KEGG   PATHWAY: pflv04020
Entry
pflv04020                   Pathway                                
Name
Calcium signaling pathway - Perca flavescens (yellow perch)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pflv04020  Calcium signaling pathway
pflv04020

Other DBs
GO: 0019722
Organism
Perca flavescens (yellow perch) [GN:pflv]
Gene
114566483  sodium/calcium exchanger 2-like [KO:K05849]
114545774  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
114566938  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
114567902  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
114546492  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
114572440  slc8a1; sodium/calcium exchanger 1 [KO:K05849]
114549381  sodium/calcium exchanger 2-like [KO:K05849]
114558726  atp2b3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
114554011  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
114559813  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
114554863  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
114549437  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
114549833  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
114547727  muscarinic acetylcholine receptor M3-like [KO:K04131]
114572111  muscarinic acetylcholine receptor M3-like [KO:K04131]
114547334  muscarinic acetylcholine receptor M5-like [KO:K04133]
114573643  muscarinic acetylcholine receptor M5-like [KO:K04133]
114570594  adenosine receptor A2a-like [KO:K04266]
114555541  adora2a; adenosine receptor A2a [KO:K04266]
114566832  adora2b; adenosine receptor A2b [KO:K04267]
114548388  adrb1; beta-1 adrenergic receptor [KO:K04141]
114566769  beta-2 adrenergic receptor-like isoform X1 [KO:K04142]
114562798  beta-2 adrenergic receptor-like [KO:K04142]
114555911  beta-1 adrenergic receptor-like [KO:K04143]
114567220  drd1; D(1A) dopamine receptor [KO:K04144]
114562656  D(1) dopamine receptor-like [KO:K04144]
114563026  D(1) dopamine receptor-like [KO:K04144]
114554795  drd5; D(1B) dopamine receptor [KO:K05840]
114548145  D(5)-like dopamine receptor [KO:K05840]
114571785  D(1)-like dopamine receptor [KO:K05840]
114567214  histamine H2 receptor-like [KO:K04150]
114563084  histamine H2 receptor-like [KO:K04150]
114571319  5-hydroxytryptamine receptor 4-like [KO:K04160]
114562692  5-hydroxytryptamine receptor 4-like [KO:K04160]
114562959  htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
114549396  htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
114558571  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
114571780  htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
114555828  5-hydroxytryptamine receptor 7-like [KO:K04163]
114558379  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
114554090  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
114564873  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
114565945  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
114560976  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
114568098  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
114556982  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
114572936  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
114557128  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
114555545  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
114572973  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
114564992  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
114565456  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
114569437  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
114565306  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
114565471  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
114568922  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
114561605  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114550904  pln; cardiac phospholamban [KO:K05852]
114553200  sln; sarcolipin [KO:K22642]
114566499  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
114569242  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
114547819  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
114555077  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like isoform X1 [KO:K05853] [EC:7.2.2.10]
114571112  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
114548240  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
114548474  cilia- and flagella-associated protein 251-like [KO:K23450]
114552432  stromal interaction molecule 1-like isoform X1 [KO:K16059]
114566665  stromal interaction molecule 1-like [KO:K16059]
114545889  stromal interaction molecule 2-like isoform X1 [KO:K18196]
114545902  stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
114570710  calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
114555649  calcium release-activated calcium channel protein 1-like isoform X1 [KO:K16056]
114567264  orai2; protein orai-2 [KO:K16057]
114549894  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
114558551  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
114553636  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
114558250  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
114553640  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
114558278  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
114569401  voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
114546705  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
114571315  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
114555208  probable voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
114564839  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
114561638  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
114547945  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
114569309  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04855]
114561173  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
114569403  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
114546896  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
114558469  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
114568365  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
114560486  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
114572303  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
114563022  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
114557707  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
114571246  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
114555343  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
114569308  grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
114569280  grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
114562591  glutamate receptor ionotropic, NMDA 2B-like [KO:K05210]
114570169  grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
114548025  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
114567939  LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 2-like [KO:K05212]
114557332  glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
114571316  glutamate receptor ionotropic, NMDA 3A-like [KO:K05213]
114547145  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
114551450  grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
114567354  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
114556003  P2X purinoceptor 2-like [KO:K05216]
114572702  P2X purinoceptor 3-like [KO:K05217]
114563172  P2X purinoceptor 3-like [KO:K05217]
114555333  P2X purinoceptor 4-like [KO:K05218]
114555334  P2X purinoceptor 4-like [KO:K05218]
114552633  P2X purinoceptor 5-like isoform X1 [KO:K05219]
114566625  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
114556126  p2rx7; P2X purinoceptor 7 [KO:K05220]
114566648  ryanodine receptor 1-like [KO:K04961]
114551697  ryanodine receptor 1-like isoform X1 [KO:K04961]
114547978  ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
114572354  LOW QUALITY PROTEIN: ryanodine receptor 2-like [KO:K04962]
114547290  ryanodine receptor 3-like [KO:K04963]
114572785  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
114572864  probable serine/threonine-protein kinase kinX [KO:K23449]
114565518  calsequestrin-1-like [KO:K23468]
114545616  calsequestrin-1-like isoform X1 [KO:K23468]
114550791  calsequestrin-2-like [KO:K23445]
114564275  calsequestrin-2-like [KO:K23445]
114565287  fibrous sheath CABYR-binding protein-like isoform X1 [KO:K00476] [EC:1.14.11.16]
114548951  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
114546142  cysteinyl leukotriene receptor 1-like [KO:K04322]
114563093  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
114560599  muscarinic acetylcholine receptor M2-like [KO:K04130]
114550376  chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
114571301  alpha-1A adrenergic receptor-like [KO:K04135]
114556160  alpha-1A adrenergic receptor-like [KO:K04135]
114566268  alpha-1A adrenergic receptor-like [KO:K04136]
114562944  alpha-1A adrenergic receptor-like [KO:K04136]
114546748  adra1d; alpha-1D adrenergic receptor [KO:K04137]
114549432  agtr1; type-1 angiotensin II receptor [KO:K04166]
114545348  endothelin receptor type B-like [KO:K04197]
114568394  ednra; endothelin-1 receptor [KO:K04197]
114562948  endothelin receptor type B-like [KO:K04198]
114565135  endothelin receptor type B-like [KO:K04198]
114564331  endothelin receptor type B-like [KO:K04198]
114571041  proteinase-activated receptor 1-like [KO:K03914]
114555884  f2r; proteinase-activated receptor 1 [KO:K03914]
114546747  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
114572847  grm1; metabotropic glutamate receptor 1 [KO:K04603]
114567045  metabotropic glutamate receptor 5-like [KO:K04604]
114551675  metabotropic glutamate receptor 5-like isoform X1 [KO:K04604]
114573537  gastrin-releasing peptide receptor-like [KO:K04169]
114563634  gastrin-releasing peptide receptor-like [KO:K04169]
114554418  hrh1; histamine H1 receptor [KO:K04149]
114545714  5-hydroxytryptamine receptor 2C-like [KO:K04157]
114561169  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
114564188  5-hydroxytryptamine receptor 2A-like [KO:K04157]
114572219  LOW QUALITY PROTEIN: lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
114559008  ntsr1; neurotensin receptor type 1 [KO:K04211]
114554060  oxtr; oxytocin receptor [KO:K04229]
114554231  isotocin receptor-like [KO:K04229]
114559858  arg8-vasotocin receptor-like [KO:K04226]
114550282  arg8-vasotocin receptor-like [KO:K04226]
114565600  leukotriene B4 receptor 1-like isoform X1 [KO:K04297]
114546310  ptafr; platelet-activating factor receptor [KO:K04279]
114569682  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
114572244  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
114561956  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
114562147  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
114559663  B2 bradykinin receptor-like [KO:K03916]
114546953  B2 bradykinin receptor-like [KO:K03916]
114547040  B2 bradykinin receptor-like [KO:K03916]
114547126  B2 bradykinin receptor-like [KO:K03916]
114547179  B2 bradykinin receptor-like [KO:K03916]
114547418  B1 bradykinin receptor-like [KO:K03916]
114571100  substance-P receptor-like [KO:K04222]
114556110  substance-P receptor-like [KO:K04222]
114557710  tacr2; substance-K receptor [KO:K04223]
114572091  neuromedin-K receptor-like [KO:K04224]
114562693  neuromedin-K receptor-like [KO:K04224]
114561899  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
114559285  thyrotropin-releasing hormone receptor-like [KO:K04282]
114568619  thyrotropin-releasing hormone receptor-like [KO:K04282]
114560265  thyrotropin-releasing hormone receptor-like [KO:K04282]
114557589  thyrotropin-releasing hormone receptor-like [KO:K04282]
114545897  cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
114563539  cholecystokinin receptor-like [KO:K04194]
114550787  cholecystokinin receptor-like [KO:K04194]
114565452  C-X-C chemokine receptor type 4-like [KO:K04189]
114563987  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
114570652  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
114555122  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
114547460  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
114561099  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
114555581  guanine nucleotide-binding protein subunit alpha-14-like isoform X1 [KO:K04636]
114561053  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
114563345  egf; pro-epidermal growth factor [KO:K04357]
114554686  tgfa; protransforming growth factor alpha [KO:K08774]
114564713  platelet-derived growth factor subunit A-like [KO:K04359]
114570050  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114548096  uncharacterized protein LOC114548096 isoform X1 [KO:K17386]
114549755  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114562955  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114566759  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114562676  fibroblast growth factor 1-like [KO:K18496]
114563146  fgf2; fibroblast growth factor 2 [KO:K18497]
114564643  fibroblast growth factor 4A-like [KO:K04358]
114552746  fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
114545548  fibroblast growth factor 20-like [KO:K04358]
114567703  fgf8; fibroblast growth factor 8 [KO:K04358]
114559523  fgf6; fibroblast growth factor 6 [KO:K04358]
114559560  fgf4; fibroblast growth factor 4 [KO:K04358]
114572247  fibroblast growth factor 8 [KO:K04358]
114555299  fgf3; fibroblast growth factor 3 [KO:K04358]
114561623  fgf22; fibroblast growth factor 22 [KO:K04358]
114555705  fgf5; fibroblast growth factor 5 [KO:K04358]
114555947  fgf17; fibroblast growth factor 17 [KO:K04358]
114562447  fibroblast growth factor 4-like [KO:K04358]
114556244  fgf10; fibroblast growth factor 10 [KO:K04358]
114562726  fibroblast growth factor 18-like isoform X1 [KO:K04358]
114563073  fibroblast growth factor 20-like [KO:K04358]
114563092  fgf16; fibroblast growth factor 16 [KO:K04358]
114550268  fibroblast growth factor 6-like [KO:K04358]
114563270  fibroblast growth factor 18-like isoform X1 [KO:K04358]
114561481  fgf19; fibroblast growth factor 19 [KO:K22603]
114548450  fibroblast growth factor 21-like [KO:K22429]
114559522  fibroblast growth factor 23-like [KO:K22428]
114550439  fgf23; fibroblast growth factor 23 [KO:K22428]
114572978  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114562277  vegfb; vascular endothelial growth factor B [KO:K05448]
114557256  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
114558708  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114550825  vascular endothelial growth factor C-like [KO:K05449]
114564168  vegfc; vascular endothelial growth factor C [KO:K05449]
114558351  nerve growth factor-like [KO:K02582]
114554921  ngf; beta-nerve growth factor [KO:K02582]
114560350  hepatocyte growth factor-like [KO:K05460]
114550128  hepatocyte growth factor-like [KO:K05460]
114554489  hepatocyte growth factor-like protein [KO:K23441]
114571162  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114555879  glial cell line-derived neurotrophic factor-like [KO:K05452]
114548913  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
114564973  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
114547884  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114559209  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
114554019  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114550836  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
114563973  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114561192  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114566403  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
114562615  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114555046  fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
114571184  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
114552491  tyrosine kinase receptor Cad96Ca-like [KO:K05093] [EC:2.7.10.1]
114571757  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
114546647  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
114566310  fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
114562330  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
114549359  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
114562616  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114561463  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
114557434  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
114571365  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
114556221  ntrk2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
114559601  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
114560571  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
114560667  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114554597  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
114554850  mst1r; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
114572052  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
114547185  immunoglobulin lambda-1 light chain-like [KO:K10785]
114547186  immunoglobulin lambda-1 light chain-like [KO:K10785]
114547196  immunoglobulin lambda-1 light chain-like [KO:K10785]
114570205  immunoglobulin lambda-1 light chain-like [KO:K10785]
114551742  immunoglobulin gamma-1 heavy chain-like [KO:K06856]
114564522  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
114564790  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
114569980  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
114548554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like isoform X1 [KO:K05857] [EC:3.1.4.11]
114549434  plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
114550687  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
114546070  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
114547102  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114571910  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
114573052  plcb4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
114572768  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
114561436  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like isoform X1 [KO:K01116] [EC:3.1.4.11]
114558144  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
114560248  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114547748  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
114560804  plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
114553974  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
114554117  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114559590  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
114558603  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
114549402  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114549422  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114549480  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114549609  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
114555243  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
114559536  tpcn2; two pore calcium channel protein 2 [KO:K14077]
114568867  mucolipin-1-like isoform X1 [KO:K04992]
114570325  mucolipin-1-like [KO:K04992]
114561860  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
114565951  mucolipin-3-like [KO:K04994]
114561148  mucolipin-3-like [KO:K04994]
114569310  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
114563520  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
114557618  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
114572485  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114566908  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114547960  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15040]
114572213  voltage-dependent anion-selective channel protein 2 [KO:K15040]
114570698  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
114555053  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
114566841  ADP/ATP translocase 2 [KO:K05863]
114573567  slc25a4; ADP/ATP translocase 1 [KO:K05863]
114562553  ADP/ATP translocase 2-like [KO:K05863]
114547741  peptidyl-prolyl cis-trans isomerase A-like isoform X1 [KO:K09565] [EC:5.2.1.8]
114571891  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
114558846  troponin C, slow skeletal and cardiac muscles [KO:K05865]
114559271  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
114558414  troponin C, skeletal muscle [KO:K12042]
114558415  troponin C, skeletal muscle-like [KO:K12042]
114546366  calm1; calmodulin-1 [KO:K02183]
114553939  calml6; calmodulin-like protein 6 isoform X1 [KO:K02183]
114560106  calml4; calmodulin-like protein 4 [KO:K02183]
114560738  calmodulin-like protein 4 isoform X1 [KO:K02183]
114571747  calm2; calmodulin-2 [KO:K02183]
114572752  calmodulin [KO:K02183]
114550186  calm3; calmodulin-3 [KO:K02183]
114548023  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
114549461  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
114545503  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
114555121  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
114561512  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
114565381  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
114568996  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
114561233  mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
114548063  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
114559050  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
114553925  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
114553983  calcium/calmodulin-dependent protein kinase type 1-like isoform X1 [KO:K08794] [EC:2.7.11.17]
114554289  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
114550168  camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
114566210  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
114545624  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
114545844  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
114570632  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
114548031  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
114555551  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
114572449  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
114561522  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
114545488  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114566730  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114570715  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114555314  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114562882  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
114568444  calcineurin subunit B type 1-like [KO:K06268]
114572606  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
114553633  transcription factor EB-like isoform X1 [KO:K15590]
114568301  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
114557221  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
114558850  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114554096  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
114552936  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114559908  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
114565021  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
114555256  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
114565730  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
114554257  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
114549114  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
114564384  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
114572960  ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
114550829  protein-tyrosine kinase 2-beta-like [KO:K05871] [EC:2.7.10.2]
114546397  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
114567281  inositol-trisphosphate 3-kinase C-like isoform X1 [KO:K00911] [EC:2.7.1.127]
114573555  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
114563386  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
114551181  inositol-trisphosphate 3-kinase C-like [KO:K00911] [EC:2.7.1.127]
114565339  prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114570388  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
114566211  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114569627  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114557331  LOW QUALITY PROTEIN: protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pflv04010  MAPK signaling pathway
pflv04070  Phosphatidylinositol signaling system
pflv04210  Apoptosis
KO pathway
ko04020   
LinkDB

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