Entry Name MicroRNAs in cancer - Vulpes lagopus (Arctic fox)
Description MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class Human Diseases; Cancer: overviewBRITE hierarchy
Pathway map Ortholog table Organism Vulpes lagopus (Arctic fox) [GN:
vlg ]
Gene 121490958 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
121496557 ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299 ]
121471376 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
121472564 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
121481964 ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560 ]
121494626 RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850 ]
121497974 SLC7A1; high affinity cationic amino acid transporter 1 [KO:K13863 ]
121473042 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
121495587 APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085 ]
121481416 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
121496480 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
121494738 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
121477352 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
121478805 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
121499678 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
121484233 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
121495965 RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461 ]
121492778 NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996 ]
121472586 LOW QUALITY PROTEIN: SUMO-conjugating enzyme UBC9-like [KO:K10577 ]
121473676 IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391 ]
121492781 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
121477887 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
121487555 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
121491690 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
121471758 MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561 ]
Reference Authors Lee YS, Dutta A
Title MicroRNAs in cancer.
Journal Reference Authors Babashah S, Soleimani M
Title The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
Journal Reference Authors Garzon R, Calin GA, Croce CM
Title MicroRNAs in Cancer.
Journal Reference Authors Chen PS, Su JL, Hung MC
Title Dysregulation of microRNAs in cancer.
Journal Reference Authors Ling H, Zhang W, Calin GA
Title Principles of microRNA involvement in human cancers.
Journal Reference Authors Iorio MV, Croce CM
Title MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
Journal Reference Authors Sayed D, Abdellatif M
Title MicroRNAs in development and disease.
Journal Reference Authors Wang Q, Wang S, Wang H, Li P, Ma Z
Title MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
Journal Reference Authors Song JH, Meltzer SJ
Title MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
Journal Reference Authors Chu Y, Zhu H, Lv L, Zhou Y, Huo J
Title MiRNA s in oesophageal squamous cancer.
Journal Neth J Med 71:69-75 (2013)
Reference Authors Kan T, Meltzer SJ
Title MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
Journal Reference Authors Smith CM, Watson DI, Michael MZ, Hussey DJ
Title MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
Journal Reference Authors Song S, Ajani JA
Title The role of microRNAs in cancers of the upper gastrointestinal tract.
Journal Reference Authors Liu WH, Yeh SH, Chen PJ
Title Role of microRNAs in hepatitis B virus replication and pathogenesis.
Journal Reference Authors Hrasovec S, Glavac D
Title MicroRNAs as Novel Biomarkers in Colorectal Cancer.
Journal Reference Authors Liu H
Title MicroRNAs in breast cancer initiation and progression.
Journal Reference Authors Li SD, Zhang JR, Wang YQ, Wan XP
Title The role of microRNAs in ovarian cancer initiation and progression.
Journal Reference Authors Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
Title Characteristic patterns of microRNA expression in human bladder cancer.
Journal Reference Authors Saini S, Majid S, Dahiya R
Title Diet, microRNAs and prostate cancer.
Journal Related KO pathway LinkDB All DBs
