KEGG   PATHWAY: pcw05202
Entry
pcw05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Phascolarctos cinereus (koala)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
pcw05202  Transcriptional misregulation in cancer
pcw05202

Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110214791  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
110192877  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110212135  myeloperoxidase-like [KO:K10789] [EC:1.11.2.2]
110211657  granulocyte-macrophage colony-stimulating factor-like [KO:K05427]
110198542  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
110206263  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110222906  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110213985  SIN3A; LOW QUALITY PROTEIN: paired amphipathic helix protein Sin3a [KO:K11644]
110222197  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
110207402  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
110198036  PER2; LOW QUALITY PROTEIN: period circadian protein homolog 2 [KO:K02633]
110223926  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
110220949  CD14; monocyte differentiation antigen CD14 [KO:K04391]
110220501  integrin alpha-M-like isoform X1 [KO:K06461]
110198453  JUP; LOW QUALITY PROTEIN: junction plakoglobin [KO:K10056]
110214069  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
110215735  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
110222963  CCNA2; cyclin-A2 [KO:K06627]
110195227  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
110220000  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
110192738  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
110193775  BCL2A1; bcl-2-related protein A1 isoform X1 [KO:K02162]
110210661  ZBTB16; zinc finger and BTB domain-containing protein 16 isoform X1 [KO:K10055]
110216083  MYC; myc proto-oncogene protein [KO:K04377]
110213205  DUSP6; LOW QUALITY PROTEIN: dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
110223537  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
110209883  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
110194197  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
110218768  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
110217305  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
110207186  DEFA6; defensin-6 [KO:K05230]
110196241  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
110220292  LOW QUALITY PROTEIN: granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
110207193  KMT2A; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
110209704  AFF1; LOW QUALITY PROTEIN: AF4/FMR2 family member 1 [KO:K15184]
110193708  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
110201473  CCNT1; cyclin-T1 isoform X1 [KO:K15188]
110223754  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
110220536  MLLT3; protein AF-9 isoform X1 [KO:K15187]
110197416  MLLT1; protein ENL isoform X1 [KO:K15187]
110223514  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
110192655  LMO2; rhombotin-2 [KO:K15612]
110194978  PBX3; LOW QUALITY PROTEIN: pre-B-cell leukemia transcription factor 3 [KO:K15610]
110213479  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
110202285  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
110212061  KLF3; Krueppel-like factor 3 [KO:K15605]
110222895  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
110213058  HOXA9; homeobox protein Hox-A9 [KO:K21950]
110213056  HOXA10; homeobox protein Hox-A10 isoform X1 [KO:K17443]
110216363  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
110211149  HMGA2; high mobility group protein HMGI-C [KO:K09283]
110214916  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
110213480  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
110212756  PROM1; prominin-1 isoform X1 [KO:K06532]
110215617  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
110209727  BMP2K; LOW QUALITY PROTEIN: BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
110192705  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110218707  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
110209167  CDK14; LOW QUALITY PROTEIN: cyclin-dependent kinase 14 [KO:K08821] [EC:2.7.11.22]
110207672  MEIS1; LOW QUALITY PROTEIN: homeobox protein Meis1 [KO:K15613]
110213057  HOXA11; homeobox protein Hox-A11 [KO:K21951]
110208437  SIX1; homeobox protein SIX1 [KO:K15614]
110208438  SIX4; homeobox protein SIX4 [KO:K15615]
110219048  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
110209335  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
110215988  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
110200953  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
110220595  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
110212397  TLX3; T-cell leukemia homeobox protein 3 isoform X1 [KO:K15607]
110194539  TLX1; T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
110222381  BCL11B; LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B [KO:K22046]
110194720  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
110214253  LYL1; protein lyl-1 [KO:K15604]
110192780  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
110201295  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
110207734  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110215022  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
110215023  baculoviral IAP repeat-containing protein 2-like isoform X1 [KO:K16060]
110211345  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
110211412  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110208102  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
110193707  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110210185  BCL6; B-cell lymphoma 6 protein [KO:K15618]
110214297  immunoglobulin alpha-2 heavy chain-like isoform X1 [KO:K06856]
110214304  Ig heavy chain Mem5-like [KO:K06856]
110193194  MAF; transcription factor Maf isoform X1 [KO:K09035]
110194074  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
110212243  NSD2; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
110215594  histone H3.3-like [KO:K11253]
110220150  histone H3 [KO:K11253]
110194436  histone H3-like [KO:K11253]
110194443  histone H3-like isoform X1 [KO:K11253]
110219374  histone H3.3 [KO:K11253]
110205518  histone H3.3 [KO:K11253]
110206580  histone H3.3-like [KO:K11253]
110220137  histone H3 isoform X1 [KO:K11253]
110194232  uncharacterized protein LOC110194232 [KO:K11253]
110194233  LOW QUALITY PROTEIN: histone H3-like centromeric protein CSE4 [KO:K11253]
110204197  histone H3 [KO:K11253]
110220540  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
110192497  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
110204887  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
110205364  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110199336  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
110209882  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
110211903  PRCC; proline-rich protein PRCC isoform X1 [KO:K13105]
110209131  proline-rich protein PRCC-like [KO:K13105]
110201082  TFE3; transcription factor E3 isoform X1 [KO:K09105]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110200872  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
110214775  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
110221495  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
110196405  PLAT; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
110214977  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
110193756  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
110211259  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
110209394  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
110223715  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
110217574  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
110198388  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
110221234  ETV5; ETS translocation variant 5 [KO:K15593]
110219638  SLC45A3; LOW QUALITY PROTEIN: solute carrier family 45 member 3 [KO:K15379]
110219526  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
110218199  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
110194881  MYCN; LOW QUALITY PROTEIN: N-myc proto-oncogene protein [KO:K09109]
110220610  MAX; protein max isoform X1 [KO:K04453]
110211045  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110194600  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110194502  BMI1; polycomb complex protein BMI-1 [KO:K11459]
110194006  SP1; transcription factor Sp1 [KO:K04684]
110198716  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
110212119  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110215860  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110216984  death domain-containing membrane protein NRADD-like [KO:K02583]
110195442  MEN1; menin [KO:K14970]
110215138  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
110192560  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
110205653  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110212646  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
110212998  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
110197536  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
110219397  FEV; protein FEV isoform X1 [KO:K09437]
110194044  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
110193839  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
110214947  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
110222528  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
110192617  WT1; Wilms tumor protein isoform X1 [KO:K09234]
110201572  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110205742  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
110222003  BAIAP3; BAI1-associated protein 3 [KO:K15621]
110203150  TSPAN7; tetraspanin-7 [KO:K06571]
110205927  tetraspanin-7-like [KO:K06571]
110210092  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
110214558  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
110221349  TAF15; TATA-binding protein-associated factor 2N [KO:K14651]
110223099  FUS; LOW QUALITY PROTEIN: RNA-binding protein FUS [KO:K13098]
110210977  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
110206651  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
110213115  IL6; interleukin-6 [KO:K05405]
110217498  NFKBIZ; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
110209686  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
110195563  RELA; transcription factor p65 isoform X1 [KO:K04735]
110209794  interleukin-8-like isoform X1 [KO:K10030]
110198725  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
110219472  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
110196617  FOXO1; forkhead box protein O1 [KO:K07201]
110203184  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
110215551  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110205171  SS18L1; calcium-responsive transactivator [KO:K15623]
110195788  SS18; LOW QUALITY PROTEIN: protein SSXT [KO:K15623]
110222064  NUPR1; nuclear protein 1 [KO:K15626]
110218246  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
110202946  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110212964  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
110223449  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110195907  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110219776  BAX; apoptosis regulator BAX [KO:K02159]
110217311  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
110223919  DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
110216585  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
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Related
pathway
pcw04115  p53 signaling pathway
pcw05211  Renal cell carcinoma
pcw05215  Prostate cancer
pcw05216  Thyroid cancer
pcw05221  Acute myeloid leukemia
KO pathway
ko05202   
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