KEGG   PATHWAY: ppad05202
Entry
ppad05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Panthera pardus (leopard)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
ppad05202  Transcriptional misregulation in cancer
ppad05202

Organism
Panthera pardus (leopard) [GN:ppad]
Gene
109249750  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
109275945  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109247205  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
109250814  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
109250815  IL3; interleukin-3 [KO:K04736]
109269481  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
109255290  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
109263573  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
109262666  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
109245811  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
109251606  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
109264827  PER2; period circadian protein homolog 2 isoform X1 [KO:K02633]
109245121  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
109252176  CD14; monocyte differentiation antigen CD14 [KO:K04391]
109259037  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
109257074  LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
109258560  JUP; junction plakoglobin [KO:K10056]
109262710  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
109247445  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
109266040  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
109248839  CCNA2; cyclin-A2 [KO:K06627]
109255033  CEBPE; CCAAT/enhancer-binding protein epsilon isoform X1 [KO:K10051]
109273563  BCL2A1; bcl-2-related protein A1 [KO:K02162]
109278625  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
109273136  MYC; myc proto-oncogene protein [KO:K04377]
109265302  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
109257652  TCF3; LOW QUALITY PROTEIN: transcription factor E2-alpha [KO:K09063]
109276638  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
109268901  WNT16; protein Wnt-16 [KO:K01558]
109271520  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
109268610  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
109257711  neutrophil elastase-like isoform X1 [KO:K01327] [EC:3.4.21.37]
109254955  granzyme B(G,H)-like isoform X1 [KO:K01353] [EC:3.4.21.79]
109254957  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
109278556  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
109276267  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
109250116  CDK9; cyclin-dependent kinase 9 isoform X1 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
109270095  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
109249042  CCNT1; cyclin-T1 [KO:K15188]
109255854  MLLT1; protein ENL [KO:K15187]
109247055  MLLT3; protein AF-9 isoform X1 [KO:K15187]
109257714  DOT1L; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-79 specific [KO:K11427] [EC:2.1.1.360]
109279158  LMO2; rhombotin-2 isoform X1 [KO:K15612]
109250163  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
109271691  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
109249934  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
109246339  KLF3; Krueppel-like factor 3 [KO:K15605]
109274878  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
109263879  HOXA9; homeobox protein Hox-A9 [KO:K21950]
109263877  HOXA10; homeobox protein Hox-A10 [KO:K17443]
109264311  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
109270451  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
109248052  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
109271692  SUPT3H; transcription initiation protein SPT3 homolog [KO:K11313]
109269628  PROM1; prominin-1 isoform X1 [KO:K06532]
109266125  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
109277095  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
109273360  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
109268629  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
109263667  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
109260357  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
109263881  HOXA11; homeobox protein Hox-A11 [KO:K21951]
109268375  SIX1; homeobox protein SIX1 [KO:K15614]
109268372  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
109269332  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
109266897  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
109262400  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
109250724  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
109268313  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
109267490  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
109272683  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
109274390  BCL11B; LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B [KO:K22046]
109272810  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
109254021  LYL1; LOW QUALITY PROTEIN: protein lyl-1 [KO:K15604]
109264661  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
109271640  PTCRA; pre T-cell antigen receptor alpha isoform X1 [KO:K06056]
109255247  REL; proto-oncogene c-Rel [KO:K09254]
109276198  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109257521  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
109257526  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109269887  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
109272592  BCL2L1; bcl-2-like protein 1 [KO:K04570]
109266469  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
109272341  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
109275292  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
109245667  MAF; transcription factor Maf [KO:K09035]
109249190  ITGB7; integrin beta-7 [KO:K06590]
109269561  NSD2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
109259607  LOW QUALITY PROTEIN: histone H3.3 [KO:K11253]
109263783  histone H3.3-like [KO:K11253]
109252626  histone H3.1 [KO:K11253]
109252658  histone H3.1-like [KO:K11253]
109252669  histone H3-like centromeric protein cpar-1 [KO:K11253]
109252670  uncharacterized protein LOC109252670 [KO:K11253]
109252675  uncharacterized protein LOC109252675 [KO:K11253]
109257083  histone H3 [KO:K11253]
109253796  histone H3.3-like [KO:K11253]
109250864  histone H3.3 [KO:K11253]
109252580  histone H3.3-like [KO:K11253]
109252583  histone H3.1 [KO:K11253]
109252584  histone H3.1 [KO:K11253]
109252586  histone H3.1 [KO:K11253]
109252587  histone H3.1 [KO:K11253]
109276921  histone H3.3 [KO:K11253]
109270136  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
109264411  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
109254341  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
109258269  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
109271425  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
109276632  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
109256317  PRCC; proline-rich protein PRCC [KO:K13105]
109248086  TFE3; transcription factor E3 isoform X1 [KO:K09105]
109271531  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
109249809  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
109249786  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
109264427  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
109262266  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
109257540  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
109272345  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
109276320  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
109254568  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
109263140  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
109263766  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
109258234  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
109275258  ETV5; ETS translocation variant 5 [KO:K15593]
109257457  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
109257408  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
109277077  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
109268302  MYCN; N-myc proto-oncogene protein [KO:K09109]
109268318  MAX; protein max isoform X1 [KO:K04453]
109270482  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
109273067  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
109245932  TP53; cellular tumor antigen p53 [KO:K04451]
109273652  BMI1; polycomb complex protein BMI-1 [KO:K11459]
109249199  SP1; transcription factor Sp1 [KO:K04684]
109274166  ZBTB17; LOW QUALITY PROTEIN: zinc finger and BTB domain-containing protein 17 [KO:K10500]
109256209  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109247323  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109246686  MEN1; menin [KO:K14970]
109253554  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
109250363  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
109265419  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109268957  ID2; DNA-binding protein inhibitor ID-2 isoform X1 [KO:K17693]
109251365  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109267951  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
109265048  FEV; protein FEV [KO:K09437]
109249108  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
109273558  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
109278700  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
109254484  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
109271306  WT1; Wilms tumor protein isoform X1 [KO:K09234]
109251089  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109265527  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
109278425  BAIAP3; BAI1-associated protein 3 [KO:K15621]
109248011  TSPAN7; tetraspanin-7 isoform X1 [KO:K06571]
109262048  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
109270076  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
109251957  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
109259028  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
109270377  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
109272282  CCAAT/enhancer-binding protein beta-like [KO:K10048]
109272283  CCAAT/enhancer-binding protein beta [KO:K10048]
109263814  IL6; interleukin-6 isoform X1 [KO:K05405]
109266335  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
109247385  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
109246747  RELA; transcription factor p65 isoform X1 [KO:K04735]
109277765  interleukin-8 [KO:K10030]
109265001  paired box protein Pax-3-like [KO:K09381]
109273883  PAX7; paired box protein Pax-7 [KO:K09381]
109264727  PAX3; paired box protein Pax-3 [KO:K09381]
109266009  FOXO1; forkhead box protein O1 [KO:K07201]
109266122  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109276471  SS18; protein SSXT isoform X1 [KO:K15623]
109253440  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
109248059  protein SSX1-like [KO:K15624]
109256532  NUPR1; nuclear protein 1 [KO:K15626]
109276758  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
109248389  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
109275530  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109266705  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109257746  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109253092  apoptosis regulator BAX isoform X1 [KO:K02159]
109253093  apoptosis regulator BAX isoform X1 [KO:K02159]
109253096  apoptosis regulator BAX-like [KO:K02159]
109271451  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
109245111  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109274988  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
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PMID:11313274
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Related
pathway
ppad04115  p53 signaling pathway
ppad05211  Renal cell carcinoma
ppad05215  Prostate cancer
ppad05216  Thyroid cancer
ppad05221  Acute myeloid leukemia
KO pathway
ko05202   
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