1 proprotein [KO:K13375]
123993600  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
123998211  transforming growth factor beta-2 proprotein-like [KO:K13376]
124006045  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
123991530  transforming growth factor beta-3 proprotein-like isoform X1 [KO:K13377]
123995452  transforming growth factor beta-3 proprotein-like [KO:K13377]
124046457  transforming growth factor beta-3 proprotein-like [KO:K13377]
124002151  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
124034501  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2-like [KO:K04500]
124036100  mothers against decapentaplegic homolog 2-like isoform X1 [KO:K04500]
124035481  mothers against decapentaplegic homolog 3 [KO:K23605]
124028264  mothers against decapentaplegic homolog 3-like [KO:K23605]
124048761  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
124034657  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
123997833  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
124005023  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
124035966  mothers against decapentaplegic homolog 4-like [KO:K04501]
123999105  mothers against decapentaplegic homolog 4-like [KO:K04501]
124013125  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
124043467  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
123991710  transcriptional regulator Myc-like [KO:K04377]
124010168  mycb; transcriptional regulator Myc-B [KO:K04377]
124039768  transcriptional regulator Myc [KO:K04377]
124003998  transcriptional regulator Myc-2-like [KO:K04377]
124008172  transcriptional regulator Myc-2-like [KO:K04377]
124045822  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
124032010  zinc finger and BTB domain-containing protein 17-like [KO:K10500]
124019047  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
123996826  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
124016160  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
123995625  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
124014035  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
124038476  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
124020704  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
124020707  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
124012615  cdkn1cb; cyclin-dependent kinase inhibitor 1B [KO:K09993]
123994661  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
124003490  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
124019911  cyclin-dependent kinase inhibitor 1B-like [KO:K06625]
124014152  cyclin-dependent kinase inhibitor 1B-like isoform X1 [KO:K06625]
123996660  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
124033162  G1/S-specific cyclin-E1-like [KO:K06626]
124035086  G1/S-specific cyclin-E1-like [KO:K06626]
124005573  G1/S-specific cyclin-E2-like [KO:K06626]
124003072  cyclin-dependent kinase 2-like isoform X1 [KO:K02206] [EC:2.7.11.22]
124031195  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
124013717  S-phase kinase-associated protein 1 [KO:K03094]
124000513  S-phase kinase-associated protein 1-like [KO:K03094]
123991258  cul1b; cullin-1b [KO:K03347]
124009652  cullin-1 [KO:K03347]
124041817  cullin-1-like [KO:K03347]
124000287  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
124015661  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
123999595  S-phase kinase-associated protein 2-like [KO:K03875]
123994121  cyclin-A2-like [KO:K06627]
124011431  cyclin-A2-like [KO:K06627]
124007328  ccna1; cyclin-A1 [KO:K06627]
124002608  cell division control protein 6 homolog [KO:K02213]
124015947  cdc6; cell division control protein 6 homolog isoform X1 [KO:K02213]
124035819  DNA replication factor Cdt1-like [KO:K10727]
124033147  DNA replication factor Cdt1-like [KO:K10727]
123996637  orc1; origin recognition complex subunit 1 [KO:K02603]
124009786  orc2; origin recognition complex subunit 2 [KO:K02604]
124001250  orc3; origin recognition complex subunit 3 [KO:K02605]
124011022  orc4; origin recognition complex subunit 4 [KO:K02606]
123994446  origin recognition complex subunit 5-like isoform X1 [KO:K02607]
124013774  origin recognition complex subunit 5-like [KO:K02607]
124035852  orc6; origin recognition complex subunit 6 [KO:K02608]
124003459  DNA replication licensing factor mcm2-like [KO:K02540] [EC:5.6.2.3]
124025725  DNA replication licensing factor mcm2 [KO:K02540] [EC:5.6.2.3]
123996715  mcm3l; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like isoform X1 [KO:K02541] [EC:5.6.2.3]
123991535  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
124041755  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
124009115  DNA replication licensing factor mcm4-A isoform X1 [KO:K02212] [EC:5.6.2.3]
124000414  DNA replication licensing factor mcm5-like [KO:K02209] [EC:5.6.2.3]
124015491  DNA replication licensing factor mcm5-like [KO:K02209] [EC:5.6.2.3]
124009915  mcm6l; MCM6 minichromosome maintenance deficient 6, like [KO:K02542] [EC:5.6.2.3]
124009515  mcm6; LOW QUALITY PROTEIN: DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
123993567  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
124035240  cdc45; cell division control protein 45 homolog [KO:K06628]
124037523  ticrr; treslin isoform X1 [KO:K26117]
124021596  mdm2-binding protein isoform X1 [KO:K26116]
124042045  cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
123998271  protein DBF4 homolog A-like [KO:K06629]
124017019  protein DBF4 homolog A-like [KO:K06629]
124047621  dbf4b; protein DBF4 homolog B [KO:K06629]
124041195  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124038297  cyclin-dependent kinase 1-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
124047880  G2/mitotic-specific cyclin-B1-like [KO:K05868]
124035070  G2/mitotic-specific cyclin-B1-like [KO:K05868]
124007134  G2/mitotic-specific cyclin-B1-like [KO:K05868]
123993890  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
124033750  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
124035731  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
124008672  G2/mitotic-specific cyclin-B3-like isoform X1 [KO:K21771]
124045371  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
124002294  M-phase inducer phosphatase 2-like isoform X1 [KO:K05866] [EC:3.1.3.48]
124007279  M-phase inducer phosphatase 1-B-like [KO:K05867] [EC:3.1.3.48]
123990608  14-3-3 protein zeta-like [KO:K16197]
123994871  14-3-3 protein zeta-like [KO:K16197]
124003263  14-3-3 protein beta/alpha-1-like [KO:K16197]
124022322  14-3-3 protein beta/alpha-A-like [KO:K16197]
124026228  14-3-3 protein beta/alpha-A-like [KO:K16197]
124008166  14-3-3 protein beta/alpha-1 [KO:K16197]
124045643  14-3-3 protein beta/alpha-2 [KO:K16197]
124001369  14-3-3 protein beta/alpha-1-like [KO:K16197]
124031666  14-3-3 protein beta/alpha-2-like [KO:K16197]
124046306  14-3-3 protein beta/alpha-1-like [KO:K16197]
123992982  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
123998749  14-3-3 protein epsilon isoform X1 [KO:K06630]
124005576  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
124012747  14-3-3 protein epsilon-like [KO:K06630]
123992755  ywhag2; 14-3-3 protein gamma-2 [KO:K16198]
124048867  ywhah; LOW QUALITY PROTEIN: 14-3-3 protein eta [KO:K16198]
124005799  14-3-3 protein gamma-2-like [KO:K16198]
124000591  14-3-3 protein gamma-1 [KO:K16198]
124007390  14-3-3 protein eta-like [KO:K16198]
124014729  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
124021791  serine/threonine-protein kinase PLK1-like isoform X1 [KO:K06631] [EC:2.7.11.21]
124022872  serine/threonine-protein kinase PLK1-like isoform X1 [KO:K06631] [EC:2.7.11.21]
124033610  wee1-like protein kinase 1-A isoform X1 [KO:K06632] [EC:2.7.11.1]
124034548  wee2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
124035595  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
124037012  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
124039262  wee1-like protein kinase 1-B isoform X1 [KO:K06632] [EC:2.7.11.1]
124048497  pkmyt1; LOW QUALITY PROTEIN: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
124036011  ccnh; cyclin-H isoform X1 [KO:K06634]
124033274  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
124038324  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1-like [KO:K03348]
124048986  anapc2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
124007131  anaphase-promoting complex subunit 2-like [KO:K03349]
123999378  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
124015543  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
123997078  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
124035186  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
124041402  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
124043740  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
124034419  anaphase-promoting complex subunit 7-like isoform X1 [KO:K03354]
124036184  anaphase-promoting complex subunit 7 [KO:K03354]
124006436  cell division cycle protein 23 homolog [KO:K03355]
124007161  cell division cycle protein 23 homolog isoform X1 [KO:K03355]
124008444  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
124003794  anaphase-promoting complex subunit 11 [KO:K03358]
124016146  anaphase-promoting complex subunit 11 [KO:K03358]
124047696  anaphase-promoting complex subunit CDC26-like [KO:K03359]
124042259  anaphase-promoting complex subunit CDC26-like [KO:K03359]
124006939  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
123998727  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
123993881  anaphase-promoting complex subunit 15-like [KO:K25228]
124006344  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
124041087  anaphase-promoting complex subunit 16-like [KO:K25229]
124041088  anaphase-promoting complex subunit 16-like [KO:K25229]
124034715  cell division cycle protein 20 homolog B-like [KO:K03363]
124041801  cell division cycle protein 20 homolog [KO:K03363]
124011536  pttg1; securin isoform X1 [KO:K06635]
124003497  espl1; separin [KO:K02365] [EC:3.4.22.49]
123997775  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
124046108  structural maintenance of chromosomes protein 1A [KO:K06636]
124032292  structural maintenance of chromosomes protein 1A-like [KO:K06636]
124015302  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
124012379  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
124043643  double-strand-break repair protein rad21 homolog A-like [KO:K06670]
124045106  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
123993566  cohesin subunit SA-2 isoform X1 [KO:K06671]
124010570  cohesin subunit SA-2-like [KO:K06671]
124010998  cohesin subunit SA-1 [KO:K06671]
124041319  si:ch211-269e2.1; cohesin subunit SA-2 [KO:K06671]
123999655  cohesin subunit SA-2-like [KO:K06671]
124008301  cohesin subunit SA-1 isoform X1 [KO:K06671]
124009482  cohesin subunit SA-2-like [KO:K06671]
123992407  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
124011081  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
124011565  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
123999806  LOW QUALITY PROTEIN: transcriptional regulator ATRX-like [KO:K10779]
124009107  transcriptional regulator ATRX-like [KO:K10779]
124036068  ddx11; LOW QUALITY PROTEIN: ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
124048756  nipped-B-like protein B isoform X1 [KO:K06672]
124034665  nipbla; nipped-B-like protein A [KO:K06672]
123999110  nipped-B-like protein B isoform X1 [KO:K06672]
123997110  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
124041670  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
123999186  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
124009627  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
124013972  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
123990752  N-acetyltransferase ESCO2-like [KO:K11268] [EC:2.3.1.-]
123995092  N-acetyltransferase ESCO2-like [KO:K11268] [EC:2.3.1.-]
124021895  sister chromatid cohesion protein PDS5 homolog A-like [KO:K11267]
124006758  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
124027494  sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
124040006  waplb; wings apart-like protein homolog isoform X1 [KO:K25163]
124048188  wings apart-like protein homolog [KO:K25163]
124041218  wings apart-like protein homolog [KO:K25163]
124007282  sororin-B-like isoform X1 [KO:K17390]
124007563  sororin-like isoform X1 [KO:K17390]
123993122  aurora kinase B-like isoform X1 [KO:K11479] [EC:2.7.11.1]
124033346  aurora kinase B-like isoform X1 [KO:K11479] [EC:2.7.11.1]
124013201  sgo1; shugoshin 1 isoform X1 [KO:K11580]
123989480  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123993708  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
124010911  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
124033974  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
124013707  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
123999690  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
124016626  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123993117  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
124004833  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123990583  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like [KO:K11584]
123990967  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
123994854  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform-like isoform X1 [KO:K11584]
123995312  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
124041352  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like isoform X1 [KO:K11584]
124014488  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
124001142  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
124038185  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
124001311  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
124046206  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
124046529  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like isoform X1 [KO:K11584]
124017503  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform-like [KO:K11584]
124033419  kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
124033421  kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
123990825  knl1; uncharacterized protein knl1 [KO:K11542]
124005378  ttk; dual specificity protein kinase Ttk [KO:K08866] [EC:2.7.12.1]
124022339  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
124024619  mitotic spindle assembly checkpoint protein MAD1-like [KO:K06679]
124014475  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
124008407  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
124045084  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
123990534  mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like isoform X1 [KO:K06637] [EC:2.7.11.1]
124002004  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
124018364  mitotic checkpoint protein BUB3 [KO:K02180]
124027946  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
124029680  mitotic checkpoint protein BUB3 [KO:K02180]
124030327  mitotic checkpoint protein BUB3 [KO:K02180]
123990647  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
123995640  mitotic checkpoint serine/threonine-protein kinase BUB1-like isoform X1 [KO:K02178] [EC:2.7.11.1]
124027618  pachytene checkpoint protein 2 homolog [KO:K22399]
124028019  pachytene checkpoint protein 2 homolog [KO:K22399]
124037288  LOW QUALITY PROTEIN: MAD2L1-binding protein [KO:K26093]
123996931  fizzy-related protein homolog isoform X1 [KO:K03364]
124009768  fizzy-related protein homolog [KO:K03364]
124041520  fizzy-related protein homolog isoform X1 [KO:K03364]
124009101  fzr1b; fizzy-related protein homolog [KO:K03364]
124041157  fbxo5; F-box only protein 5 [KO:K10292]
124037254  F-box only protein 5-like [KO:K10292]
123997359  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124010242  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124034089  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
123997770  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124036556  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
124040150  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
123998802  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
123999415  LOW QUALITY PROTEIN: CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
124015936  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
124038761  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
124016518  crebbpa; LOW QUALITY PROTEIN: histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
123991347  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
124010804  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
124004686  LOW QUALITY PROTEIN: serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
124018750  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
124018751  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
124005493  tp53; cellular tumor antigen p53 [KO:K04451]
124014289  cellular tumor antigen p53-like isoform X1 [KO:K04451]
124008155  cellular tumor antigen p53-like [KO:K04451]
123996632  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
123996771  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
123991377  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
124009719  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
124033224  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
124047881  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
124047882  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
124040993  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
124036554  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
124006633  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
124007199  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
124037900  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
124034195  proliferating cell nuclear antigen [KO:K04802]
124036453  proliferating cell nuclear antigen-like [KO:K04802]
124007528  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
124034568  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
124036029  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
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D-type cyclin-binding regions of proliferating cell nuclear antigen.
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J Biol Chem 269:11030-6 (1994)
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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
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Cell 75:779-90 (1993)
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CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
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J Cell Sci 121:3853-7 (2008)
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CDK inhibitors: positive and negative regulators of G1-phase progression.
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Genes Dev 13:1501-12 (1999)
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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Cell 113:685-700 (2003)
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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
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Cardiovasc Res 69:198-206 (2006)
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Reference
PMID:15838523
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Harris SL, Levine AJ.
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The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
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Reference
PMID:11099028
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Vogelstein B, Lane D, Levine AJ
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Surfing the p53 network.
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Nature 408:307-10 (2000)
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Reference
PMID:7973727
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
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Reference
PMID:9029154
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Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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Reference
PMID:15876871
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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Cell Cycle 4:572-7 (2005)
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Musacchio A, Salmon ED
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The spindle-assembly checkpoint in space and time.
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Nat Rev Mol Cell Biol 8:379-93 (2007)
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Reference
PMID:12573239
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Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
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Curr Biol 13:R104-14 (2003)
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Reference
PMID:15568976
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Stegmeier F, Amon A
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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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Reference
PMID:9618481
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Moustakas A, Kardassis D
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Reference
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Controlling the response to DNA damage by the APC/C-Cdh1.
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Cell Mol Life Sci 73:949-60 (2016)
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Reference
PMID:20935501
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Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
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APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
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Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
ogo03030  DNA replication
ogo04010  MAPK signaling pathway
ogo04120  Ubiquitin mediated proteolysis
ogo04210  Apoptosis
KO pathway
ko04110   
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