KEGG   PATHWAY: pgeo04621
Entry
pgeo04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Pseudochaenichthys georgianus (South Georgia icefish)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
pgeo04621  NOD-like receptor signaling pathway
pgeo04621

Organism
Pseudochaenichthys georgianus (South Georgia icefish) [GN:pgeo]
Gene
117460814  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
117462151  ripk2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
117448867  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
117448869  LOW QUALITY PROTEIN: NF-kappa-B essential modulator-like [KO:K07210]
117459464  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117465106  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117452298  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117467352  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117440292  NF-kappa-B inhibitor alpha-like [KO:K04734]
117442241  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
117463457  rela; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
117452565  interleukin-1 beta-like [KO:K04519]
117455618  interleukin-6-like [KO:K05405]
117455047  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
117463405  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
117453602  cxcl8a; interleukin-8 [KO:K10030]
117441096  nod2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
117467728  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
117439745  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117440997  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
117440205  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
117445210  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
117451293  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117451854  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117459620  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117464330  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
117453597  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117455943  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117468320  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117439284  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
117448716  mapk12a; LOW QUALITY PROTEIN: mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117449171  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117449611  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117449928  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
117446514  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
117462217  transcription factor AP-1-like [KO:K04448]
117455908  june; LOW QUALITY PROTEIN: junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
117445372  jun; transcription factor AP-1 [KO:K04448]
117441224  atg16l1; autophagy-related protein 16-1 [KO:K17890]
117461039  atg5; autophagy protein 5 [KO:K08339]
117461492  atg12; ubiquitin-like protein ATG12 [KO:K08336]
117460451  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
117463813  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
117449255  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
117443025  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
117454077  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
117448017  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
117441514  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
117451705  map1lc3c; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
117462754  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
117462095  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
117465727  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
117447342  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
117466075  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
117444189  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
117462841  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
117454071  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117463796  trip6; thyroid receptor-interacting protein 6 [KO:K12792]
117456175  erbin; erbin isoform X1 [KO:K12796]
117458383  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117456685  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117456137  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117452000  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
117449999  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
117463949  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117459543  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
117467714  flocculation protein FLO11-like [KO:K12648]
117447238  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
117466971  tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
117464722  irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
117448551  irf7; interferon regulatory factor 7 [KO:K09447]
117465098  interferon a3-like [KO:K05414]
117465100  interferon a3-like [KO:K05414]
117465104  interferon a3-like [KO:K05414]
117465108  interferon a3-like [KO:K05414]
117441935  interferon a3-like [KO:K05414]
117457440  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
117459337  antxr1d; anthrax toxin receptor 1 isoform X1 [KO:K20909]
117464624  antxr1c; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
117455875  antxr1b; anthrax toxin receptor 1 isoform X1 [KO:K20909]
117455980  anthrax toxin receptor 2-like [KO:K20909]
117452378  antxr2a; ANTXR cell adhesion molecule 2a [KO:K20909]
117453067  LOW QUALITY PROTEIN: anthrax toxin receptor 1-like [KO:K20909]
117460862  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
117455465  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
117457271  caspa; caspase a isoform X1 [KO:K01370] [EC:3.4.22.36]
117462238  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117447420  bcl-2-like protein 1 [KO:K04570]
117449218  bcl2l1; bcl-2-like protein 1 [KO:K04570]
117439472  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
117440140  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
117453688  pannexin-1-like isoform X1 [KO:K03443]
117457496  pannexin-1-like [KO:K03443]
117452986  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
117466214  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
117440326  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
117459110  casr; extracellular calcium-sensing receptor [KO:K04612]
117460622  gprc6a; LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A [KO:K04622]
117440001  G-protein coupled receptor family C group 6 member A [KO:K04622]
117459268  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
117467860  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117463549  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117439770  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
117440025  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117446472  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
117446722  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117447615  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
117449155  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117458719  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117459875  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
117464537  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
117455783  zgc:56235; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
117452300  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117459894  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
117458902  dhx33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
117445264  LOW QUALITY PROTEIN: mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
117449196  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
117462675  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
117463677  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
117448727  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
117439023  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
117447716  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
117452728  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
117468429  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
117446191  nampt2; nicotinamide phosphoribosyltransferase 2 [KO:K03462] [EC:2.4.2.12]
117441459  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
117442916  cytochrome b-245 light chain [KO:K08009]
117455066  txnipa; thioredoxin interacting protein a [KO:K20910]
117463332  txn; thioredoxin [KO:K03671]
117463354  thioredoxin-like [KO:K03671]
117451670  txn2; thioredoxin, mitochondrial [KO:K03671]
117441756  serine/threonine-protein kinase Nek7-like [KO:K20876] [EC:2.7.11.34]
117456035  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
117439680  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
117439900  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
117440374  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
117448404  caspase recruitment domain-containing protein 8-like isoform X1 [KO:K12801]
117447656  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a isoform X1 [KO:K12804]
117440062  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
117467008  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
117462527  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
117463024  caspase-3-like isoform X1 [KO:K04398] [EC:3.4.22.61]
117463391  fadd; FAS-associated death domain protein [KO:K02373]
117447434  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
117446645  prkcdb; protein kinase C, delta b isoform X1 [KO:K06068] [EC:2.7.11.13]
117463418  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
117449082  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117450100  rho-related GTP-binding protein RhoA-D [KO:K04513]
117450101  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117450179  rho-related GTP-binding protein RhoA-C [KO:K04513]
117446482  rho-related GTP-binding protein RhoA-B [KO:K04513]
117446884  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
117461824  pkn2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
117444313  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
117466578  interferon alpha/beta receptor 2-like [KO:K05131]
117445389  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
117450938  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
117466574  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
117441669  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
117446139  stat2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
117466089  irf9; interferon regulatory factor 9 [KO:K04693]
117462890  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
117465800  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117447743  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117454095  sting1; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
pgeo04010  MAPK signaling pathway
pgeo04140  Autophagy - animal
pgeo04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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