KEGG   PATHWAY: plop04072
Entry
plop04072                   Pathway                                
Name
Phospholipase D signaling pathway - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
Class
Environmental Information Processing; Signal transduction
Pathway map
plop04072  Phospholipase D signaling pathway
plop04072

Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125341585  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
125339510  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125358224  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
125349532  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125364930  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
125360533  Kitlg; kit ligand isoform X1 [KO:K05461]
125346757  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125364960  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125339985  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125364419  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
125348697  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
125365698  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
125341644  Gab1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
125362370  Gab2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
125360001  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
125347922  Shc2; SHC-transforming protein 2 [KO:K17447]
125355540  Shc3; SHC-transforming protein 3 [KO:K17448]
125340436  Shc4; SHC-transforming protein 4 [KO:K17449]
125349100  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
125356532  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125363420  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125342925  Kras; GTPase KRas isoform X1 [KO:K07827]
125355453  Nras; GTPase NRas [KO:K07828]
125338815  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
125362309  Rras2; ras-related protein R-Ras2 [KO:K07830]
125364257  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125350781  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
125344534  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125344567  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125344605  ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125352435  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125352446  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125352469  LOW QUALITY PROTEIN: ral guanine nucleotide dissociation stimulator-like [KO:K08732]
125346686  Rala; ras-related protein Ral-A [KO:K07834]
125339312  ras-related protein Ral-B-like [KO:K07835]
125368361  Ralb; ras-related protein Ral-B [KO:K07835]
125354550  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125342393  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125351954  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125367817  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125355095  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125348916  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125338979  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125363440  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
125363452  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125359645  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125350743  Tsc1; hamartin isoform X1 [KO:K07206]
125340703  Tsc2; tuberin isoform X1 [KO:K07207]
125347331  Rheb; GTP-binding protein Rheb [KO:K07208]
125354571  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125367464  transforming protein RhoA-like [KO:K04513]
125347858  transforming protein RhoA-like [KO:K04513]
125342586  Rhoa; transforming protein RhoA [KO:K04513]
125359998  Arf1; ADP-ribosylation factor 1 [KO:K07937]
125366524  ADP-ribosylation factor 2 [KO:K07937]
125363162  Arf6; ADP-ribosylation factor 6 [KO:K07941]
125353663  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
125357867  Plcg2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
125359267  Fcer1a; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
125361646  Ms4a2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
125359050  Fcer1g; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
125357194  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
125346974  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125351980  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
125365880  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
125368091  Pla2g4c; LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
125340442  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
125340633  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
125340635  Pla2g4b; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
125340742  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
125359009  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125351130  Agpat2; LOW QUALITY PROTEIN: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
125352741  Agpat1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
125357472  Agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
125339341  Agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
125338852  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
125365222  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
125358819  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125340362  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125348606  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125340951  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
125348631  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
125359078  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
125347186  Dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
125361212  Dgkz; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
125348240  Dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
125363153  Dgka; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
125343116  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
125350165  Dgkd; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
125364474  Dgkq; diacylglycerol kinase theta isoform X1 [KO:K00901] [EC:2.7.1.107]
125351905  Dgkg; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
125365798  Dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
125345807  Dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
125367813  Plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
125348549  Plpp2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
125355210  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
125362150  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
125367128  Agt; angiotensinogen [KO:K09821]
125352333  vasopressin-neurophysin 2-copeptin [KO:K05242]
125365001  Cxcl8; interleukin-8 [KO:K10030]
125342450  Agtr1; type-1 angiotensin II receptor [KO:K04166]
125367653  F2r; proteinase-activated receptor 1 [KO:K03914]
125357375  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
125342388  Grm2; metabotropic glutamate receptor 2 [KO:K04605]
125345825  Grm3; metabotropic glutamate receptor 3 [KO:K04606]
125352686  Grm4; metabotropic glutamate receptor 4 isoform X1 [KO:K04607]
125361415  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
125341810  Grm6; metabotropic glutamate receptor 6 [KO:K04608]
125358771  Grm7; metabotropic glutamate receptor 7 isoform X1 [KO:K04609]
125347095  Grm8; metabotropic glutamate receptor 8 isoform X1 [KO:K04610]
125361799  Avpr1a; vasopressin V1a receptor [KO:K04226]
125359750  Avpr1b; vasopressin V1b receptor [KO:K04227]
125343836  Avpr2; vasopressin V2 receptor [KO:K04228]
125346394  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
125347962  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
125355349  Lpar3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
125343970  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
125348279  Lpar6; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 6 [KO:K04273]
125355332  Ptgfr; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
125350836  Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175]
125349904  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
125353265  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125353267  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
125340765  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125362680  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125339093  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
125339296  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
125365237  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
125346892  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
125365865  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
125365866  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
125353721  Cyth4; cytohesin-4 [KO:K18441]
125365406  Cyth1; LOW QUALITY PROTEIN: cytohesin-1 [KO:K18441]
125338481  Cyth2; cytohesin-2 [KO:K18441]
125366743  Cyth3; cytohesin-3 [KO:K18441]
125353923  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125352423  neuroendocrine secretory protein 55-like [KO:K04632]
125345732  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125367715  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
125356676  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125363469  Adcy4; LOW QUALITY PROTEIN: adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
125345042  LOW QUALITY PROTEIN: adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
125351778  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125365347  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125358478  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125360503  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125340976  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
125365569  Rapgef3; rap guanine nucleotide exchange factor 3 [KO:K08014]
125350552  Rapgef4; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 4 [KO:K04351]
125360255  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
125349549  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
125348724  Dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C00639  Prostaglandin F2alpha
C00681  1-Acyl-sn-glycerol 3-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:17245604
  Authors
Oude Weernink PA, Lopez de Jesus M, Schmidt M
  Title
Phospholipase D signaling: orchestration by PIP2 and small GTPases.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 374:399-411 (2007)
DOI:10.1007/s00210-007-0131-4
Reference
PMID:21936578
  Authors
Selvy PE, Lavieri RR, Lindsley CW, Brown HA
  Title
Phospholipase D: enzymology, functionality, and chemical modulation.
  Journal
Chem Rev 111:6064-119 (2011)
DOI:10.1021/cr200296t
Reference
PMID:24995811
  Authors
Brandenburg LO, Pufe T, Koch T
  Title
Role of phospholipase d in g-protein coupled receptor function.
  Journal
Membranes (Basel) 4:302-18 (2014)
DOI:10.3390/membranes4030302
Reference
PMID:17054901
  Authors
Oude Weernink PA, Han L, Jakobs KH, Schmidt M
  Title
Dynamic phospholipid signaling by G protein-coupled receptors.
  Journal
Biochim Biophys Acta 1768:888-900 (2007)
DOI:10.1016/j.bbamem.2006.09.012
Reference
PMID:24990952
  Authors
Foster DA, Salloum D, Menon D, Frias MA
  Title
Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).
  Journal
J Biol Chem 289:22583-8 (2014)
DOI:10.1074/jbc.R114.566091
Reference
PMID:16143829
  Authors
Jenkins GM, Frohman MA
  Title
Phospholipase D: a lipid centric review.
  Journal
Cell Mol Life Sci 62:2305-16 (2005)
DOI:10.1007/s00018-005-5195-z
Reference
PMID:19815110
  Authors
Metcalfe DD, Peavy RD, Gilfillan AM
  Title
Mechanisms of mast cell signaling in anaphylaxis.
  Journal
J Allergy Clin Immunol 124:639-46; quiz 647-8 (2009)
DOI:10.1016/j.jaci.2009.08.035
Reference
PMID:18936782
  Authors
Kalesnikoff J, Galli SJ
  Title
New developments in mast cell biology.
  Journal
Nat Immunol 9:1215-23 (2008)
DOI:10.1038/ni.f.216
Reference
PMID:12217395
  Authors
Cockcroft S, Way G, O'Luanaigh N, Pardo R, Sarri E, Fensome A
  Title
Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.
  Journal
Mol Immunol 38:1277-82 (2002)
DOI:10.1016/S0161-5890(02)00075-5
Reference
PMID:19410013
  Authors
Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH
  Title
The roles of phospholipase D in EGFR signaling.
  Journal
Biochim Biophys Acta 1791:862-8 (2009)
DOI:10.1016/j.bbalip.2009.04.007
Reference
PMID:16622417
  Authors
Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH
  Title
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis.
  Journal
Nat Cell Biol 8:477-84 (2006)
DOI:10.1038/ncb1401
Reference
PMID:14769825
  Authors
Kam Y, Exton JH
  Title
Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.
  Journal
FASEB J 18:311-9 (2004)
DOI:10.1096/fj.03-0731com
Reference
PMID:9310372
  Authors
Kozawa O, Blume-Jensen P, Heldin CH, Ronnstrand L
  Title
Involvement of phosphatidylinositol 3'-kinase in stem-cell-factor-induced phospholipase D activation and arachidonic acid release.
  Journal
Eur J Biochem 248:149-55 (1997)
DOI:10.1111/j.1432-1033.1997.00149.x
Reference
PMID:11042115
  Authors
Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K
  Title
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
  Journal
Biochem J 351 Pt 3:613-9 (2000)
DOI:10.1042/bj3510613
Reference
PMID:11991733
  Authors
Fahimi-Vahid M, Gosau N, Michalek C, Han L, Jakobs KH, Schmidt M, Roberts N, Avkiran M, Wieland T
  Title
Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin.
  Journal
J Mol Cell Cardiol 34:441-53 (2002)
DOI:10.1006/jmcc.2002.1525
Reference
PMID:10666319
  Authors
Freeman EJ
  Title
The Ang II-induced growth of vascular smooth muscle cells involves a phospholipase D-mediated signaling mechanism.
  Journal
Arch Biochem Biophys 374:363-70 (2000)
DOI:10.1006/abbi.1999.1608
Reference
PMID:9119890
  Authors
Naro F, Donchenko V, Minotti S, Zolla L, Molinaro M, Adamo S
  Title
Role of phospholipase C and D signalling pathways in vasopressin-dependent myogenic differentiation.
  Journal
J Cell Physiol 171:34-42 (1997)
DOI:10.1002/(SICI)1097-4652(199704)171:1<34::AID-JCP5>3.0.CO;2-I
Reference
PMID:10807766
  Authors
Murdoch C, Finn A
  Title
Chemokine receptors and their role in inflammation and infectious diseases.
  Journal
Blood 95:3032-43 (2000)
Reference
PMID:8135758
  Authors
Sugiyama T, Sakai T, Nozawa Y, Oka N
  Title
Prostaglandin F2 alpha-stimulated phospholipase D activation in osteoblast-like MC3T3-E1 cells: involvement in sustained 1,2-diacylglycerol production.
  Journal
Biochem J 298 ( Pt 2):479-84 (1994)
DOI:10.1042/bj2980479
Reference
PMID:17210675
  Authors
Foster DA
  Title
Regulation of mTOR by phosphatidic acid?
  Journal
Cancer Res 67:1-4 (2007)
DOI:10.1158/0008-5472.CAN-06-3016
Reference
PMID:15310762
  Authors
Delon C, Manifava M, Wood E, Thompson D, Krugmann S, Pyne S, Ktistakis NT
  Title
Sphingosine kinase 1 is an intracellular effector of phosphatidic acid.
  Journal
J Biol Chem 279:44763-74 (2004)
DOI:10.1074/jbc.M405771200
Reference
PMID:23076158
  Authors
Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH
  Title
Phospholipase signalling networks in cancer.
  Journal
Nat Rev Cancer 12:782-92 (2012)
DOI:10.1038/nrc3379
Reference
PMID:19264150
  Authors
Foster DA
  Title
Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.
  Journal
Biochim Biophys Acta 1791:949-55 (2009)
DOI:10.1016/j.bbalip.2009.02.009
Related
pathway
plop00561  Glycerolipid metabolism
plop04010  MAPK signaling pathway
plop04014  Ras signaling pathway
plop04020  Calcium signaling pathway
plop04024  cAMP signaling pathway
plop04071  Sphingolipid signaling pathway
plop04144  Endocytosis
plop04150  mTOR signaling pathway
plop04151  PI3K-Akt signaling pathway
plop04664  Fc epsilon RI signaling pathway
KO pathway
ko04072   
LinkDB

DBGET integrated database retrieval system