KEGG   PATHWAY: plep04510
Entry
plep04510                   Pathway                                
Name
Focal adhesion - Plectropomus leopardus (leopard coralgrouper)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
plep04510  Focal adhesion
plep04510

Other DBs
GO: 0005925
Organism
Plectropomus leopardus (leopard coralgrouper) [GN:plep]
Gene
121958474  col1a1b; collagen, type I, alpha 1b [KO:K06236]
121956874  col1a1a; LOW QUALITY PROTEIN: collagen, type I, alpha 1a [KO:K06236]
121957433  col1a2; collagen alpha-2(I) chain [KO:K06236]
121946779  col2a1a; collagen, type II, alpha 1a [KO:K19719]
121957426  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
121942815  col4a3; LOW QUALITY PROTEIN: collagen alpha-5(IV) chain [KO:K06237]
121943441  col4a4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
121949437  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
121949439  col4a1; collagen alpha-1(IV) chain [KO:K06237]
121962341  col4a5; collagen alpha-5(IV) chain [KO:K06237]
121962342  col4a6; collagen alpha-6(IV) chain [KO:K06237]
121951868  collagen alpha-5(IV) chain-like [KO:K06237]
121951869  collagen alpha-4(IV) chain-like [KO:K06237]
121948882  LOW QUALITY PROTEIN: collagen alpha-3(VI) chain-like [KO:K06238]
121949511  collagen alpha-2(VI) chain-like isoform X1 [KO:K06238]
121945378  col6a4a; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
121945558  collagen alpha-6(VI) chain-like [KO:K06238]
121951182  col6a1; collagen alpha-1(VI) chain [KO:K06238]
121951183  collagen alpha-2(VI) chain-like [KO:K06238]
121946879  col9a3; collagen alpha-3(IX) chain [KO:K08131]
121958166  col9a2; collagen alpha-2(IX) chain [KO:K08131]
121958267  LOW QUALITY PROTEIN: collagen alpha-1(IX) chain-like [KO:K08131]
121954757  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
121948678  laminin subunit alpha-1-like [KO:K05637]
121955856  lama2; laminin subunit alpha-2 [KO:K05637]
121946551  lama5; laminin subunit alpha-5 [KO:K06240]
121950945  laminin subunit alpha-3-like [KO:K06240]
121955403  lama4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
121946733  lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
121947291  lamb2l; laminin subunit beta-2 [KO:K06243]
121952214  laminin subunit beta-3-like [KO:K06244]
121951333  lamc2; laminin subunit gamma-2 [KO:K06246]
121959739  lamc3; laminin subunit gamma-3 [KO:K06247]
121958497  chad; chondroadherin [KO:K06248]
121949879  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
121953263  thrombospondin-1-like [KO:K16857]
121955248  thbs1b; thrombospondin-1 [KO:K16857]
121959583  thbs4b; thrombospondin-4-B [KO:K04659]
121954406  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
121944686  thbs4a; thrombospondin-4a [KO:K04659]
121962346  cartilage oligomeric matrix protein [KO:K04659]
121945915  LOW QUALITY PROTEIN: thrombospondin-3a-like [KO:K04659]
121947868  fn1b; fibronectin 1b isoform X1 [KO:K05717]
121949574  fn1a; fibronectin 1a isoform X1 [KO:K05717]
121952590  vtnb; vitronectin b [KO:K06251]
121943185  vtna; LOW QUALITY PROTEIN: vitronectin a [KO:K06251]
121959790  tnca; tenascin isoform X1 [KO:K06252]
121944261  tenascin-like isoform X1 [KO:K06252]
121951060  tnn; tenascin-N [KO:K06252]
121951594  tnr; tenascin-R [KO:K06252]
121949858  vwf; von Willebrand factor [KO:K03900]
121959781  itga1; integrin alpha-1 [KO:K06480]
121944191  integrin alpha-2-like [KO:K06481]
121958881  itga3b; integrin alpha-3b [KO:K06482]
121956879  integrin alpha-3-like isoform X1 [KO:K06482]
121948858  itga4; integrin alpha-4 isoform X1 [KO:K06483]
121946575  itga5; integrin alpha-5 [KO:K06484]
121952645  integrin alpha-5-like [KO:K06484]
121948837  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
121957487  itga7; integrin alpha-7 [KO:K06583]
121946070  itga8; integrin alpha-8 [KO:K06584]
121954488  itga9; integrin alpha-9 [KO:K06585]
121945894  itga10; integrin alpha-10 [KO:K06586]
121946780  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
121960477  integrin beta-1-like isoform X1 [KO:K05719]
121958498  itgb3b; integrin beta-3b [KO:K06493]
121956048  integrin beta-3-like [KO:K06493]
121958520  itgb4; integrin beta-4 isoform X1 [KO:K06525]
121948823  itgb5; integrin beta-5 [KO:K06588]
121947844  itgb6; integrin beta-6 [KO:K06589]
121957740  itgb8; integrin beta-8 [KO:K06591]
121956855  emp2; epithelial membrane protein 2 [KO:K26256]
121942499  platelet-derived growth factor subunit A-like [KO:K04359]
121957233  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
121942406  si:ch211-79m20.1; nuclear transcription factor Y subunit beta [KO:K17386]
121948201  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
121943688  pdgfd; platelet-derived growth factor D [KO:K05450]
121947780  egf; pro-epidermal growth factor [KO:K04357]
121947581  igf3; insulin-like growth factor 3 [KO:K05459]
121961360  igf1; insulin-like growth factor I [KO:K05459]
121948436  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
121955995  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
121945536  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
121953602  pgfb; vascular endothelial growth factor A [KO:K16859]
121955958  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
121942292  vegfc; vascular endothelial growth factor C [KO:K05449]
121944945  vegfd; vascular endothelial growth factor D [KO:K05449]
121963084  vascular endothelial growth factor C-like [KO:K05449]
121961520  hgfa; hepatocyte growth factor a [KO:K05460]
121950574  hepatocyte growth factor [KO:K05460]
121940421  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
121947843  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121939111  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
121941149  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
121949679  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121940403  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121951033  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121947692  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
121960979  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121947759  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
121950165  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121956849  epithelial membrane protein 2-like [KO:K26255]
121942122  emp1; epithelial membrane protein 1 [KO:K26255]
121946548  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
121956703  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
121952439  arhgap35b; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
121943717  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
121953903  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
121946466  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
121966262  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
121947389  rho-related GTP-binding protein RhoA-D [KO:K04513]
121947390  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
121947494  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
121959201  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
121962278  rho-related GTP-binding protein RhoA-C [KO:K04513]
121956625  rho-related GTP-binding protein RhoA-B [KO:K04513]
121947924  LOW QUALITY PROTEIN: protein diaphanous homolog 1-like [KO:K05740]
121950967  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
121954076  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121955159  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
121949397  myl2a; myosin regulatory light chain 2a [KO:K10351]
121944028  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
121960117  myosin light chain 5-like [KO:K12753]
121944019  myl7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
121954133  myosin regulatory light polypeptide 9 [KO:K12755]
121960731  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
121951332  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
121958627  mylpfb; myosin light chain, phosphorylatable, fast skeletal muscle b [KO:K12758]
121957014  mylpfa; myosin light chain, phosphorylatable, fast skeletal muscle a [KO:K12758]
121963586  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
121958438  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
121953625  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
121955123  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
121944027  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
121961997  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
121956454  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
121950090  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121961097  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121946950  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K12329]
121942236  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
121959160  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
121956704  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121963547  mylk4b; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121951941  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121959662  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
121944336  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
121951196  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
121945661  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
121939412  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
121957587  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
121941735  actb1; actin, cytoplasmic 1 [KO:K05692]
121944078  actin, cytoplasmic 1-like isoform X1 [KO:K05692]
121944669  LOW QUALITY PROTEIN: actin, cytoplasmic 1-like [KO:K05692]
121957309  actb2; actin, cytoplasmic 2 [KO:K05692]
121942768  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
121950049  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
121942132  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
121953172  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
121942761  LOW QUALITY PROTEIN: alpha-actinin-4-like [KO:K05699]
121959638  tln1; talin-1 [KO:K06271]
121960475  tln2a; talin-2a isoform X1 [KO:K06271]
121949726  tln2b; talin-2 isoform X1 [KO:K06271]
121946580  flna; filamin-A isoform X1 [KO:K04437]
121948759  LOW QUALITY PROTEIN: filamin-B [KO:K27392]
121954296  LOW QUALITY PROTEIN: paxillin-like [KO:K05760]
121944253  uncharacterized protein LOC121944253 [KO:K05760]
121963158  flocculation protein FLO11-like [KO:K05760]
121952817  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
121943289  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
121945247  zyx; zyxin [KO:K06273]
121943210  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
121958663  vinculin [KO:K05700]
121954668  vinculin-like isoform X1 [KO:K05700]
121950060  parvaa; parvin, alpha a [KO:K06275]
121950392  parvg; gamma-parvin [KO:K06275]
121950625  parvb; beta-parvin isoform X1 [KO:K06275]
121958807  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
121952131  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
121941580  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121953281  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121943028  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121954611  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121948765  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121945159  ctnnb1; catenin beta-1 [KO:K02105]
121957504  catenin beta-1-like [KO:K02105]
121941841  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
121956776  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
121941709  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
121957205  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121945942  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
121945745  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
121957499  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
121947071  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121942910  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121951130  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121963985  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121939825  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121959511  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
121951302  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
121938061  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
121962939  pik3r3b; LOW QUALITY PROTEIN: phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
121951926  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121958959  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121954358  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121941726  proto-oncogene vav-like isoform X1 [KO:K05730]
121959593  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
121960358  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3 [KO:K05730]
121951493  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
121958494  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121956256  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
121941566  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121958523  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
121943500  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121940948  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
121953443  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
121952544  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
121943157  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
121963815  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
121955138  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
121953611  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
121946633  cell division control protein 42 homolog isoform X1 [KO:K04393]
121952675  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121945302  cdc42l; cell division cycle 42, like [KO:K04393]
121957557  cell division control protein 42 homolog [KO:K04393]
121939291  breast cancer anti-estrogen resistance protein 1-like [KO:K05726]
121952270  adapter molecule crk-like [KO:K04438]
121959826  crkl; crk-like protein [KO:K04438]
121943251  crk; adapter molecule crk [KO:K04438]
121963423  adapter molecule crk-like [KO:K04438]
121958875  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
121959531  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
121946624  ras-related protein Rap-1A [KO:K04353]
121957019  ras-related protein Rap-1A-like [KO:K04353]
121947706  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
121958808  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
121959676  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121954271  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121960294  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
121963101  jun; transcription factor AP-1 [KO:K04448]
121951914  transcription factor AP-1-like [KO:K04448]
121961201  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121950655  cav1; caveolin-1 [KO:K06278]
121958418  zgc:172270; caveolin-2 [KO:K12958]
121956181  LOW QUALITY PROTEIN: caveolin-2-like [KO:K12958]
121950662  cav2; LOW QUALITY PROTEIN: caveolin-2 [KO:K12958]
121939000  caveolin-2-like [KO:K12958]
121958429  caveolin-1-like [KO:K12959]
121956189  cav3; caveolin-3 [KO:K12959]
121953490  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
121955340  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
121945480  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
121938139  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
121960165  shc3; SHC-transforming protein 3 [KO:K17448]
121945679  LOW QUALITY PROTEIN: SHC-transforming protein 4-like [KO:K17449]
121942232  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
121956174  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
121953241  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121949870  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121946649  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
121950008  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121944320  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121956713  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121964884  G1/S-specific cyclin-D1-like [KO:K04503]
121950245  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121964485  G1/S-specific cyclin-D1 [KO:K04503]
121949734  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
121961335  G1/S-specific cyclin-D2-like [KO:K10151]
121957267  ccndx; cyclin Dx [KO:K10151]
121956400  ccnd3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
121952415  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
121947947  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
121962343  badb; BCL2 associated agonist of cell death b [KO:K02158]
121951449  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
plep04010  MAPK signaling pathway
plep04060  Cytokine-cytokine receptor interaction
plep04070  Phosphatidylinositol signaling system
plep04110  Cell cycle
plep04310  Wnt signaling pathway
plep04512  ECM-receptor interaction
plep04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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