KEGG   PATHWAY: ray05167
Entry
ray05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Rousettus aegyptiacus (Egyptian rousette)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
ray05167  Kaposi sarcoma-associated herpesvirus infection
ray05167

Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107511212  C3; complement C3 [KO:K03990]
107510436  TLR3; toll-like receptor 3 [KO:K05401]
107510780  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
107521368  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
107502229  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
107508222  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
107507145  IRF7; interferon regulatory factor 7 [KO:K09447]
107507611  interferon alpha-1-like [KO:K05414]
107507614  interferon alpha-1-like [KO:K05414]
107508852  interferon alpha-1-like [KO:K05414]
107511568  interferon alpha-1-like [KO:K05414]
107518584  interferon alpha-1-like [KO:K05414]
107518586  interferon alpha-1-like [KO:K05414]
107518587  interferon alpha-4-like [KO:K05414]
107508426  interferon alpha-1-like [KO:K05414]
107507170  interferon alpha-1-like [KO:K05414]
107507171  interferon alpha-1-like [KO:K05414]
107507175  interferon alpha-1-like [KO:K05414]
107509253  interferon alpha-1-like [KO:K05414]
107511342  interferon alpha-1-like [KO:K05414]
107510611  interferon omega-1-like [KO:K05414]
107506761  interferon omega-1-like [KO:K05414]
107507612  interferon omega-1-like [KO:K05414]
107507173  interferon omega-1-like [KO:K05414]
107507179  interferon omega-1-like [KO:K05414]
107498821  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
107519708  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107505594  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107521673  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
107508087  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
107518589  IFNB1; interferon beta [KO:K05415]
107519592  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107519578  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
107517940  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
107515075  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
107519182  STAT1; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
107521231  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
107498009  IRF9; interferon regulatory factor 9 [KO:K04693]
107519635  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
107497883  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107497895  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107500264  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
107500274  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
107502219  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
107510279  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
107521829  ZFP36; tristetraprolin [KO:K15308]
107518120  IL6; interleukin-6 isoform X1 [KO:K05405]
107497048  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
107509058  CCR3; C-C chemokine receptor type 3 [KO:K04178]
107509099  C-C chemokine receptor type 5-like [KO:K04180]
107509096  CCR1; C-C chemokine receptor type 1 [KO:K04176]
107508778  CCR4; C-C chemokine receptor type 4 [KO:K04179]
107499588  CCR8; C-C chemokine receptor type 8 [KO:K04183]
107502212  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
107503382  FADD; FAS-associated death domain protein [KO:K02373]
107503155  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
107500447  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
107498831  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107511968  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
107518128  cytochrome c [KO:K08738]
107501830  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
107510456  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
107519788  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
107520081  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
107503081  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107499756  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107501353  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107499585  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
107514416  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
107517900  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107497522  RELA; transcription factor p65 [KO:K04735]
107515689  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
107514682  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
107501504  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107519055  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
107520925  RB1; retinoblastoma-associated protein [KO:K06618]
107519491  E2F1; transcription factor E2F1 [KO:K17454]
107501037  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
107501692  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
107505290  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107503252  HLA class I histocompatibility antigen, B-48 alpha chain-like isoform X1 [KO:K06751]
107517540  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
107519335  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
107506412  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
107506470  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
107506555  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
107509876  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
107511741  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107520746  HLA class I histocompatibility antigen, A-30 alpha chain-like isoform X1 [KO:K06751]
107521730  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
107507129  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
107506218  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
107498449  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
107521298  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
107515099  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
107497773  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
107506523  LOW QUALITY PROTEIN: MHC class I polypeptide-related sequence B-like [KO:K07985]
107502067  CLEC2B; C-type lectin domain family 2 member B [KO:K10071]
107503736  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
107503842  LOW QUALITY PROTEIN: ubiquitin-like [KO:K02927]
107519689  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
107497131  ubiquitin-60S ribosomal protein L40-like [KO:K02977]
107511054  UBB; polyubiquitin-B [KO:K04551]
107513845  BECN1; beclin-1 [KO:K08334]
107497279  BECN2; beclin-2 [KO:K08334]
107510917  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
107500133  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
107513717  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
107502341  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
107507227  LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
107500801  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
107510694  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
107500009  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
107519797  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
107518411  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
107519728  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
107498117  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
107501581  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
107520069  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
107511584  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
107520101  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
107516040  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
107502631  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
107518824  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
107519408  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
107520565  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107506102  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
107518812  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
107517574  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
107507127  HRAS; GTPase HRas isoform X1 [KO:K02833]
107497434  KRAS; GTPase KRas isoform X1 [KO:K07827]
107499847  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
107519729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107508942  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
107510634  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
107515836  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
107497830  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107509336  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
107505295  hypoxia-inducible factor 1-alpha [KO:K08268]
107518352  JUN; transcription factor AP-1 [KO:K04448]
107498912  FOS; proto-oncogene c-Fos [KO:K04379]
107511488  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
107515658  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
107515659  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
107520152  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107517828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107513958  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107521668  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
107517899  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107498704  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107513978  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107521783  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107498395  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107513109  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
107510319  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
107515925  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107512328  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107509910  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107515392  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
107513699  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
107513713  CD200R1; cell surface glycoprotein CD200 receptor 1 [KO:K21668]
107518638  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
107512598  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107512878  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
107500716  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
107517401  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
107519926  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107521319  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
107506741  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
107504134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107497427  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
107511965  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107509556  CALM2; calmodulin [KO:K02183]
107508927  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
107515457  CALM1; calmodulin [KO:K02183]
107516034  CALM3; calmodulin [KO:K02183]
107501627  calmodulin-like protein 5 [KO:K02183]
107516843  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107517885  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107509227  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107506933  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
107499586  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
107500851  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107510349  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
107498687  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
107520480  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107498045  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
107515317  C-X-C motif chemokine 15-like [KO:K10030]
107515319  CXCL8; interleukin-8 [KO:K10030]
107521616  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
107515315  growth-regulated protein homolog [KO:K05505]
107515316  growth-regulated protein homolog gamma-like [KO:K05505]
107520373  RCAN1; calcipressin-1 [KO:K17901]
107520360  uncharacterized protein LOC107520360 [KO:K17901]
107518501  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
107502007  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107502078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
107504264  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
107509633  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
107518627  interleukin-6 receptor subunit beta-like [KO:K05060]
107507294  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
107513823  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
107517741  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107519993  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
107506797  TCF7; transcription factor 7 isoform X1 [KO:K02620]
107506285  TCF7L1; transcription factor 7-like 1 [KO:K04490]
107511705  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
107511497  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
107505169  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
107503391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107506202  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
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The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
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J Exp Med 189:1993-8 (1999)
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The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
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Trends Mol Med 11:309-12 (2005)
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Biochim Biophys Acta 1766:140-58 (2006)
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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Curr Opin Virol 20:11-19 (2016)
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PLoS Pathog 8:e1002927 (2012)
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J Virol 88:13161-72 (2014)
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J Virol 81:42-58 (2007)
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Cancer Res 66:3658-66 (2006)
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
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Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
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Related
pathway
ray04010  MAPK signaling pathway
ray04064  NF-kappa B signaling pathway
ray04110  Cell cycle
ray04115  p53 signaling pathway
ray04140  Autophagy - animal
ray04144  Endocytosis
ray04151  PI3K-Akt signaling pathway
ray04210  Apoptosis
ray04310  Wnt signaling pathway
ray04610  Complement and coagulation cascades
ray04620  Toll-like receptor signaling pathway
ray04630  JAK-STAT signaling pathway
ray04650  Natural killer cell mediated cytotoxicity
ray04668  TNF signaling pathway
KO pathway
ko05167   
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