KEGG   PATHWAY: oha05132
Entry
oha05132                    Pathway                                
Name
Salmonella infection - Opisthocomus hoazin (hoatzin)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
oha05132  Salmonella infection
oha05132

Organism
Opisthocomus hoazin (hoatzin) [GN:oha]
Gene
104336780  PODXL; podocalyxin [KO:K06817]
104329713  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
104333312  RAB5A; ras-related protein Rab-5A [KO:K07887]
104333123  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104335628  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
104333177  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
104338908  RAB7B; ras-related protein Rab-7b [KO:K07898]
104327977  PLEKHM1; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 1 [KO:K23282]
104332846  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
104328161  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104335856  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
104328182  VPS39; vam6/Vps39-like protein [KO:K20183]
104337156  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
104332804  RILP; rab-interacting lysosomal protein [KO:K13883]
104331579  DYNC1H1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
104333062  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
104330910  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
104328974  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
104332658  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
104338257  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
104327928  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
104331444  dynein light chain 1, cytoplasmic-like [KO:K10418]
104331425  dynein light chain 1, cytoplasmic [KO:K10418]
104328041  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
104339233  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
104334563  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
104330838  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
104338644  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
104336821  DCTN3; dynactin subunit 3 [KO:K10425]
104326901  DCTN4; LOW QUALITY PROTEIN: dynactin subunit 4 [KO:K10426]
104339556  DCTN5; dynactin subunit 5 [KO:K10427]
104330324  DCTN6; dynactin subunit 6 [KO:K10428]
104335828  ACTR1A; alpha-centractin [KO:K16575]
104338418  ACTR10; actin-related protein 10 [KO:K16576]
104327336  tubulin alpha-8 chain isoform X1 [KO:K07374]
104332147  LOW QUALITY PROTEIN: tubulin alpha-8 chain-like [KO:K07374]
104339160  tubulin alpha-4A chain-like [KO:K07374]
104339161  LOW QUALITY PROTEIN: tubulin alpha-5 chain-like [KO:K07374]
104334810  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
104334819  tubulin alpha chain-like [KO:K07374]
104336581  tubulin alpha-3 chain-like [KO:K07374]
104327415  tubulin beta chain [KO:K07375]
104327422  tubulin beta chain-like [KO:K07375]
104328798  TUBB1; tubulin beta-1 chain [KO:K07375]
104326198  tubulin beta chain-like [KO:K07375]
104333428  TUBB6; tubulin beta-6 chain [KO:K07375]
104335360  tubulin beta chain [KO:K07375]
104336877  FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
104330050  ADP-ribosylation factor-like protein 8B [KO:K07955]
104338376  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
104338994  PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348]
104339044  KIF5B; kinesin-1 heavy chain [KO:K10396]
104331761  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
104333600  KLC4; kinesin light chain 4 [KO:K10407]
104336530  KLC1; LOW QUALITY PROTEIN: kinesin light chain 1 [KO:K10407]
104331992  ACBD3; Golgi resident protein GCP60 [KO:K23935]
104338436  RHOA; transforming protein RhoA [KO:K04513]
104332468  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
104334955  RAB9A; ras-related protein Rab-9A [KO:K07899]
104329527  RAB9B; ras-related protein Rab-9B [KO:K07900]
104339372  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
104327858  PFN3; profilin-3 [KO:K05759]
104332424  PFN4; LOW QUALITY PROTEIN: profilin-4 [KO:K05759]
104336574  PFN2; profilin-2 [KO:K05759]
104337270  EXOC7; exocyst complex component 7 [KO:K07195]
104335832  EXOC5; exocyst complex component 5 [KO:K19984]
104334821  EXOC4; exocyst complex component 4 [KO:K06111]
104333508  EXOC2; exocyst complex component 2 [KO:K17637]
104337153  RALA; ras-related protein Ral-A [KO:K07834]
104330516  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104330628  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
104334680  actin, cytoplasmic 2-like [KO:K05692]
104337394  ANXA2; annexin A2 [KO:K17092]
104328553  LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
104330065  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
104336564  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
104333812  rho-related GTP-binding protein RhoG [KO:K07863]
104335717  rho-related GTP-binding protein RhoG-like [KO:K07863]
104328648  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
104333283  ELMO2; engulfment and cell motility protein 2 [KO:K18985]
104332046  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
104335849  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104333122  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
104328643  MYL10; myosin regulatory light chain 10 [KO:K12756]
104326624  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
104326625  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104328617  FHOD1; FH1/FH2 domain-containing protein 1 [KO:K23938]
104332991  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104329097  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104338569  NCKAP1; nck-associated protein 1 [KO:K05750]
104326371  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
104336743  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
104339005  ABI1; abl interactor 1 isoform X1 [KO:K23649]
104337306  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
104338522  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
104333810  ACTR2; actin-related protein 2 [KO:K17260]
104337191  ACTR3B; actin-related protein 3B [KO:K18584]
104333262  ACTR3; actin-related protein 3 [KO:K18584]
104335652  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
104331315  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104331861  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104333994  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104326264  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
104339087  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104334530  MYO6; LOW QUALITY PROTEIN: unconventional myosin-VI [KO:K10358]
104332891  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104334418  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104335409  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104328724  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
104330100  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
104337113  PIK3C2G; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
104333025  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta-like [KO:K00923] [EC:2.7.1.154]
104329075  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
104332369  CYTH4; cytohesin-4 [KO:K18441]
104327777  ARF6; ADP-ribosylation factor 6 [KO:K07941]
104326550  ARF1; ADP-ribosylation factor 1 [KO:K07937]
104330816  SNX9; sorting nexin-9 isoform X1 [KO:K17923]
104337784  SNX18; sorting nexin-18 [KO:K17923]
104335486  SNX33; LOW QUALITY PROTEIN: sorting nexin-33 [KO:K17923]
104330030  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104330359  toll-like receptor 1 [KO:K10169]
104326194  toll-like receptor 2 type-2 [KO:K10159]
104335820  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
104337212  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104328278  CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
104330230  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
104334843  LY96; lymphocyte antigen 96 [KO:K05400]
104331971  TLR5; toll-like receptor 5 [KO:K10168]
104337513  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104330076  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
104333487  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104329864  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104328697  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104338648  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
104330387  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104333228  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104338140  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104331648  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104332643  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
104331519  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
104326696  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
104338270  HSP90B1; endoplasmin [KO:K09487]
104337551  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
104335244  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
104328769  CSE1L; exportin-2 isoform X1 [KO:K18423]
104327315  KPNA1; importin subunit alpha-5 [KO:K23940]
104334386  KPNA4; importin subunit alpha-3 [KO:K23583]
104336962  KPNA3; importin subunit alpha-4 [KO:K23583]
104335340  HRAS; GTPase HRas [KO:K02833]
104335221  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104339270  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104330857  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104334853  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104335669  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104335932  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104330023  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104330049  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104336307  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
104336312  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104332595  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104326885  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104337811  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104331780  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104328027  JUN; transcription factor AP-1 [KO:K04448]
104338114  interleukin-1 receptor antagonist protein-like [KO:K04519]
104326589  IL6; interleukin-6 [KO:K05405]
104331888  interleukin-8 [KO:K10030]
104331889  interleukin-8-like [KO:K10030]
104330186  CTNNB1; catenin beta-1 [KO:K02105]
104338062  TCF7; transcription factor 7 [KO:K02620]
104329504  TCF7L2; transcription factor 7-like 2 [KO:K04491]
104327260  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
104337427  FBXO22; F-box only protein 22 [KO:K10302]
104338055  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
104335960  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104338189  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104334768  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104333030  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
104333489  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
104327414  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
104334459  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104338557  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
104330757  FADD; FAS-associated death domain protein [KO:K02373]
104334215  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104335697  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
104328951  cytochrome c, somatic-like [KO:K08738]
104335603  cytochrome c [KO:K08738]
104328901  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104329491  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
104339564  caspase-3-like [KO:K04397] [EC:3.4.22.60]
104333817  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
104330311  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
104336356  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104335294  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104336332  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104333462  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
104338045  TXN2; thioredoxin, mitochondrial [KO:K03671]
104338370  thioredoxin-like [KO:K03671]
104337935  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
104329304  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
104334769  caspase-1-like [KO:K01370] [EC:3.4.22.36]
104338587  IL18; interleukin-18 isoform X1 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
oha04010  MAPK signaling pathway
oha04210  Apoptosis
oha04217  Necroptosis
oha04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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