KEGG   PATHWAY: pgeo04210
Entry
pgeo04210                   Pathway                                
Name
Apoptosis - Pseudochaenichthys georgianus (South Georgia icefish)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
pgeo04210  Apoptosis
pgeo04210

Other DBs
GO: 0006915
Organism
Pseudochaenichthys georgianus (South Georgia icefish) [GN:pgeo]
Gene
117466096  tnfsf10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
117467829  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117456180  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
117444879  tumor necrosis factor receptor superfamily member 23-like [KO:K04722]
117454183  cd40lg; CD40 ligand [KO:K04389]
117445724  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117459708  fas; tumor necrosis factor receptor superfamily member 23 [KO:K04390]
117463391  fadd; FAS-associated death domain protein [KO:K02373]
117455047  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117461523  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
117449688  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117461162  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
117466861  CASP8 and FADD-like apoptosis regulator [KO:K04724]
117467008  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
117462527  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
117463024  caspase-3-like isoform X1 [KO:K04398] [EC:3.4.22.61]
117449372  caspase-6-like [KO:K04396] [EC:3.4.22.59]
117448400  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
117440899  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117464790  casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
117444606  caspase-7-like [KO:K04397] [EC:3.4.22.60]
117447969  bida; BH3 interacting domain death agonist isoform X1 [KO:K04726]
117463551  zgc:153993; apoptosis regulator BAX [KO:K02159]
117451402  apoptosis regulator BAX-like [KO:K02159]
117457635  diabloa; diablo, IAP-binding mitochondrial protein a [KO:K10522]
117457854  diablo homolog, mitochondrial-like [KO:K10522]
117457908  diablo homolog, mitochondrial-like [KO:K10522]
117457620  sept4b; septin 4b isoform X1 [KO:K16943]
117467719  serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
117467087  cytochrome c-like [KO:K08738]
117455253  cytochrome c-a [KO:K08738]
117441119  cytochrome c [KO:K08738]
117468439  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
117449676  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
117454240  perforin-1-like [KO:K07818]
117454905  perforin-1-like [KO:K07818]
117451173  perforin-1-like [KO:K07818]
117451635  perforin-1-like [KO:K07818]
117452125  prf1.5; perforin 1.5 [KO:K07818]
117466522  granzyme B-like [KO:K01353] [EC:3.4.21.79]
117466722  granzyme B-like [KO:K01353] [EC:3.4.21.79]
117445272  granzyme B(G,H)-like [KO:K01353] [EC:3.4.21.79]
117445273  si:ch211-212d10.1; granzyme E [KO:K01353] [EC:3.4.21.79]
117466596  tubulin alpha chain-like [KO:K07374]
117460233  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
117457867  tubulin alpha-4A chain-like [KO:K07374]
117449176  tubulin alpha-1C chain-like [KO:K07374]
117449410  tubulin alpha-1C chain-like [KO:K07374]
117449495  tubulin alpha-1B chain isoform X1 [KO:K07374]
117449496  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
117449498  tubulin alpha-1B chain-like [KO:K07374]
117449499  tubulin alpha chain-like [KO:K07374]
117442932  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
117450024  tubulin alpha chain-like [KO:K07374]
117444413  tubulin alpha-1D chain [KO:K07374]
117450801  tubulin alpha chain [KO:K07374]
117450817  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
117450885  tubulin alpha chain-like [KO:K07374]
117450886  tubulin alpha chain-like [KO:K07374]
117451887  tubulin alpha-1C chain-like [KO:K07374]
117452353  tubulin alpha-1C chain-like [KO:K07374]
117461214  mcl1b; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1b [KO:K02539]
117447644  actb1; actin, cytoplasmic 1 [KO:K05692]
117451022  actin, cytoplasmic 1-like [KO:K05692]
117451156  actin, cytoplasmic 1-like [KO:K05692]
117451232  actin, cytoplasmic 1-like [KO:K05692]
117451766  actin, cytoplasmic 1 [KO:K05692]
117451768  actin, cytoplasmic 1-like [KO:K05692]
117455915  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
117460242  lamin-A-like [KO:K12641]
117462373  lmnl3; lamin L3 [KO:K12641]
117454925  lamin-A-like [KO:K12641]
117456349  lmnb1; LOW QUALITY PROTEIN: lamin-B1 [KO:K07611]
117445395  lmnb2; lamin-B2 [KO:K07611]
117440085  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
117466903  parp4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.30]
117462017  parp2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
117447108  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
117450023  dffa; DNA fragmentation factor subunit alpha [KO:K02310]
117449472  dffb; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
117458974  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
117447907  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117451036  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
117456685  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117456137  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117452000  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
117446472  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
117446722  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117447615  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117449155  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117459872  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
117463801  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
117458007  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
117442465  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
117459873  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117459874  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117441997  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
117467518  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
117440376  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
117451381  atf4b; activating transcription factor 4b [KO:K04374]
117446267  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
117439472  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
117440140  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
117457219  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
117463560  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
117450701  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
117453756  ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
117461038  pro-cathepsin H-like [KO:K01366] [EC:3.4.22.16]
117448148  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
117460845  ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
117467534  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117467535  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117452281  ctsla; LOW QUALITY PROTEIN: cathepsin La [KO:K01365] [EC:3.4.22.15]
117454284  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
117460976  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117461754  cathepsin Z isoform X1 [KO:K08568] [EC:3.4.18.1]
117446330  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
117458383  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117454071  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117464985  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 5-like [KO:K08731]
117465002  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
117449321  birc5b; baculoviral IAP repeat-containing protein 5b [KO:K08731]
117460037  bcl-2-like protein 11 [KO:K16341]
117447420  bcl-2-like protein 1 [KO:K04570]
117449218  bcl2l1; bcl-2-like protein 1 [KO:K04570]
117462238  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117454816  daxx; death domain-associated protein 6 [KO:K02308]
117462675  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
117455833  disabled homolog 2-interacting protein-like isoform X1 [KO:K19901]
117461107  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
117439553  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117459620  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117464330  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117453597  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117455943  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117463516  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
117462217  transcription factor AP-1-like [KO:K04448]
117455908  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117445372  jun; transcription factor AP-1 [KO:K04448]
117468017  proto-oncogene c-Fos-like [KO:K04379]
117440361  si:ch211-153j24.3; proto-oncogene c-Fos [KO:K04379]
117440362  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
117463689  tp53; cellular tumor antigen p53 [KO:K04451]
117464499  uncharacterized protein LOC117464499 [KO:K04466] [EC:2.7.11.25]
117451148  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117459464  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117465106  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117452298  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117448867  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
117448869  LOW QUALITY PROTEIN: NF-kappa-B essential modulator-like [KO:K07210]
117467352  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117440292  NF-kappa-B inhibitor alpha-like [KO:K04734]
117442241  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
117463457  rela; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
117455918  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
117463026  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117455771  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
117456515  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117445415  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117445442  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117452398  gadd45ga; growth arrest and DNA-damage-inducible, gamma a isoform X1 [KO:K04402]
117457163  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
117448435  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
117444833  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
117450088  ngfa; neurotrophin-7 [KO:K02582]
117446265  ngfb; nerve growth factor [KO:K02582]
117461351  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
117450909  csf2rb; LOW QUALITY PROTEIN: cytokine receptor common subunit beta [KO:K04738]
117462023  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117457177  pik3cb; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117449291  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117445314  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117462047  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117462274  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117455737  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117445092  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117445659  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117464693  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117459577  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117467542  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117458421  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117456863  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117450800  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117448041  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
117448736  kras; GTPase KRas isoform X1 [KO:K07827]
117450798  zgc:55558; GTPase HRas [KO:K07827]
117449273  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117447861  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117462440  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117445380  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117451293  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117451854  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
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Related
pathway
pgeo04010  MAPK signaling pathway
pgeo04020  Calcium signaling pathway
pgeo04115  p53 signaling pathway
pgeo04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
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