KEGG   PATHWAY: plop04010
Entry
plop04010                   Pathway                                
Name
MAPK signaling pathway - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
plop04010  MAPK signaling pathway
plop04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125338601  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
125338637  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
125338661  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
125338673  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125338677  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
125338685  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125338815  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
125338868  Ntf4; neurotrophin-4 [KO:K12457]
125338869  Fgf21; fibroblast growth factor 21 [KO:K22429]
125338979  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125339049  Flt3lg; fms-related tyrosine kinase 3 ligand [KO:K05454]
125339093  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
125339226  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125339236  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
125339311  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
125339355  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125339510  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125339512  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125339553  Vegfc; vascular endothelial growth factor C [KO:K05449]
125339607  Fgf20; fibroblast growth factor 20 [KO:K04358]
125339659  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125339698  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125339912  Fgf1; fibroblast growth factor 1 [KO:K18496]
125339978  Efna5; ephrin-A5 isoform X1 [KO:K05462]
125339985  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125340026  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
125340058  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125340063  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125340095  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
125340107  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
125340110  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
125340362  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125340403  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
125340442  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
125340531  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125340633  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
125340635  Pla2g4b; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
125340650  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
125340742  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
125340785  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125340786  Rasgrp1; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1 [KO:K04350]
125340791  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125340912  Fgf7; fibroblast growth factor 7 [KO:K04358]
125341080  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
125341424  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125341437  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
125341585  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
125341650  Fgf2; fibroblast growth factor 2 [KO:K18497]
125341680  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125341845  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125341935  Fgf18; fibroblast growth factor 18 [KO:K04358]
125341968  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125342051  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125342070  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
125342411  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
125342420  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
125342631  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
125342682  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
125342697  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125342716  Cacna1c; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
125342829  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125342834  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125342925  Kras; GTPase KRas isoform X1 [KO:K07827]
125343037  [KO:K04392]
125343265  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125343285  Flna; filamin-A isoform X1 [KO:K04437]
125343296  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
125343344  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125343348  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
125343391  Vegfd; vascular endothelial growth factor D [KO:K05449]
125343466  Dusp9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
125343498  Fgf16; fibroblast growth factor 16 [KO:K04358]
125343550  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
125343817  Irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
125344151  [KO:K05096] [EC:2.7.10.1]
125344236  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
125344289  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
125345116  [KO:K04729]
125345313  [KO:K05093] [EC:2.7.10.1]
125345750  [KO:K07836]
125345861  [KO:K04393]
125345915  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125345984  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125346070  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125346113  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
125346119  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125346167  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125346313  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
125346456  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125346549  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125346757  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125346769  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125346953  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
125346954  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
125347055  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125347185  Cacna1i; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
125347225  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125347918  Efna2; ephrin-A2 isoform X1 [KO:K05462]
125347931  Nrtn; neurturin [KO:K25414]
125348386  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125348391  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125348427  Fgf9; fibroblast growth factor 9 [KO:K04358]
125348480  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
125348544  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
125348565  Pspn; persephin [KO:K25416]
125348606  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125348658  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
125348683  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125348697  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
125348751  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
125348811  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125348843  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
125348920  Jund; transcription factor JunD [KO:K04449]
125349069  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
125349115  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125349344  Crkl; crk-like protein [KO:K04438]
125349532  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125349671  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
125350336  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
125350538  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
125350551  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
125350665  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
125350813  Map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
125351242  [KO:K04381]
125351527  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
125351829  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
125351875  [KO:K04723]
125351910  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
125351997  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
125352032  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
125352181  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125352543  Vegfa; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
125352568  Srf; serum response factor [KO:K04378]
125352654  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125352700  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
125352770  [KO:K03283]
125352771  [KO:K03283]
125352772  [KO:K03283]
125352808  Tnf; tumor necrosis factor [KO:K03156]
125353128  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125353300  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
125353338  Angpt4; angiopoietin-4 isoform X1 [KO:K05467]
125353688  [KO:K04358]
125353732  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125353776  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
125353820  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
125354623  Epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
125354689  Cdc42; cell division control protein 42 homolog [KO:K04393]
125354748  Stmn1; stathmin [KO:K04381]
125354763  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125354783  Map3k6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
125355106  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
125355221  Jun; transcription factor Jun [KO:K04448]
125355283  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
125355284  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125355340  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
125355399  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
125355432  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
125355453  Nras; GTPase NRas [KO:K07828]
125355459  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
125356088  Il1a; interleukin-1 alpha [KO:K04383]
125356110  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
125356117  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
125356276  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
125356489  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
125356526  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
125356532  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125356569  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
125356681  Mapk11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
125356783  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
125356827  Il1b; interleukin-1 beta [KO:K04519]
125356867  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
125357039  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
125357128  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125357320  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
125357392  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
125357471  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
125357612  [KO:K04373] [EC:2.7.11.1]
125357613  [KO:K04373] [EC:2.7.11.1]
125358158  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125358195  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
125358224  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
125358263  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125358313  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125358575  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
125358578  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125358819  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125358982  Efna3; ephrin-A3 isoform X1 [KO:K05462]
125358984  Efna4; ephrin-A4 [KO:K05462]
125358985  Efna1; ephrin-A1 [KO:K05462]
125359009  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125359114  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
125359178  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
125359327  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
125359378  Elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
125359379  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
125359484  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
125359645  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125360177  Ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125360227  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
125360245  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
125360260  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125360527  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125360533  Kitlg; kit ligand isoform X1 [KO:K05461]
125360808  Myc; myc proto-oncogene protein [KO:K04377]
125360924  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
125360970  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
125361173  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
125361180  [KO:K04370]
125361231  Ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
125361234  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
125361340  Fgf4; fibroblast growth factor 4 [KO:K04358]
125361448  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
125361483  Rap1b; ras-related protein Rap-1b [KO:K07836]
125361532  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125361587  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
125361599  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
125361688  Rps6ka4; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
125361933  Rela; transcription factor p65 isoform X1 [KO:K04735]
125362282  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
125362293  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
125362309  Rras2; ras-related protein R-Ras2 [KO:K07830]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125362355  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
125362619  Rasgrp2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
125362638  Fgf19; fibroblast growth factor 19 [KO:K22603]
125362639  Fgf3; fibroblast growth factor 3 [KO:K04358]
125362653  Dusp8; LOW QUALITY PROTEIN: dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125362670  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
125362735  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
125362755  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
125362864  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
125363063  Max; protein max isoform X1 [KO:K04453]
125363113  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125363230  Fos; protein c-Fos [KO:K04379]
125363264  Map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
125363309  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
125363322  Pgf; placenta growth factor isoform X1 [KO:K16859]
125363420  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125363440  [KO:K04456] [EC:2.7.11.1]
125363452  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125363627  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
125363835  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125363880  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
125364405  Kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125364419  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
125364429  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125364508  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125364638  Areg; amphiregulin [KO:K09782]
125364642  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
125364700  Ereg; proepiregulin [KO:K09784]
125364712  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125364746  Fgf5; fibroblast growth factor 5 [KO:K04358]
125364930  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
125364960  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125365123  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
125365137  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
125365151  Nf1; neurofibromin isoform X1 [KO:K08052]
125365164  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
125365304  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
125365324  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
125365364  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
125365478  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
125365518  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
125365521  Crk; adapter molecule crk isoform X1 [KO:K04438]
125365648  Cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
125365698  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
125365780  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
125365792  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125365807  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
125365886  Tp53; cellular tumor antigen p53 [KO:K04451]
125365887  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
125365921  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
125365936  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125366093  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125366140  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
125366228  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125366398  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125366443  Prkca; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125366471  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
125366515  Mapt; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
125366701  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125367139  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
125367239  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
125367414  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
125367500  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
125367755  Fgf10; fibroblast growth factor 10 [KO:K04358]
125367917  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
125368088  Hspb1; heat shock protein beta-1 [KO:K04455]
125368091  Pla2g4c; LOW QUALITY PROTEIN: cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
125368265  Relb; transcription factor RelB [KO:K09253]
125368335  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
125368418  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
125368520  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
125368530  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
plop04070  Phosphatidylinositol signaling system
plop04110  Cell cycle
plop04115  p53 signaling pathway
plop04210  Apoptosis
plop04310  Wnt signaling pathway
plop04668  TNF signaling pathway
KO pathway
ko04010   

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