KEGG   PATHWAY: opi04148
Entry
opi04148                    Pathway                                
Name
Efferocytosis - Ochotona princeps (American pika)
Class
Cellular Processes; Transport and catabolism
Pathway map
opi04148  Efferocytosis
opi04148

Organism
Ochotona princeps (American pika) [GN:opi]
Gene
101531640  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101528295  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101520418  PANX1; pannexin-1 [KO:K03443]
101517327  P2RY2; P2Y purinoceptor 2 [KO:K04269]
101530462  P2RY6; P2Y purinoceptor 6 [KO:K04272]
105942613  P2RY12; P2Y purinoceptor 12 [KO:K04298]
101522075  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101529238  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101533483  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
101526582  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101516816  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
101534712  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
101532279  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
101527689  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
101523842  CX3CL1; fractalkine [KO:K05508]
101527202  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101525829  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
101518851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101536244  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
101527799  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101523241  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101532703  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
101530535  EPO; erythropoietin [KO:K05437]
101517852  EPOR; erythropoietin receptor [KO:K05079]
101518245  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101530701  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101525427  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101518300  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
101533802  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101530642  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
101517589  MFGE8; lactadherin [KO:K17253]
101522765  GAS6; growth arrest-specific protein 6 [KO:K05464]
101536772  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
101516681  CD36; platelet glycoprotein 4 [KO:K06259]
101521365  THBS1; thrombospondin-1 [KO:K16857]
101533612  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105942099  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
101529486  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101536557  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101529940  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101535837  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
101530024  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
101532574  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101533379  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101529904  transforming growth factor beta-1 proprotein-like [KO:K13375]
101534898  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101528226  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101534415  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101519593  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101528216  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X11 [KO:K04515] [EC:2.7.11.17]
101524356  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
101535936  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101525120  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101525684  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101524339  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101524571  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101529341  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101534185  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101518498  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
118760816  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101532878  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101521982  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101530308  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101528854  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101517636  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101525954  ANO6; anoctamin-6 [KO:K19500]
101529688  ANO3; anoctamin-3 isoform X1 [KO:K19498]
101530126  ANO4; anoctamin-4 [KO:K19499]
101520578  ANO5; anoctamin-5 [KO:K19480]
101517214  anoctamin-9 [KO:K19503]
101521425  BSG; basigin [KO:K06535]
101530786  basigin-like [KO:K06535]
101528894  XKR8; XK-related protein 8 [KO:K26813]
101534387  XKR9; XK-related protein 9 [KO:K26814]
101519269  XKR7; XK-related protein 7 [KO:K26811]
101530169  XKR6; XK-related protein 6 [KO:K26811]
101532029  XKR4; XK-related protein 4 [KO:K26811]
101535813  phospholipid-transporting ATPase IB-like [KO:K14802] [EC:7.6.2.1]
101536302  phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
101522277  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
101528064  ATP11C; phospholipid-transporting ATPase IG [KO:K26934] [EC:7.6.2.1]
101534887  ATP11B; LOW QUALITY PROTEIN: probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
101524675  probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
101518769  TMEM30A; cell cycle control protein 50A [KO:K26935]
101524050  TMEM30B; cell cycle control protein 50B [KO:K26935]
101519550  cell cycle control protein 50C-like isoform X2 [KO:K26935]
101528267  PROS1; vitamin K-dependent protein S [KO:K03908]
101535157  ITGAV; integrin alpha-V [KO:K06487]
101535964  ITGB3; integrin beta-3 [KO:K06493]
101525317  ITGB5; integrin beta-5 [KO:K06588]
101530156  AXL; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
101535662  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
101516244  ADGRB1; LOW QUALITY PROTEIN: adhesion G protein-coupled receptor B1 [KO:K04596]
101532867  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
101532622  HAVCR1; hepatitis A virus cellular receptor 1 [KO:K20413]
101532379  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
101535661  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101520322  STAB1; stabilin-1 [KO:K19020]
101529136  STAB2; stabilin-2 [KO:K19013]
101527700  PTK2; focal adhesion kinase 1 isoform X21 [KO:K05725] [EC:2.7.10.2]
101522546  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
101527001  CRK; adapter molecule crk isoform X1 [KO:K04438]
101519209  CRKL; crk-like protein [KO:K04438]
101524938  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
105941538  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101532428  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101527518  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101518508  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
101523445  calreticulin-like [KO:K08057]
101518973  CALR; calreticulin [KO:K08057]
101516603  C1QA; complement C1q subcomponent subunit A [KO:K03986]
101516369  C1QB; complement C1q subcomponent subunit B [KO:K03987]
118758587  C1QC; complement C1q subcomponent subunit C [KO:K03988]
101521616  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
101533861  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X2 [KO:K24068]
101519193  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
101528090  SCARF1; scavenger receptor class F member 1 [KO:K24318]
101533607  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
101526847  RAB17; ras-related protein Rab-17 [KO:K07909]
101522222  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101516760  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
101527032  RAB5C; ras-related protein Rab-5C isoform X2 [KO:K07889]
101517265  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
101529830  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
101536248  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X3 [KO:K20179]
101530612  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
101517281  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
101534744  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
101532319  RAB14; ras-related protein Rab-14 isoform X1 [KO:K07881]
101534517  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
101523270  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
101519184  RAB7A; ras-related protein Rab-7a [KO:K07897]
101531948  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
101525852  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
101521468  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
101522725  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
101520411  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
101528461  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
101526478  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
101516951  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
101517526  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101518024  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
101526250  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
101528514  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
101530924  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
101520130  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101534216  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
101521634  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
101529586  IL10; interleukin-10 [KO:K05443]
101528217  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
101536491  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
101522489  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
101534006  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101527923  LOW QUALITY PROTEIN: solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
101534048  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
101526325  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
101535952  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
105942243  leukocyte surface antigen CD47-like isoform X1 [KO:K06266]
101524539  CD24; signal transducer CD24 [KO:K06469]
101532072  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
101520462  sialic acid-binding Ig-like lectin 10 [KO:K06749]
101520822  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
101520581  tyrosine-protein phosphatase non-receptor type substrate 1 [KO:K06551]
101517856  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
101529639  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
opi00010  Glycolysis / Gluconeogenesis
opi04140  Autophagy - animal
opi04145  Phagosome
KO pathway
ko04148   
LinkDB

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